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The map label for this gene is cvrA [H]

Identifier: 33864239

GI number: 33864239

Start: 2083574

End: 2084935

Strand: Reverse

Name: cvrA [H]

Synonym: PMT1974

Alternate gene names: 33864239

Gene position: 2084935-2083574 (Counterclockwise)

Preceding gene: 33864241

Following gene: 33864238

Centisome position: 86.48

GC content: 54.7

Gene sequence:

>1362_bases
TTGAGGGCTGCCGTGGCCTTTGCTGGTGCAGATGTTTCGGCCATGACGTGGTTTTCTCTAAGACTCAGGCTAGAACCTCC
TCAGGAACACCAACATTCTGATTTGGGTCATTCACTCGCCCTCTATTTTTTGGCCTTCGGAGCTCTGTTGCTTGTAGCCG
TGCTTCTCGATGACATGGCGGCTCGCGTGAGGGTTCCGGGGATCCTGATGGTGCTGATTCTTGGTTTGTTGGTTGATAAC
CATTTGACTGTGGCTTCGGATGCGGCTGATGCGCTCCCTCCCTTGCTTTCCTTGGTCCACGCAGACCAAATCACGCAGGC
AGCACTTGTTTTAGTGCTTTTCTTCGGGGGGCTCACGACGAATTGGGCAGAGATGCGCTCTGTGATCCCATCGGCCCTAA
GGCTGGCAAGTTTTGGTGCTTTATTCACAGCCCTTCTGATCACCTTGGCGATGCTTGGATTTGGCTTGGCCGAAGGGAGT
GCTGGTTGGGTGGTGTTGTTCCCGCAGGCTTTGTTCGTGGGCGCGATGTTGTCCAGTACGGATGCATCTGCGACCTTTGC
TCTCTTGCGGCCTCTCGCTGGACGCCTACCTAAGCCTGTTTTGGACCTGATTGAGACGGAGTCGGGCTTCAACGACCCTG
TCGCTGTGGTTTTGGCAGGGGTGGCAATGGCTTTGGCAGGCGGGGAGGGTGTTGCTCCGGCTGCTTTGGTGACTGTGGTG
TTACGTCAGTTTCTGTTGGGCATCTTGCTTGGCTTTCTCGGGGGGAGTCTCACCACTCAGGTGCTCGGTAGTCGTAGGTC
TCTAAATACCAATTCCATGTTGCCAGTTGTGAGTCTTGCTTTGTTGATGGTGCTTGCAGGTGGAACCACCTTGATGGGTG
GCAGTGCCTTGTTGGCTGCTTATGTGGCGGGGCTTGTGCTCGGCAATGGTTCAAGCACCGATCAGTTGGTGCTTGCGGAG
GCCCATTCCAGTTTTGCAAAAATGGCTGAACTGCTTTTGTTTCTTTGTATGGGGCTGGTGGTTTCCCCTGAGGACGTTGT
TCGAGCAGCTGGCGGAGCATTCCTACTGTTTCTCTTAATGCAGGTGGTGCGTTGGTTGATTGTTCACTTTCTGCTCTTAC
GCAGCTCATTTTCGTTAGGGCAGCGGACGTTTGTGTGCTGGGCTGGCCTGCGTGGTGCGGTGCCTATTGCTTTAGCGATT
CAGGTCTGGGCTTCGTCGTCGGTGAGTTGGGGAAAAACCATGCCTCCCCTCGCCCTGGCGGTGGTTTTGTTCGGATTGTT
GTTCCAGGGGTTTGCTTTAGTGCCTATTGCAAATCGCCTTGGGCTAGCTAGTCCACTGAAGGCTCCGCTCTCAGCCCCTT
AG

Upstream 100 bases:

>100_bases
TGGACCTTCGAAAATGTAGTCGGGGGGAGAAGGATCACTGGCCGCTGCTTCAGTGCTGCTGCTAAAGGCGTGCCTATTGA
CCCGAACAAGGGCTCCTTTT

Downstream 100 bases:

>100_bases
TCTCGCGGCCAATGCCGTCAGTTCTTTTATGCGCCTTCTACTTGTTGGTTGCACAGGTTTTGTCGGCCGTGAGCTGGTCC
CCCAGTTGTTGGCAGCCAAG

Product: CPA1 family Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRAAVAFAGADVSAMTWFSLRLRLEPPQEHQHSDLGHSLALYFLAFGALLLVAVLLDDMAARVRVPGILMVLILGLLVDN
HLTVASDAADALPPLLSLVHADQITQAALVLVLFFGGLTTNWAEMRSVIPSALRLASFGALFTALLITLAMLGFGLAEGS
AGWVVLFPQALFVGAMLSSTDASATFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVV
LRQFLLGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAAYVAGLVLGNGSSTDQLVLAE
AHSSFAKMAELLLFLCMGLVVSPEDVVRAAGGAFLLFLLMQVVRWLIVHFLLLRSSFSLGQRTFVCWAGLRGAVPIALAI
QVWASSSVSWGKTMPPLALAVVLFGLLFQGFALVPIANRLGLASPLKAPLSAP

Sequences:

>Translated_453_residues
MRAAVAFAGADVSAMTWFSLRLRLEPPQEHQHSDLGHSLALYFLAFGALLLVAVLLDDMAARVRVPGILMVLILGLLVDN
HLTVASDAADALPPLLSLVHADQITQAALVLVLFFGGLTTNWAEMRSVIPSALRLASFGALFTALLITLAMLGFGLAEGS
AGWVVLFPQALFVGAMLSSTDASATFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVV
LRQFLLGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAAYVAGLVLGNGSSTDQLVLAE
AHSSFAKMAELLLFLCMGLVVSPEDVVRAAGGAFLLFLLMQVVRWLIVHFLLLRSSFSLGQRTFVCWAGLRGAVPIALAI
QVWASSSVSWGKTMPPLALAVVLFGLLFQGFALVPIANRLGLASPLKAPLSAP
>Mature_453_residues
MRAAVAFAGADVSAMTWFSLRLRLEPPQEHQHSDLGHSLALYFLAFGALLLVAVLLDDMAARVRVPGILMVLILGLLVDN
HLTVASDAADALPPLLSLVHADQITQAALVLVLFFGGLTTNWAEMRSVIPSALRLASFGALFTALLITLAMLGFGLAEGS
AGWVVLFPQALFVGAMLSSTDASATFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVV
LRQFLLGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAAYVAGLVLGNGSSTDQLVLAE
AHSSFAKMAELLLFLCMGLVVSPEDVVRAAGGAFLLFLLMQVVRWLIVHFLLLRSSFSLGQRTFVCWAGLRGAVPIALAI
QVWASSSVSWGKTMPPLALAVVLFGLLFQGFALVPIANRLGLASPLKAPLSAP

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=346, Percent_Identity=32.3699421965318, Blast_Score=101, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 47190; Mature: 47190

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAVAFAGADVSAMTWFSLRLRLEPPQEHQHSDLGHSLALYFLAFGALLLVAVLLDDMA
CCCCEEECCCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARVRVPGILMVLILGLLVDNHLTVASDAADALPPLLSLVHADQITQAALVLVLFFGGLTT
HHHCCCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NWAEMRSVIPSALRLASFGALFTALLITLAMLGFGLAEGSAGWVVLFPQALFVGAMLSST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHCC
DASATFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVV
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LRQFLLGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAA
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHH
YVAGLVLGNGSSTDQLVLAEAHSSFAKMAELLLFLCMGLVVSPEDVVRAAGGAFLLFLLM
HHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHH
QVVRWLIVHFLLLRSSFSLGQRTFVCWAGLRGAVPIALAIQVWASSSVSWGKTMPPLALA
HHHHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHH
VVLFGLLFQGFALVPIANRLGLASPLKAPLSAP
HHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRAAVAFAGADVSAMTWFSLRLRLEPPQEHQHSDLGHSLALYFLAFGALLLVAVLLDDMA
CCCCEEECCCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARVRVPGILMVLILGLLVDNHLTVASDAADALPPLLSLVHADQITQAALVLVLFFGGLTT
HHHCCCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NWAEMRSVIPSALRLASFGALFTALLITLAMLGFGLAEGSAGWVVLFPQALFVGAMLSST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHCC
DASATFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVV
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LRQFLLGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAA
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHH
YVAGLVLGNGSSTDQLVLAEAHSSFAKMAELLLFLCMGLVVSPEDVVRAAGGAFLLFLLM
HHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHH
QVVRWLIVHFLLLRSSFSLGQRTFVCWAGLRGAVPIALAIQVWASSSVSWGKTMPPLALA
HHHHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHH
VVLFGLLFQGFALVPIANRLGLASPLKAPLSAP
HHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]