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The map label for this gene is hisC [H]

Identifier: 33864334

GI number: 33864334

Start: 2175698

End: 2176837

Strand: Reverse

Name: hisC [H]

Synonym: PMT2069

Alternate gene names: 33864334

Gene position: 2176837-2175698 (Counterclockwise)

Preceding gene: 33864335

Following gene: 33864327

Centisome position: 90.29

GC content: 55.61

Gene sequence:

>1140_bases
ATGGGGTCTTCACCTGCACGAATGAGTTCTGGTGCCCCCGCTCCTCGGGTGGAAGTGGAGTGTCTGAAGGCCTATAGCGC
TCCGCTTGAGGGACGCCGTGGATTGCTGCGTCTTGATTTTAATGAGAATACGATCGGCCCTAGCCCTCGTGTACTCGAGG
CGTTGCGAGCGATTCCTGCTGATCAGATCGCCGTTTATCCGGAGTACGACGGGTTGCGAGAAGCGGTGGTGGCCAATTTG
AGCAATCGTGATCAGGGCCGACCAGGGCTGACCCAGCCACTCAGCCCTAGTCAGATTGGCTTATTTAACGGCGTTGATGC
AGCGATTCACGCCATCTTTCATGCCTATGGCGATCGTGGTGATCGCTTACTGACAACGAGCCCTACCTTTGGCTACTACA
CGCCCTGCGCCCAGATGCAGGGGATGAAGATTCTGGCAATTCCCTATGAAGGCAGCGATTTTCGCTTCCCTCTGCAGGTG
ATCCGCACGCTTTTGCAGCAGAAGCGGCCGAGGCTGCTGTTGCTCTGCAATCCCAACAACCCCACAGGCACGCGCTTGGC
GCCTGAGCAGATCCTTGAGCTGGCTGTTGCAGCGCCTGAAACGTTGGTGGTAGTCGATGAGCTTTATGAGGCGTTCACGG
GCGATAGCGTTTTGCCGCAAGCAGATTTCAGTGTTACCCCGAATCTGTTGGTGTTGCGTTCGCTGGCCAAAACCGCAGGT
TTGGCTGGTCTGCGCATGGGGTTTGCGATCGGCTCTGCTGATGTGATCGATCGCGTCAGTCGTGTGACTGGGCCTTATGA
CATCAATAGCTTTGCGGTAACAGCAGCTTTCGCGGCTCTTGATGATCAGGCTTACGTGGATGCCTACGTGGCTGATGTGT
TGAAGGCGCGTGATTGGATTAGCGCTCGTCTTGATGCTTCTGGTGTGCCTTACCACCTTGATGGAGGGAATTACCTGTTG
ATCTGGCCGCAGCAGCAACCAACAGAGGTGGAAGCAGCCTTACGCAAGCGAGGCATCTTGGTTCGGCTGATGACTGGCAA
ACCGCTGATTGATGGATCCTTGCGGGTCAGCATCGGCACGATTGAGCAAATGCAGCAATTTTGGCAAGCCTTTGCCACTG
TTGAGTCTCTTGCAGCCTGA

Upstream 100 bases:

>100_bases
AACCTTCTCGTAGCTGTCGCCTTGCACTCTGCCGGCTCACGGCAGATACCCTAAAACTAGGGCTGTCGTTGTTGGGTATT
CCCACGCTGGAGCGGATGTG

Downstream 100 bases:

>100_bases
GTGATCGGCAAGACATGCTGATCGACTCACTCAGGCTATGGATGCGCTGTTAGCGCATCACCTCAATGACGGGTCCATCA
CCCAGATCGCTCGGCAGGCT

Product: aminotransferase class-I

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MGSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPADQIAVYPEYDGLREAVVANL
SNRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRGDRLLTTSPTFGYYTPCAQMQGMKILAIPYEGSDFRFPLQV
IRTLLQQKRPRLLLLCNPNNPTGTRLAPEQILELAVAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAG
LAGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWISARLDASGVPYHLDGGNYLL
IWPQQQPTEVEAALRKRGILVRLMTGKPLIDGSLRVSIGTIEQMQQFWQAFATVESLAA

Sequences:

>Translated_379_residues
MGSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPADQIAVYPEYDGLREAVVANL
SNRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRGDRLLTTSPTFGYYTPCAQMQGMKILAIPYEGSDFRFPLQV
IRTLLQQKRPRLLLLCNPNNPTGTRLAPEQILELAVAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAG
LAGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWISARLDASGVPYHLDGGNYLL
IWPQQQPTEVEAALRKRGILVRLMTGKPLIDGSLRVSIGTIEQMQQFWQAFATVESLAA
>Mature_378_residues
GSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPADQIAVYPEYDGLREAVVANLS
NRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRGDRLLTTSPTFGYYTPCAQMQGMKILAIPYEGSDFRFPLQVI
RTLLQQKRPRLLLLCNPNNPTGTRLAPEQILELAVAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAGL
AGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWISARLDASGVPYHLDGGNYLLI
WPQQQPTEVEAALRKRGILVRLMTGKPLIDGSLRVSIGTIEQMQQFWQAFATVESLAA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=289, Percent_Identity=29.0657439446367, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1786816, Length=209, Percent_Identity=27.7511961722488, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=362, Percent_Identity=26.5193370165746, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41126; Mature: 40994

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPA
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCC
DQIAVYPEYDGLREAVVANLSNRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRG
CCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
DRLLTTSPTFGYYTPCAQMQGMKILAIPYEGSDFRFPLQVIRTLLQQKRPRLLLLCNPNN
CEEEEECCCCCCCCCHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCCC
PTGTRLAPEQILELAVAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAG
CCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHC
LAGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWI
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SARLDASGVPYHLDGGNYLLIWPQQQPTEVEAALRKRGILVRLMTGKPLIDGSLRVSIGT
HHHCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHCCEEEEEECCCCEECCCEEEEEHH
IEQMQQFWQAFATVESLAA
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPA
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCC
DQIAVYPEYDGLREAVVANLSNRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRG
CCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
DRLLTTSPTFGYYTPCAQMQGMKILAIPYEGSDFRFPLQVIRTLLQQKRPRLLLLCNPNN
CEEEEECCCCCCCCCHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCCC
PTGTRLAPEQILELAVAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAG
CCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHC
LAGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWI
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SARLDASGVPYHLDGGNYLLIWPQQQPTEVEAALRKRGILVRLMTGKPLIDGSLRVSIGT
HHHCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHCCEEEEEECCCCEECCCEEEEEHH
IEQMQQFWQAFATVESLAA
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA