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The map label for this gene is guaB [H]

Identifier: 34496758

GI number: 34496758

Start: 1372814

End: 1374277

Strand: Reverse

Name: guaB [H]

Synonym: CV_1303

Alternate gene names: 34496758

Gene position: 1374277-1372814 (Counterclockwise)

Preceding gene: 34496767

Following gene: 34496755

Centisome position: 28.93

GC content: 65.98

Gene sequence:

>1464_bases
ATGCGCATCATCGAGAAAGCCTACACCTTCGACGACGTCCTCCTCGTCCCGGCCCATTCTGAAGTTCTGCCGCGCGATGT
AGCGCTCAGCACCAAACTCACCCGCAACATCACGCTCAATCTGCCGCTGGTTTCCGCCGCCATGGACACCGTGACCGAAG
CCCGCCTCGCCATCGCCATGGCCCAGGAAGGCGGCATCGGCATCGTGCACAAGAACATGAGCGTGGAAAAGCAGGCGGCC
GAGGTTTCCAAGGTGAAGCGCCATGAAAGCGGCGTGGTGAAAGACCCGATCACCATCGCGCCGGACATGCTGGTGCGCGA
CCTGGTCCTGCTGACCCGCCAGTACAAGATTTCCGGCCTACCGGTGATCGAAGCCGGCAAGGTGGTGGGCATCGTCACCA
ACCGCGACCTGCGCTTTGAAACCCGCCTCGACCAGACCGTCGGCTCCATCATGACCCCGCGCGAGCGCCTGATCACCGTC
AAGGAAGGCGCCAGCATCGACGAAGCCCGCGAGCTGATGCACACCCACCGCCTCGAGCGCGTGCTGGTGATCAACGACGC
CTGGGAGCTAAAGGGCCTGATCACGGTCAAGGACATCATCAAGACCAGCGAACATCCGAACGCCAATAAGGACAGCCAGG
GCCGCCTGCGCGTCGGCGCGGCGGTCGGCACCGGCGCCGACACCGAAGAGCGCGTCAAGGCGCTGGTTGCCGCCGGCGTA
GACGTGATCGTGGTCGACACCGCCCACGGCCACAGCCAGGGCGTGCTGGAACGCGTGCGCTGGGTCAAGCAGAACTTCCC
GCAAGTGGACGTGATCGGCGGCAACATCGCCACCGCCCAGGCGGCGCTGGATCTGGTCAAGGCCGGCGCCGACGGCGTCA
AGGTCGGCATCGGCCCCGGCTCGATCTGCACCACCCGCATCGTCGCCGGCGTGGGCGTGCCGCAACTGACCGCCATCCAC
AATGTGTCCGAAGCGCTGAAGGGCACCGGCGTGCCGATGATCGCCGACGGCGGCATCCGCTTCTCCGGCGACATCGCCAA
GGCGCTGGCGGCCGGCGGCAACGCGGTAATGCTGGGCGGCATGTTCGCCGGCACCGAGGAAGCCCCGGGCGAGGTGGAAC
TGTTCCAGGGCCGTTCGTACAAGTCCTACCGCGGCATGGGTTCGCTGGGCGCGATGAGCCAGGGTTCGGCCGACCGCTAC
TTCCAGGAAAGCTCCAACGCCGCCGACAAGTTCGTGCCGGAAGGCATCGAAGGCCGCGTGCCGTACAAGGGCCCGATCGC
CCAAGTGATCCACCAGCTGGTGGGCGGCCTGCGCTCGTCGATGGGCTACCTCGGCTGCCCGAGCATCGACCAACTGCACC
AGAAGGCCCAATTCGTCGAGATCACCTCGGCCGGCATCCGCGAATCCCACGTCCACGACGTGCAGATCACCAAGGAAGCG
CCGAACTACCACGTGGAGCGCTAA

Upstream 100 bases:

>100_bases
TAAAGCCTGCCCTCCAGCCGCGCAAAAAGCCGCGTCACGCCGCTTTTGCAGAAAAGTCGACGGTTCGGTATAATGCGGCT
TTGCCGCCTAAGGAAATGCG

Downstream 100 bases:

>100_bases
GGCGCCTTCCGCTGGAAGCGAAAAAGCCCGCGTTGCGCAACGCGGGCTTTTTTTCGCGCCGGCCGATCAGGCCAGCGACA
GCAGCAACAAGGTTTTCAGC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MRIIEKAYTFDDVLLVPAHSEVLPRDVALSTKLTRNITLNLPLVSAAMDTVTEARLAIAMAQEGGIGIVHKNMSVEKQAA
EVSKVKRHESGVVKDPITIAPDMLVRDLVLLTRQYKISGLPVIEAGKVVGIVTNRDLRFETRLDQTVGSIMTPRERLITV
KEGASIDEARELMHTHRLERVLVINDAWELKGLITVKDIIKTSEHPNANKDSQGRLRVGAAVGTGADTEERVKALVAAGV
DVIVVDTAHGHSQGVLERVRWVKQNFPQVDVIGGNIATAQAALDLVKAGADGVKVGIGPGSICTTRIVAGVGVPQLTAIH
NVSEALKGTGVPMIADGGIRFSGDIAKALAAGGNAVMLGGMFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMSQGSADRY
FQESSNAADKFVPEGIEGRVPYKGPIAQVIHQLVGGLRSSMGYLGCPSIDQLHQKAQFVEITSAGIRESHVHDVQITKEA
PNYHVER

Sequences:

>Translated_487_residues
MRIIEKAYTFDDVLLVPAHSEVLPRDVALSTKLTRNITLNLPLVSAAMDTVTEARLAIAMAQEGGIGIVHKNMSVEKQAA
EVSKVKRHESGVVKDPITIAPDMLVRDLVLLTRQYKISGLPVIEAGKVVGIVTNRDLRFETRLDQTVGSIMTPRERLITV
KEGASIDEARELMHTHRLERVLVINDAWELKGLITVKDIIKTSEHPNANKDSQGRLRVGAAVGTGADTEERVKALVAAGV
DVIVVDTAHGHSQGVLERVRWVKQNFPQVDVIGGNIATAQAALDLVKAGADGVKVGIGPGSICTTRIVAGVGVPQLTAIH
NVSEALKGTGVPMIADGGIRFSGDIAKALAAGGNAVMLGGMFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMSQGSADRY
FQESSNAADKFVPEGIEGRVPYKGPIAQVIHQLVGGLRSSMGYLGCPSIDQLHQKAQFVEITSAGIRESHVHDVQITKEA
PNYHVER
>Mature_487_residues
MRIIEKAYTFDDVLLVPAHSEVLPRDVALSTKLTRNITLNLPLVSAAMDTVTEARLAIAMAQEGGIGIVHKNMSVEKQAA
EVSKVKRHESGVVKDPITIAPDMLVRDLVLLTRQYKISGLPVIEAGKVVGIVTNRDLRFETRLDQTVGSIMTPRERLITV
KEGASIDEARELMHTHRLERVLVINDAWELKGLITVKDIIKTSEHPNANKDSQGRLRVGAAVGTGADTEERVKALVAAGV
DVIVVDTAHGHSQGVLERVRWVKQNFPQVDVIGGNIATAQAALDLVKAGADGVKVGIGPGSICTTRIVAGVGVPQLTAIH
NVSEALKGTGVPMIADGGIRFSGDIAKALAAGGNAVMLGGMFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMSQGSADRY
FQESSNAADKFVPEGIEGRVPYKGPIAQVIHQLVGGLRSSMGYLGCPSIDQLHQKAQFVEITSAGIRESHVHDVQITKEA
PNYHVER

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=452, Percent_Identity=42.2566371681416, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI34328930, Length=452, Percent_Identity=42.2566371681416, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI156616279, Length=452, Percent_Identity=42.2566371681416, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI34328928, Length=452, Percent_Identity=42.2566371681416, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=40.3326403326403, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI217035152, Length=449, Percent_Identity=42.3162583518931, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI217035148, Length=452, Percent_Identity=41.3716814159292, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI217035150, Length=452, Percent_Identity=39.1592920353982, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=36.2595419847328, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI50541956, Length=266, Percent_Identity=36.4661654135338, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI50541954, Length=266, Percent_Identity=36.4661654135338, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI50541952, Length=266, Percent_Identity=36.4661654135338, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI50541948, Length=266, Percent_Identity=36.4661654135338, Blast_Score=172, Evalue=9e-43,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=64.4897959183673, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1786293, Length=237, Percent_Identity=34.1772151898734, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=474, Percent_Identity=37.7637130801688, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=40, Blast_Score=282, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=34.7280334728033, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=39.3374741200828, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.1393442622951, Blast_Score=343, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=39.1304347826087, Blast_Score=334, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=336, Percent_Identity=38.3928571428571, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=42.8571428571429, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=40.4166666666667, Blast_Score=344, Evalue=8e-95,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=40.4166666666667, Blast_Score=344, Evalue=8e-95,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=40.5895691609977, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52050; Mature: 52050

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIEKAYTFDDVLLVPAHSEVLPRDVALSTKLTRNITLNLPLVSAAMDTVTEARLAIAM
CCCHHHHCCCCCEEEEECCCCCCCCHHHHHHEEECEEEEECCHHHHHHHHHHHHHHEEEE
AQEGGIGIVHKNMSVEKQAAEVSKVKRHESGVVKDPITIAPDMLVRDLVLLTRQYKISGL
ECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
PVIEAGKVVGIVTNRDLRFETRLDQTVGSIMTPRERLITVKEGASIDEARELMHTHRLER
CEEECCCEEEEEECCCEEEHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHCE
VLVINDAWELKGLITVKDIIKTSEHPNANKDSQGRLRVGAAVGTGADTEERVKALVAAGV
EEEEECCHHHCEEEEHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCC
DVIVVDTAHGHSQGVLERVRWVKQNFPQVDVIGGNIATAQAALDLVKAGADGVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQLTAIHNVSEALKGTGVPMIADGGIRFSGDIAKALAAGGNAVMLGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCCEEEEEE
MFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMSQGSADRYFQESSNAADKFVPEGIEGRV
EECCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCC
PYKGPIAQVIHQLVGGLRSSMGYLGCPSIDQLHQKAQFVEITSAGIRESHVHDVQITKEA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEHHCCCCCCCCEEEEEEECC
PNYHVER
CCCCCCC
>Mature Secondary Structure
MRIIEKAYTFDDVLLVPAHSEVLPRDVALSTKLTRNITLNLPLVSAAMDTVTEARLAIAM
CCCHHHHCCCCCEEEEECCCCCCCCHHHHHHEEECEEEEECCHHHHHHHHHHHHHHEEEE
AQEGGIGIVHKNMSVEKQAAEVSKVKRHESGVVKDPITIAPDMLVRDLVLLTRQYKISGL
ECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
PVIEAGKVVGIVTNRDLRFETRLDQTVGSIMTPRERLITVKEGASIDEARELMHTHRLER
CEEECCCEEEEEECCCEEEHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHCE
VLVINDAWELKGLITVKDIIKTSEHPNANKDSQGRLRVGAAVGTGADTEERVKALVAAGV
EEEEECCHHHCEEEEHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCC
DVIVVDTAHGHSQGVLERVRWVKQNFPQVDVIGGNIATAQAALDLVKAGADGVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQLTAIHNVSEALKGTGVPMIADGGIRFSGDIAKALAAGGNAVMLGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCCEEEEEE
MFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMSQGSADRYFQESSNAADKFVPEGIEGRV
EECCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCC
PYKGPIAQVIHQLVGGLRSSMGYLGCPSIDQLHQKAQFVEITSAGIRESHVHDVQITKEA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEHHCCCCCCCCEEEEEEECC
PNYHVER
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA