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The map label for this gene is panC

Identifier: 33863956

GI number: 33863956

Start: 1791542

End: 1793059

Strand: Reverse

Name: panC

Synonym: PMT1689

Alternate gene names: 33863956

Gene position: 1793059-1791542 (Counterclockwise)

Preceding gene: 33863957

Following gene: 33863950

Centisome position: 74.37

GC content: 54.48

Gene sequence:

>1518_bases
TTGCATCAATGGCGTAAGCATCAGCAGTCTTCGGTTCATTTCGTACCCACCATGGGCGCTTTGCACCGCGGTCATGGCCA
GCTGATCAAGTCAGTTCATGGATTTGGCAGGCTTCAACCAGCCGCTGTGTTGGTGAGTGTTTTCGTGAATCCTTTGCAGT
TTGGCCCTGCCGAGGATTTCGATAGTTATCCTCGTGATCTTGAGGCCGATTGTGAGTTGGCATCAAGATCAGGTGCTTCT
GCACTCTGGGCTCCTTCAGTTGATCAGGTTTTTCCTGGGGGGGCTTCTTCCCACTTCAGGATTCAGGTTCCTTCTCATCT
TCAGGCACATTTGTGTGGGGCGAGTAGGCCTGGTCACTTTGATGGTGTGGTCACGGTGGTGGCTCGCCTTTTGGCTCTAG
TTCGGCCAGAGGTGCTTGTGCTTGGTGAAAAGGATTGGCAGCAATTGGTGATCCTGCGCCATTTGGTTGCCCAGTTGGGT
TTGCCGGTGCGGGTGCATGGGATAGCCACTGTGCGCGATGACGATGGCTTGGCTTGTAGTTCCCGTAATCGTTACCTCAT
GACTCAACAGCGCCAGCAGGCGTTGGCCTTGCCTCAGCTACTTGCTCGAGCTGCTCGGGAGTCTCAGGATGGACGAGCAG
TTGATCTTGCAGGGCTCCGGTGCGCATGGGAGCAACTTGGCTTGGAGGTTGAGTATGTAGAAAAGGTAGATGCCTTTAAC
CTGCAGCCTTTGCATGCTGGCCGCAAGCTTTGCCTTCTGGCGGCGGCTGTGCGTTGCGGGGAGACTCGTCTCATCGATCA
CACTTTTCTGATGTCTCGTCAGCCAATTGTTGCTATAGATGGGCCTGCCGGTGCTGGTAAAAGCACCGTGACAAGAGCCT
TTGCTGAACGGCTTGGCCTGCTCTACCTCGATACGGGGGCCATGTATCGGGCGGTCACTTGGTTGACTCAACAACATGAT
GTTGATCCGCACGACCCTGTAGCAGTCAAAACCATCCTTGAGAATCTTGAGCTTGAGCTTGAGCCATCTCAATCAGGAGC
ACAGACGGTTCGGATCAATGGTCATGACGTAACAGAGGCGATCAGATCGCCGGAAGTGACGTCCTCGGTTTCAGTGGTTG
CTGCTCACGGCTGTGTTCGTAAGGCTTTGACGGCTCAGCAACAGAGGATGGGTGTACGAGGCGGTTTGGTTGCTGAAGGA
CGGGATATTGGTACGGCCGTTTTCCCAGATGCAGAGTTGAAGGTGTTCCTCACCGCCAGCCCGGCTGAACGTGCCAGGCG
TCGTGCTCTGGACCTGGACAATCGTGGTTTCCCGGTTCCTGATCTGGCTGAGTTGGAAACACAAATCGAGGAACGTGATC
GAATGGATAGCACCCGCGAAGTTGCTCCTTTACGCCAAGCTGAAGATGCCACTGAGTTGATCAGTGACGGCATGACGATT
GAGGAGGTGATTGAGACTTTGATCGATCTGTTTCGAGTGCAGGTTCCCGAGGAGGTTTGGCCTACAGCTGGGCGCTGA

Upstream 100 bases:

>100_bases
ATGGTGCTGCCCATGAGCTTGGTTTGATATCGAGTGGTATTGCCCAAGTGCGTCTTGAGGTGCTGCGCTGAGTTTTTCTG
TTCTCAGTTCAACGGCTGAG

Downstream 100 bases:

>100_bases
GTTCAATGAGCAGGCCTTCACAGGCGTCTTCAAGCAGATCGAGTACTTTCTCGAAGCCTGCATCTCCTCCGTAATAAGGG
TCTGGCACCTCTTCAAGTGA

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Pantothenate synthetase; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MHQWRKHQQSSVHFVPTMGALHRGHGQLIKSVHGFGRLQPAAVLVSVFVNPLQFGPAEDFDSYPRDLEADCELASRSGAS
ALWAPSVDQVFPGGASSHFRIQVPSHLQAHLCGASRPGHFDGVVTVVARLLALVRPEVLVLGEKDWQQLVILRHLVAQLG
LPVRVHGIATVRDDDGLACSSRNRYLMTQQRQQALALPQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVEKVDAFN
LQPLHAGRKLCLLAAAVRCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGLLYLDTGAMYRAVTWLTQQHD
VDPHDPVAVKTILENLELELEPSQSGAQTVRINGHDVTEAIRSPEVTSSVSVVAAHGCVRKALTAQQQRMGVRGGLVAEG
RDIGTAVFPDAELKVFLTASPAERARRRALDLDNRGFPVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMTI
EEVIETLIDLFRVQVPEEVWPTAGR

Sequences:

>Translated_505_residues
MHQWRKHQQSSVHFVPTMGALHRGHGQLIKSVHGFGRLQPAAVLVSVFVNPLQFGPAEDFDSYPRDLEADCELASRSGAS
ALWAPSVDQVFPGGASSHFRIQVPSHLQAHLCGASRPGHFDGVVTVVARLLALVRPEVLVLGEKDWQQLVILRHLVAQLG
LPVRVHGIATVRDDDGLACSSRNRYLMTQQRQQALALPQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVEKVDAFN
LQPLHAGRKLCLLAAAVRCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGLLYLDTGAMYRAVTWLTQQHD
VDPHDPVAVKTILENLELELEPSQSGAQTVRINGHDVTEAIRSPEVTSSVSVVAAHGCVRKALTAQQQRMGVRGGLVAEG
RDIGTAVFPDAELKVFLTASPAERARRRALDLDNRGFPVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMTI
EEVIETLIDLFRVQVPEEVWPTAGR
>Mature_505_residues
MHQWRKHQQSSVHFVPTMGALHRGHGQLIKSVHGFGRLQPAAVLVSVFVNPLQFGPAEDFDSYPRDLEADCELASRSGAS
ALWAPSVDQVFPGGASSHFRIQVPSHLQAHLCGASRPGHFDGVVTVVARLLALVRPEVLVLGEKDWQQLVILRHLVAQLG
LPVRVHGIATVRDDDGLACSSRNRYLMTQQRQQALALPQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVEKVDAFN
LQPLHAGRKLCLLAAAVRCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGLLYLDTGAMYRAVTWLTQQHD
VDPHDPVAVKTILENLELELEPSQSGAQTVRINGHDVTEAIRSPEVTSSVSVVAAHGCVRKALTAQQQRMGVRGGLVAEG
RDIGTAVFPDAELKVFLTASPAERARRRALDLDNRGFPVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMTI
EEVIETLIDLFRVQVPEEVWPTAGR

Specific function: Pantothenate biosynthesis; last step. [C]

COG id: COG0283

COG function: function code F; Cytidylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1786325, Length=264, Percent_Identity=37.8787878787879, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1787139, Length=218, Percent_Identity=43.1192660550459, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6322046, Length=221, Percent_Identity=35.2941176470588, Blast_Score=133, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANCY_PROMM (Q7V583)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895516.1
- ProteinModelPortal:   Q7V583
- STRING:   Q7V583
- GeneID:   1728207
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1689
- NMPDR:   fig|74547.1.peg.1683
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   LGEKDWQ
- ProtClustDB:   PRK13477
- BioCyc:   PMAR74547:PMT1689-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01349
- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00017
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase

EC number: =6.3.2.1; =2.7.4.14

Molecular weight: Translated: 55364; Mature: 55364

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQWRKHQQSSVHFVPTMGALHRGHGQLIKSVHGFGRLQPAAVLVSVFVNPLQFGPAEDF
CCCHHHHCCCCEEEEECHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCH
DSYPRDLEADCELASRSGASALWAPSVDQVFPGGASSHFRIQVPSHLQAHLCGASRPGHF
HCCCCCCCCHHHHHHCCCCCEECCCCHHHHCCCCCCCEEEEECCCHHHHHHCCCCCCCCC
DGVVTVVARLLALVRPEVLVLGEKDWQQLVILRHLVAQLGLPVRVHGIATVRDDDGLACS
HHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEC
SRNRYLMTQQRQQALALPQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVEKVDAFN
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCEEEHHHHCCCCC
LQPLHAGRKLCLLAAAVRCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGL
CCHHHHCHHHHHHHHHHHCCCCEEEHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCE
LYLDTGAMYRAVTWLTQQHDVDPHDPVAVKTILENLELELEPSQSGAQTVRINGHDVTEA
EEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEECCCCCCCCEEEECCCHHHHH
IRSPEVTSSVSVVAAHGCVRKALTAQQQRMGVRGGLVAEGRDIGTAVFPDAELKVFLTAS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCCEEEEEECC
PAERARRRALDLDNRGFPVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMTI
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCH
EEVIETLIDLFRVQVPEEVWPTAGR
HHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure
MHQWRKHQQSSVHFVPTMGALHRGHGQLIKSVHGFGRLQPAAVLVSVFVNPLQFGPAEDF
CCCHHHHCCCCEEEEECHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCH
DSYPRDLEADCELASRSGASALWAPSVDQVFPGGASSHFRIQVPSHLQAHLCGASRPGHF
HCCCCCCCCHHHHHHCCCCCEECCCCHHHHCCCCCCCEEEEECCCHHHHHHCCCCCCCCC
DGVVTVVARLLALVRPEVLVLGEKDWQQLVILRHLVAQLGLPVRVHGIATVRDDDGLACS
HHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEC
SRNRYLMTQQRQQALALPQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVEKVDAFN
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCEEEHHHHCCCCC
LQPLHAGRKLCLLAAAVRCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGL
CCHHHHCHHHHHHHHHHHCCCCEEEHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCE
LYLDTGAMYRAVTWLTQQHDVDPHDPVAVKTILENLELELEPSQSGAQTVRINGHDVTEA
EEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEECCCCCCCCEEEECCCHHHHH
IRSPEVTSSVSVVAAHGCVRKALTAQQQRMGVRGGLVAEGRDIGTAVFPDAELKVFLTAS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCCEEEEEECC
PAERARRRALDLDNRGFPVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMTI
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCH
EEVIETLIDLFRVQVPEEVWPTAGR
HHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642