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The map label for this gene is moeB [H]

Identifier: 33863986

GI number: 33863986

Start: 1822364

End: 1823593

Strand: Reverse

Name: moeB [H]

Synonym: PMT1719

Alternate gene names: 33863986

Gene position: 1823593-1822364 (Counterclockwise)

Preceding gene: 33863987

Following gene: 33863984

Centisome position: 75.64

GC content: 50.73

Gene sequence:

>1230_bases
ATGAGGTTGCGCATTTGGGACAGTGGTAAGGGCATAGCTAGCGGCACTCTTTCCCCTATGGGTCTTCACGAAACCGTTGA
TGTTGACCTGAGCCCCGATGAGTTAGAGCGTTTTTCTCGTCATCTCACCCTGCCAGAGGTTGGGATGAATGGTCAGAAAC
GACTCAAGGCGGCTTCTGTGTTGTGTGTGGGTAGTGGCGGGCTCGGTTCGCCGTTGCTGCTTTATTTGGCTGCTGCTGGT
GTAGGCCATATTGGGATTGTCGATTTCGATGTTGTTGAGCTCTCTAATTTGCAGCGCCAGGTGATCCATGGCACGAGTTG
GGTAGGTCAAGCAAAAACGCATTCTGCTCGGGCTCGCATCCTTGAAATCAATCCCCATTGTCAAGTGGATGTCTACGAGA
AAGCGCTGAGGCGAGATAACGCTTTTGAGATCATTCAGCCGTACGACATTGTTTGTGACTGCACTGATAATTTCCCTAGC
CGTTACCTGGTGAATGACGCTTGTGTGCTTTTAGGTAAGCCCAGTATTTATGGATCGATTCATCGCTTTGAAGGTCAGGC
CACGGTGTTTAACCTTGATGCTGAGAGTCCTAACTATCGTGATCTGGTGCCCGAACCGCCACCCGCTGGCTTGGTGCCTT
CTTGCATTGAAGGCGGTGTGATGGGGATCCTTCCGGGATTGATTGGTTTAATTCAGTCCGCGGAGGTCATTAAAATCATT
ACTGGTATCGGCACGACGTTGAGTGGTCGGCTGCTGGTTGTTGATGCCTTGGCGATGACGTTTCGGGAGATGGCTTTACG
CCCGAGTCAACCGCGAGTTGTGATTGACCAGCTCATTGATTATCAAGACTTTTGTGGTTCTGGGGCTGATAAACCAGCTC
ACGAGAAGGTTGCTGGGTTGGAGAGTATTTCAGTTAAGGATCTCAAGTCTTTACTCGATCTTGGCGCTGAGGATTTTGCC
CTGGTGGATGTGCGTAATCCCAATGAGGCTGAGATTGCTTGCATTGCTGGTTCAGAATTGATCCCGTTGAACAAGATTGA
GAGTGGTGAGGCGATTGAGAAGGTCCGGCAGTTGGCCTCTGGCCGGCGATTGTATGTCTATTGTAAGCTGGGTGGTCGCT
CGGCAAAGGCTTTGACCACTCTCAAACGTCATGGCATTGAAGGTGTCAATGTGACTGGTGGCATTGATGCTTGGGCCAAG
GAAGTTGATCGCTCATTGCCTCGCTACTGA

Upstream 100 bases:

>100_bases
GATCATCGCTGGGCCATTTTGCCGTCGTTACTGGTGATCGTGGCTGGTTCAGGCAATGTGCGCGCTTGGTGGATGACAGG
AGTGCAACCTGGCCAGCAGC

Downstream 100 bases:

>100_bases
GTGGATCGTGATTTATATAGGCACTCATTGTTGAAGGGATTTCAATCAGCCCGCTTCAATTATTACCAGCTGAGGCAGGT
GTTTAGGACAGTCAATTAAA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRLRIWDSGKGIASGTLSPMGLHETVDVDLSPDELERFSRHLTLPEVGMNGQKRLKAASVLCVGSGGLGSPLLLYLAAAG
VGHIGIVDFDVVELSNLQRQVIHGTSWVGQAKTHSARARILEINPHCQVDVYEKALRRDNAFEIIQPYDIVCDCTDNFPS
RYLVNDACVLLGKPSIYGSIHRFEGQATVFNLDAESPNYRDLVPEPPPAGLVPSCIEGGVMGILPGLIGLIQSAEVIKII
TGIGTTLSGRLLVVDALAMTFREMALRPSQPRVVIDQLIDYQDFCGSGADKPAHEKVAGLESISVKDLKSLLDLGAEDFA
LVDVRNPNEAEIACIAGSELIPLNKIESGEAIEKVRQLASGRRLYVYCKLGGRSAKALTTLKRHGIEGVNVTGGIDAWAK
EVDRSLPRY

Sequences:

