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The map label for this gene is betA [H]

Identifier: 34496755

GI number: 34496755

Start: 1369148

End: 1370800

Strand: Reverse

Name: betA [H]

Synonym: CV_1300

Alternate gene names: 34496755

Gene position: 1370800-1369148 (Counterclockwise)

Preceding gene: 34496758

Following gene: 34496754

Centisome position: 28.85

GC content: 69.69

Gene sequence:

>1653_bases
ATGCTCAGCGGAGAATTCGACTACATCATCGTCGGCGCCGGCAGCGCCGGCTGCCTGCTGGCCAACCGCCTGTCCGCGGA
TCCGGACAAGCGCGTGCTGCTGCTGGAAGCCGGCGGCAAGGACGACTACCCGTGGATACACATCCCGGTCGGCTACCTGT
TCTGCATCGGCAACCCGCGCACCGACTGGTGCTACCGCACCGCGCCGGAAAATGGGCTGGGCGGCCGCTCGCTCGGCTAT
CCGCGCGGCCGGGTGCTGGGCGGCTCATCCTCGATCAACGGCATGATCTACATGCGCGGCCAGGCGGCCGATTACGACGG
CTGGGAGGCGCTCGGCAACGCCGGCTGGGGCTGGCGCGACGTGCTGCCGCACTTCGTCTCGATGGAAGACCATTACGACG
CGGACCGCCCTCTGCACGGGCACGGCGGCGAATGGCGGGTGGAGAAGCAGCGGCTGTCTTGGGAAATCCTGGACGCCTTC
CGCGCCGCCGCCGCCGAACAGGGCATCGCGCCGGTGGAGGACTTCAATACCGGCGACAACGCCGGCTGCGGCTATTTCGA
AGTCAATCAAAAGGGCGGCTGGCGCTGGAGCAGCGCCCGCGCCTTCCTGCATCCCGTCCGCCGTCGCGGCAACCTGACGG
TGCTGACCGGCGCGGAAGCCGACAGGCTGATCCTGGAGCGCGGCCGCGCCGCCGCCATCGCATTTATGCAACACGGCCGC
CGGCGGCAGGCGCGCTGCCGCGGCGAGATCATCCTCGCCGCCGGCGCGATCGGCTCGCCGCTGTTGCTGCAGCGCAGCGG
CATCGGTCCGGCGCCCTTGCTGGCAAGCCACGGCATCGAACCGCTGCGCATCCTGCCCGGCGTGGGCGCCAATCTGCAGG
ACCACCTGCAGCTGAGAATGATATTCAAGGTGCAGGGCGCGGCCACGCTGAACCGGCGCGCGGCGAGCTGGAGCGGCAAG
CTGGCGATGGCCTGGGAGTATCTGTGGAAGCGCAGCGGCCCGCTGTCTATGGCGCCCAGCCAGCTCGGCGTCTTCGCTCG
CAGCGGGCCGGACGCCGCCCATCCTGACCTGGAATACCACGTGCAGCCGCTGTCGCTTGAACGCTTCGGCGAACCGCTGC
ACCCCTTCCCCGCCTTCACCGCCTCGGTATGCCAGCTGAGGCCGGCCAGCCGCGGCCAGGTGGCGATAGGCGGCGCCGAT
CCGTCCGCCGCGCCGCTTATCCAGCCCAACTACCTCAGCGCCCCGGAAGACCTGCGCGCCGCAGCGGCGGCCATCCGGCT
GACCCGTCGCATCGCCGCGTCTCCGGCGCTCTCGCGCTACCTTCCGGAAGAATACCGGCCCGGCCTGCAGTACCAGAGCG
ACAGCGAGCTGGCGGAAGCCGCCGCCCTGATCGGCACCACCATCTTCCACCCAGTCGGCACCTGCAAGATGGGACGCGAC
GCGCTGGCGGTGGTCGACGACAGGCTGCGGGTGCATGGCGTCGCCGGCCTCAGGGTGGCCGACGCGTCCATCATGCCCGC
CATCACCTCCGGCAACACCAACAGCCCCACGCTGATGATCGCCGCCAAGGCGGCGCAGATGATCGCGCAGGACAACAAGC
AAGCGGGACCGATACGAACGCCCGCTCCACCCGAAAAGGAGACCTGGACATGA

Upstream 100 bases:

>100_bases
TTAAAAAATTAACATAGGTTGTTTTCCGCTGGCTATTCCCAGCCGGGCGCGCTTCGGTTTAGATACCGGTTAAGACAACG
ACATGAGCAGACCACGCACC

Downstream 100 bases:

>100_bases
GCAACAGCATCGCATCGACGACGACGTCGGCCGGCATCAGCCGCGCCGAACGCAAGGTGATACTCGCCTCGTCGCTCGGC
ACGGTATTCGAGTGGTACGA

Product: glucose-methanol-choline oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MLSGEFDYIIVGAGSAGCLLANRLSADPDKRVLLLEAGGKDDYPWIHIPVGYLFCIGNPRTDWCYRTAPENGLGGRSLGY
PRGRVLGGSSSINGMIYMRGQAADYDGWEALGNAGWGWRDVLPHFVSMEDHYDADRPLHGHGGEWRVEKQRLSWEILDAF
RAAAAEQGIAPVEDFNTGDNAGCGYFEVNQKGGWRWSSARAFLHPVRRRGNLTVLTGAEADRLILERGRAAAIAFMQHGR
RRQARCRGEIILAAGAIGSPLLLQRSGIGPAPLLASHGIEPLRILPGVGANLQDHLQLRMIFKVQGAATLNRRAASWSGK
LAMAWEYLWKRSGPLSMAPSQLGVFARSGPDAAHPDLEYHVQPLSLERFGEPLHPFPAFTASVCQLRPASRGQVAIGGAD
PSAAPLIQPNYLSAPEDLRAAAAAIRLTRRIAASPALSRYLPEEYRPGLQYQSDSELAEAAALIGTTIFHPVGTCKMGRD
ALAVVDDRLRVHGVAGLRVADASIMPAITSGNTNSPTLMIAAKAAQMIAQDNKQAGPIRTPAPPEKETWT

Sequences:

>Translated_550_residues
MLSGEFDYIIVGAGSAGCLLANRLSADPDKRVLLLEAGGKDDYPWIHIPVGYLFCIGNPRTDWCYRTAPENGLGGRSLGY
PRGRVLGGSSSINGMIYMRGQAADYDGWEALGNAGWGWRDVLPHFVSMEDHYDADRPLHGHGGEWRVEKQRLSWEILDAF
RAAAAEQGIAPVEDFNTGDNAGCGYFEVNQKGGWRWSSARAFLHPVRRRGNLTVLTGAEADRLILERGRAAAIAFMQHGR
RRQARCRGEIILAAGAIGSPLLLQRSGIGPAPLLASHGIEPLRILPGVGANLQDHLQLRMIFKVQGAATLNRRAASWSGK
LAMAWEYLWKRSGPLSMAPSQLGVFARSGPDAAHPDLEYHVQPLSLERFGEPLHPFPAFTASVCQLRPASRGQVAIGGAD
PSAAPLIQPNYLSAPEDLRAAAAAIRLTRRIAASPALSRYLPEEYRPGLQYQSDSELAEAAALIGTTIFHPVGTCKMGRD
ALAVVDDRLRVHGVAGLRVADASIMPAITSGNTNSPTLMIAAKAAQMIAQDNKQAGPIRTPAPPEKETWT
>Mature_550_residues
MLSGEFDYIIVGAGSAGCLLANRLSADPDKRVLLLEAGGKDDYPWIHIPVGYLFCIGNPRTDWCYRTAPENGLGGRSLGY
PRGRVLGGSSSINGMIYMRGQAADYDGWEALGNAGWGWRDVLPHFVSMEDHYDADRPLHGHGGEWRVEKQRLSWEILDAF
RAAAAEQGIAPVEDFNTGDNAGCGYFEVNQKGGWRWSSARAFLHPVRRRGNLTVLTGAEADRLILERGRAAAIAFMQHGR
RRQARCRGEIILAAGAIGSPLLLQRSGIGPAPLLASHGIEPLRILPGVGANLQDHLQLRMIFKVQGAATLNRRAASWSGK
LAMAWEYLWKRSGPLSMAPSQLGVFARSGPDAAHPDLEYHVQPLSLERFGEPLHPFPAFTASVCQLRPASRGQVAIGGAD
PSAAPLIQPNYLSAPEDLRAAAAAIRLTRRIAASPALSRYLPEEYRPGLQYQSDSELAEAAALIGTTIFHPVGTCKMGRD
ALAVVDDRLRVHGVAGLRVADASIMPAITSGNTNSPTLMIAAKAAQMIAQDNKQAGPIRTPAPPEKETWT

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=533, Percent_Identity=40.3377110694184, Blast_Score=367, Evalue=1e-101,
Organism=Escherichia coli, GI1786503, Length=532, Percent_Identity=38.7218045112782, Blast_Score=334, Evalue=8e-93,
Organism=Caenorhabditis elegans, GI17532301, Length=552, Percent_Identity=35.6884057971014, Blast_Score=350, Evalue=8e-97,
Organism=Drosophila melanogaster, GI24642042, Length=594, Percent_Identity=35.6902356902357, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI45551458, Length=570, Percent_Identity=35.0877192982456, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI45549471, Length=570, Percent_Identity=35.0877192982456, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24642055, Length=573, Percent_Identity=35.0785340314136, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24642039, Length=581, Percent_Identity=36.4888123924269, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24642048, Length=609, Percent_Identity=33.6617405582923, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI18859995, Length=569, Percent_Identity=35.676625659051, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI17137792, Length=559, Percent_Identity=35.0626118067979, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24642059, Length=572, Percent_Identity=34.0909090909091, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24650267, Length=568, Percent_Identity=33.2746478873239, Blast_Score=275, Evalue=8e-74,
Organism=Drosophila melanogaster, GI24642051, Length=571, Percent_Identity=32.9246935201401, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI18859993, Length=567, Percent_Identity=33.8624338624339, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24642037, Length=569, Percent_Identity=33.3919156414763, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24642035, Length=304, Percent_Identity=37.171052631579, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24642057, Length=583, Percent_Identity=29.8456260720412, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24645930, Length=578, Percent_Identity=29.757785467128, Blast_Score=159, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 59402; Mature: 59402

