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The map label for this gene is adhC [H]

Identifier: 34496195

GI number: 34496195

Start: 760802

End: 761941

Strand: Reverse

Name: adhC [H]

Synonym: CV_0740

Alternate gene names: 34496195

Gene position: 761941-760802 (Counterclockwise)

Preceding gene: 34496198

Following gene: 34496194

Centisome position: 16.04

GC content: 65.35

Gene sequence:

>1140_bases
ATGAGCCATGACATCATCCGCTGCCAGGCTGCCGTAGCCTGGGCCGCCGGCCAACCGTTGAGCATCGAAGAGATCGAGGT
GCATCCGCCCAAGGCCGGCGAGGTGCGCGTGAAGATGGTGGCCACCGGCGTCTGCCACACCGACGCCTTCACCCTGTCCG
GCGCGGACCCGGAAGGCGTGTTCCCCTGCATCCTGGGCCATGAGGGCGGCGGCGTCGTCGAATCCGTCGGCCCCGGCGTC
ACCAGCGTGGCGGTGGGCGACCACGTGATCCCGCTATACACGCCGGAATGCCGCGAGTGCAAGTTCTGCCTGTCCGGCAA
GACCAATCTGTGCCAGAAAATCCGCGCCACCCAGGGCAAGGGCCTGATGCCGGATGGCACCAGCCGCTTTTCCAAGGACG
GCAAACCGATCTACCACTACATGGGCACCTCCACCTTCAGCGAGTACACGGTGCTGCCGGAAATCTCGCTGGCCAAGGTG
AACAAGGCCGCGCCGCTGGAAGAAGTGTGCCTGCTGGGCTGCGGCGTCACCACCGGCATGGGCGCGGTGGTCAACACCGC
CAAGGTGAAGGCCGGCGACAACGTGGCCGTCTTCGGCCTGGGCGGCATCGGCCTGTCCGCCATCATCGGCGCGCGGATGG
CCGGCGCCGGCCGCATCATCGGCATCGACATCAATGAAGGCAAGTTCGAGCTGGCGAAAAAACTGGGCGCCACCGATTGC
GTCAATCCGAATGGCTTCGACAAGCCGATCCAGGACGTGATCGTGGAAATGACCGACGGCGGCGTCGATTTCTCCTTCGA
GTGCATCGGCAACGTCAAGGTGATGCGCGCGGCGCTGGAATGCTGCCACAAGGGCTGGGGCGAATCGGTGATCATCGGCG
TGGCCGGCGCCGGGCAGGAAATCTCCACCCGTCCGTTCCAGCTGGTCACCGGCCGGGTATGGCGCGGCTCCGCCTTCGGC
GGCGTGCGCGGCCGCACCGAGCTGCCGGAATACGTGGAGCGCTATCTGAAAGGCGAATTCCGCCTGGACGACTTCATCAC
CCATACCATGCCGCTGGAGCGCGTCAACGAAGCCTTCGACCTGATGCATGAAGGCAAGAGCATACGCTCCGTCATCCATT
ACGCGGCGGAGCCGGCATGA

Upstream 100 bases:

>100_bases
GAAAAAATCATTTACCAATTCAGCCGATTATCGATAACCGGCAAAAAAATACAATGGTTGATTACCCTAGAGAACCGTCA
ATGCGAACAAGGAGTCGCCG

Downstream 100 bases:

>100_bases
ACGGGCTGCAGAAAATCGCCGACAGCCTGGCTTTCGGCGGCCGCCAGCAGCAGTGGCTGCACGATTCGGAAACGCTCTGC
TGCCGGATGCGCTTCAGCGT

Product: alcohol dehydrogenase class III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSHDIIRCQAAVAWAAGQPLSIEEIEVHPPKAGEVRVKMVATGVCHTDAFTLSGADPEGVFPCILGHEGGGVVESVGPGV
TSVAVGDHVIPLYTPECRECKFCLSGKTNLCQKIRATQGKGLMPDGTSRFSKDGKPIYHYMGTSTFSEYTVLPEISLAKV
NKAAPLEEVCLLGCGVTTGMGAVVNTAKVKAGDNVAVFGLGGIGLSAIIGARMAGAGRIIGIDINEGKFELAKKLGATDC
VNPNGFDKPIQDVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFG
GVRGRTELPEYVERYLKGEFRLDDFITHTMPLERVNEAFDLMHEGKSIRSVIHYAAEPA

Sequences:

>Translated_379_residues
MSHDIIRCQAAVAWAAGQPLSIEEIEVHPPKAGEVRVKMVATGVCHTDAFTLSGADPEGVFPCILGHEGGGVVESVGPGV
TSVAVGDHVIPLYTPECRECKFCLSGKTNLCQKIRATQGKGLMPDGTSRFSKDGKPIYHYMGTSTFSEYTVLPEISLAKV
NKAAPLEEVCLLGCGVTTGMGAVVNTAKVKAGDNVAVFGLGGIGLSAIIGARMAGAGRIIGIDINEGKFELAKKLGATDC
VNPNGFDKPIQDVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFG
GVRGRTELPEYVERYLKGEFRLDDFITHTMPLERVNEAFDLMHEGKSIRSVIHYAAEPA
>Mature_378_residues
SHDIIRCQAAVAWAAGQPLSIEEIEVHPPKAGEVRVKMVATGVCHTDAFTLSGADPEGVFPCILGHEGGGVVESVGPGVT
SVAVGDHVIPLYTPECRECKFCLSGKTNLCQKIRATQGKGLMPDGTSRFSKDGKPIYHYMGTSTFSEYTVLPEISLAKVN
KAAPLEEVCLLGCGVTTGMGAVVNTAKVKAGDNVAVFGLGGIGLSAIIGARMAGAGRIIGIDINEGKFELAKKLGATDCV
NPNGFDKPIQDVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGG
VRGRTELPEYVERYLKGEFRLDDFITHTMPLERVNEAFDLMHEGKSIRSVIHYAAEPA

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=66.9354838709677, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=53.7837837837838, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=53.7433155080214, Blast_Score=427, Evalue=1e-120,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=52.972972972973, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=52.1621621621622, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=50, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=50, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=50.1355013550135, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=50.4132231404959, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=69.9186991869919, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI87082125, Length=369, Percent_Identity=26.2872628726287, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=25.4285714285714, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790045, Length=360, Percent_Identity=25.5555555555556, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87081918, Length=340, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788073, Length=349, Percent_Identity=26.647564469914, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788407, Length=230, Percent_Identity=29.5652173913043, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786825, Length=364, Percent_Identity=24.4505494505494, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786518, Length=373, Percent_Identity=24.9329758713137, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI226510992, Length=370, Percent_Identity=23.2432432432432, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=60.2666666666667, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=59.946949602122, Blast_Score=479, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=58.5294117647059, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17562876, Length=361, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=382, Percent_Identity=27.7486910994764, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=376, Percent_Identity=27.6595744680851, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=379, Percent_Identity=24.5382585751979, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=362, Percent_Identity=26.5193370165746, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=60.1078167115903, Blast_Score=475, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6323729, Length=383, Percent_Identity=29.242819843342, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=355, Percent_Identity=27.0422535211268, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=358, Percent_Identity=28.4916201117318, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=27.9005524861878, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=27.9005524861878, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=369, Percent_Identity=28.7262872628726, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=248, Percent_Identity=29.0322580645161, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=238, Percent_Identity=27.7310924369748, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17737895, Length=372, Percent_Identity=66.9354838709677, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI17137530, Length=252, Percent_Identity=30.5555555555556, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17737897, Length=224, Percent_Identity=29.0178571428571, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 40230; Mature: 40099

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDIIRCQAAVAWAAGQPLSIEEIEVHPPKAGEVRVKMVATGVCHTDAFTLSGADPEGV
CCCCCEEHHHHHHECCCCCCCEEEEEECCCCCCCEEEEEEEECEEECCEEEECCCCCCCC
FPCILGHEGGGVVESVGPGVTSVAVGDHVIPLYTPECRECKFCLSGKTNLCQKIRATQGK
EEEEEECCCCCCHHHCCCCCEEEECCCEEEEECCCCHHCCCEEECCCHHHHHHHHHCCCC
GLMPDGTSRFSKDGKPIYHYMGTSTFSEYTVLPEISLAKVNKAAPLEEVCLLGCGVTTGM
CCCCCCCHHHCCCCCEEEEECCCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCCHHCC
GAVVNTAKVKAGDNVAVFGLGGIGLSAIIGARMAGAGRIIGIDINEGKFELAKKLGATDC
CHHEEEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCC
VNPNGFDKPIQDVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQE
CCCCCCCCCHHHHHEEECCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCC
ISTRPFQLVTGRVWRGSAFGGVRGRTELPEYVERYLKGEFRLDDFITHTMPLERVNEAFD
CCCCCEEEEECEEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
LMHEGKSIRSVIHYAAEPA
HHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SHDIIRCQAAVAWAAGQPLSIEEIEVHPPKAGEVRVKMVATGVCHTDAFTLSGADPEGV
CCCCEEHHHHHHECCCCCCCEEEEEECCCCCCCEEEEEEEECEEECCEEEECCCCCCCC
FPCILGHEGGGVVESVGPGVTSVAVGDHVIPLYTPECRECKFCLSGKTNLCQKIRATQGK
EEEEEECCCCCCHHHCCCCCEEEECCCEEEEECCCCHHCCCEEECCCHHHHHHHHHCCCC
GLMPDGTSRFSKDGKPIYHYMGTSTFSEYTVLPEISLAKVNKAAPLEEVCLLGCGVTTGM
CCCCCCCHHHCCCCCEEEEECCCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCCHHCC
GAVVNTAKVKAGDNVAVFGLGGIGLSAIIGARMAGAGRIIGIDINEGKFELAKKLGATDC
CHHEEEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCC
VNPNGFDKPIQDVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQE
CCCCCCCCCHHHHHEEECCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCC
ISTRPFQLVTGRVWRGSAFGGVRGRTELPEYVERYLKGEFRLDDFITHTMPLERVNEAFD
CCCCCEEEEECEEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
LMHEGKSIRSVIHYAAEPA
HHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]