>Translated_409_residues
MRLRIWDSGKGIASGTLSPMGLHETVDVDLSPDELERFSRHLTLPEVGMNGQKRLKAASVLCVGSGGLGSPLLLYLAAAG
VGHIGIVDFDVVELSNLQRQVIHGTSWVGQAKTHSARARILEINPHCQVDVYEKALRRDNAFEIIQPYDIVCDCTDNFPS
RYLVNDACVLLGKPSIYGSIHRFEGQATVFNLDAESPNYRDLVPEPPPAGLVPSCIEGGVMGILPGLIGLIQSAEVIKII
TGIGTTLSGRLLVVDALAMTFREMALRPSQPRVVIDQLIDYQDFCGSGADKPAHEKVAGLESISVKDLKSLLDLGAEDFA
LVDVRNPNEAEIACIAGSELIPLNKIESGEAIEKVRQLASGRRLYVYCKLGGRSAKALTTLKRHGIEGVNVTGGIDAWAK
EVDRSLPRY
>Mature_409_residues
MRLRIWDSGKGIASGTLSPMGLHETVDVDLSPDELERFSRHLTLPEVGMNGQKRLKAASVLCVGSGGLGSPLLLYLAAAG
VGHIGIVDFDVVELSNLQRQVIHGTSWVGQAKTHSARARILEINPHCQVDVYEKALRRDNAFEIIQPYDIVCDCTDNFPS
RYLVNDACVLLGKPSIYGSIHRFEGQATVFNLDAESPNYRDLVPEPPPAGLVPSCIEGGVMGILPGLIGLIQSAEVIKII
TGIGTTLSGRLLVVDALAMTFREMALRPSQPRVVIDQLIDYQDFCGSGADKPAHEKVAGLESISVKDLKSLLDLGAEDFA
LVDVRNPNEAEIACIAGSELIPLNKIESGEAIEKVRQLASGRRLYVYCKLGGRSAKALTTLKRHGIEGVNVTGGIDAWAK
EVDRSLPRY

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=408, Percent_Identity=43.1372549019608, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI4885649, Length=132, Percent_Identity=31.0606060606061, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787048, Length=238, Percent_Identity=41.1764705882353, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87082356, Length=237, Percent_Identity=36.7088607594937, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17540406, Length=397, Percent_Identity=36.0201511335013, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI193203301, Length=165, Percent_Identity=26.0606060606061, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=409, Percent_Identity=35.4523227383863, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6320598, Length=141, Percent_Identity=29.7872340425532, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325438, Length=123, Percent_Identity=30.0813008130081, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582879, Length=397, Percent_Identity=40.0503778337531, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24660640, Length=136, Percent_Identity=32.3529411764706, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 44183; Mature: 44183

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRIWDSGKGIASGTLSPMGLHETVDVDLSPDELERFSRHLTLPEVGMNGQKRLKAASV
CEEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHEEEE
LCVGSGGLGSPLLLYLAAAGVGHIGIVDFDVVELSNLQRQVIHGTSWVGQAKTHSARARI
EEECCCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
LEINPHCQVDVYEKALRRDNAFEIIQPYDIVCDCTDNFPSRYLVNDACVLLGKPSIYGSI
EEECCCCCCHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCEEECCEEEEEECCCHHCCC
HRFEGQATVFNLDAESPNYRDLVPEPPPAGLVPSCIEGGVMGILPGLIGLIQSAEVIKII
EEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCHHHHHHH
TGIGTTLSGRLLVVDALAMTFREMALRPSQPRVVIDQLIDYQDFCGSGADKPAHEKVAGL
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHCCCCCCCHHHHHHCC
ESISVKDLKSLLDLGAEDFALVDVRNPNEAEIACIAGSELIPLNKIESGEAIEKVRQLAS
CCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHC
GRRLYVYCKLGGRSAKALTTLKRHGIEGVNVTGGIDAWAKEVDRSLPRY
CCEEEEEEEECCCCHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLRIWDSGKGIASGTLSPMGLHETVDVDLSPDELERFSRHLTLPEVGMNGQKRLKAASV
CEEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHEEEE
LCVGSGGLGSPLLLYLAAAGVGHIGIVDFDVVELSNLQRQVIHGTSWVGQAKTHSARARI
EEECCCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
LEINPHCQVDVYEKALRRDNAFEIIQPYDIVCDCTDNFPSRYLVNDACVLLGKPSIYGSI
EEECCCCCCHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCEEECCEEEEEECCCHHCCC
HRFEGQATVFNLDAESPNYRDLVPEPPPAGLVPSCIEGGVMGILPGLIGLIQSAEVIKII
EEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCHHHHHHH
TGIGTTLSGRLLVVDALAMTFREMALRPSQPRVVIDQLIDYQDFCGSGADKPAHEKVAGL
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHCCCCCCCHHHHHHCC
ESISVKDLKSLLDLGAEDFALVDVRNPNEAEIACIAGSELIPLNKIESGEAIEKVRQLAS
CCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHC
GRRLYVYCKLGGRSAKALTTLKRHGIEGVNVTGGIDAWAKEVDRSLPRY
CCEEEEEEEECCCCHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]