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSGEFDYIIVGAGSAGCLLANRLSADPDKRVLLLEAGGKDDYPWIHIPVGYLFCIGNPR
CCCCCCCEEEEECCCCCCHHHHCCCCCCCCEEEEEECCCCCCCCEEEEECEEEEEECCCC
TDWCYRTAPENGLGGRSLGYPRGRVLGGSSSINGMIYMRGQAADYDGWEALGNAGWGWRD
CCCEEECCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHH
VLPHFVSMEDHYDADRPLHGHGGEWRVEKQRLSWEILDAFRAAAAEQGIAPVEDFNTGDN
HHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AGCGYFEVNQKGGWRWSSARAFLHPVRRRGNLTVLTGAEADRLILERGRAAAIAFMQHGR
CCCCEEEECCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCHHHHHHHHCCC
RRQARCRGEIILAAGAIGSPLLLQRSGIGPAPLLASHGIEPLRILPGVGANLQDHLQLRM
HHHHHCCCCEEEEECCCCCCEEEEECCCCCCCHHHHCCCCCEEECCCCCCCHHHHEEEEE
IFKVQGAATLNRRAASWSGKLAMAWEYLWKRSGPLSMAPSQLGVFARSGPDAAHPDLEYH
EEEECCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHCEEECCCCCCCCCCCEEE
VQPLSLERFGEPLHPFPAFTASVCQLRPASRGQVAIGGADPSAAPLIQPNYLSAPEDLRA
EECEEHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHH
AAAAIRLTRRIAASPALSRYLPEEYRPGLQYQSDSELAEAAALIGTTIFHPVGTCKMGRD
HHHHHHHHHHHHCCHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
ALAVVDDRLRVHGVAGLRVADASIMPAITSGNTNSPTLMIAAKAAQMIAQDNKQAGPIRT
HHHHHHCCEEEEEECCEEEECCCCCEEEECCCCCCCEEEEEHHHHHHHHHCCCCCCCCCC
PAPPEKETWT
CCCCCCCCCC
>Mature Secondary Structure
MLSGEFDYIIVGAGSAGCLLANRLSADPDKRVLLLEAGGKDDYPWIHIPVGYLFCIGNPR
CCCCCCCEEEEECCCCCCHHHHCCCCCCCCEEEEEECCCCCCCCEEEEECEEEEEECCCC
TDWCYRTAPENGLGGRSLGYPRGRVLGGSSSINGMIYMRGQAADYDGWEALGNAGWGWRD
CCCEEECCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHH
VLPHFVSMEDHYDADRPLHGHGGEWRVEKQRLSWEILDAFRAAAAEQGIAPVEDFNTGDN
HHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AGCGYFEVNQKGGWRWSSARAFLHPVRRRGNLTVLTGAEADRLILERGRAAAIAFMQHGR
CCCCEEEECCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCHHHHHHHHCCC
RRQARCRGEIILAAGAIGSPLLLQRSGIGPAPLLASHGIEPLRILPGVGANLQDHLQLRM
HHHHHCCCCEEEEECCCCCCEEEEECCCCCCCHHHHCCCCCEEECCCCCCCHHHHEEEEE
IFKVQGAATLNRRAASWSGKLAMAWEYLWKRSGPLSMAPSQLGVFARSGPDAAHPDLEYH
EEEECCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHCEEECCCCCCCCCCCEEE
VQPLSLERFGEPLHPFPAFTASVCQLRPASRGQVAIGGADPSAAPLIQPNYLSAPEDLRA
EECEEHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHH
AAAAIRLTRRIAASPALSRYLPEEYRPGLQYQSDSELAEAAALIGTTIFHPVGTCKMGRD
HHHHHHHHHHHHCCHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
ALAVVDDRLRVHGVAGLRVADASIMPAITSGNTNSPTLMIAAKAAQMIAQDNKQAGPIRT
HHHHHHCCEEEEEECCEEEECCCCCEEEECCCCCCCEEEEEHHHHHHHHHCCCCCCCCCC
PAPPEKETWT
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11390693 [H]