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The map label for this gene is pyrH [H]

Identifier: 33863512

GI number: 33863512

Start: 1332133

End: 1332846

Strand: Direct

Name: pyrH [H]

Synonym: PMT1244

Alternate gene names: 33863512

Gene position: 1332133-1332846 (Clockwise)

Preceding gene: 33863511

Following gene: 33863513

Centisome position: 55.26

GC content: 54.62

Gene sequence:

>714_bases
ATGGCTTACGCGCGAGTCCTTCTAAAACTCAGCGGCGAAGCGCTGATGGGTGATCAGAGTTATGGCATCGATCCAGCAAT
TGTTCAATCCATCGCAGAGGATGTAGCCAAAGTGGTGGCCAAGGGCACCCAATTGGCGATCGTGGTGGGCGGTGGCAACA
TTTTTCGAGGCCTAAAGGGTTCTGCCGCGGGCATGGATCGGGCCACGGCCGACTACGTCGGCATGTTGGCCACAGTGATG
AATGCCATCACATTGCAGGACGGCTTAGAGCGAGCGGGGGTACCAACCCGAGTACAAACTGCAATCGAAATGCAAGAGGT
GGCGGAGCCTTACATCCGTCGGCGAGCCATTCGTCATCTAGAGAAAGGCCGAGTGGTTGTGTTTGGTGGAGGCTGCGGTA
ATCCATTCTTCACAACTGACACCACGGCCTCACTTCGGGCTGCGGAAATCAACGCTGATGTGGTGTTCAAAGCCACGAAG
GTGGATGGGGTTTATGACCGTGATCCCAAACGCTTCCCTGATGCAACACGCTATGACTCACTCACCTTCCAGCAAGTACT
AAGCGGCGAGCTGGCGGTGATGGACAGCACTGCCATTGCCCTATGCAAAGACAACAATATCCCGATCGTTGTATTTGACC
TCTTTGAACCTGGCAACATCGGCAAAGCAGTGGCTGGCGAAGCAATCGGCTCCCGTATCAGCAATGCAACCTAA

Upstream 100 bases:

>100_bases
CTTCATCCAAGCGAATCTGAGAATCGACAACCCTTCAGACCATCCAGCTCAAGGACGATTCGGAGAAGGCTTGCTACTCT
CTTCGGGATCTGGACGATGA

Downstream 100 bases:

>100_bases
ACAGGCCATCCCAACTCATCCCTTCACCCAGCCTTCGCCTCTCTGAAGCCATGTCGAACCAGGAACTCAAAGACAACATG
CACAAATCAGTGGAGGCCAC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MAYARVLLKLSGEALMGDQSYGIDPAIVQSIAEDVAKVVAKGTQLAIVVGGGNIFRGLKGSAAGMDRATADYVGMLATVM
NAITLQDGLERAGVPTRVQTAIEMQEVAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTASLRAAEINADVVFKATK
VDGVYDRDPKRFPDATRYDSLTFQQVLSGELAVMDSTAIALCKDNNIPIVVFDLFEPGNIGKAVAGEAIGSRISNAT

Sequences:

>Translated_237_residues
MAYARVLLKLSGEALMGDQSYGIDPAIVQSIAEDVAKVVAKGTQLAIVVGGGNIFRGLKGSAAGMDRATADYVGMLATVM
NAITLQDGLERAGVPTRVQTAIEMQEVAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTASLRAAEINADVVFKATK
VDGVYDRDPKRFPDATRYDSLTFQQVLSGELAVMDSTAIALCKDNNIPIVVFDLFEPGNIGKAVAGEAIGSRISNAT
>Mature_236_residues
AYARVLLKLSGEALMGDQSYGIDPAIVQSIAEDVAKVVAKGTQLAIVVGGGNIFRGLKGSAAGMDRATADYVGMLATVMN
AITLQDGLERAGVPTRVQTAIEMQEVAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTASLRAAEINADVVFKATKV
DGVYDRDPKRFPDATRYDSLTFQQVLSGELAVMDSTAIALCKDNNIPIVVFDLFEPGNIGKAVAGEAIGSRISNAT

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=48.2758620689655, Blast_Score=229, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25145; Mature: 25014

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYARVLLKLSGEALMGDQSYGIDPAIVQSIAEDVAKVVAKGTQLAIVVGGGNIFRGLKG
CHHHHEEHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHCCCCC
SAAGMDRATADYVGMLATVMNAITLQDGLERAGVPTRVQTAIEMQEVAEPYIRRRAIRHL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKGRVVVFGGGCGNPFFTTDTTASLRAAEINADVVFKATKVDGVYDRDPKRFPDATRYDS
HCCCEEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCHHCC
LTFQQVLSGELAVMDSTAIALCKDNNIPIVVFDLFEPGNIGKAVAGEAIGSRISNAT
HHHHHHHCCCEEEECCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AYARVLLKLSGEALMGDQSYGIDPAIVQSIAEDVAKVVAKGTQLAIVVGGGNIFRGLKG
HHHHEEHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHCCCCC
SAAGMDRATADYVGMLATVMNAITLQDGLERAGVPTRVQTAIEMQEVAEPYIRRRAIRHL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKGRVVVFGGGCGNPFFTTDTTASLRAAEINADVVFKATKVDGVYDRDPKRFPDATRYDS
HCCCEEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCHHCC
LTFQQVLSGELAVMDSTAIALCKDNNIPIVVFDLFEPGNIGKAVAGEAIGSRISNAT
HHHHHHHCCCEEEECCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA