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The map label for this gene is uvrD [H]

Identifier: 33864183

GI number: 33864183

Start: 2022796

End: 2025204

Strand: Reverse

Name: uvrD [H]

Synonym: PMT1917

Alternate gene names: 33864183

Gene position: 2025204-2022796 (Counterclockwise)

Preceding gene: 33864186

Following gene: 33864182

Centisome position: 84.0

GC content: 53.47

Gene sequence:

>2409_bases
ATGAGTTTCCTGGCTGGCCTCAATGACGCTCAGCGAAGGGCGGTGGATCATCACGAGGGCCCGTTGTTGTTGGTGGCCGG
TGCGGGCAGCGGCAAAACGCGAGCTCTGACCCATCGCATCGCCCATCTCATCGGCGAACACGGAGCCGATCCGTCTCAGA
TCCTTGCGGTGACTTTCACCAACAAGGCGGCCCGGGAGATGAAGGAGCGTCTTGAGCTGTTGCTGGCTCAGCGTCTTGCG
CAGAGTCAGTTTGGGCAGCCCTGGAGCACCCTGCCACCTGTGGAGCAGCGTCAGCTGCGCACCCGCATCTACCGCGAGGT
GACCAAGGAGCTGTGGATCGGCACCTTCCATGCCCTGTTCGCGCGAATGTTGCGTTACGACATAGACAAGTTCAAAGACA
AGGAGGGACTCACCTGGACGAAGCAGTTCTCGATTTACGACGAGGCCGATGCCCAGAGTTTGGTTAAGGAGATTGTGACT
CAGGAGCTACAGCTCGATCCCAAGCGCTTTGAGCCTAAGAAGGTGCGCTGGGCGATTAGTAACGCCAAAAATCAAGGCTG
GTTTCCTGATCAATTGGCAGCACAGGTCGATGGTCAGCGAGGCAAGCTCACGGTTGAGACGTATCGGCGTTATCGCAAGG
CATTAGCGGCGAACAACGCTCTTGATTTTGACGACCTGCTGTTGTTGCCCGTCCAGTTACTTCAGCAGAACGAGCAGATA
CGACGTTATTGGCACAATCGTTTTCGACATGTGTTGGTTGATGAATACCAAGACACCAATCGCACTCAGTACGAGTTGAT
CAAGTTGTTGGTTACCGATGGTCGTGAACCTGAAACCTTTGAGGATTGGCAGGGCCGTTCAGTTTTTGTGGTCGGCGATG
CAGATCAAAGCATCTACAGCTTCCGTGCGGCTGACTTCACGATCTTAATGGGCTTTCAGGACGACTTTGGCGACAAAGCA
TCAGACGATTCCACTCGCACCATGGTGAAGTTGGAGGAGAATTATCGCTCTACCTCAACAATTCTGGAGGCAGCTAATGC
CTTGATCGCTAACAATACAGAGCGGATTGACAAGGTATTGCGAGCTACCCGTGGCGAGGGGGAGTTGATCACCCTTACTC
GCTGTGACGATGAGATCGCAGAAGCTGAAGCTGTAGTGCATCGAATGCGCATGCTGGAAGCTGCTCATCCAGAATTTCGC
TGGGGAGATGTGGCAGTGTTGTACCGCACCAATGCCCAGTCAAGGGCGATTGAGGAGTCGTTGGTGCGTTGGCGTATTCC
TTACATTGTCGTGGGCGGATTACGTTTTTATGACAGGCGTGAAATCAAGGATGTTTTGGCCTATTTACGCTTATTGGTCA
ACCCCGCCGATACGGTGAGCCTGCTCAGAGTCATCAATGTGCCCAAGCGAGGCATTGGCAAGACCACCTTGCAGAGACTT
GCTGATGCTGCCAATCAACTTGGGATTCCTTTGTGGGATGTGGTGAGTGATGCCGAAGCAGTGCGCTCACTAGGAGGCAG
ATCGGCGAAGGGGTTGTTGCAGTTCTGTGAATTGATCAATGACTTGCAATGCTCGAGTCAAGATCAGATTCCTTCGGAGA
TGATTCAGCAGGTGATGGAGAAGAGTGGCTATATCAGTGAGCTGATAACTGAAGCTACCGATGAGGCAGAGGAGAGGCGA
CGCAATTTGCAAGAACTTGTGAATGCTGCTTTGCAATACCAGGAAGAAAATGAAGAGAGCAATCTTGAGGGCTTTTTAGC
CTCCGCTGCGTTGGCCAGCGATGCTGATAGCAAGGATACGGCTGCTGATCGGGTGACGTTAATGACCTTGCATAGCAGTA
AGGGACTGGAGTTTCCCTTGGTCTTTCTGGTTGGTATGGAGCAGGGGCTTTTCCCTAGCTATCGCTCCCTTGATGATCAA
TCCTCTTTGGAGGAAGAACGACGCCTTTGCTATGTGGGGATGACACGTGCCAAAGAACGTTTGTTTTTGTCTCATGCCAG
TGAGCGAAGACTTTGGGGTGGCATGCGACAGCCTGCTGTTCCCTCACTATTTCTTGCTGAGTTGCCCGAGGGTTTGGTGC
AGGGTGATCTCCCTCAAATTGGTGGTGTGGCATTACGGCGTGAGCGACGGCTTGACCGTTTGACGCGGGTTGATCGCGCT
GACAATCAAAGGATCAAAGTCGGTGGTGTGAGCGGAGCCCCTAGCAATGCAGTGCGGCGGCGGCAGGCTGGGCCTGCTCC
AGGCAAGGCATGGGTCGTGGGCGACCGGGTCGTTCATTCCAGCTTTGGCGAAGGGGAGATTACCCATACCTTCGGCAGTG
GCGAAAAAGTGTCGATTGCTGTCAAGTTTGCTGGTATGGGGCCAAAGATTCTTGATCCACGTTTGGCCCCGATTGAGCCT
TTGGATTAG

Upstream 100 bases:

>100_bases
CCGGCCTTGTTTCATGTGCGAACCGGATCAGGCGGTTGCGGTGCATTCCTTCCCTGTTTTGGTAATACCGAATTTAAGGT
GAGCCCAAATCGGATGTTTG

Downstream 100 bases:

>100_bases
GCCATGAGGACATGGCATATAAAAACTGCTCTTGATCCGAGGCCTGGGCCATAGCTGCACCACCATTCTCGATTTGGCAT
TGGGGAGCCACCCACGCATG

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 802; Mature: 801

Protein sequence:

>802_residues
MSFLAGLNDAQRRAVDHHEGPLLLVAGAGSGKTRALTHRIAHLIGEHGADPSQILAVTFTNKAAREMKERLELLLAQRLA
QSQFGQPWSTLPPVEQRQLRTRIYREVTKELWIGTFHALFARMLRYDIDKFKDKEGLTWTKQFSIYDEADAQSLVKEIVT
QELQLDPKRFEPKKVRWAISNAKNQGWFPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQI
RRYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPETFEDWQGRSVFVVGDADQSIYSFRAADFTILMGFQDDFGDKA
SDDSTRTMVKLEENYRSTSTILEAANALIANNTERIDKVLRATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPEFR
WGDVAVLYRTNAQSRAIEESLVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRL
ADAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQCSSQDQIPSEMIQQVMEKSGYISELITEATDEAEERR
RNLQELVNAALQYQEENEESNLEGFLASAALASDADSKDTAADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDQ
SSLEEERRLCYVGMTRAKERLFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRA
DNQRIKVGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIAVKFAGMGPKILDPRLAPIEP
LD

Sequences:

>Translated_802_residues
MSFLAGLNDAQRRAVDHHEGPLLLVAGAGSGKTRALTHRIAHLIGEHGADPSQILAVTFTNKAAREMKERLELLLAQRLA
QSQFGQPWSTLPPVEQRQLRTRIYREVTKELWIGTFHALFARMLRYDIDKFKDKEGLTWTKQFSIYDEADAQSLVKEIVT
QELQLDPKRFEPKKVRWAISNAKNQGWFPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQI
RRYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPETFEDWQGRSVFVVGDADQSIYSFRAADFTILMGFQDDFGDKA
SDDSTRTMVKLEENYRSTSTILEAANALIANNTERIDKVLRATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPEFR
WGDVAVLYRTNAQSRAIEESLVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRL
ADAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQCSSQDQIPSEMIQQVMEKSGYISELITEATDEAEERR
RNLQELVNAALQYQEENEESNLEGFLASAALASDADSKDTAADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDQ
SSLEEERRLCYVGMTRAKERLFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRA
DNQRIKVGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIAVKFAGMGPKILDPRLAPIEP
LD
>Mature_801_residues
SFLAGLNDAQRRAVDHHEGPLLLVAGAGSGKTRALTHRIAHLIGEHGADPSQILAVTFTNKAAREMKERLELLLAQRLAQ
SQFGQPWSTLPPVEQRQLRTRIYREVTKELWIGTFHALFARMLRYDIDKFKDKEGLTWTKQFSIYDEADAQSLVKEIVTQ
ELQLDPKRFEPKKVRWAISNAKNQGWFPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQIR
RYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPETFEDWQGRSVFVVGDADQSIYSFRAADFTILMGFQDDFGDKAS
DDSTRTMVKLEENYRSTSTILEAANALIANNTERIDKVLRATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPEFRW
GDVAVLYRTNAQSRAIEESLVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRLA
DAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQCSSQDQIPSEMIQQVMEKSGYISELITEATDEAEERRR
NLQELVNAALQYQEENEESNLEGFLASAALASDADSKDTAADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDQS
SLEEERRLCYVGMTRAKERLFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRAD
NQRIKVGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIAVKFAGMGPKILDPRLAPIEPL
D

Specific function: Essential helicase. May act as a helicase in plasmid pT181 replication [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=804, Percent_Identity=37.6865671641791, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI48994965, Length=694, Percent_Identity=38.7608069164265, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1787196, Length=399, Percent_Identity=27.5689223057644, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322369, Length=781, Percent_Identity=27.6568501920615, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6324477, Length=723, Percent_Identity=22.4066390041494, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 90554; Mature: 90423

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLAGLNDAQRRAVDHHEGPLLLVAGAGSGKTRALTHRIAHLIGEHGADPSQILAVTFT
CCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHEEEEEEC
NKAAREMKERLELLLAQRLAQSQFGQPWSTLPPVEQRQLRTRIYREVTKELWIGTFHALF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARMLRYDIDKFKDKEGLTWTKQFSIYDEADAQSLVKEIVTQELQLDPKRFEPKKVRWAIS
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEC
NAKNQGWFPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQI
CCCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHH
RRYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPETFEDWQGRSVFVVGDADQSIYS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHH
FRAADFTILMGFQDDFGDKASDDSTRTMVKLEENYRSTSTILEAANALIANNTERIDKVL
HHCCCEEEEEECCCCCCCCCCCCCHHEEEEEHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
RATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPEFRWGDVAVLYRTNAQSRAIEES
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHH
LVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRL
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHH
ADAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQCSSQDQIPSEMIQQVME
HHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
KSGYISELITEATDEAEERRRNLQELVNAALQYQEENEESNLEGFLASAALASDADSKDT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCH
AADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDQSSLEEERRLCYVGMTRAKER
HHCEEEEEEEECCCCCCCHHHEEEECCCCCCCCHHCCCCHHHHHHHHHEEHHHHHHHHHH
LFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRA
HHHHHCHHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
DNQRIKVGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIA
CCCEEEEECCCCCCHHHHHHHCCCCCCCCEEEEECHHHHCCCCCCCEEEEECCCCEEEEE
VKFAGMGPKILDPRLAPIEPLD
EEEECCCCHHCCCCCCCCCCCC
>Mature Secondary Structure 
SFLAGLNDAQRRAVDHHEGPLLLVAGAGSGKTRALTHRIAHLIGEHGADPSQILAVTFT
CCCCCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHEEEEEEC
NKAAREMKERLELLLAQRLAQSQFGQPWSTLPPVEQRQLRTRIYREVTKELWIGTFHALF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARMLRYDIDKFKDKEGLTWTKQFSIYDEADAQSLVKEIVTQELQLDPKRFEPKKVRWAIS
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEC
NAKNQGWFPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQI
CCCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHH
RRYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPETFEDWQGRSVFVVGDADQSIYS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHH
FRAADFTILMGFQDDFGDKASDDSTRTMVKLEENYRSTSTILEAANALIANNTERIDKVL
HHCCCEEEEEECCCCCCCCCCCCCHHEEEEEHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
RATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPEFRWGDVAVLYRTNAQSRAIEES
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHH
LVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRL
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHH
ADAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQCSSQDQIPSEMIQQVME
HHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
KSGYISELITEATDEAEERRRNLQELVNAALQYQEENEESNLEGFLASAALASDADSKDT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCH
AADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDQSSLEEERRLCYVGMTRAKER
HHCEEEEEEEECCCCCCCHHHEEEECCCCCCCCHHCCCCHHHHHHHHHEEHHHHHHHHHH
LFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRA
HHHHHCHHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
DNQRIKVGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIA
CCCEEEEECCCCCCHHHHHHHCCCCCCCCEEEEECHHHHCCCCCCCEEEEECCCCEEEEE
VKFAGMGPKILDPRLAPIEPLD
EEEECCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232203 [H]