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The map label for this gene is ubiB [C]

Identifier: 33864536

GI number: 33864536

Start: 2406987

End: 2408876

Strand: Direct

Name: ubiB [C]

Synonym: PMT2272

Alternate gene names: 33864536

Gene position: 2406987-2408876 (Clockwise)

Preceding gene: 33864531

Following gene: 33864537

Centisome position: 99.84

GC content: 47.51

Gene sequence:

>1890_bases
ATGATCAAGACCCCACTCAGGATGGAAACAGAACTCGGGGATTTCATCGAGGCGGCAGGCCTACTTGAATACGACCCTGC
TGCAATTACCAGAATTTATGCCGGCCATCCACAGCGCCTTTTGCGCCGACTCTGGCAAACACTTCTACCAATTGGTCTCT
TCCTGGTTGGCTTAGCAGGGGACAAAGTTTTTGGCTTACTGAACGATGCAAATCGTGCTCGTTCCCGAGCACGAGAATTC
GCGGAACTCTTAGTAGAGCTTGGCCCTGCTTTCATTAAGGCTGGACAAGCTCTTTCCAGTCGACCAGACCTAGTACCACC
AGTTCTACTGGAAGAACTTTCACAACTACAAGACCAATTACCAGGCTTCGACAGTGTCATGGCTATGGCCTGCATAGAAG
AAGACCTTGAAACACCAATCGAAGAGATCTACGAACAACTCGACAAAGAACCCATCTCTGCCGCCTCTCTAGGACAGGTC
CACCGAGGCGTACTCAAAGGAGGTCAACAGGTGGCCGTCAAGGTACAACGACCAGGACTTCGGGAACAAATCACCCTTGA
TCTCTACATCGTACGGAACATTGCCGCATGGCTCAAAAGCAATGTGAGGTTGATACGTAGTGATCTTGTGGCGCTGATTG
ATGAGCTAGGCCGAAGAGTATTTGAAGAGATGGATTACCTTAATGAAGCTGCCAATGCAGAGCGTTTCCGCACGCTTCAC
AGCCATAATCAACGCATCGCTGTACCAATAATCTATCGACAAGCTACTAGCCGTAGAGTGCTTACAATGGAATGGATTGA
TGGAGTAAAACTCACTAATCTAAAGGCAGTGAGAGAGCTAGGAATCGATCCCAATAATATGGTTGAAGTCGGAGTTAACT
GCAGCTTGCAACAGTTGTTGGAACACGGGTTTTTCCACGCTGATCCACATCCTGGAAACCTTCTGGCTATGGCCGATGGG
CGGCTCTGCTACCTCGATTTCGGAATGATGAGTGAGGTAAGCCGAGAATCACGTACAGGCTTAATTGAAGCAGTAGTACA
TCTGGTAAACCGTAATTTCAAGAACCTTTCACGAGACTTTGTAAAACTCGGTTTTCTAGCAGAAGATGTCAATCTCGAAC
CAATTGTACCTGCGTTTGAAAGTGTCTTCAGCCAAGCTCTAGAGATGGGTGTAAGTCGCCTTGATTTCAAAAGCGTAACT
GATGACCTATCTGGCGTAATGTACAGGTTCCCTTTCAAGGTACCTCCATACTACGCATTAATTATTCGTTCACTGATAAC
CCTTGAAGGCATCGCATTAAGCGTAGATTCAGAATTCAAAATTCTTGGTGCCGCTTATCCTTACTTCGCTCGGCGACTCA
TGGAAGATCCCGACCCTCAATTACGCCAAAGCCTCAAAGAAATGCTTTTTGACGGAGAAATCTTCCGCTGGACTCGACTA
GAAAACCTTGTAGCAAGTGCTGCAAGCCAAGCCCAGCTCGACTTGGAAAGCTTAATTGATCAGGTCATCGATTTCCTCTT
CTCAATCAACGGTGGTCTCTTGAGAGAACAACTTGTTGAAGCACTAATCAACCGCCTTGACGCCTTTGGCTGGCAAACAT
TTCAACGTCTGGGTCGTAACCTACCGCGATCCTTGCAACCTCCACTTATAGCCATTGGTTCGGAGTCTGAAAATTCTGAC
GATGGCTCACTGCTTGATTTAGAACCAATTCGACAACTGATCGTTATCTTGCAAAACCTGCCAGACTTCACTCCTGAACT
AGTCCTCAGCCGCCTACCAAGACTGATCCGCGAACCTGATACCCACAAAATGGGTATAAAAGTTGCGCAGGGTCTCGCCG
AACGTGGTGTTGTCCGTCTTGTCAAGGTAGCAGCAGGAATTTCACCCTAA

Upstream 100 bases:

>100_bases
CTCGATCAGAGCTATGTTCTGCAGCAGCAGACCGGTGAGCACGTCCAGCCCTGTGATGATTCCGACCGTAGCGGCAGCAC
GGTTCGTTTAGAAGGGGTGA

Downstream 100 bases:

>100_bases
ATTCTGTGACTAAAGGGTTCACTAATGAATCAATCAAAAAAACATTCTTATCGATCTCTGATGGCTCTCTGCCTAGGTTT
GGGATTAAGTCTGTTTTCAA

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MIKTPLRMETELGDFIEAAGLLEYDPAAITRIYAGHPQRLLRRLWQTLLPIGLFLVGLAGDKVFGLLNDANRARSRAREF
AELLVELGPAFIKAGQALSSRPDLVPPVLLEELSQLQDQLPGFDSVMAMACIEEDLETPIEEIYEQLDKEPISAASLGQV
HRGVLKGGQQVAVKVQRPGLREQITLDLYIVRNIAAWLKSNVRLIRSDLVALIDELGRRVFEEMDYLNEAANAERFRTLH
SHNQRIAVPIIYRQATSRRVLTMEWIDGVKLTNLKAVRELGIDPNNMVEVGVNCSLQQLLEHGFFHADPHPGNLLAMADG
RLCYLDFGMMSEVSRESRTGLIEAVVHLVNRNFKNLSRDFVKLGFLAEDVNLEPIVPAFESVFSQALEMGVSRLDFKSVT
DDLSGVMYRFPFKVPPYYALIIRSLITLEGIALSVDSEFKILGAAYPYFARRLMEDPDPQLRQSLKEMLFDGEIFRWTRL
ENLVASAASQAQLDLESLIDQVIDFLFSINGGLLREQLVEALINRLDAFGWQTFQRLGRNLPRSLQPPLIAIGSESENSD
DGSLLDLEPIRQLIVILQNLPDFTPELVLSRLPRLIREPDTHKMGIKVAQGLAERGVVRLVKVAAGISP

Sequences:

>Translated_629_residues
MIKTPLRMETELGDFIEAAGLLEYDPAAITRIYAGHPQRLLRRLWQTLLPIGLFLVGLAGDKVFGLLNDANRARSRAREF
AELLVELGPAFIKAGQALSSRPDLVPPVLLEELSQLQDQLPGFDSVMAMACIEEDLETPIEEIYEQLDKEPISAASLGQV
HRGVLKGGQQVAVKVQRPGLREQITLDLYIVRNIAAWLKSNVRLIRSDLVALIDELGRRVFEEMDYLNEAANAERFRTLH
SHNQRIAVPIIYRQATSRRVLTMEWIDGVKLTNLKAVRELGIDPNNMVEVGVNCSLQQLLEHGFFHADPHPGNLLAMADG
RLCYLDFGMMSEVSRESRTGLIEAVVHLVNRNFKNLSRDFVKLGFLAEDVNLEPIVPAFESVFSQALEMGVSRLDFKSVT
DDLSGVMYRFPFKVPPYYALIIRSLITLEGIALSVDSEFKILGAAYPYFARRLMEDPDPQLRQSLKEMLFDGEIFRWTRL
ENLVASAASQAQLDLESLIDQVIDFLFSINGGLLREQLVEALINRLDAFGWQTFQRLGRNLPRSLQPPLIAIGSESENSD
DGSLLDLEPIRQLIVILQNLPDFTPELVLSRLPRLIREPDTHKMGIKVAQGLAERGVVRLVKVAAGISP
>Mature_629_residues
MIKTPLRMETELGDFIEAAGLLEYDPAAITRIYAGHPQRLLRRLWQTLLPIGLFLVGLAGDKVFGLLNDANRARSRAREF
AELLVELGPAFIKAGQALSSRPDLVPPVLLEELSQLQDQLPGFDSVMAMACIEEDLETPIEEIYEQLDKEPISAASLGQV
HRGVLKGGQQVAVKVQRPGLREQITLDLYIVRNIAAWLKSNVRLIRSDLVALIDELGRRVFEEMDYLNEAANAERFRTLH
SHNQRIAVPIIYRQATSRRVLTMEWIDGVKLTNLKAVRELGIDPNNMVEVGVNCSLQQLLEHGFFHADPHPGNLLAMADG
RLCYLDFGMMSEVSRESRTGLIEAVVHLVNRNFKNLSRDFVKLGFLAEDVNLEPIVPAFESVFSQALEMGVSRLDFKSVT
DDLSGVMYRFPFKVPPYYALIIRSLITLEGIALSVDSEFKILGAAYPYFARRLMEDPDPQLRQSLKEMLFDGEIFRWTRL
ENLVASAASQAQLDLESLIDQVIDFLFSINGGLLREQLVEALINRLDAFGWQTFQRLGRNLPRSLQPPLIAIGSESENSD
DGSLLDLEPIRQLIVILQNLPDFTPELVLSRLPRLIREPDTHKMGIKVAQGLAERGVVRLVKVAAGISP

