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The map label for this gene is adk [H]

Identifier: 33864018

GI number: 33864018

Start: 1845863

End: 1846411

Strand: Direct

Name: adk [H]

Synonym: PMT1751

Alternate gene names: 33864018

Gene position: 1845863-1846411 (Clockwise)

Preceding gene: 33864017

Following gene: 33864019

Centisome position: 76.56

GC content: 51.91

Gene sequence:

>549_bases
ATGAAGCAACGTCTCCTATTCCTAGGGCCCCCTGGCGCAGGCAAAGGGACCCAGGCTGAACGTCTCTGCGCAGCTCATGA
ATTAATGCACCTATCTACTGGTGATTTACTGCGTACTGAGGTCGGCGCCAAAACACCCCTTGGTCAGGAGGCGGCTGCTG
TTATGAACCGAGGCGAGCTGGTCAGCGATGAGCTGGTGCTCGCCATCGTCGAAAATCAACTCAAGAACCAAAATGGTGGT
TGGCTCTTGGATGGTTTTCCACGCACCTTGATCCAAGCCAAAGCACTCGAACCCTTACTTGAGGAACTCAAGCAACCAAT
TGAGGCTGTTGTACTACTGGAACTCAACGATGCAGTCTTAATTGAACGGTTAATTTCCCGAGGCCGCAGTGATGACAACG
AGAGCGTGATTCGTAATCGCCTTGAGGTCTACCGCGAGAAAACAGCCCCCCTCATCGACCATTACCGCCAACAAGGACTG
CTGCAAACGGTGGAAGCCCACGGCAGTATCGAATCAATCGCTATCAGCATCGAAAAATCCTTATGTTGA

Upstream 100 bases:

>100_bases
GCAAAACAAGTTCAGACCTATGTGATTTCTCAACGCTACGAAGGCCTTGTCCGCCAATGAACCATTCCCCACTCCGTCTG
AAAGCCCTTTTTTGCCATCC

Downstream 100 bases:

>100_bases
CCTACGTGGTATGGTTGCCGTTTGGAAATTTGGAGAGCCACACTCCATGAAGGTGCGTGCCTCGGTCAAGAAAATGTGTG
ACAAATGCCGGGTGATCCGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRTEVGAKTPLGQEAAAVMNRGELVSDELVLAIVENQLKNQNGG
WLLDGFPRTLIQAKALEPLLEELKQPIEAVVLLELNDAVLIERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGL
LQTVEAHGSIESIAISIEKSLC

Sequences:

>Translated_182_residues
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRTEVGAKTPLGQEAAAVMNRGELVSDELVLAIVENQLKNQNGG
WLLDGFPRTLIQAKALEPLLEELKQPIEAVVLLELNDAVLIERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGL
LQTVEAHGSIESIAISIEKSLC
>Mature_182_residues
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRTEVGAKTPLGQEAAAVMNRGELVSDELVLAIVENQLKNQNGG
WLLDGFPRTLIQAKALEPLLEELKQPIEAVVLLELNDAVLIERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGL
LQTVEAHGSIESIAISIEKSLC

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=216, Percent_Identity=36.1111111111111, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI7524346, Length=207, Percent_Identity=36.7149758454106, Blast_Score=140, Evalue=7e-34,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=37.7049180327869, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI19923437, Length=193, Percent_Identity=32.1243523316062, Blast_Score=103, Evalue=8e-23,
Organism=Homo sapiens, GI7706497, Length=187, Percent_Identity=31.0160427807487, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=31.5217391304348, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=31.5217391304348, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI310110345, Length=188, Percent_Identity=33.5106382978723, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI53832003, Length=188, Percent_Identity=33.5106382978723, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI8051579, Length=188, Percent_Identity=33.5106382978723, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI53832001, Length=188, Percent_Identity=33.5106382978723, Blast_Score=95, Evalue=3e-20,
Organism=Escherichia coli, GI1786680, Length=188, Percent_Identity=33.5106382978723, Blast_Score=112, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=35.8851674641148, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17567503, Length=177, Percent_Identity=36.7231638418079, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=32.0855614973262, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=175, Percent_Identity=33.1428571428571, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25147457, Length=168, Percent_Identity=27.3809523809524, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=34.5177664974619, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=186, Percent_Identity=32.258064516129, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=31.8181818181818, Blast_Score=104, Evalue=8e-24,
Organism=Drosophila melanogaster, GI22026816, Length=206, Percent_Identity=35.9223300970874, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24663208, Length=186, Percent_Identity=30.6451612903226, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17647141, Length=186, Percent_Identity=30.6451612903226, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17737899, Length=200, Percent_Identity=31, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645822, Length=200, Percent_Identity=31, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221459597, Length=186, Percent_Identity=29.5698924731183, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21356893, Length=186, Percent_Identity=29.5698924731183, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20049; Mature: 20049

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRTEVGAKTPLGQEAAAVMNRGEL
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHCCCC
VSDELVLAIVENQLKNQNGGWLLDGFPRTLIQAKALEPLLEELKQPIEAVVLLELNDAVL
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHH
IERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGLLQTVEAHGSIESIAISIEKS
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
LC
CC
>Mature Secondary Structure
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRTEVGAKTPLGQEAAAVMNRGEL
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHCCCC
VSDELVLAIVENQLKNQNGGWLLDGFPRTLIQAKALEPLLEELKQPIEAVVLLELNDAVL
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHH
IERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGLLQTVEAHGSIESIAISIEKS
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
LC
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA