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The map label for this gene is tktA [H]

Identifier: 33864222

GI number: 33864222

Start: 2067001

End: 2069010

Strand: Direct

Name: tktA [H]

Synonym: PMT1957

Alternate gene names: 33864222

Gene position: 2067001-2069010 (Clockwise)

Preceding gene: 33864221

Following gene: 33864223

Centisome position: 85.74

GC content: 56.12

Gene sequence:

>2010_bases
ATGGTCGCTGCGACTGCTTCCCTAGACACGCTCTGCATCAACAGCATTCGCATGCTGGCCGTCGATGCGGTCAACAAGGC
CAACAGCGGCCACCCTGGTCTTCCCATGGGCTGTGCCCCCATGGGCTACACCCTCTGGGACCAATTTCTGCATCACAACC
CCAAGAATCCTCAGTGGTTCAACCGCGACCGCTTTGTCCTCTCAGCAGGTCACGGCTGCATGTTGGTTTACGCGCTGTTG
CATCTCACCGGGTATGACTCGGTAAGCATCGAGGACATCAAGCAGTTCCGCCAATGGGGCTCCCGCACTCCTGGACATCC
CGAAACATTTGAAACCCCTGGAGTCGAAGTCACCGCAGGCCCCCTTGGTGCTGGGATCTCTAATGCCGTTGGCCTTGCGA
TCGCTGAAGCTCACCTTGCGGCCAAATTCAATAAACCCGAAGCAAAGATCGTTGATCACTACACCTACGTGGTGATGGGC
GATGGCTGCAACCAAGAAGGTATTGCCTCGGAGGCCTGCTCCCTTGCCGGCCACCTCAAGCTAGGAAAACTGATCGCCCT
CTACGACGACAACCACATCACGATCGACGGCCGCACAGACGTTTCCTTCACCGAAGACGTGCTCAAGCGCTACGAGGCCT
ATGGCTGGCATGTACAACATGTCGCCAATGGCGACACCGACGTGAATGCCATCGCCAAGGCGATCGCTGCCGCCAAGGCC
GTGACCGATAAGCCTTCGATTATCAAGGTGACCACCACCATTGGTTACGGCTCCCCTAACAAAAGCGATACTGCCGGCGT
GCACGGGGCCCCCCTTGGCGAAGAAGAAGCCACTCTCACTCGCCAACAACTGGGATGGAACTATGGCCCTTTTGAAATTC
CCCAAGAGGCCTACGACCAATACCGCAAGGCCATCGATCAAGGCGCTCGCCTTGAATCTGAGTGGAATCAAGCACTCGCC
AACTACAGAAGTCAATACCCAAATGAAGCAGCTGAATTCGAGCGGATGTTGCGCGGTGAGCTTCCCAAGGGGTGGGAAAA
AGATCTACCGACCTATACCCCTGCAGACAGCGGCCTCGCAACGCGTAAGCACTCCCAGATCTGCCTGGGCGCTCTCGGCC
CAAACCTACCGGAACTCATCGGCGGCTCTGCCGACCTCACTCACTCCAATTACACCGATATCAAAGGTGAAACCGGCTCC
TTCCAACCGGAAACACCCGAAAAGCGTTATCTACATTTCGGTGTGCGCGAGCACGCCATGGCCGCCATCCTCAATGGCAT
CGCTTACCACAACAGTGGCCTAATCCCCTACGGCGGAACCTTCCTGGTTTTTGCTGACTACATGCGCGGATCAATGCGCC
TTTCAGCCTTAAGTGAGCTTGGCGTGATCTACGTACTCACCCATGACTCAATCGGCGTCGGTGAAGATGGGCCTACCCAC
CAACCGGTCGAAACCATTCCCTCCCTGCGCGCCATGCCAAACATGCTGGTGTTCCGTCCCGGAGATGGTAATGAGACCAG
CGGAGCGTACAAAGTAGCCATCCAGAATCGCAAACGCCCCAGCTCTCTTTGCCTGAGCCGTCAGGGCATGGCCAACCAAG
CCAATTCATCCATCGAAAATGTCGCTCTCGGCGGCTACGTGCTGGAAGATTGCGAAGGCACAGCTGATCTGATCCTGATC
GGTACAGGCACAGAGCTTGACCTTTGCGTGCAAGCCGCCAAGCAACTCAGTGCTGAAGGCCACAAGATTCGCGTGGTCTC
GATGCCTTGCGTAGAACTTTTCGAAGAGCAGAGCAGCGCATACAAACAAGAGGTGCTGCCAAACGCTGTACGCAAGCGCA
TCGTGGTGGAAGCCGCCGAATCATTTGGCTGGTACAAGTACATCGGCCTTGATGGCGACAGTGTGACCATGAACAGCTTT
GGCGCTTCTGCACCAGGTGGCACATGCATGGAGAAATTTGGCTTCACCGTAGAGAATGTGGTAGCGAAGTCAAAAGCGTT
GCTGAATTGA

Upstream 100 bases:

>100_bases
GGCTTCGGCGGCCACAACGTCTGCCTCGCCTTCCGCCAAATGCCCTAAGCGGCTCTACCGCCTCCATCCTTCAGACTCCC
TGCTATCCCATCTCAACACC

Downstream 100 bases:

>100_bases
TCTGCAAGTGAATCAATAGCTCTAGCAAGCCCCGTTTCTGCTCCGCATCTCTACAGGTGCGGAGCTTTGTTATTGATATC
AAGTGAGCAGACATCTCCGC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MVAATASLDTLCINSIRMLAVDAVNKANSGHPGLPMGCAPMGYTLWDQFLHHNPKNPQWFNRDRFVLSAGHGCMLVYALL
HLTGYDSVSIEDIKQFRQWGSRTPGHPETFETPGVEVTAGPLGAGISNAVGLAIAEAHLAAKFNKPEAKIVDHYTYVVMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQHVANGDTDVNAIAKAIAAAKA
VTDKPSIIKVTTTIGYGSPNKSDTAGVHGAPLGEEEATLTRQQLGWNYGPFEIPQEAYDQYRKAIDQGARLESEWNQALA
NYRSQYPNEAAEFERMLRGELPKGWEKDLPTYTPADSGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQPETPEKRYLHFGVREHAMAAILNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKVAIQNRKRPSSLCLSRQGMANQANSSIENVALGGYVLEDCEGTADLILI
GTGTELDLCVQAAKQLSAEGHKIRVVSMPCVELFEEQSSAYKQEVLPNAVRKRIVVEAAESFGWYKYIGLDGDSVTMNSF
GASAPGGTCMEKFGFTVENVVAKSKALLN

Sequences:

>Translated_669_residues
MVAATASLDTLCINSIRMLAVDAVNKANSGHPGLPMGCAPMGYTLWDQFLHHNPKNPQWFNRDRFVLSAGHGCMLVYALL
HLTGYDSVSIEDIKQFRQWGSRTPGHPETFETPGVEVTAGPLGAGISNAVGLAIAEAHLAAKFNKPEAKIVDHYTYVVMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQHVANGDTDVNAIAKAIAAAKA
VTDKPSIIKVTTTIGYGSPNKSDTAGVHGAPLGEEEATLTRQQLGWNYGPFEIPQEAYDQYRKAIDQGARLESEWNQALA
NYRSQYPNEAAEFERMLRGELPKGWEKDLPTYTPADSGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQPETPEKRYLHFGVREHAMAAILNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKVAIQNRKRPSSLCLSRQGMANQANSSIENVALGGYVLEDCEGTADLILI
GTGTELDLCVQAAKQLSAEGHKIRVVSMPCVELFEEQSSAYKQEVLPNAVRKRIVVEAAESFGWYKYIGLDGDSVTMNSF
GASAPGGTCMEKFGFTVENVVAKSKALLN
>Mature_669_residues
MVAATASLDTLCINSIRMLAVDAVNKANSGHPGLPMGCAPMGYTLWDQFLHHNPKNPQWFNRDRFVLSAGHGCMLVYALL
HLTGYDSVSIEDIKQFRQWGSRTPGHPETFETPGVEVTAGPLGAGISNAVGLAIAEAHLAAKFNKPEAKIVDHYTYVVMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQHVANGDTDVNAIAKAIAAAKA
VTDKPSIIKVTTTIGYGSPNKSDTAGVHGAPLGEEEATLTRQQLGWNYGPFEIPQEAYDQYRKAIDQGARLESEWNQALA
NYRSQYPNEAAEFERMLRGELPKGWEKDLPTYTPADSGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQPETPEKRYLHFGVREHAMAAILNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKVAIQNRKRPSSLCLSRQGMANQANSSIENVALGGYVLEDCEGTADLILI
GTGTELDLCVQAAKQLSAEGHKIRVVSMPCVELFEEQSSAYKQEVLPNAVRKRIVVEAAESFGWYKYIGLDGDSVTMNSF
GASAPGGTCMEKFGFTVENVVAKSKALLN

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=578, Percent_Identity=26.8166089965398, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI4507521, Length=578, Percent_Identity=26.8166089965398, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI133778974, Length=576, Percent_Identity=25.3472222222222, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI225637459, Length=579, Percent_Identity=21.9343696027634, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI225637463, Length=478, Percent_Identity=23.8493723849372, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI225637461, Length=478, Percent_Identity=23.8493723849372, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=53.5444947209653, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=51.8853695324284, Blast_Score=682, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=577, Percent_Identity=24.4367417677643, Blast_Score=129, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6325331, Length=665, Percent_Identity=53.6842105263158, Blast_Score=685, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=678, Percent_Identity=49.5575221238938, Blast_Score=647, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=582, Percent_Identity=26.8041237113402, Blast_Score=170, Evalue=4e-42,
Organism=Drosophila melanogaster, GI45550715, Length=582, Percent_Identity=26.8041237113402, Blast_Score=170, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24645119, Length=554, Percent_Identity=26.8953068592058, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24666278, Length=582, Percent_Identity=25.085910652921, Blast_Score=142, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72363; Mature: 72363

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAATASLDTLCINSIRMLAVDAVNKANSGHPGLPMGCAPMGYTLWDQFLHHNPKNPQWF
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLVYALLHLTGYDSVSIEDIKQFRQWGSRTPGHPETFETPGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGAGISNAVGLAIAEAHLAAKFNKPEAKIVDHYTYVVMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCC
LGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQHVANGDTDVNAIAKAIAAAKA
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHH
VTDKPSIIKVTTTIGYGSPNKSDTAGVHGAPLGEEEATLTRQQLGWNYGPFEIPQEAYDQ
HCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
YRKAIDQGARLESEWNQALANYRSQYPNEAAEFERMLRGELPKGWEKDLPTYTPADSGLA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCC
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGSFQPETPEKRYLHFGVREHAM
CCCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEECCHHHHHH
AAILNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHHCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKVAIQNRKRPSSLCLSRQGMANQANSSIEN
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHCCCHHH
VALGGYVLEDCEGTADLILIGTGTELDLCVQAAKQLSAEGHKIRVVSMPCVELFEEQSSA
EEECCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHH
YKQEVLPNAVRKRIVVEAAESFGWYKYIGLDGDSVTMNSFGASAPGGTCMEKFGFTVENV
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCHHHHHHCCCHHHH
VAKSKALLN
HHHHHHHCC
>Mature Secondary Structure
MVAATASLDTLCINSIRMLAVDAVNKANSGHPGLPMGCAPMGYTLWDQFLHHNPKNPQWF
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLVYALLHLTGYDSVSIEDIKQFRQWGSRTPGHPETFETPGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGAGISNAVGLAIAEAHLAAKFNKPEAKIVDHYTYVVMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCC
LGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQHVANGDTDVNAIAKAIAAAKA
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHH
VTDKPSIIKVTTTIGYGSPNKSDTAGVHGAPLGEEEATLTRQQLGWNYGPFEIPQEAYDQ
HCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
YRKAIDQGARLESEWNQALANYRSQYPNEAAEFERMLRGELPKGWEKDLPTYTPADSGLA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCC
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGSFQPETPEKRYLHFGVREHAM
CCCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEECCHHHHHH
AAILNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHHCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKVAIQNRKRPSSLCLSRQGMANQANSSIEN
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHCCCHHH
VALGGYVLEDCEGTADLILIGTGTELDLCVQAAKQLSAEGHKIRVVSMPCVELFEEQSSA
EEECCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHH
YKQEVLPNAVRKRIVVEAAESFGWYKYIGLDGDSVTMNSFGASAPGGTCMEKFGFTVENV
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCHHHHHHCCCHHHH
VAKSKALLN
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]