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The map label for this gene is mtnA [H]

Identifier: 33864167

GI number: 33864167

Start: 2002289

End: 2003401

Strand: Direct

Name: mtnA [H]

Synonym: PMT1901

Alternate gene names: 33864167

Gene position: 2002289-2003401 (Clockwise)

Preceding gene: 33864165

Following gene: 33864168

Centisome position: 83.05

GC content: 56.24

Gene sequence:

>1113_bases
ATGAACATTGATGGCACAGCCTGGCGCACCATCTGGCTTGAAAAAGATGGGCATTCAGTCGGCGTGATCGATCAAACCCA
ACTGCCCCACAAGTTCAGCACCCTCAAGCTCAGCAACTGCCAAGAGGCCGCAACCGCAATTAGCACCATGATAGTGCGTG
GGGCTCCATTGATCGGAGTTACCGGAGCCTATGGATTAATGCTGGCCCTACAAGAAGACCCCAGCGATAACGCCCTAGAA
GCGGCCTTTAAGCAACTCAATGCCACCCGGCCAACAGCAGTCAATCTGCGCTGGGCCCTCAAACGAATCCGAGACAAAGT
AAAACCGCTTCAACCAGCTAAGCGGGCAGAGGCCGCCAGAGCCGAGTCTGCCCTCATTGCCGAGGAGGACGTGGCCATGT
GTGAGGCCATCGGCAACCATGGCTTAGCAATCATCCAAAAGCTAGCTGCAGGCAGACCAAGCGTGCGGCAAAAAGAGCCC
ATACAAGTGCTCACCCACTGTAATGCTGGCTGGCTAGCCACCGTTGATTGGGGGACCGCGCTGGCACCGATTTACAAGGC
CCACCGGGCTGGCCTAAACATTCATGTATGGGTTGACGAGACACGCCCCCGCAACCAGGGCGCAAGCCTCACTGCCTACG
AACTAGGTCGTGAAGGCGTACCCCATACCGTGATCGTGGATAACGCGGGTGGGCACCTTATGCAGCAAGGATATGTTGAC
GCAGTCGTCGTAGGTAGCGACCGAACCACACGTAGCGGTGACGTGTGCAACAAAATCGGCACCTATCTCAAGGCCTTAGC
GGCTCTAGACAACGGCGTGCCCTTTTATGTGGCCCTACCCGCCTCAACAATCGACTGGTCAATCTCGGATGGGGTCGCAG
AAATCCCTATCGAAACCCGCTCGGCGATGGAAGTGACCCACATCCAAGGACGAAACAACAACGCTTCTAGCAACAACCAA
CTCACCACCGTGCAACTCACTCCCAATCAAAGCGAAGGATTCAACCCTGCTTTTGATGTAACCCCTGCGCGCCTCGTAAC
GGCCCTAATCACCGAACGCGGAGTCGCGGCAGCAAGCGAGACGGGCCTCATGGAGCTTTACTGCGATGATTAA

Upstream 100 bases:

>100_bases
AATTAGCCATGCAACCTGACCGCTTTAGAAATCAGGATCTGCCTAGGCATAACATCGACTCGATCAACACTGCCCAGGAT
CATCTAAATGGTGAAATGTC

Downstream 100 bases:

>100_bases
AAATCAAAGCCAATGAATGCAAAAATATCACTACGGAAAGATTGATAAATAGTTAGTCAAACTCAAGGTAGTCTTTAATC
ATAGAAAAATCTTCACAGCA

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MNIDGTAWRTIWLEKDGHSVGVIDQTQLPHKFSTLKLSNCQEAATAISTMIVRGAPLIGVTGAYGLMLALQEDPSDNALE
AAFKQLNATRPTAVNLRWALKRIRDKVKPLQPAKRAEAARAESALIAEEDVAMCEAIGNHGLAIIQKLAAGRPSVRQKEP
IQVLTHCNAGWLATVDWGTALAPIYKAHRAGLNIHVWVDETRPRNQGASLTAYELGREGVPHTVIVDNAGGHLMQQGYVD
AVVVGSDRTTRSGDVCNKIGTYLKALAALDNGVPFYVALPASTIDWSISDGVAEIPIETRSAMEVTHIQGRNNNASSNNQ
LTTVQLTPNQSEGFNPAFDVTPARLVTALITERGVAAASETGLMELYCDD

Sequences:

>Translated_370_residues
MNIDGTAWRTIWLEKDGHSVGVIDQTQLPHKFSTLKLSNCQEAATAISTMIVRGAPLIGVTGAYGLMLALQEDPSDNALE
AAFKQLNATRPTAVNLRWALKRIRDKVKPLQPAKRAEAARAESALIAEEDVAMCEAIGNHGLAIIQKLAAGRPSVRQKEP
IQVLTHCNAGWLATVDWGTALAPIYKAHRAGLNIHVWVDETRPRNQGASLTAYELGREGVPHTVIVDNAGGHLMQQGYVD
AVVVGSDRTTRSGDVCNKIGTYLKALAALDNGVPFYVALPASTIDWSISDGVAEIPIETRSAMEVTHIQGRNNNASSNNQ
LTTVQLTPNQSEGFNPAFDVTPARLVTALITERGVAAASETGLMELYCDD
>Mature_370_residues
MNIDGTAWRTIWLEKDGHSVGVIDQTQLPHKFSTLKLSNCQEAATAISTMIVRGAPLIGVTGAYGLMLALQEDPSDNALE
AAFKQLNATRPTAVNLRWALKRIRDKVKPLQPAKRAEAARAESALIAEEDVAMCEAIGNHGLAIIQKLAAGRPSVRQKEP
IQVLTHCNAGWLATVDWGTALAPIYKAHRAGLNIHVWVDETRPRNQGASLTAYELGREGVPHTVIVDNAGGHLMQQGYVD
AVVVGSDRTTRSGDVCNKIGTYLKALAALDNGVPFYVALPASTIDWSISDGVAEIPIETRSAMEVTHIQGRNNNASSNNQ
LTTVQLTPNQSEGFNPAFDVTPARLVTALITERGVAAASETGLMELYCDD

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=359, Percent_Identity=37.3259052924791, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI23943880, Length=352, Percent_Identity=34.375, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17557462, Length=347, Percent_Identity=35.7348703170029, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17557123, Length=250, Percent_Identity=26.4, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=407, Percent_Identity=29.4840294840295, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21357667, Length=360, Percent_Identity=37.7777777777778, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24651647, Length=360, Percent_Identity=37.7777777777778, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 39775; Mature: 39775

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDGTAWRTIWLEKDGHSVGVIDQTQLPHKFSTLKLSNCQEAATAISTMIVRGAPLIGV
CCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEE
TGAYGLMLALQEDPSDNALEAAFKQLNATRPTAVNLRWALKRIRDKVKPLQPAKRAEAAR
CCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHH
AESALIAEEDVAMCEAIGNHGLAIIQKLAAGRPSVRQKEPIQVLTHCNAGWLATVDWGTA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHEEECCCCEEEEECCCHH
LAPIYKAHRAGLNIHVWVDETRPRNQGASLTAYELGREGVPHTVIVDNAGGHLMQQGYVD
HHHHHHHHHCCCEEEEEEECCCCCCCCCEEEHHHHCCCCCCEEEEEECCCCCHHHCCCEE
AVVVGSDRTTRSGDVCNKIGTYLKALAALDNGVPFYVALPASTIDWSISDGVAEIPIETR
EEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCEEECCCCCC
SAMEVTHIQGRNNNASSNNQLTTVQLTPNQSEGFNPAFDVTPARLVTALITERGVAAASE
CCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
TGLMELYCDD
CCEEEEEECC
>Mature Secondary Structure
MNIDGTAWRTIWLEKDGHSVGVIDQTQLPHKFSTLKLSNCQEAATAISTMIVRGAPLIGV
CCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEE
TGAYGLMLALQEDPSDNALEAAFKQLNATRPTAVNLRWALKRIRDKVKPLQPAKRAEAAR
CCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHH
AESALIAEEDVAMCEAIGNHGLAIIQKLAAGRPSVRQKEPIQVLTHCNAGWLATVDWGTA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHEEECCCCEEEEECCCHH
LAPIYKAHRAGLNIHVWVDETRPRNQGASLTAYELGREGVPHTVIVDNAGGHLMQQGYVD
HHHHHHHHHCCCEEEEEEECCCCCCCCCEEEHHHHCCCCCCEEEEEECCCCCHHHCCCEE
AVVVGSDRTTRSGDVCNKIGTYLKALAALDNGVPFYVALPASTIDWSISDGVAEIPIETR
EEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCEEECCCCCC
SAMEVTHIQGRNNNASSNNQLTTVQLTPNQSEGFNPAFDVTPARLVTALITERGVAAASE
CCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
TGLMELYCDD
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA