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The map label for this gene is pabB [H]

Identifier: 33864487

GI number: 33864487

Start: 2350045

End: 2351385

Strand: Direct

Name: pabB [H]

Synonym: PMT2223

Alternate gene names: 33864487

Gene position: 2350045-2351385 (Clockwise)

Preceding gene: 33864486

Following gene: 33864488

Centisome position: 97.48

GC content: 53.84

Gene sequence:

>1341_bases
ATGACTTCTCTAGAGCGGCGACTTTGCCGCTGGCAAGAACCAGCGAAGTTGGCAAAACAACTCACCAAAACTTGGGGAGA
AGCTGGGCTTGTCTGGCTGGATGGAGACGGCAGTGGTCTAGGTCGTTGGGCGACCCTGGCAGTCGATCCCATTAATCAGA
TTTGTTGCCGAGGCATCCCTGGCGAAAAAGGCGCCAGCAACCCATTCGAAGCCCTACGTGATCTAGAACCAGGACACTGG
ACAGGCTGGCTTAGCTACGAAGCAGCAGCATGGATAGAACCCAAAAATCCCTGGAAAGCAGATTGCATGGCGACTCTGTG
GATGGCGCAACATGACCCAGTACTGCGATTTGACCTTCAAAAGCATCAACTCTGGATTGAAGGATGTCATCCCAAACGAC
TGCAAGAATTGGCAAGCTGGCTAGAAGCCAACCCACCTGAAGATGCACCTAAAAGGAGCAAAGATGAGTCGTTACTTGCA
ACAACAGACCTCAATATTCCCGTCAATGCATGGCAATGGCTCACCACTAGAGCTGACTATGCACGTGATGTGCAGCAGAT
CAGACATTGGATTGCCAACGGCGATATTTTCCAAGCCAATCTCAGCGCTTGCTGTACCACCACGATCCCTTCCGGAAGCT
TCGCCGTAGACCTTTTCCTAAAACTTCGTCACCACAACCCAGCTCCATTTGCCGGCCTAGTGATAGCTGCAGGCCTTGCA
AACGGTGAAGCCGTGATCTCCGCCTCTCCAGAGCGTTTCCTAAAAGCACTCCCCACAGGAGAAATTGAAACTCGACCAAT
CAAAGGGACCCGACCACGCCACCCCAATCAAAGCCAAGACTCTGATCTGGCAGCTGATCTTGTTTGCAGCAGCAAAGACC
GAGCTGAAAACGTGATGATCGTCGATCTATTGCGCAACGATCTAGGGCGAGTCTGTCAACCCGGCTCCATCACAGTGCCT
CAATTGGTAGGCCTTGAGAGCTATCCCCATGTGCATCACCTCACCTCAATAGTGCAAGGACGGCTTCGATCAGACCAATC
TTGGGTAGACCTACTACAAGCCTGTTGGCCGGGAGGCTCCATCAGCGGTGCCCCCAAGCTGCGCGCCTGTCAGCGGCTGA
ACGAACTGGAACCAACAGCACGCGGGCCCTATTGCGGATCGTTGTTGCATCTCAACTGGGATGGGCAGCTCGACAGCAGC
ATTCTGATTCGCTCGATGTTGCTCGAGGGGAACACGTTACGAGCCCATGCCGGCTGCGGCATCGTGACCGGTTCCGACCC
CTATTGCGAAGCTGATGAGCTGAACTGGAAACTGCTGCCACTACTGGAGGCACTGCAATGA

Upstream 100 bases:

>100_bases
GCGGAGGCGATCATGCCTGCGGTATATGCGACAGCTGCCGCATCCGCGATGCAGCTTTGAGCGAGGCTGGCAGATCAGAT
CTCTGCAGCAAGTCAACACC

Downstream 100 bases:

>100_bases
AAAACCAGATTGCCTGGATCGATGGCAGCTGGGGTAGCACTGCGGAGCTCGCTCTTCCTCTAGGAGATCGAGGCCTGCAG
CTTGCCGATGGCATCTTTGA

Product: p-aminobenzoate synthetase

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTSLERRLCRWQEPAKLAKQLTKTWGEAGLVWLDGDGSGLGRWATLAVDPINQICCRGIPGEKGASNPFEALRDLEPGHW
TGWLSYEAAAWIEPKNPWKADCMATLWMAQHDPVLRFDLQKHQLWIEGCHPKRLQELASWLEANPPEDAPKRSKDESLLA
TTDLNIPVNAWQWLTTRADYARDVQQIRHWIANGDIFQANLSACCTTTIPSGSFAVDLFLKLRHHNPAPFAGLVIAAGLA
NGEAVISASPERFLKALPTGEIETRPIKGTRPRHPNQSQDSDLAADLVCSSKDRAENVMIVDLLRNDLGRVCQPGSITVP
QLVGLESYPHVHHLTSIVQGRLRSDQSWVDLLQACWPGGSISGAPKLRACQRLNELEPTARGPYCGSLLHLNWDGQLDSS
ILIRSMLLEGNTLRAHAGCGIVTGSDPYCEADELNWKLLPLLEALQ

Sequences:

>Translated_446_residues
MTSLERRLCRWQEPAKLAKQLTKTWGEAGLVWLDGDGSGLGRWATLAVDPINQICCRGIPGEKGASNPFEALRDLEPGHW
TGWLSYEAAAWIEPKNPWKADCMATLWMAQHDPVLRFDLQKHQLWIEGCHPKRLQELASWLEANPPEDAPKRSKDESLLA
TTDLNIPVNAWQWLTTRADYARDVQQIRHWIANGDIFQANLSACCTTTIPSGSFAVDLFLKLRHHNPAPFAGLVIAAGLA
NGEAVISASPERFLKALPTGEIETRPIKGTRPRHPNQSQDSDLAADLVCSSKDRAENVMIVDLLRNDLGRVCQPGSITVP
QLVGLESYPHVHHLTSIVQGRLRSDQSWVDLLQACWPGGSISGAPKLRACQRLNELEPTARGPYCGSLLHLNWDGQLDSS
ILIRSMLLEGNTLRAHAGCGIVTGSDPYCEADELNWKLLPLLEALQ
>Mature_445_residues
TSLERRLCRWQEPAKLAKQLTKTWGEAGLVWLDGDGSGLGRWATLAVDPINQICCRGIPGEKGASNPFEALRDLEPGHWT
GWLSYEAAAWIEPKNPWKADCMATLWMAQHDPVLRFDLQKHQLWIEGCHPKRLQELASWLEANPPEDAPKRSKDESLLAT
TDLNIPVNAWQWLTTRADYARDVQQIRHWIANGDIFQANLSACCTTTIPSGSFAVDLFLKLRHHNPAPFAGLVIAAGLAN
GEAVISASPERFLKALPTGEIETRPIKGTRPRHPNQSQDSDLAADLVCSSKDRAENVMIVDLLRNDLGRVCQPGSITVPQ
LVGLESYPHVHHLTSIVQGRLRSDQSWVDLLQACWPGGSISGAPKLRACQRLNELEPTARGPYCGSLLHLNWDGQLDSSI
LIRSMLLEGNTLRAHAGCGIVTGSDPYCEADELNWKLLPLLEALQ

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=308, Percent_Identity=39.9350649350649, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1787518, Length=269, Percent_Identity=36.8029739776952, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1786809, Length=208, Percent_Identity=29.3269230769231, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082077, Length=207, Percent_Identity=29.951690821256, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=448, Percent_Identity=28.5714285714286, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324361, Length=287, Percent_Identity=28.2229965156794, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890
- InterPro:   IPR005802 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 49356; Mature: 49224

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLERRLCRWQEPAKLAKQLTKTWGEAGLVWLDGDGSGLGRWATLAVDPINQICCRGIP
CCHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCHHHHHHCCCC
GEKGASNPFEALRDLEPGHWTGWLSYEAAAWIEPKNPWKADCMATLWMAQHDPVLRFDLQ
CCCCCCCHHHHHHCCCCCCEEEEEEECEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECH
KHQLWIEGCHPKRLQELASWLEANPPEDAPKRSKDESLLATTDLNIPVNAWQWLTTRADY
HHEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
ARDVQQIRHWIANGDIFQANLSACCTTTIPSGSFAVDLFLKLRHHNPAPFAGLVIAAGLA
HHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCHHEEHHHHHHCCCCCCHHHHHHHHHCC
NGEAVISASPERFLKALPTGEIETRPIKGTRPRHPNQSQDSDLAADLVCSSKDRAENVMI
CCCEEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEE
VDLLRNDLGRVCQPGSITVPQLVGLESYPHVHHLTSIVQGRLRSDQSWVDLLQACWPGGS
HHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
ISGAPKLRACQRLNELEPTARGPYCGSLLHLNWDGQLDSSILIRSMLLEGNTLRAHAGCG
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCE
IVTGSDPYCEADELNWKLLPLLEALQ
EEECCCCCCCCCCCCEEHHHHHHHCC
>Mature Secondary Structure 
TSLERRLCRWQEPAKLAKQLTKTWGEAGLVWLDGDGSGLGRWATLAVDPINQICCRGIP
CHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCHHHHHHCCCC
GEKGASNPFEALRDLEPGHWTGWLSYEAAAWIEPKNPWKADCMATLWMAQHDPVLRFDLQ
CCCCCCCHHHHHHCCCCCCEEEEEEECEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECH
KHQLWIEGCHPKRLQELASWLEANPPEDAPKRSKDESLLATTDLNIPVNAWQWLTTRADY
HHEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
ARDVQQIRHWIANGDIFQANLSACCTTTIPSGSFAVDLFLKLRHHNPAPFAGLVIAAGLA
HHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCHHEEHHHHHHCCCCCCHHHHHHHHHCC
NGEAVISASPERFLKALPTGEIETRPIKGTRPRHPNQSQDSDLAADLVCSSKDRAENVMI
CCCEEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEE
VDLLRNDLGRVCQPGSITVPQLVGLESYPHVHHLTSIVQGRLRSDQSWVDLLQACWPGGS
HHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
ISGAPKLRACQRLNELEPTARGPYCGSLLHLNWDGQLDSSILIRSMLLEGNTLRAHAGCG
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCE
IVTGSDPYCEADELNWKLLPLLEALQ
EEECCCCCCCCCCCCEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3057324; 11677609; 2251281 [H]