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The map label for this gene is yeiG [H]

Identifier: 34496194

GI number: 34496194

Start: 759966

End: 760805

Strand: Reverse

Name: yeiG [H]

Synonym: CV_0739

Alternate gene names: 34496194

Gene position: 760805-759966 (Counterclockwise)

Preceding gene: 34496195

Following gene: 34496193

Centisome position: 16.01

GC content: 71.19

Gene sequence:

>840_bases
ATGAACGGGCTGCAGAAAATCGCCGACAGCCTGGCTTTCGGCGGCCGCCAGCAGCAGTGGCTGCACGATTCGGAAACGCT
CTGCTGCCGGATGCGCTTCAGCGTGTTCCTGCCGCCAGCGGCCGACCATGGCAAGCTGCCATGGCTGCTGTGGCTGTCCG
GGCTCACCTGCACCGACGAGAACTTCAGCCACAAGGCAGGCGCGCAGCGGCTGGCGGCCGAGCTCGGCATCGCGCTGGTG
GTGCCGGACACCAGCCCCCGCGGCGAAGGCGTGGCCGACGACGCGGCCTACGACCTGGGCCAGGGGGCCGGCTTCTACCT
CAACGCCGAGCGCGAGCCGTGGCGCCGCCACTACCGGATGTACGACTACGTCAGCGAGGAACTGCCGGCGCTGCTGCGAC
GCCATTTCCCGCTGAACGGCCGCTGCGCGATCGCCGGCCACTCGATGGGCGGCCACGGCGCGCTGATCTGCGCGATCCGT
CGCCCGCAGGACTACGTGTCGGCGTCGGCGTTCAGCCCGATCTGCAATCCGAGCCAGGCGCCCTGGGGCCGCAAGGCCTT
CGCCGCCTACCTGGGCGGCGACGAGGCCGCCTGGGCCGAGTGGGACGCCAGCCTGCTGCTGGCCGAGCGCGGCTGCCCGC
TGCCGCTCAGGGTGGACATCGGCCTGGCCGATACCTTCCTCGCCGAGCAGCTGCGGCCGGACGCGCTGCAGCAGGCGGCG
CGCAGCAGCGATGCGCGGCTGGAACTGCACCGCCACGCCGGCTACGACCACGGCTACTATTTCGTCGCCAGCTTCATCGA
CCAGCACCTGCGTTTCCACGCCCGCCATCTGCGGGCCTGA

Upstream 100 bases:

>100_bases
TCACCCATACCATGCCGCTGGAGCGCGTCAACGAAGCCTTCGACCTGATGCATGAAGGCAAGAGCATACGCTCCGTCATC
CATTACGCGGCGGAGCCGGC

Downstream 100 bases:

>100_bases
CGCCACGCGCGGAACGCAAAAAAGCCAGGCTCGAGAGCCTGGCTTTTTTGTTGAATCTGGTGGAGGGAGAAGGATTCGAA
CCTTCGAAGGCAGAGCCGTC

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MNGLQKIADSLAFGGRQQQWLHDSETLCCRMRFSVFLPPAADHGKLPWLLWLSGLTCTDENFSHKAGAQRLAAELGIALV
VPDTSPRGEGVADDAAYDLGQGAGFYLNAEREPWRRHYRMYDYVSEELPALLRRHFPLNGRCAIAGHSMGGHGALICAIR
RPQDYVSASAFSPICNPSQAPWGRKAFAAYLGGDEAAWAEWDASLLLAERGCPLPLRVDIGLADTFLAEQLRPDALQQAA
RSSDARLELHRHAGYDHGYYFVASFIDQHLRFHARHLRA

Sequences:

>Translated_279_residues
MNGLQKIADSLAFGGRQQQWLHDSETLCCRMRFSVFLPPAADHGKLPWLLWLSGLTCTDENFSHKAGAQRLAAELGIALV
VPDTSPRGEGVADDAAYDLGQGAGFYLNAEREPWRRHYRMYDYVSEELPALLRRHFPLNGRCAIAGHSMGGHGALICAIR
RPQDYVSASAFSPICNPSQAPWGRKAFAAYLGGDEAAWAEWDASLLLAERGCPLPLRVDIGLADTFLAEQLRPDALQQAA
RSSDARLELHRHAGYDHGYYFVASFIDQHLRFHARHLRA
>Mature_279_residues
MNGLQKIADSLAFGGRQQQWLHDSETLCCRMRFSVFLPPAADHGKLPWLLWLSGLTCTDENFSHKAGAQRLAAELGIALV
VPDTSPRGEGVADDAAYDLGQGAGFYLNAEREPWRRHYRMYDYVSEELPALLRRHFPLNGRCAIAGHSMGGHGALICAIR
RPQDYVSASAFSPICNPSQAPWGRKAFAAYLGGDEAAWAEWDASLLLAERGCPLPLRVDIGLADTFLAEQLRPDALQQAA
RSSDARLELHRHAGYDHGYYFVASFIDQHLRFHARHLRA

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=48.5714285714286, Blast_Score=287, Evalue=9e-78,
Organism=Escherichia coli, GI1788477, Length=276, Percent_Identity=58.3333333333333, Blast_Score=321, Evalue=3e-89,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=51.2727272727273, Blast_Score=301, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17510185, Length=277, Percent_Identity=44.043321299639, Blast_Score=230, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6322393, Length=286, Percent_Identity=42.6573426573427, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI45551932, Length=282, Percent_Identity=48.936170212766, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24648347, Length=282, Percent_Identity=48.936170212766, Blast_Score=265, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30982; Mature: 30982

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLQKIADSLAFGGRQQQWLHDSETLCCRMRFSVFLPPAADHGKLPWLLWLSGLTCTDE
CCHHHHHHHHHHCCCCCHHHHCCCHHHEEEEEEEEEECCCCCCCCCCHHHHCCCCEECCC
NFSHKAGAQRLAAELGIALVVPDTSPRGEGVADDAAYDLGQGAGFYLNAEREPWRRHYRM
CCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCCCCCEEEECCCCHHHHHHHH
YDYVSEELPALLRRHFPLNGRCAIAGHSMGGHGALICAIRRPQDYVSASAFSPICNPSQA
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCC
PWGRKAFAAYLGGDEAAWAEWDASLLLAERGCPLPLRVDIGLADTFLAEQLRPDALQQAA
CCCHHHHHHHHCCCCCCHHHCCCEEEEECCCCCCEEEEECCCHHHHHHHHCCHHHHHHHH
RSSDARLELHRHAGYDHGYYFVASFIDQHLRFHARHLRA
CCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGLQKIADSLAFGGRQQQWLHDSETLCCRMRFSVFLPPAADHGKLPWLLWLSGLTCTDE
CCHHHHHHHHHHCCCCCHHHHCCCHHHEEEEEEEEEECCCCCCCCCCHHHHCCCCEECCC
NFSHKAGAQRLAAELGIALVVPDTSPRGEGVADDAAYDLGQGAGFYLNAEREPWRRHYRM
CCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCCCCCEEEECCCCHHHHHHHH
YDYVSEELPALLRRHFPLNGRCAIAGHSMGGHGALICAIRRPQDYVSASAFSPICNPSQA
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCC
PWGRKAFAAYLGGDEAAWAEWDASLLLAERGCPLPLRVDIGLADTFLAEQLRPDALQQAA
CCCHHHHHHHHCCCCCCHHHCCCEEEEECCCCCCEEEEECCCHHHHHHHHCCHHHHHHHH
RSSDARLELHRHAGYDHGYYFVASFIDQHLRFHARHLRA
CCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA