Click here to switch to the map view.

The map label for this gene is cysS [H]

Identifier: 33863429

GI number: 33863429

Start: 1250259

End: 1251794

Strand: Direct

Name: cysS [H]

Synonym: PMT1159

Alternate gene names: 33863429

Gene position: 1250259-1251794 (Clockwise)

Preceding gene: 33863428

Following gene: 161350044

Centisome position: 51.86

GC content: 56.51

Gene sequence:

>1536_bases
GTGGCCCTAGCCTCAAAGCAAACTCCAGACCTGCCAGTGTCACTGCGGCTCACAAACACCCTCACCCGCCGCACGGAACC
CTTCACTCCGCTCAAGGACGGGCACGTCAGCATTTACTGCTGCGGCGTCACGGTCTACGACCTCTGCCATCTCGGCCATG
CCCGCAGCTACATCGCCTGGGATGTGCTGCGTCGCTATTTGATCTGGCGTGGTTACACAGTCACCTTCGTGCAGAACTTC
ACTGATATCGACGACAAAATCCTCAAGCGTGCCGCTGAAAAGGAATGCTCCATGCAGGAGATCAGCGAGCAAAACATCGA
AGCCTTCCATCAAGACATGGATTCCCTAGGCATCCTGCGGCCCGATCGCATGCCCCGCGCCACCCAATGTCTAGATGGGA
TACGCAGTTTGATCGGTGAATTAGAAGCTAGTGGGGCTGCCTACTCTGTCGATGGCGATGTCTACTTCGCCGTGATGAAA
CATCACGGCTACGGCAAGCTCAGTGGTCGTGATCTCAATGAGCAGCAACAAAACGCCGATGGTCGTGTGGCCGATGCCGA
AGAGGCGCGCAAGCAACACTCCTTTGATTTCGCACTATGGAAGGGAGCTAAAAGCGGAGAGCCAAGCTTTCCCTCACCCT
GGGGAGCAGGGCGCCCGGGCTGGCATATCGAGTGTTCCGCCATGGTGCGCGAGGAATTGGGCGAAACAATCGACATCCAC
CTGGGGGGAGCTGACCTGATCTTCCCTCATCACGAAAACGAGATCGCTCAATCTGAGGCAGCTACCGGCAAGCAGCTTGC
TCGCTATTGGCTACACAACGGCATGGTGAATGTCGGCGGTCAGAAAATGAGCAAGTCACTCGGCAACTTCACCACGATCA
GAGCCCTACTAGAAAACGGCGTCTCCCCAATGACGTTACGCCTGTTCATTCTGCAGGCCCATTACCGCAAACCGCTCGAC
TTCACAGCCGATGCCATCAACGCTGCAGCCACCGGATGGAAAGGTCTTAACGCAGCCCTTGGCCTCGGGAACATCTATAG
CGAAACCCTGAACTGGCCTGAATGCAAACCCCTACCACAAGGAGTCATTCAAGCCGCCCATCCCTCCAATCAGGAGCAAT
GCAACAAAATACGTCAACACTTCATCGATGCACTGGACGATGACCTCAATAGCTCAGGGGCCATCGCCGTGCTGTTCGAT
CTTGCCCGCCCCCTGCGTGCCCTAGCGAACCGCTTGAAGCGTGGTGACACAAAGGCAATTCAAGAAACAGCGAAGCTGAA
CTTGCTCCCACGTTGGCAACTGCTGGTGGAGCTGGCCAATGTGCTCGGGCTTGAGGCCGAAAAAGCCGCGCAACCGGCCC
CCGAGAGAAACAACAGGGTTGATGAAAACCATATCCAACGCGCCATTGCCACTCGCAAAGAGGCCAAAGCTGCCCGTGAT
TTCGCCAAAGCCGATCTCATCCGCGACGAGCTGCGCGCCCAAGGGATCGAACTGATCGATAAACCAGGAGGCCTCACAGA
CTGGATCAGCAGCTGA

Upstream 100 bases:

>100_bases
GGCTGGGAGCGGCCACTTGTGCAATGGCGTGAAGAACTAAGGCTGCCTCACCCCAACGCGAGCTAAGAATCAGCCCGAGC
CGAACGCAGGTTCAGAACGC

Downstream 100 bases:

>100_bases
TCATCATCCGCGGAACGTTCTAGTTTTCAACCATCAGCGCCACGATGAGCGACTTCGGCTTCGCCAGCTCTAGGGATACA
AACGCTTCAGCCAAATCGAC

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MALASKQTPDLPVSLRLTNTLTRRTEPFTPLKDGHVSIYCCGVTVYDLCHLGHARSYIAWDVLRRYLIWRGYTVTFVQNF
TDIDDKILKRAAEKECSMQEISEQNIEAFHQDMDSLGILRPDRMPRATQCLDGIRSLIGELEASGAAYSVDGDVYFAVMK
HHGYGKLSGRDLNEQQQNADGRVADAEEARKQHSFDFALWKGAKSGEPSFPSPWGAGRPGWHIECSAMVREELGETIDIH
LGGADLIFPHHENEIAQSEAATGKQLARYWLHNGMVNVGGQKMSKSLGNFTTIRALLENGVSPMTLRLFILQAHYRKPLD
FTADAINAAATGWKGLNAALGLGNIYSETLNWPECKPLPQGVIQAAHPSNQEQCNKIRQHFIDALDDDLNSSGAIAVLFD
LARPLRALANRLKRGDTKAIQETAKLNLLPRWQLLVELANVLGLEAEKAAQPAPERNNRVDENHIQRAIATRKEAKAARD
FAKADLIRDELRAQGIELIDKPGGLTDWISS

Sequences:

>Translated_511_residues
MALASKQTPDLPVSLRLTNTLTRRTEPFTPLKDGHVSIYCCGVTVYDLCHLGHARSYIAWDVLRRYLIWRGYTVTFVQNF
TDIDDKILKRAAEKECSMQEISEQNIEAFHQDMDSLGILRPDRMPRATQCLDGIRSLIGELEASGAAYSVDGDVYFAVMK
HHGYGKLSGRDLNEQQQNADGRVADAEEARKQHSFDFALWKGAKSGEPSFPSPWGAGRPGWHIECSAMVREELGETIDIH
LGGADLIFPHHENEIAQSEAATGKQLARYWLHNGMVNVGGQKMSKSLGNFTTIRALLENGVSPMTLRLFILQAHYRKPLD
FTADAINAAATGWKGLNAALGLGNIYSETLNWPECKPLPQGVIQAAHPSNQEQCNKIRQHFIDALDDDLNSSGAIAVLFD
LARPLRALANRLKRGDTKAIQETAKLNLLPRWQLLVELANVLGLEAEKAAQPAPERNNRVDENHIQRAIATRKEAKAARD
FAKADLIRDELRAQGIELIDKPGGLTDWISS
>Mature_510_residues
ALASKQTPDLPVSLRLTNTLTRRTEPFTPLKDGHVSIYCCGVTVYDLCHLGHARSYIAWDVLRRYLIWRGYTVTFVQNFT
DIDDKILKRAAEKECSMQEISEQNIEAFHQDMDSLGILRPDRMPRATQCLDGIRSLIGELEASGAAYSVDGDVYFAVMKH
HGYGKLSGRDLNEQQQNADGRVADAEEARKQHSFDFALWKGAKSGEPSFPSPWGAGRPGWHIECSAMVREELGETIDIHL
GGADLIFPHHENEIAQSEAATGKQLARYWLHNGMVNVGGQKMSKSLGNFTTIRALLENGVSPMTLRLFILQAHYRKPLDF
TADAINAAATGWKGLNAALGLGNIYSETLNWPECKPLPQGVIQAAHPSNQEQCNKIRQHFIDALDDDLNSSGAIAVLFDL
ARPLRALANRLKRGDTKAIQETAKLNLLPRWQLLVELANVLGLEAEKAAQPAPERNNRVDENHIQRAIATRKEAKAARDF
AKADLIRDELRAQGIELIDKPGGLTDWISS

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI13375695, Length=319, Percent_Identity=43.5736677115987, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI303304987, Length=239, Percent_Identity=42.2594142259414, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI21269877, Length=239, Percent_Identity=42.2594142259414, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI62240992, Length=239, Percent_Identity=42.2594142259414, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI10835051, Length=239, Percent_Identity=42.2594142259414, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1786737, Length=496, Percent_Identity=43.5483870967742, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17509795, Length=309, Percent_Identity=34.6278317152104, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17509797, Length=309, Percent_Identity=34.6278317152104, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324082, Length=242, Percent_Identity=40.9090909090909, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19922218, Length=523, Percent_Identity=31.3575525812619, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI19922364, Length=242, Percent_Identity=43.3884297520661, Blast_Score=189, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080 [H]

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e [H]

EC number: =6.1.1.16 [H]

Molecular weight: Translated: 56774; Mature: 56643

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALASKQTPDLPVSLRLTNTLTRRTEPFTPLKDGHVSIYCCGVTVYDLCHLGHARSYIAW
CCCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHCCHHHHHHH
DVLRRYLIWRGYTVTFVQNFTDIDDKILKRAAEKECSMQEISEQNIEAFHQDMDSLGILR
HHHHHHHHHCCCEEEEHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
PDRMPRATQCLDGIRSLIGELEASGAAYSVDGDVYFAVMKHHGYGKLSGRDLNEQQQNAD
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCCCCCCCCCHHHHCCC
GRVADAEEARKQHSFDFALWKGAKSGEPSFPSPWGAGRPGWHIECSAMVREELGETIDIH
CCCCCHHHHHHHCCCCHHEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEE
LGGADLIFPHHENEIAQSEAATGKQLARYWLHNGMVNVGGQKMSKSLGNFTTIRALLENG
ECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHHHCC
VSPMTLRLFILQAHYRKPLDFTADAINAAATGWKGLNAALGLGNIYSETLNWPECKPLPQ
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHCCCCCCCCCCH
GVIQAAHPSNQEQCNKIRQHFIDALDDDLNSSGAIAVLFDLARPLRALANRLKRGDTKAI
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
QETAKLNLLPRWQLLVELANVLGLEAEKAAQPAPERNNRVDENHIQRAIATRKEAKAARD
HHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FAKADLIRDELRAQGIELIDKPGGLTDWISS
HHHHHHHHHHHHHCCCHHHCCCCCCHHHHCC
>Mature Secondary Structure 
ALASKQTPDLPVSLRLTNTLTRRTEPFTPLKDGHVSIYCCGVTVYDLCHLGHARSYIAW
CCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHCCHHHHHHH
DVLRRYLIWRGYTVTFVQNFTDIDDKILKRAAEKECSMQEISEQNIEAFHQDMDSLGILR
HHHHHHHHHCCCEEEEHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
PDRMPRATQCLDGIRSLIGELEASGAAYSVDGDVYFAVMKHHGYGKLSGRDLNEQQQNAD
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCCCCCCCCCHHHHCCC
GRVADAEEARKQHSFDFALWKGAKSGEPSFPSPWGAGRPGWHIECSAMVREELGETIDIH
CCCCCHHHHHHHCCCCHHEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEE
LGGADLIFPHHENEIAQSEAATGKQLARYWLHNGMVNVGGQKMSKSLGNFTTIRALLENG
ECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHHHCC
VSPMTLRLFILQAHYRKPLDFTADAINAAATGWKGLNAALGLGNIYSETLNWPECKPLPQ
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHCCCCCCCCCCH
GVIQAAHPSNQEQCNKIRQHFIDALDDDLNSSGAIAVLFDLARPLRALANRLKRGDTKAI
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
QETAKLNLLPRWQLLVELANVLGLEAEKAAQPAPERNNRVDENHIQRAIATRKEAKAARD
HHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FAKADLIRDELRAQGIELIDKPGGLTDWISS
HHHHHHHHHHHHHCCCHHHCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA