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The map label for this gene is rpaA [H]

Identifier: 33864253

GI number: 33864253

Start: 2101516

End: 2102322

Strand: Direct

Name: rpaA [H]

Synonym: PMT1988

Alternate gene names: 33864253

Gene position: 2101516-2102322 (Clockwise)

Preceding gene: 33864252

Following gene: 33864257

Centisome position: 87.17

GC content: 53.41

Gene sequence:

>807_bases
ATGAAGCCTTGCATCCTGCTGATCGAAGACGACCAGGACATGCGTGAACTGGTAAGCAGCCATTTAGAGCACAATGGTTT
TGACGTACAGAACGCTGAAGACGGCATCAAAGGTCAGGCTCTTGCCCTTCAGTACACCCCAGACCTGATTTTGCTCGACT
TGATGCTTCCCAACGTAGATGGGCTAACTCTCTGCCAGAGGTTGCGTCGAGACGAGCGCACCGCGGGGATTCCGATCTTG
ATGATCACCGCCTTGGCAGGCACAAAAGATAAGGTCACCGGCTTCAATTCAGGCGCGGATGATTACCTAACAAAGCCTTT
TGATCTTGAAGAATTGCAAGTGAGGGTGAAATCCCTACTACGTCGCACCGATCGAGCGCCGGTGGGCACCAACGCTCATC
ACGAGATCCTCAGCTATGGCCCTCTCACACTCGTGCCTGAGCGATTTGAAGTGATTTGGTTTGAGCGTCCCGTACGGCTC
ACGCACCTGGAATTTGAGCTGCTCCACTGCCTACTTCAGCGCCATGGACAGACCGTGGCACCTTCTCTAATCCTTAAGGA
GGTATGGGGCTATGAACCTGATGATGACATCGAAACCATCCGAGTACATGTTCGCCACCTGCGCACCAAGCTGGAACCCG
ATCCGCGCAAACCCCGCTTCATTAAAACCGTCTACGGTGCTGGTTACTGCCTTGAATTGCCTACAGGAGGACAACTCGAA
GGGATCCAAGACCTCCTAATCCAAGCACGCCAAGAGAGGGAAGCCAGAGAAGCACAAAACAAGCAAGGAGAGCGCGCCAG
CGCTTAA

Upstream 100 bases:

>100_bases
ATGCCAATGATGCACCTCAAAGCAAATCTTGAGAGAATCTGACAAGCGCTGACTTCACAGCACCCCGATGATTTCAAATT
CCTCCTGGACTCCGATCTAA

Downstream 100 bases:

>100_bases
GCGCGAGGAATCAATTCCAGCAAAGCCACTTCCCAGGCCAGCCTGGGTTGCACAAACCCCAGCAGGTGTGAACGCAGCCT
TTCCAAACGTTTCAGTGGTG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MKPCILLIEDDQDMRELVSSHLEHNGFDVQNAEDGIKGQALALQYTPDLILLDLMLPNVDGLTLCQRLRRDERTAGIPIL
MITALAGTKDKVTGFNSGADDYLTKPFDLEELQVRVKSLLRRTDRAPVGTNAHHEILSYGPLTLVPERFEVIWFERPVRL
THLEFELLHCLLQRHGQTVAPSLILKEVWGYEPDDDIETIRVHVRHLRTKLEPDPRKPRFIKTVYGAGYCLELPTGGQLE
GIQDLLIQARQEREAREAQNKQGERASA

Sequences:

>Translated_268_residues
MKPCILLIEDDQDMRELVSSHLEHNGFDVQNAEDGIKGQALALQYTPDLILLDLMLPNVDGLTLCQRLRRDERTAGIPIL
MITALAGTKDKVTGFNSGADDYLTKPFDLEELQVRVKSLLRRTDRAPVGTNAHHEILSYGPLTLVPERFEVIWFERPVRL
THLEFELLHCLLQRHGQTVAPSLILKEVWGYEPDDDIETIRVHVRHLRTKLEPDPRKPRFIKTVYGAGYCLELPTGGQLE
GIQDLLIQARQEREAREAQNKQGERASA
>Mature_268_residues
MKPCILLIEDDQDMRELVSSHLEHNGFDVQNAEDGIKGQALALQYTPDLILLDLMLPNVDGLTLCQRLRRDERTAGIPIL
MITALAGTKDKVTGFNSGADDYLTKPFDLEELQVRVKSLLRRTDRAPVGTNAHHEILSYGPLTLVPERFEVIWFERPVRL
THLEFELLHCLLQRHGQTVAPSLILKEVWGYEPDDDIETIRVHVRHLRTKLEPDPRKPRFIKTVYGAGYCLELPTGGQLE
GIQDLLIQARQEREAREAQNKQGERASA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=37.3333333333333, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786784, Length=232, Percent_Identity=38.3620689655172, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=36.5638766519824, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=34.9344978165939, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=32.3404255319149, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=35.9649122807018, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=34.3612334801762, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787375, Length=233, Percent_Identity=30.4721030042918, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=31.140350877193, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=34.3478260869565, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=33.7662337662338, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.5676855895196, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=33.0508474576271, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=110, Percent_Identity=29.0909090909091, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=125, Percent_Identity=33.6, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 30498; Mature: 30498

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPCILLIEDDQDMRELVSSHLEHNGFDVQNAEDGIKGQALALQYTPDLILLDLMLPNVD
CCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEEHHCCCCC
GLTLCQRLRRDERTAGIPILMITALAGTKDKVTGFNSGADDYLTKPFDLEELQVRVKSLL
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHH
RRTDRAPVGTNAHHEILSYGPLTLVPERFEVIWFERPVRLTHLEFELLHCLLQRHGQTVA
HHHCCCCCCCCCHHHHHHCCCEEECCCCEEEEEEECCEEEEHHHHHHHHHHHHHCCCCCH
PSLILKEVWGYEPDDDIETIRVHVRHLRTKLEPDPRKPRFIKTVYGAGYCLELPTGGQLE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCEEEECCCCCCHH
GIQDLLIQARQEREAREAQNKQGERASA
HHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKPCILLIEDDQDMRELVSSHLEHNGFDVQNAEDGIKGQALALQYTPDLILLDLMLPNVD
CCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEEHHCCCCC
GLTLCQRLRRDERTAGIPILMITALAGTKDKVTGFNSGADDYLTKPFDLEELQVRVKSLL
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHH
RRTDRAPVGTNAHHEILSYGPLTLVPERFEVIWFERPVRLTHLEFELLHCLLQRHGQTVA
HHHCCCCCCCCCHHHHHHCCCEEECCCCEEEEEEECCEEEEHHHHHHHHHHHHHCCCCCH
PSLILKEVWGYEPDDDIETIRVHVRHLRTKLEPDPRKPRFIKTVYGAGYCLELPTGGQLE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCEEEECCCCCCHH
GIQDLLIQARQEREAREAQNKQGERASA
HHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]