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The map label for this gene is ubiB [C]

Identifier: 33864346

GI number: 33864346

Start: 2194841

End: 2196520

Strand: Direct

Name: ubiB [C]

Synonym: PMT2082

Alternate gene names: 33864346

Gene position: 2194841-2196520 (Clockwise)

Preceding gene: 33864345

Following gene: 33864348

Centisome position: 91.04

GC content: 54.82

Gene sequence:

>1680_bases
ATGGCTTGTCCGTCCCTGCTGGTAGCGATTCGGCGTGGGCTGCGTGCGCTACGTATTTGGCGTGCAGTTTTGACGTTAAT
CATCTTTGTTTGGTGGGATGCCCGTCATTGGACTTATCCAGGTGGTTGTACCAGTGAGCGGCGGCAGGCCCGCCAAACGA
TTCGAGCTCGTTGGCTCACTACAGAATTGCTCCAACTTGGTTCAGCTTTTATCAAGCTTGGACAGTTGCTCTCGGCACGT
CCTGATGTTTTGCCAGTTCAATGGGTATCTGAACTGGCTGATCTTCAGGACAAGGTCCCTGCATTTAGTTTTGAGCAAGC
TCAAATTCTGCTGGAGCAGGAATTGGGGGACCGCTGTGCAGAGATCATTGATCTTGATGATCAGCCCCTTGCCGCCGCCT
CCCTAGCTCAGGTTCATCGCGCCAGTCTGCGCAGCGGTCGGCAAGTTGTCCTGAAGATTCAACGGCCTCGCCTGGAGCGA
TTGTTTCGCCTGGATTTGCAAATCATGCAGCAGGTCGCTGCTGTACTGCAACGTCACCCCAAATGGGGACGTGGACGCGA
CTGGGTGGGGATTGCTCAGGAATGCCGTCGGGTCTTGTTAAGGGAGCTCGACTTTCGTGTAGAGGCTCAGTACGCAGCTC
GGTTTCGTCAACAGTTTCTTGATGATTCTCGTATTCGCGTGCCTGCAGTGGTCTGGGAGCTCAGCACCCGGCGTGTTCTT
TGTCTCGATTATTTGCCAGGCATCAAGGTGAATGATCTTGATGCTTTATTGAAGGCCGGCATTGATCCCTCGGCCGTAGC
GGAGCTTGGAGCCGCCAGTTATCTGCAGCAGCTCGTGCGATTCGGTTTTTTTCATGCCGATCCCCATCCAGGCAACCTTG
CCGTGGCCCCTGATGGAGCTCTCATTTACTACGACTTCGGCATGATGGGGCTGCTCTCCGATTCTTTACGACGTCGGCTC
GGTTCGATGATTCGTGCGGCGGCGGCTAGAGATGCGGCAGCCCTGGTTGAGGAGTTGCAGGCTGCGGGTTTGATTGCTTA
TGGCATCGACGTTGGACCTGTGCGGCGGTTGGTGCGAGTGATGTTTCAAGACGCTTTGACGCCCCCCTTCAGCGCCAATG
TGATCGAGAAACTTTCCGGAGATCTGTACGAGTTGGTTTATGGCCAACCCTTTCGGCTGCCAGTTGAGCTGATTTTTGTG
ATGCGTGCTCTCTCCACCTTTGAAGGTGTGGGGCGAAGCCTCGACTCAGGCTTTAGTTTGATGGCTATAGCCAAGCCATA
TTTACTGCCACTGATGACTTCAAGCGGTTCTGGTCCAAACGATTTGTTCAATGAGCTCGGACGTCAGGTCGGTGCTATTG
GCAGCCGGGCGGCAGCCTTGCCAAGACGTCTGGACGAAAGCCTTGAACGACTGGAACAAGGAGATCTGCAATTGCAGATC
CGGATGGGTGAATCCGATCGACAGTTGCGGCGCATGATCAGCGTTCAGAAGGCCCTTGGTCAATCGGTGTTATTGGGCTC
TCTAGGTATTGCAGCTGCTCTTTTGGGGGCAAGTAGTCGGCCGATTTGGGCTGTCTTGCCGTTGGTCGCGGCTCTCCCGG
TGGGCTTCGGTTGGTTCAAATTGCAGATCAAGCTGGGACGTGAGTCGCGCATGGATCATCTGTCGAGTCAGAGTCGCTGA

Upstream 100 bases:

>100_bases
CCTCATCGCCAGTTTCTAATCAAGAACAGGCTCAGGATCAGATCGATCGTCTTAGAGCAAAGGTGGCAGACCTCAATCGC
CAAGTTGAGATCAACCAGTA

Downstream 100 bases:

>100_bases
AAGTCTTCCAAAGTGATCCCCGTCCAGCCCCTTTGAGGCCTTTGCTTAGCTTCGCCCCCGTGGCCCTTGTCCTGTGGCAC
CGGCATAGACCGCTTGGCTA

Product: kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MACPSLLVAIRRGLRALRIWRAVLTLIIFVWWDARHWTYPGGCTSERRQARQTIRARWLTTELLQLGSAFIKLGQLLSAR
PDVLPVQWVSELADLQDKVPAFSFEQAQILLEQELGDRCAEIIDLDDQPLAAASLAQVHRASLRSGRQVVLKIQRPRLER
LFRLDLQIMQQVAAVLQRHPKWGRGRDWVGIAQECRRVLLRELDFRVEAQYAARFRQQFLDDSRIRVPAVVWELSTRRVL
CLDYLPGIKVNDLDALLKAGIDPSAVAELGAASYLQQLVRFGFFHADPHPGNLAVAPDGALIYYDFGMMGLLSDSLRRRL
GSMIRAAAARDAAALVEELQAAGLIAYGIDVGPVRRLVRVMFQDALTPPFSANVIEKLSGDLYELVYGQPFRLPVELIFV
MRALSTFEGVGRSLDSGFSLMAIAKPYLLPLMTSSGSGPNDLFNELGRQVGAIGSRAAALPRRLDESLERLEQGDLQLQI
RMGESDRQLRRMISVQKALGQSVLLGSLGIAAALLGASSRPIWAVLPLVAALPVGFGWFKLQIKLGRESRMDHLSSQSR

Sequences:

>Translated_559_residues
MACPSLLVAIRRGLRALRIWRAVLTLIIFVWWDARHWTYPGGCTSERRQARQTIRARWLTTELLQLGSAFIKLGQLLSAR
PDVLPVQWVSELADLQDKVPAFSFEQAQILLEQELGDRCAEIIDLDDQPLAAASLAQVHRASLRSGRQVVLKIQRPRLER
LFRLDLQIMQQVAAVLQRHPKWGRGRDWVGIAQECRRVLLRELDFRVEAQYAARFRQQFLDDSRIRVPAVVWELSTRRVL
CLDYLPGIKVNDLDALLKAGIDPSAVAELGAASYLQQLVRFGFFHADPHPGNLAVAPDGALIYYDFGMMGLLSDSLRRRL
GSMIRAAAARDAAALVEELQAAGLIAYGIDVGPVRRLVRVMFQDALTPPFSANVIEKLSGDLYELVYGQPFRLPVELIFV
MRALSTFEGVGRSLDSGFSLMAIAKPYLLPLMTSSGSGPNDLFNELGRQVGAIGSRAAALPRRLDESLERLEQGDLQLQI
RMGESDRQLRRMISVQKALGQSVLLGSLGIAAALLGASSRPIWAVLPLVAALPVGFGWFKLQIKLGRESRMDHLSSQSR
>Mature_558_residues
ACPSLLVAIRRGLRALRIWRAVLTLIIFVWWDARHWTYPGGCTSERRQARQTIRARWLTTELLQLGSAFIKLGQLLSARP
DVLPVQWVSELADLQDKVPAFSFEQAQILLEQELGDRCAEIIDLDDQPLAAASLAQVHRASLRSGRQVVLKIQRPRLERL
FRLDLQIMQQVAAVLQRHPKWGRGRDWVGIAQECRRVLLRELDFRVEAQYAARFRQQFLDDSRIRVPAVVWELSTRRVLC
LDYLPGIKVNDLDALLKAGIDPSAVAELGAASYLQQLVRFGFFHADPHPGNLAVAPDGALIYYDFGMMGLLSDSLRRRLG
SMIRAAAARDAAALVEELQAAGLIAYGIDVGPVRRLVRVMFQDALTPPFSANVIEKLSGDLYELVYGQPFRLPVELIFVM
RALSTFEGVGRSLDSGFSLMAIAKPYLLPLMTSSGSGPNDLFNELGRQVGAIGSRAAALPRRLDESLERLEQGDLQLQIR
MGESDRQLRRMISVQKALGQSVLLGSLGIAAALLGASSRPIWAVLPLVAALPVGFGWFKLQIKLGRESRMDHLSSQSR

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=313, Percent_Identity=30.6709265175719, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI41393593, Length=357, Percent_Identity=30.812324929972, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI217035081, Length=199, Percent_Identity=33.1658291457286, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI27363457, Length=231, Percent_Identity=31.6017316017316, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI217416386, Length=231, Percent_Identity=31.6017316017316, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI34147522, Length=301, Percent_Identity=24.9169435215947, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI2367309, Length=521, Percent_Identity=27.2552783109405, Blast_Score=162, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17559152, Length=259, Percent_Identity=30.5019305019305, Blast_Score=132, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI32565180, Length=303, Percent_Identity=26.7326732673267, Blast_Score=86, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323282, Length=277, Percent_Identity=28.8808664259928, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6325148, Length=259, Percent_Identity=27.7992277992278, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6321319, Length=238, Percent_Identity=26.890756302521, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI22024280, Length=293, Percent_Identity=33.1058020477816, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24662575, Length=376, Percent_Identity=30.3191489361702, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18859849, Length=312, Percent_Identity=26.9230769230769, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62292; Mature: 62161

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACPSLLVAIRRGLRALRIWRAVLTLIIFVWWDARHWTYPGGCTSERRQARQTIRARWLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TELLQLGSAFIKLGQLLSARPDVLPVQWVSELADLQDKVPAFSFEQAQILLEQELGDRCA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
EIIDLDDQPLAAASLAQVHRASLRSGRQVVLKIQRPRLERLFRLDLQIMQQVAAVLQRHP
HHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
KWGRGRDWVGIAQECRRVLLRELDFRVEAQYAARFRQQFLDDSRIRVPAVVWELSTRRVL
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCEEE
CLDYLPGIKVNDLDALLKAGIDPSAVAELGAASYLQQLVRFGFFHADPHPGNLAVAPDGA
EECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCE
LIYYDFGMMGLLSDSLRRRLGSMIRAAAARDAAALVEELQAAGLIAYGIDVGPVRRLVRV
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHH
MFQDALTPPFSANVIEKLSGDLYELVYGQPFRLPVELIFVMRALSTFEGVGRSLDSGFSL
HHHHHCCCCCCHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCHH
MAIAKPYLLPLMTSSGSGPNDLFNELGRQVGAIGSRAAALPRRLDESLERLEQGDLQLQI
HHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
RMGESDRQLRRMISVQKALGQSVLLGSLGIAAALLGASSRPIWAVLPLVAALPVGFGWFK
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEE
LQIKLGRESRMDHLSSQSR
EEEEECCHHHHHHHHCCCC
>Mature Secondary Structure 
ACPSLLVAIRRGLRALRIWRAVLTLIIFVWWDARHWTYPGGCTSERRQARQTIRARWLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TELLQLGSAFIKLGQLLSARPDVLPVQWVSELADLQDKVPAFSFEQAQILLEQELGDRCA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
EIIDLDDQPLAAASLAQVHRASLRSGRQVVLKIQRPRLERLFRLDLQIMQQVAAVLQRHP
HHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
KWGRGRDWVGIAQECRRVLLRELDFRVEAQYAARFRQQFLDDSRIRVPAVVWELSTRRVL
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCEEE
CLDYLPGIKVNDLDALLKAGIDPSAVAELGAASYLQQLVRFGFFHADPHPGNLAVAPDGA
EECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCE
LIYYDFGMMGLLSDSLRRRLGSMIRAAAARDAAALVEELQAAGLIAYGIDVGPVRRLVRV
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHH
MFQDALTPPFSANVIEKLSGDLYELVYGQPFRLPVELIFVMRALSTFEGVGRSLDSGFSL
HHHHHCCCCCCHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCHH
MAIAKPYLLPLMTSSGSGPNDLFNELGRQVGAIGSRAAALPRRLDESLERLEQGDLQLQI
HHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
RMGESDRQLRRMISVQKALGQSVLLGSLGIAAALLGASSRPIWAVLPLVAALPVGFGWFK
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEE
LQIKLGRESRMDHLSSQSR
EEEEECCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]