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The map label for this gene is rrmA [C]

Identifier: 33863510

GI number: 33863510

Start: 1330456

End: 1331085

Strand: Direct

Name: rrmA [C]

Synonym: PMT1242

Alternate gene names: 33863510

Gene position: 1330456-1331085 (Clockwise)

Preceding gene: 33863509

Following gene: 33863511

Centisome position: 55.19

GC content: 52.06

Gene sequence:

>630_bases
ATGACCTCACCACTAAGAACCTTTGCCTACGAGCATCGCTGGTTTTATGACCTAGTGACAACCATTTCGGCCCTCAGCGT
AGGGGGTGTAAAGCGGTTGAGGTCCTTAGGGCTGACTGCTCTTCAAGACAAGATTTCTAAAGGAGCACCAGTTTTGGATC
TTTGCTGTGGGTCTGGCGAAACAGCAGCACCATGGATCGAGGCTGGTTTCGCTGTAACAGGTTTAGATCTTTCACCAAAG
GCACTGGCACTAGCAGCTGAACGAACCCCCCAACTGCAATGCATCGAGGGAATGGCAGAAAAACCACCGCTGAACACCAG
CCAATTTGCGGCCATCCAAATCAGCCTGGCCTTGCACGAATTCAGCTCAGAAGAACGACAACAAGTGCTCAAAGCCTGCA
TGCGCCTTTTGCAACCGGGGGGTTGGCTAGTGCTGATAGACCTCCATCCAGCAGGCCCCTGCCTCAAACTGCCCCAACAG
TTGTTTTGTGCCCTGTTCGAAACTGAAACCGCTCTCACAATGCTGCAAGCAGACTTGCCCAAGCAACTTCGGGAGATGGG
TTACAGCACTATTGAGCAAGAACTATTAGCAGGCCGAGCACTACAACGAATCACAGCCCGCCTTCCATAA

Upstream 100 bases:

>100_bases
GCCATTCAGTGGCTATTCATACCCGCACCTATCACCACTGGATCACCCGACGTGACCAACAACAAGCGGTAGATGCAGCC
CTAGCTCGACAGCTCAGCCC

Downstream 100 bases:

>100_bases
GCAACCCAACTCAAAGCATGCTCAAGACCTTGCCAACACTTTGATGACCAACCCGCCAGCTCCGCATTCGCCCTCTTCAA
CCGAACTCGATCACAGCGCA

Product: methyltransferase

Products: S-adenosyl-L-homocysteine +rRNA containing Nmethylguanine [C]

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTSPLRTFAYEHRWFYDLVTTISALSVGGVKRLRSLGLTALQDKISKGAPVLDLCCGSGETAAPWIEAGFAVTGLDLSPK
ALALAAERTPQLQCIEGMAEKPPLNTSQFAAIQISLALHEFSSEERQQVLKACMRLLQPGGWLVLIDLHPAGPCLKLPQQ
LFCALFETETALTMLQADLPKQLREMGYSTIEQELLAGRALQRITARLP

Sequences:

>Translated_209_residues
MTSPLRTFAYEHRWFYDLVTTISALSVGGVKRLRSLGLTALQDKISKGAPVLDLCCGSGETAAPWIEAGFAVTGLDLSPK
ALALAAERTPQLQCIEGMAEKPPLNTSQFAAIQISLALHEFSSEERQQVLKACMRLLQPGGWLVLIDLHPAGPCLKLPQQ
LFCALFETETALTMLQADLPKQLREMGYSTIEQELLAGRALQRITARLP
>Mature_208_residues
TSPLRTFAYEHRWFYDLVTTISALSVGGVKRLRSLGLTALQDKISKGAPVLDLCCGSGETAAPWIEAGFAVTGLDLSPKA
LALAAERTPQLQCIEGMAEKPPLNTSQFAAIQISLALHEFSSEERQQVLKACMRLLQPGGWLVLIDLHPAGPCLKLPQQL
FCALFETETALTMLQADLPKQLREMGYSTIEQELLAGRALQRITARLP

Specific function: Specifically Methylates The Guanosine In Position 745 Of 23s rRNA. [C]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.51 [C]

Molecular weight: Translated: 22833; Mature: 22702

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPLRTFAYEHRWFYDLVTTISALSVGGVKRLRSLGLTALQDKISKGAPVLDLCCGSGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEECCCCC
TAAPWIEAGFAVTGLDLSPKALALAAERTPQLQCIEGMAEKPPLNTSQFAAIQISLALHE
CCCHHHHCCCEEECCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHEEHHHHHHH
FSSEERQQVLKACMRLLQPGGWLVLIDLHPAGPCLKLPQQLFCALFETETALTMLQADLP
HCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQLREMGYSTIEQELLAGRALQRITARLP
HHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSPLRTFAYEHRWFYDLVTTISALSVGGVKRLRSLGLTALQDKISKGAPVLDLCCGSGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEECCCCC
TAAPWIEAGFAVTGLDLSPKALALAAERTPQLQCIEGMAEKPPLNTSQFAAIQISLALHE
CCCHHHHCCCEEECCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHEEHHHHHHH
FSSEERQQVLKACMRLLQPGGWLVLIDLHPAGPCLKLPQQLFCALFETETALTMLQADLP
HCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQLREMGYSTIEQELLAGRALQRITARLP
HHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Unidentified protein factor B [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-methionine; rRNA [C]

Specific reaction: S-Adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine +rRNA containing Nmethylguanine [C]

General reaction: Methyl group transfer [C]

Inhibitor: Mg2+; Unidentified protein factor A1 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]