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The map label for this gene is sdaA2 [H]

Identifier: 34496863

GI number: 34496863

Start: 1483082

End: 1484482

Strand: Reverse

Name: sdaA2 [H]

Synonym: CV_1408

Alternate gene names: 34496863

Gene position: 1484482-1483082 (Counterclockwise)

Preceding gene: 34496864

Following gene: 34496862

Centisome position: 31.25

GC content: 65.95

Gene sequence:

>1401_bases
ATGTTCAGCATGAGCGACATCTACAAAATCGGCGTAGGCCCCTCCAGCTCCCACACCGTCGGCCCGATGAAGGCCGGCCA
CCAGTTCCTCGGCGCGCTCAAGGAAACCGGCAAGTTCAACCAGGTCAACCGCGTCCATGTCGACTGCTACGGCTCGCTCG
CCCTCACCGGCAAGGGCCACTGCACCGACCAGGCCATCATCCTCGGCCTCGCCGGCAATCTGCCCGACACCGTGGACCCG
GACGCCAGCGCCAGCCTGATCGCAGACGTGGAGCAAACCAGCCAGCTGACGCTGGGCCGCACCCACCAGCGCGTGGCCTT
CGGCATGGACTTCCACACCGCCAATCTGCCGCTGCACGAAAACGGCATGCAGATCCACGCCTTCGTCGACGACGAAAAAG
TCCTGACCAAGACCTACTATTCGATCGGCGGCGGCTTCATCGTCGACGAAGAGCACTTCAACCAGTCCAGCTGCAGCGAC
ACCCCGGTGCCCTACCATTTCGTCACCGCCCAGCAGCTGATCGACATGTGCGAGGAAACCGGCCTGTCCATCGCCGCGCT
GGTGATGGAAAACGAGAAAGCCTTCCACGACGTCAAGGACACCCAGGCCCACTTCCGCCGCGTGTGGGAAGTGATGAAGA
GCAGCATCGAGCGCGGCATGCGCACCGAAGGCAACCTGCCCGGCCCGATGCGCATCCCCCGCCGCGCGCCCGCGCTGCAC
CGGATGCTGACCAGCTCGCTCACCGTGGCCAAGGACCCGATGAGCGTGATGGACTGGGTCAATATGTACGCGATGGCGAT
GTCCGAGGAAAACGCGGCCGGCGGCCGCGTGGTCACCGCGCCGACCAACGGCGCCTGCGGCATCGTGCCGGCCGTGCTCG
CCTACTACAACCACTTCATCCAGCCGCTGGACGACGACAGCTGCCTGCGCTTCTTCCTGTCCTCCGGCGCCATCGGCTGC
CTGTTCAAGCTGAACGCGTCGATCTCCGGCGCCGAAGTCGGCTGCCAGGGCGAGGTGGGCGTCGCCTGTTCGATGGCGGC
CGCCGGCCTGACCGAACTGATGGGCGGCAGCCCGTCCCAGGTATGCATGGCGGCCGAGATCGCCATGGAGCACAACCTGG
GCCTGACTTGCGACCCGGTGGGCGGCCAGGTGCAGATCCCCTGCATCGAGCGCAACGCCATCGCCGCGGTCAAGGCCATC
AACGCCGCCCGCATGGCCATGCACCGCGTCAGCAGCCCCAAGGTGTCGCTGGACAAGGTGATCGCCGCGATGTACGAAAC
CGGCAAGGACATGGACGCCAAGTACCGCGAAACCTCCTGCGGCGGCCTCGCGCTGCAGATCAAGGCGGAAAACAAGGTGG
TGCCGACCCAGGCCATCCGCTGGATCGACGACGCGGCCTGA

Upstream 100 bases:

>100_bases
GCCGGGCCCTCCGGAATCGCCCCCACTCACGTGTCGGCAGCCTGACAGGCCGCGGATCGCGCCTGTCTTCCCGCCGCACC
CGCTTCAAAGAGGCAGCATC

Downstream 100 bases:

>100_bases
GCCCGCGAGTTCCCATCGACGCCGCCGGATTTCCGGCGGCGTTTTTGCATGTGGCGCGAATGGCCACACGGCGCAAGCTC
CGCCCAGTCTAACTCTCCAG

Product: L-serine dehydratase

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MFSMSDIYKIGVGPSSSHTVGPMKAGHQFLGALKETGKFNQVNRVHVDCYGSLALTGKGHCTDQAIILGLAGNLPDTVDP
DASASLIADVEQTSQLTLGRTHQRVAFGMDFHTANLPLHENGMQIHAFVDDEKVLTKTYYSIGGGFIVDEEHFNQSSCSD
TPVPYHFVTAQQLIDMCEETGLSIAALVMENEKAFHDVKDTQAHFRRVWEVMKSSIERGMRTEGNLPGPMRIPRRAPALH
RMLTSSLTVAKDPMSVMDWVNMYAMAMSEENAAGGRVVTAPTNGACGIVPAVLAYYNHFIQPLDDDSCLRFFLSSGAIGC
LFKLNASISGAEVGCQGEVGVACSMAAAGLTELMGGSPSQVCMAAEIAMEHNLGLTCDPVGGQVQIPCIERNAIAAVKAI
NAARMAMHRVSSPKVSLDKVIAAMYETGKDMDAKYRETSCGGLALQIKAENKVVPTQAIRWIDDAA

Sequences:

>Translated_466_residues
MFSMSDIYKIGVGPSSSHTVGPMKAGHQFLGALKETGKFNQVNRVHVDCYGSLALTGKGHCTDQAIILGLAGNLPDTVDP
DASASLIADVEQTSQLTLGRTHQRVAFGMDFHTANLPLHENGMQIHAFVDDEKVLTKTYYSIGGGFIVDEEHFNQSSCSD
TPVPYHFVTAQQLIDMCEETGLSIAALVMENEKAFHDVKDTQAHFRRVWEVMKSSIERGMRTEGNLPGPMRIPRRAPALH
RMLTSSLTVAKDPMSVMDWVNMYAMAMSEENAAGGRVVTAPTNGACGIVPAVLAYYNHFIQPLDDDSCLRFFLSSGAIGC
LFKLNASISGAEVGCQGEVGVACSMAAAGLTELMGGSPSQVCMAAEIAMEHNLGLTCDPVGGQVQIPCIERNAIAAVKAI
NAARMAMHRVSSPKVSLDKVIAAMYETGKDMDAKYRETSCGGLALQIKAENKVVPTQAIRWIDDAA
>Mature_466_residues
MFSMSDIYKIGVGPSSSHTVGPMKAGHQFLGALKETGKFNQVNRVHVDCYGSLALTGKGHCTDQAIILGLAGNLPDTVDP
DASASLIADVEQTSQLTLGRTHQRVAFGMDFHTANLPLHENGMQIHAFVDDEKVLTKTYYSIGGGFIVDEEHFNQSSCSD
TPVPYHFVTAQQLIDMCEETGLSIAALVMENEKAFHDVKDTQAHFRRVWEVMKSSIERGMRTEGNLPGPMRIPRRAPALH
RMLTSSLTVAKDPMSVMDWVNMYAMAMSEENAAGGRVVTAPTNGACGIVPAVLAYYNHFIQPLDDDSCLRFFLSSGAIGC
LFKLNASISGAEVGCQGEVGVACSMAAAGLTELMGGSPSQVCMAAEIAMEHNLGLTCDPVGGQVQIPCIERNAIAAVKAI
NAARMAMHRVSSPKVSLDKVIAAMYETGKDMDAKYRETSCGGLALQIKAENKVVPTQAIRWIDDAA

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=454, Percent_Identity=65.8590308370044, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=453, Percent_Identity=64.2384105960265, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI48994925, Length=451, Percent_Identity=62.7494456762749, Blast_Score=582, Evalue=1e-167,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 50051; Mature: 50051

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSMSDIYKIGVGPSSSHTVGPMKAGHQFLGALKETGKFNQVNRVHVDCYGSLALTGKGH
CCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCC
CTDQAIILGLAGNLPDTVDPDASASLIADVEQTSQLTLGRTHQRVAFGMDFHTANLPLHE
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCEEECCCCCCC
NGMQIHAFVDDEKVLTKTYYSIGGGFIVDEEHFNQSSCSDTPVPYHFVTAQQLIDMCEET
CCCEEEEEECCCHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHC
GLSIAALVMENEKAFHDVKDTQAHFRRVWEVMKSSIERGMRTEGNLPGPMRIPRRAPALH
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
RMLTSSLTVAKDPMSVMDWVNMYAMAMSEENAAGGRVVTAPTNGACGIVPAVLAYYNHFI
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHC
QPLDDDSCLRFFLSSGAIGCLFKLNASISGAEVGCQGEVGVACSMAAAGLTELMGGSPSQ
CCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHH
VCMAAEIAMEHNLGLTCDPVGGQVQIPCIERNAIAAVKAINAARMAMHRVSSPKVSLDKV
HHHHHHHHHHCCCCEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IAAMYETGKDMDAKYRETSCGGLALQIKAENKVVPTQAIRWIDDAA
HHHHHHCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MFSMSDIYKIGVGPSSSHTVGPMKAGHQFLGALKETGKFNQVNRVHVDCYGSLALTGKGH
CCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCC
CTDQAIILGLAGNLPDTVDPDASASLIADVEQTSQLTLGRTHQRVAFGMDFHTANLPLHE
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCEEECCCCCCC
NGMQIHAFVDDEKVLTKTYYSIGGGFIVDEEHFNQSSCSDTPVPYHFVTAQQLIDMCEET
CCCEEEEEECCCHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHC
GLSIAALVMENEKAFHDVKDTQAHFRRVWEVMKSSIERGMRTEGNLPGPMRIPRRAPALH
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
RMLTSSLTVAKDPMSVMDWVNMYAMAMSEENAAGGRVVTAPTNGACGIVPAVLAYYNHFI
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHC
QPLDDDSCLRFFLSSGAIGCLFKLNASISGAEVGCQGEVGVACSMAAAGLTELMGGSPSQ
CCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHH
VCMAAEIAMEHNLGLTCDPVGGQVQIPCIERNAIAAVKAINAARMAMHRVSSPKVSLDKV
HHHHHHHHHHCCCCEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IAAMYETGKDMDAKYRETSCGGLALQIKAENKVVPTQAIRWIDDAA
HHHHHHCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]