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=293, Percent_Identity=29.6928327645051, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI41393593, Length=262, Percent_Identity=31.6793893129771, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI217035081, Length=234, Percent_Identity=29.0598290598291, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI27363457, Length=291, Percent_Identity=31.6151202749141, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI217416386, Length=261, Percent_Identity=32.183908045977, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI34147522, Length=324, Percent_Identity=29.320987654321, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI2367309, Length=394, Percent_Identity=28.4263959390863, Blast_Score=172, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17559152, Length=268, Percent_Identity=30.9701492537313, Blast_Score=128, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32565180, Length=389, Percent_Identity=26.4781491002571, Blast_Score=89, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323282, Length=238, Percent_Identity=32.3529411764706, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6325148, Length=250, Percent_Identity=26, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=242, Percent_Identity=28.5123966942149, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24662575, Length=277, Percent_Identity=31.0469314079422, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI22024280, Length=242, Percent_Identity=30.1652892561983, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI18859849, Length=286, Percent_Identity=28.6713286713287, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 70587; Mature: 70587

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTPLRMETELGDFIEAAGLLEYDPAAITRIYAGHPQRLLRRLWQTLLPIGLFLVGLAG
CCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
DKVFGLLNDANRARSRAREFAELLVELGPAFIKAGQALSSRPDLVPPVLLEELSQLQDQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHHHC
PGFDSVMAMACIEEDLETPIEEIYEQLDKEPISAASLGQVHRGVLKGGQQVAVKVQRPGL
CCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
REQITLDLYIVRNIAAWLKSNVRLIRSDLVALIDELGRRVFEEMDYLNEAANAERFRTLH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHNQRIAVPIIYRQATSRRVLTMEWIDGVKLTNLKAVRELGIDPNNMVEVGVNCSLQQLL
HCCCEEEEEEEEECCCCCCEEEEHHHCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
EHGFFHADPHPGNLLAMADGRLCYLDFGMMSEVSRESRTGLIEAVVHLVNRNFKNLSRDF
HCCCCCCCCCCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VKLGFLAEDVNLEPIVPAFESVFSQALEMGVSRLDFKSVTDDLSGVMYRFPFKVPPYYAL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IIRSLITLEGIALSVDSEFKILGAAYPYFARRLMEDPDPQLRQSLKEMLFDGEIFRWTRL
HHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHH
ENLVASAASQAQLDLESLIDQVIDFLFSINGGLLREQLVEALINRLDAFGWQTFQRLGRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LPRSLQPPLIAIGSESENSDDGSLLDLEPIRQLIVILQNLPDFTPELVLSRLPRLIREPD
CCCCCCCCEEEECCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
THKMGIKVAQGLAERGVVRLVKVAAGISP
CHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKTPLRMETELGDFIEAAGLLEYDPAAITRIYAGHPQRLLRRLWQTLLPIGLFLVGLAG
CCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
DKVFGLLNDANRARSRAREFAELLVELGPAFIKAGQALSSRPDLVPPVLLEELSQLQDQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHHHC
PGFDSVMAMACIEEDLETPIEEIYEQLDKEPISAASLGQVHRGVLKGGQQVAVKVQRPGL
CCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
REQITLDLYIVRNIAAWLKSNVRLIRSDLVALIDELGRRVFEEMDYLNEAANAERFRTLH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHNQRIAVPIIYRQATSRRVLTMEWIDGVKLTNLKAVRELGIDPNNMVEVGVNCSLQQLL
HCCCEEEEEEEEECCCCCCEEEEHHHCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
EHGFFHADPHPGNLLAMADGRLCYLDFGMMSEVSRESRTGLIEAVVHLVNRNFKNLSRDF
HCCCCCCCCCCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VKLGFLAEDVNLEPIVPAFESVFSQALEMGVSRLDFKSVTDDLSGVMYRFPFKVPPYYAL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IIRSLITLEGIALSVDSEFKILGAAYPYFARRLMEDPDPQLRQSLKEMLFDGEIFRWTRL
HHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHH
ENLVASAASQAQLDLESLIDQVIDFLFSINGGLLREQLVEALINRLDAFGWQTFQRLGRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LPRSLQPPLIAIGSESENSDDGSLLDLEPIRQLIVILQNLPDFTPELVLSRLPRLIREPD
CCCCCCCCEEEECCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
THKMGIKVAQGLAERGVVRLVKVAAGISP
CHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]