Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 33864255

GI number: 33864255

Start: 2103296

End: 2103946

Strand: Reverse

Name: tmk [H]

Synonym: PMT1990

Alternate gene names: 33864255

Gene position: 2103946-2103296 (Counterclockwise)

Preceding gene: 33864256

Following gene: 33864254

Centisome position: 87.27

GC content: 53.76

Gene sequence:

>651_bases
ATGAGTGGTCGCTTTCTTGTTCTGGAGGGTATTGACGGCTGTGGCAAGACCACTCAGCTTCGTCACCTTGCCAACTGGCT
GCCACGCAGCGGTTTGATGCCTGAGGGTGCAAGGTTGCATCTCACCCGTGAGCCCGGTGGTACGGCTTTGGGTATTGCCT
TGCGCAAGTTGGTTCTTCACCCGCCTGGGGATGCCTCCCCAGAACCCCTTGCGGAACTGTTGTTGTATGCGGCTGATCGA
GCCCAGCACGTGGCTCAGTTGATCCGACCGGCGCTTGAGCAGGGGCACTGGGTTCTCAGTGATCGTTTTAGTGGCTCTAC
CCTTGCTTATCAGGGTTATGGAAGAGAGTTGGATCTGGATTTGATTCAGCAACTCGAGCAGATCGCCACGGCTGGACTTG
TCCCGGACCTAACTTTTTGGTTGGAGTTGCCTGTAGAAGAAAGTCTGCTTCGGCGTGATGCAAGATCTAACGATCGAATC
GAAGCGGAAGGAGTTGATTTTTTAACCAGGGTGGCAACTGGATTTGCTGTTTTGGCTAGGGAACGATCTTGGGTGCCGTT
GCAGGCGGATCAACAAGTTGAGTCAGTTAGTTCTGCTTTGGAGAGCCAGCTGAAGCACCATTTTGGGCCTTTGCAAGAGA
GCATGCGATGA

Upstream 100 bases:

>100_bases
TGCCGGGCTTTGGGTTATTGCTCTCCCCACCCATCGCAGCTCTATTGATGGCCCTTAGTTCAATCACGGTGGTCGTGAAC
GCTTTGGCACTGCGTACTAC

Downstream 100 bases:

>100_bases
GCCTTGAGATTGAGTCGCGTGGGCTGTTTGAAGATTTGATCGCTCAGCCGTTGGCAGTTGCATTGCTGGAGGCAGCGTTG
AGTCAGGGTCGACTGGCTCC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MSGRFLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGIALRKLVLHPPGDASPEPLAELLLYAADR
AQHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLDLIQQLEQIATAGLVPDLTFWLELPVEESLLRRDARSNDRI
EAEGVDFLTRVATGFAVLARERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR

Sequences:

>Translated_216_residues
MSGRFLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGIALRKLVLHPPGDASPEPLAELLLYAADR
AQHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLDLIQQLEQIATAGLVPDLTFWLELPVEESLLRRDARSNDRI
EAEGVDFLTRVATGFAVLARERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR
>Mature_215_residues
SGRFLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGIALRKLVLHPPGDASPEPLAELLLYAADRA
QHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLDLIQQLEQIATAGLVPDLTFWLELPVEESLLRRDARSNDRIE
AEGVDFLTRVATGFAVLARERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=210, Percent_Identity=37.6190476190476, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23900; Mature: 23768

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRFLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGIALRKLVLH
CCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCC
PPGDASPEPLAELLLYAADRAQHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCHH
LIQQLEQIATAGLVPDLTFWLELPVEESLLRRDARSNDRIEAEGVDFLTRVATGFAVLAR
HHHHHHHHHHHCCCCCHHHHEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
ERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
SGRFLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGIALRKLVLH
CCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCC
PPGDASPEPLAELLLYAADRAQHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCHH
LIQQLEQIATAGLVPDLTFWLELPVEESLLRRDARSNDRIEAEGVDFLTRVATGFAVLAR
HHHHHHHHHHHCCCCCHHHHEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
ERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA