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The map label for this gene is fabF [H]

Identifier: 33864221

GI number: 33864221

Start: 2065701

End: 2066948

Strand: Direct

Name: fabF [H]

Synonym: PMT1956

Alternate gene names: 33864221

Gene position: 2065701-2066948 (Clockwise)

Preceding gene: 33864220

Following gene: 33864222

Centisome position: 85.68

GC content: 56.41

Gene sequence:

>1248_bases
ATGATGGAGGATCTCCATCGGGTTGTGATCACCGGTCTCGGAGCGGTCACACCGATTGGCAACACGGTCGCGGACTATTT
AGAAGGGTTGAAGACAGCCAACAATGGCGTAGGCGCCATAAGCCTGTTTGACGCGTCAGCCCATGCATGTCGCTTTGCCG
CAGAGGTCAAAGACTTTGACCCAACCGGTTTCCTCGAAGCGAAGGAATCAAAAAGATGGGATCGATTCAGCAAATTCGGT
GTTGTAGCAGCCAAGCAGGCAGTTGCTGATGCCGGGCTAAGCATCGAAGAGGAAAATTCCTCCCGCATCGGGGTGATTAT
TGGTTCAGGTGTCGGTGGTCTGCTCACCATGGAGACCCAAGCCCACGTTTTGAATGAGAAAGGTCCCGGTCGGGTCAGCC
CATTCACAGTGCCGATGATGATCCCCAACATGGCTACTGGGCTTGCCGCCATTGCGTTGGGGGCCAAAGGACCCAGCTCA
GCAGTGGCCACAGCCTGTGCAGCTGGATCCAATGCCATCGGCGATGCCTTCCGGCTGCTGCAACTCGGCAAAGCGGATGT
CATGGTGTGTGGTGGTGCAGAAGCAAGCATCACACCACTAGGTGTGGCTGGCTTCGCCAGTGCCAAGGCCCTCTCCTTCC
GCAATGACGACCCCACCACGGCTAGCCGTCCGTTCGATGCAGAACGAGATGGATTCGTCATCGGTGAAGGCTCTGGCGTC
CTGGTCCTTGAAACCCTTGAGCACGCCAAAAATCGCGATGCCACGATCCATGCTGAGATTGTGGGCTATGGCATGACCTG
CGATGCCCACCACATCACTGCCCCAACCCCTGGCGGCGTTGGTGGTGCAGAAGCAATCCGCCTGGCCCTAAAAGACGGAA
AGCTGGAGCCCACCAGCGTGGATTACATCAATGCCCATGGCACCAGTACTCCTGCCAATGACAGCAACGAAACAGCAGCC
ATCAAAAATGCTCTCGGCGAAAGGGCTTCTCAGATTCCTGTGAGCTCCACAAAATCCATGACGGGTCACCTTCTTGGTGG
ATCGGGCGGCATTGAAGCTGTGGCGTGCGTGCTTGCCCTTCAGCACGACATGGTGCCTCCCACAATTAATTACCTCAACC
CAGATCCACAGTGTGATCTCGACTATGTCCCCAACATGGCCAGAGAACACAGATTAAGCGTGGTGCTCTCCAATTCCTTC
GGCTTCGGCGGCCACAACGTCTGCCTCGCCTTCCGCCAAATGCCCTAA

Upstream 100 bases:

>100_bases
AGGCCTTTGATATCGAGATCCCAGACGAGGCGGCTGAGGGCATCACGACCGTCGGTGATGCCGTCAAGTACATCGAAGAC
AAGCAAGCCTGAGGATCGGC

Downstream 100 bases:

>100_bases
GCGGCTCTACCGCCTCCATCCTTCAGACTCCCTGCTATCCCATCTCAACACCATGGTCGCTGCGACTGCTTCCCTAGACA
CGCTCTGCATCAACAGCATT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MMEDLHRVVITGLGAVTPIGNTVADYLEGLKTANNGVGAISLFDASAHACRFAAEVKDFDPTGFLEAKESKRWDRFSKFG
VVAAKQAVADAGLSIEEENSSRIGVIIGSGVGGLLTMETQAHVLNEKGPGRVSPFTVPMMIPNMATGLAAIALGAKGPSS
AVATACAAGSNAIGDAFRLLQLGKADVMVCGGAEASITPLGVAGFASAKALSFRNDDPTTASRPFDAERDGFVIGEGSGV
LVLETLEHAKNRDATIHAEIVGYGMTCDAHHITAPTPGGVGGAEAIRLALKDGKLEPTSVDYINAHGTSTPANDSNETAA
IKNALGERASQIPVSSTKSMTGHLLGGSGGIEAVACVLALQHDMVPPTINYLNPDPQCDLDYVPNMAREHRLSVVLSNSF
GFGGHNVCLAFRQMP

Sequences:

>Translated_415_residues
MMEDLHRVVITGLGAVTPIGNTVADYLEGLKTANNGVGAISLFDASAHACRFAAEVKDFDPTGFLEAKESKRWDRFSKFG
VVAAKQAVADAGLSIEEENSSRIGVIIGSGVGGLLTMETQAHVLNEKGPGRVSPFTVPMMIPNMATGLAAIALGAKGPSS
AVATACAAGSNAIGDAFRLLQLGKADVMVCGGAEASITPLGVAGFASAKALSFRNDDPTTASRPFDAERDGFVIGEGSGV
LVLETLEHAKNRDATIHAEIVGYGMTCDAHHITAPTPGGVGGAEAIRLALKDGKLEPTSVDYINAHGTSTPANDSNETAA
IKNALGERASQIPVSSTKSMTGHLLGGSGGIEAVACVLALQHDMVPPTINYLNPDPQCDLDYVPNMAREHRLSVVLSNSF
GFGGHNVCLAFRQMP
>Mature_415_residues
MMEDLHRVVITGLGAVTPIGNTVADYLEGLKTANNGVGAISLFDASAHACRFAAEVKDFDPTGFLEAKESKRWDRFSKFG
VVAAKQAVADAGLSIEEENSSRIGVIIGSGVGGLLTMETQAHVLNEKGPGRVSPFTVPMMIPNMATGLAAIALGAKGPSS
AVATACAAGSNAIGDAFRLLQLGKADVMVCGGAEASITPLGVAGFASAKALSFRNDDPTTASRPFDAERDGFVIGEGSGV
LVLETLEHAKNRDATIHAEIVGYGMTCDAHHITAPTPGGVGGAEAIRLALKDGKLEPTSVDYINAHGTSTPANDSNETAA
IKNALGERASQIPVSSTKSMTGHLLGGSGGIEAVACVLALQHDMVPPTINYLNPDPQCDLDYVPNMAREHRLSVVLSNSF
GFGGHNVCLAFRQMP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=42.654028436019, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=46.6216216216216, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI41872631, Length=430, Percent_Identity=25.1162790697674, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=51.7073170731707, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=37.046004842615, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=34.2168674698795, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=37.8787878787879, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=369, Percent_Identity=26.0162601626016, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=277, Percent_Identity=26.7148014440433, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=35.7142857142857, Blast_Score=259, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=41.3461538461538, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI19920632, Length=376, Percent_Identity=26.3297872340426, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI221330659, Length=376, Percent_Identity=26.3297872340426, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24581345, Length=424, Percent_Identity=24.0566037735849, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42865; Mature: 42865

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEDLHRVVITGLGAVTPIGNTVADYLEGLKTANNGVGAISLFDASAHACRFAAEVKDFD
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCC
PTGFLEAKESKRWDRFSKFGVVAAKQAVADAGLSIEEENSSRIGVIIGSGVGGLLTMETQ
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCEEEEECH
AHVLNEKGPGRVSPFTVPMMIPNMATGLAAIALGAKGPSSAVATACAAGSNAIGDAFRLL
HHHHCCCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCHHHHHHHHCCCCHHHHHHHHH
QLGKADVMVCGGAEASITPLGVAGFASAKALSFRNDDPTTASRPFDAERDGFVIGEGSGV
HCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCE
LVLETLEHAKNRDATIHAEIVGYGMTCDAHHITAPTPGGVGGAEAIRLALKDGKLEPTSV
EEEEEHHHHCCCCCEEEEEEEEECEEECCCEECCCCCCCCCHHHHEEEEECCCCCCCCCE
DYINAHGTSTPANDSNETAAIKNALGERASQIPVSSTKSMTGHLLGGSGGIEAVACVLAL
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
QHDMVPPTINYLNPDPQCDLDYVPNMAREHRLSVVLSNSFGFGGHNVCLAFRQMP
HHCCCCCEECCCCCCCCCCHHHCCCHHHHCEEEEEEECCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MMEDLHRVVITGLGAVTPIGNTVADYLEGLKTANNGVGAISLFDASAHACRFAAEVKDFD
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCC
PTGFLEAKESKRWDRFSKFGVVAAKQAVADAGLSIEEENSSRIGVIIGSGVGGLLTMETQ
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCEEEEECH
AHVLNEKGPGRVSPFTVPMMIPNMATGLAAIALGAKGPSSAVATACAAGSNAIGDAFRLL
HHHHCCCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCHHHHHHHHCCCCHHHHHHHHH
QLGKADVMVCGGAEASITPLGVAGFASAKALSFRNDDPTTASRPFDAERDGFVIGEGSGV
HCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCE
LVLETLEHAKNRDATIHAEIVGYGMTCDAHHITAPTPGGVGGAEAIRLALKDGKLEPTSV
EEEEEHHHHCCCCCEEEEEEEEECEEECCCEECCCCCCCCCHHHHEEEEECCCCCCCCCE
DYINAHGTSTPANDSNETAAIKNALGERASQIPVSSTKSMTGHLLGGSGGIEAVACVLAL
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
QHDMVPPTINYLNPDPQCDLDYVPNMAREHRLSVVLSNSFGFGGHNVCLAFRQMP
HHCCCCCEECCCCCCCCCCHHHCCCHHHHCEEEEEEECCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]