Click here to switch to the map view.

The map label for this gene is cobO [H]

Identifier: 33863511

GI number: 33863511

Start: 1331129

End: 1331821

Strand: Direct

Name: cobO [H]

Synonym: PMT1243

Alternate gene names: 33863511

Gene position: 1331129-1331821 (Clockwise)

Preceding gene: 33863510

Following gene: 33863512

Centisome position: 55.21

GC content: 53.1

Gene sequence:

>693_bases
ATGACCAACCCGCCAGCTCCGCATTCGCCCTCTTCAACCGAACTCGATCACAGCGCAGAAGTTCTCGGCATAGGCGGGCA
TTTAGCCCCCGAAACCGACCAACAGAGCTACCGCAAACGCATGCAGCGCCGACAAGACATTCAGCGCCAACGTGTAGGAG
AACGAGACAAAGAGAAAGGCCTCATCCTTGTGTTCACAGGACATGGCAAAGGTAAAACCACAGCAGCGCTAGGGCTAGCC
TTACGCACCCTTGGCCATGGCGAGCATGTTGCAGTCGTGCAATTCATTAAAGGGAGTTGGCAGCCAGGCGAAGCAAAAGC
GTTAAAAGTTTTTGGTGACGCATTGAGCTGGCATGCGTTTGGAGAGGGCTTCACCTGGACAACCCAAGACCGGGAAAGAG
ATCAGCAATTGGTATCAAAAGCCTGGCAACAGGCTCTGATTTACCTCCACAGCAACACCCACAAACTTGTAGTGCTTGAT
GAGGTCAATGTGGCGATGAAACTGGGATATCTCAAGGTAGAAGAAGTACTAGGGGGGATCACGGAAAGGCCACCCCTAAC
CCACGTAGCACTCACTGGCCGAGGCGCACCAAAGGAGCTCATTGAACGTGCAGATCTGGTCACAGAAATGACCTTGGTGC
ACCACCCCTTCAAGGAGCAAGGCGTCAAAGCACAAGCAGGCATTGAGTTTTGA

Upstream 100 bases:

>100_bases
GAGCAAGAACTATTAGCAGGCCGAGCACTACAACGAATCACAGCCCGCCTTCCATAAGCAACCCAACTCAAAGCATGCTC
AAGACCTTGCCAACACTTTG

Downstream 100 bases:

>100_bases
AGCAATCAATCATCTCACCTCTAAATGCACATCCAATAGCTGATCTGTAGCAACAAAAACCGACAGACCGTTCACCAGCA
AAGCTCTATGCACAATGAGC

Product: cob(I)alamin adenosyltransferase

Products: NA

Alternate protein names: Cob(I)alamin adenosyltransferase; Corrinoid adenosyltransferase [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MTNPPAPHSPSSTELDHSAEVLGIGGHLAPETDQQSYRKRMQRRQDIQRQRVGERDKEKGLILVFTGHGKGKTTAALGLA
LRTLGHGEHVAVVQFIKGSWQPGEAKALKVFGDALSWHAFGEGFTWTTQDRERDQQLVSKAWQQALIYLHSNTHKLVVLD
EVNVAMKLGYLKVEEVLGGITERPPLTHVALTGRGAPKELIERADLVTEMTLVHHPFKEQGVKAQAGIEF

Sequences:

>Translated_230_residues
MTNPPAPHSPSSTELDHSAEVLGIGGHLAPETDQQSYRKRMQRRQDIQRQRVGERDKEKGLILVFTGHGKGKTTAALGLA
LRTLGHGEHVAVVQFIKGSWQPGEAKALKVFGDALSWHAFGEGFTWTTQDRERDQQLVSKAWQQALIYLHSNTHKLVVLD
EVNVAMKLGYLKVEEVLGGITERPPLTHVALTGRGAPKELIERADLVTEMTLVHHPFKEQGVKAQAGIEF
>Mature_229_residues
TNPPAPHSPSSTELDHSAEVLGIGGHLAPETDQQSYRKRMQRRQDIQRQRVGERDKEKGLILVFTGHGKGKTTAALGLAL
RTLGHGEHVAVVQFIKGSWQPGEAKALKVFGDALSWHAFGEGFTWTTQDRERDQQLVSKAWQQALIYLHSNTHKLVVLDE
VNVAMKLGYLKVEEVLGGITERPPLTHVALTGRGAPKELIERADLVTEMTLVHHPFKEQGVKAQAGIEF

Specific function: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids [H]

COG id: COG2109

COG function: function code H; ATP:corrinoid adenosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Cob(I)alamin adenosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1787525, Length=196, Percent_Identity=43.3673469387755, Blast_Score=161, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003724 [H]

Pfam domain/function: PF02572 CobA_CobO_BtuR [H]

EC number: =2.5.1.17 [H]

Molecular weight: Translated: 25471; Mature: 25340

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPPAPHSPSSTELDHSAEVLGIGGHLAPETDQQSYRKRMQRRQDIQRQRVGERDKEKG
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCC
LILVFTGHGKGKTTAALGLALRTLGHGEHVAVVQFIKGSWQPGEAKALKVFGDALSWHAF
EEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
GEGFTWTTQDRERDQQLVSKAWQQALIYLHSNTHKLVVLDEVNVAMKLGYLKVEEVLGGI
CCCCEECCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCEEHHCCCEEHHHHHCCC
TERPPLTHVALTGRGAPKELIERADLVTEMTLVHHPFKEQGVKAQAGIEF
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC
>Mature Secondary Structure 
TNPPAPHSPSSTELDHSAEVLGIGGHLAPETDQQSYRKRMQRRQDIQRQRVGERDKEKG
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCC
LILVFTGHGKGKTTAALGLALRTLGHGEHVAVVQFIKGSWQPGEAKALKVFGDALSWHAF
EEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
GEGFTWTTQDRERDQQLVSKAWQQALIYLHSNTHKLVVLDEVNVAMKLGYLKVEEVLGGI
CCCCEECCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCEEHHCCCEEHHHHHCCC
TERPPLTHVALTGRGAPKELIERADLVTEMTLVHHPFKEQGVKAQAGIEF
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]