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The map label for this gene is ilvD

Identifier: 34496732

GI number: 34496732

Start: 1342943

End: 1344799

Strand: Direct

Name: ilvD

Synonym: CV_1277

Alternate gene names: 34496732

Gene position: 1342943-1344799 (Clockwise)

Preceding gene: 34496727

Following gene: 34496736

Centisome position: 28.27

GC content: 68.01

Gene sequence:

>1857_bases
ATGCCTCAATACCGCTCCCGCACTTCCACCGCCGGCCGCAACATGGCGGGTGCCCGCGCGCTATGGCGCGCCACCGGGAT
GACCGACGCCGACTTCGGCAAGCCCATCATCGCCATCGCCAACTCCTTCACCCAGTTCGTGCCCGGCCACGTGCACCTGC
AGAACATGGGCCAGCTGGTGGCGCGCGAGATCGAAAAAGCCGGCGGCGTCGCCAAGGAATTCAACACCATCGCCATCGAC
GACGGCATCGCGATGGGCCACGGCGGCATGCTGTACAGCCTGCCTTCCCGCGACCTGATCGCCGACAGCGTCGAGTACAT
GGTCAACGCCCACTGCGCCGACGCGCTGGTGTGCATCTCCAACTGCGACAAGATCACCCCCGGCATGCTGATGGCGGCGA
TGCGGCTCAACATTCCGGTGGTGTTCGTCTCCGGCGGGCCGATGGAGGCCGGCAAGGTGCAGTGGGGCAACGAAGTGCGC
AAGCTGGACCTGGTGGACGCGATGGTGGAGGCCGCCAACAGCGCGGTGTCCGACGCCGACGTCGACCGCGTCGAGCGCTC
AGCCTGTCCGACCTGCGGCTCCTGCTCCGGCATGTTCACCGCGAACTCGATGAATTGCCTGACCGAGGCGCTGGGCCTCA
GCCTGCCCGGCAACGGCAGCCTGGTGGCCACCCACGCGGACCGGAAAGAATTGTTCCTCAAGGCCGGCCGCCTGATCGTC
GAATTGGCCAAGCGCCATTACGAGGGCGAGGACTATTCCATCCTGCCGCGCGGCATCGCCACCAAACAGGCCTTCGAGAA
CGCGATGAGCCTGGACGTGGCGATGGGCGGCTCCACCAATACCGTGCTGCACCTGTTGGCCGCCGCCAGCGAGGCCGGCG
TGGACTTCAAGATGGCCGACATCGACCGCATCAGCCGCGGCGTGCCCTGCCTGTCCAAGGTGGCGCCGGCGACGCAAAAA
TACCATATGGAGGACGTGCACCGCGCCGGCGGCGTGATCGGCATCCTGGCCGAGCTGGACCGCGCCGGCCTGATCCACCG
CGACGTCGCCACCGTGCACAGCCCCAGCCTGGGGGCAGCCATCGAGCAGTGGGACGTGATGCGCCACGGCGAAGGCAGCG
AGCCGCACCGCCTGTTCCGCGCGGCGCCGGGCGGCGTGGCCACCACCATCGCCTTCAGCCAGAGCATGCGCTACCCGACG
CTGGACGACGACCGCGCCGACGGCTGCATCCGCGACCAGGCGCACGCCTATTCGCAGGACGGCGGCCTGGCGGTGCTGTA
TGGCAATATCGCCGAGCGCGGCTGCATCGTGAAGACAGCCGGCGTTGACGAATCGATACTGAAATTCACCGGCCGCGCCC
GCATCTTCGAAAGCCAGGACGCGGCGGTGGAAGGCATCCTCGCCGACCAGATCGTCGCCGGCGACATCGTCATCATCCGC
TACGAGGGACCGAAGGGCGGACCAGGCATGCAGGAGATGCTGTACCCGACTTCGTATCTGAAGTCCAAGGGGCTGGGCAA
GGCCTGCGCCTTGCTGACCGACGGCCGCTTCTCCGGCGGCACCTCCGGCCTGTCCATCGGCCACGCCTCGCCGGAGGCGG
CCGAGGGCGGCGCGATCGGTCTGGCGCAAGAGGGCGACACGGTGGAGATCGACATCCCTAACCGCCGCATCCATCTGGCC
GTTTCCGATGAGGAGTTGGCCAAGCGCCGCGCGGCGATGGAGGCGAAAGGCCGCGACGCCTGGAAACCGCTGGGCCGCGA
ACGGGTGGTCAGCCCGGCGCTGCGCGCCTACGCGGCGATGACCACCAGCGCCGACACCGGCGCGGTGCGCGATGTGTCGC
AAGTGGAACGCAAATAA

Upstream 100 bases:

>100_bases
CTGGTTGGTCCACCCGGCACCCGCGGATCAGCCGCCGCCAGCTTACCCTGCCGGCGTGACGGAACGGCGACCGGTTTTGT
TTACAGATCAAGGAAGCATC

Downstream 100 bases:

>100_bases
TCCGAGGTAGGGTGCCGTCACCCCGTAGGGGCGACGCACCGAATAGGAAGGGGAGGCCGAGCGCCTCCCCTTCTTCATGT
TTCCAGTTTCCAGGCGGGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MPQYRSRTSTAGRNMAGARALWRATGMTDADFGKPIIAIANSFTQFVPGHVHLQNMGQLVAREIEKAGGVAKEFNTIAID
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVQWGNEVR
KLDLVDAMVEAANSAVSDADVDRVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLVATHADRKELFLKAGRLIV
ELAKRHYEGEDYSILPRGIATKQAFENAMSLDVAMGGSTNTVLHLLAAASEAGVDFKMADIDRISRGVPCLSKVAPATQK
YHMEDVHRAGGVIGILAELDRAGLIHRDVATVHSPSLGAAIEQWDVMRHGEGSEPHRLFRAAPGGVATTIAFSQSMRYPT
LDDDRADGCIRDQAHAYSQDGGLAVLYGNIAERGCIVKTAGVDESILKFTGRARIFESQDAAVEGILADQIVAGDIVIIR
YEGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAEGGAIGLAQEGDTVEIDIPNRRIHLA
VSDEELAKRRAAMEAKGRDAWKPLGRERVVSPALRAYAAMTTSADTGAVRDVSQVERK

Sequences:

>Translated_618_residues
MPQYRSRTSTAGRNMAGARALWRATGMTDADFGKPIIAIANSFTQFVPGHVHLQNMGQLVAREIEKAGGVAKEFNTIAID
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVQWGNEVR
KLDLVDAMVEAANSAVSDADVDRVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLVATHADRKELFLKAGRLIV
ELAKRHYEGEDYSILPRGIATKQAFENAMSLDVAMGGSTNTVLHLLAAASEAGVDFKMADIDRISRGVPCLSKVAPATQK
YHMEDVHRAGGVIGILAELDRAGLIHRDVATVHSPSLGAAIEQWDVMRHGEGSEPHRLFRAAPGGVATTIAFSQSMRYPT
LDDDRADGCIRDQAHAYSQDGGLAVLYGNIAERGCIVKTAGVDESILKFTGRARIFESQDAAVEGILADQIVAGDIVIIR
YEGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAEGGAIGLAQEGDTVEIDIPNRRIHLA
VSDEELAKRRAAMEAKGRDAWKPLGRERVVSPALRAYAAMTTSADTGAVRDVSQVERK
>Mature_617_residues
PQYRSRTSTAGRNMAGARALWRATGMTDADFGKPIIAIANSFTQFVPGHVHLQNMGQLVAREIEKAGGVAKEFNTIAIDD
GIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVQWGNEVRK
LDLVDAMVEAANSAVSDADVDRVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLVATHADRKELFLKAGRLIVE
LAKRHYEGEDYSILPRGIATKQAFENAMSLDVAMGGSTNTVLHLLAAASEAGVDFKMADIDRISRGVPCLSKVAPATQKY
HMEDVHRAGGVIGILAELDRAGLIHRDVATVHSPSLGAAIEQWDVMRHGEGSEPHRLFRAAPGGVATTIAFSQSMRYPTL
DDDRADGCIRDQAHAYSQDGGLAVLYGNIAERGCIVKTAGVDESILKFTGRARIFESQDAAVEGILADQIVAGDIVIIRY
EGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAEGGAIGLAQEGDTVEIDIPNRRIHLAV
SDEELAKRRAAMEAKGRDAWKPLGRERVVSPALRAYAAMTTSADTGAVRDVSQVERK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=74.9593495934959, Blast_Score=960, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=563, Percent_Identity=31.7939609236234, Blast_Score=196, Evalue=5e-51,
Organism=Escherichia coli, GI1786464, Length=588, Percent_Identity=29.7619047619048, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1788157, Length=549, Percent_Identity=27.6867030965392, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322476, Length=609, Percent_Identity=36.7816091954023, Blast_Score=352, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_CHRVO (Q7NYJ7)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_900947.1
- GeneID:   2550877
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1277
- NMPDR:   fig|243365.1.peg.1277
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q7NYJ7
- ProtClustDB:   PRK12448
- BioCyc:   CVIO243365:CV_1277-MONOMER
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65583; Mature: 65452

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQYRSRTSTAGRNMAGARALWRATGMTDADFGKPIIAIANSFTQFVPGHVHLQNMGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHH
AREIEKAGGVAKEFNTIAIDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADALVCIS
HHHHHHHCCCHHHCCEEEEECCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVQWGNEVRKLDLVDAMVEAANSAVSDAD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCH
VDRVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLVATHADRKELFLKAGRLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ELAKRHYEGEDYSILPRGIATKQAFENAMSLDVAMGGSTNTVLHLLAAASEAGVDFKMAD
HHHHHHCCCCCCEECCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCEEEHH
IDRISRGVPCLSKVAPATQKYHMEDVHRAGGVIGILAELDRAGLIHRDVATVHSPSLGAA
HHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEHHHHHHCCCHHHHHHHHCCCCCHHH
IEQWDVMRHGEGSEPHRLFRAAPGGVATTIAFSQSMRYPTLDDDRADGCIRDQAHAYSQD
HHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCCCCCCHHHHHHHHCCC
GGLAVLYGNIAERGCIVKTAGVDESILKFTGRARIFESQDAAVEGILADQIVAGDIVIIR
CCEEEEECCCCCCCCEEEECCCCHHHHHHCCCCEEECCCCHHHHHHHHHHEEECCEEEEE
YEGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAEGGAIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEE
LAQEGDTVEIDIPNRRIHLAVSDEELAKRRAAMEAKGRDAWKPLGRERVVSPALRAYAAM
EECCCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHH
TTSADTGAVRDVSQVERK
CCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PQYRSRTSTAGRNMAGARALWRATGMTDADFGKPIIAIANSFTQFVPGHVHLQNMGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHH
AREIEKAGGVAKEFNTIAIDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADALVCIS
HHHHHHHCCCHHHCCEEEEECCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVQWGNEVRKLDLVDAMVEAANSAVSDAD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCH
VDRVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLVATHADRKELFLKAGRLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ELAKRHYEGEDYSILPRGIATKQAFENAMSLDVAMGGSTNTVLHLLAAASEAGVDFKMAD
HHHHHHCCCCCCEECCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCEEEHH
IDRISRGVPCLSKVAPATQKYHMEDVHRAGGVIGILAELDRAGLIHRDVATVHSPSLGAA
HHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEHHHHHHCCCHHHHHHHHCCCCCHHH
IEQWDVMRHGEGSEPHRLFRAAPGGVATTIAFSQSMRYPTLDDDRADGCIRDQAHAYSQD
HHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCCCCCCHHHHHHHHCCC
GGLAVLYGNIAERGCIVKTAGVDESILKFTGRARIFESQDAAVEGILADQIVAGDIVIIR
CCEEEEECCCCCCCCEEEECCCCHHHHHHCCCCEEECCCCHHHHHHHHHHEEECCEEEEE
YEGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAEGGAIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEE
LAQEGDTVEIDIPNRRIHLAVSDEELAKRRAAMEAKGRDAWKPLGRERVVSPALRAYAAM
EECCCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHH
TTSADTGAVRDVSQVERK
CCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782