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The map label for this gene is hisC/cobC [H]

Identifier: 33864364

GI number: 33864364

Start: 2213711

End: 2214793

Strand: Direct

Name: hisC/cobC [H]

Synonym: PMT2100

Alternate gene names: 33864364

Gene position: 2213711-2214793 (Clockwise)

Preceding gene: 33864362

Following gene: 33864366

Centisome position: 91.82

GC content: 56.14

Gene sequence:

>1083_bases
TTGAGCTCCGCTCCCTCCCTTCACGGTGGCAATCGCATTGATGAGGCGCAACGGCTGGGTTGTCGTCCGGAGCAGCTTTT
GGATGCCAGTGCCTCTTTGGTGCCTTTCCCTCCATCACGAGCTTTACAAGGGTGTTTAAGAAGGGCTCTAACTGACAACA
CGCTGAGGGATTATCCGGATCGCAGCCATCAGCGCTTGCGAGACGTGATCAGCAACTGGCATGGGGTTGATCCCCTGATG
GTATTGCCGGGAAATGGCGCAGCGGAACTGTTCACCTGGGCCGCTCGTGATGCGGCGTCTGAGGGCGTGAGTGGCCTGCC
TAGTCCAGGCTTTGCTGATTACGGCAGGGCTCTGAGGTGCTGGCAAGCCTGCCAGCAAGCTTTGCCACTGCCCCTCTCCT
GGTCTGGTGAGATGCCTCAGCCTTTTCCGCTGCTATCGAATAGCGATGTTCTTTGGATTACCAATCCCCATAACCCTACT
GGTCAGTTGTGGAGCAGAGCATCGCTTGAACCGTTGCTAGCGCGTTATCAGCTGGTTATCTGTGATGAAGCGTTTTTGCC
ATTGGTGCCCGATGGGGAGCGCCAGTCTCTTGTTTCGCTGGTGGTCAACCACCCCAATCTTGTGGTAATTCGCAGTTTGA
CAAAGTTGTTTGCCTTGGCCGGATTGCGTTTGGGTTATGCCATTGGCACGCCTGAGCGTTTACAACGTTGGCAGCAATGG
CGAGATCCATGGCCTCTTAATGGGTTGGCGATTGCTGCAGGGATTGCATTGATGGCGGATCGTCCTGCCTTCGAGCGCTG
GATAGCGCGGGTCCAGGGATGGGTTGCTCAGGAAGGTCTTTGGATGCAAACTCAACTGCGTTGCCTACCAGGGATCCGGT
CTTATCCATCTGCCGCCAACTTCTTGTTGATTCGTGGCGATGTCTCCCTTGTGCCATTACGAGAGAGAATGGCTCATCGG
CGCGTGCTGTTGCGTGACTGCCGCTCCTTTGCAGAACTTGGGGAGCGCTGGTTGCGCATTGGTTTGCAGCAGAGGTCAGC
CAATCGCCGCATCCTTGCTGCGTTCAAAGCCCTGCTCCGATGA

Upstream 100 bases:

>100_bases
ATTAGAAATTTGCTATGCCATTGCTTTCTATCGGCTTTTTTGAGCACGTCGACTCCCTCCCACTCGGCAGGATGGATTGT
TGTTATGGGTCGCCATTGAC

Downstream 100 bases:

>100_bases
GTTGCTTCAGCAATGTCACCAGCAGCTGGTCTGCCTCACGCACTGCCAACTTCCTCATGCCTTGCTTCATGGGAATTAAA
GGGTTGCTGGCAGCAGCGTT

Product: aminotransferase class-I

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSSAPSLHGGNRIDEAQRLGCRPEQLLDASASLVPFPPSRALQGCLRRALTDNTLRDYPDRSHQRLRDVISNWHGVDPLM
VLPGNGAAELFTWAARDAASEGVSGLPSPGFADYGRALRCWQACQQALPLPLSWSGEMPQPFPLLSNSDVLWITNPHNPT
GQLWSRASLEPLLARYQLVICDEAFLPLVPDGERQSLVSLVVNHPNLVVIRSLTKLFALAGLRLGYAIGTPERLQRWQQW
RDPWPLNGLAIAAGIALMADRPAFERWIARVQGWVAQEGLWMQTQLRCLPGIRSYPSAANFLLIRGDVSLVPLRERMAHR
RVLLRDCRSFAELGERWLRIGLQQRSANRRILAAFKALLR

Sequences:

>Translated_360_residues
MSSAPSLHGGNRIDEAQRLGCRPEQLLDASASLVPFPPSRALQGCLRRALTDNTLRDYPDRSHQRLRDVISNWHGVDPLM
VLPGNGAAELFTWAARDAASEGVSGLPSPGFADYGRALRCWQACQQALPLPLSWSGEMPQPFPLLSNSDVLWITNPHNPT
GQLWSRASLEPLLARYQLVICDEAFLPLVPDGERQSLVSLVVNHPNLVVIRSLTKLFALAGLRLGYAIGTPERLQRWQQW
RDPWPLNGLAIAAGIALMADRPAFERWIARVQGWVAQEGLWMQTQLRCLPGIRSYPSAANFLLIRGDVSLVPLRERMAHR
RVLLRDCRSFAELGERWLRIGLQQRSANRRILAAFKALLR
>Mature_359_residues
SSAPSLHGGNRIDEAQRLGCRPEQLLDASASLVPFPPSRALQGCLRRALTDNTLRDYPDRSHQRLRDVISNWHGVDPLMV
LPGNGAAELFTWAARDAASEGVSGLPSPGFADYGRALRCWQACQQALPLPLSWSGEMPQPFPLLSNSDVLWITNPHNPTG
QLWSRASLEPLLARYQLVICDEAFLPLVPDGERQSLVSLVVNHPNLVVIRSLTKLFALAGLRLGYAIGTPERLQRWQQWR
DPWPLNGLAIAAGIALMADRPAFERWIARVQGWVAQEGLWMQTQLRCLPGIRSYPSAANFLLIRGDVSLVPLRERMAHRR
VLLRDCRSFAELGERWLRIGLQQRSANRRILAAFKALLR

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=352, Percent_Identity=26.1363636363636, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40299; Mature: 40168

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAPSLHGGNRIDEAQRLGCRPEQLLDASASLVPFPPSRALQGCLRRALTDNTLRDYPD
CCCCCCCCCCCCCCHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCC
RSHQRLRDVISNWHGVDPLMVLPGNGAAELFTWAARDAASEGVSGLPSPGFADYGRALRC
HHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
WQACQQALPLPLSWSGEMPQPFPLLSNSDVLWITNPHNPTGQLWSRASLEPLLARYQLVI
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHHEE
CDEAFLPLVPDGERQSLVSLVVNHPNLVVIRSLTKLFALAGLRLGYAIGTPERLQRWQQW
ECCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RDPWPLNGLAIAAGIALMADRPAFERWIARVQGWVAQEGLWMQTQLRCLPGIRSYPSAAN
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCC
FLLIRGDVSLVPLRERMAHRRVLLRDCRSFAELGERWLRIGLQQRSANRRILAAFKALLR
EEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SSAPSLHGGNRIDEAQRLGCRPEQLLDASASLVPFPPSRALQGCLRRALTDNTLRDYPD
CCCCCCCCCCCCCHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCC
RSHQRLRDVISNWHGVDPLMVLPGNGAAELFTWAARDAASEGVSGLPSPGFADYGRALRC
HHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
WQACQQALPLPLSWSGEMPQPFPLLSNSDVLWITNPHNPTGQLWSRASLEPLLARYQLVI
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHHEE
CDEAFLPLVPDGERQSLVSLVVNHPNLVVIRSLTKLFALAGLRLGYAIGTPERLQRWQQW
ECCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RDPWPLNGLAIAAGIALMADRPAFERWIARVQGWVAQEGLWMQTQLRCLPGIRSYPSAAN
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCC
FLLIRGDVSLVPLRERMAHRRVLLRDCRSFAELGERWLRIGLQQRSANRRILAAFKALLR
EEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]