Click here to switch to the map view.

The map label for this gene is dxr [H]

Identifier: 161350044

GI number: 161350044

Start: 1253362

End: 1254615

Strand: Direct

Name: dxr [H]

Synonym: PMT1161

Alternate gene names: 161350044

Gene position: 1253362-1254615 (Clockwise)

Preceding gene: 33863429

Following gene: 33863432

Centisome position: 51.99

GC content: 58.05

Gene sequence:

>1254_bases
GTGAAAGCCATCAGCGTGCTGGGCTCCACAGGTTCGATCGGTACTCAAACCCTCGAGATTGCCGAAGAATTCCCTGAGCG
CTTCAGGGTGGTGGCACTCACGGCCGGCACGAACGTCTCTCTTGTCGTGGAGCAGATCCAACGACATCATCCCGAGGTTG
TAGCGCTCGCCGACGCGTCGCTACTGCCAGAGCTAAAGCAGCAACTCAACGCACTGCCTAGCGAGCAACAACCACCTCAC
TTACCTCAGTTGTTAGCGGGCCCAGAAGGGCTCAATGTGGCCGCCTCATGGGATAGCGCTGATCTAGTGGTCAGCGGCAT
CGTCGGCTGTGCGGGGCTACTGCCAACACTTGCAGCAATCAAAGCCGGCAAGGATCTTGCCCTCGCCAACAAGGAAACCC
TGATCGCTGCAGCACCTGTCGTGCTGCCGGAATTAAAACGCAGCGGCAGTCGGCTGCTTCCAGCAGATTCCGAACACTCG
GCCATTTTCCAGTGTCTGCAAGGAACACCCTGGGCTGAGAACGCCCGCCTATCAACAGGAGTTCCTACCCCTGGGCTGCG
CCACATCCAGCTCACAGCATCTGGAGGTGCCTTCCGCGACTGGTCAGCAAAAGACCTTGAGAAAGCCACCATTGCCGATG
CAACCAGCCACCCCAACTGGAGCATGGGACGCAAAATCACCGTGGATTCAGCCACCTTGATGAATAAAGGGCTAGAGGTC
ATCGAAGCCCATTACCTCTTTGGCATCGACTACAACCAAATCGAGATCGTGATCCACCCTCAAAGCATCATCCACTCGAT
GATCGAGTTGGCTGATTCCTCCGTGCTGGGGCAGCTCGGCTGGCCAGACATGAAACTACCTATCCTCTACTGCCTGAGCT
GGCCGGAGCGGCTCGAAACTCCTTGGCGGCGACTGAATCTCGCCGAAGTAGGCGAACTCACCTTCCGCGCCCCTGATACC
AAAAAATACCCCTGCATGAAACTTGCCTACGCCGCAGGACGGGCCGGCGGAACCATGCCAGCCGTCCTCAATGCTGCCAA
TGAAGAAGCAGTGGCCCAGTTCCTTGAGGAGCGCATCCATTTTCTTGACATCCCGGAAGTGATCGAGGCTGCCTGTGAAC
GCCACAAGCCCGACCTGCAGACACAACCCCAGCTTGATGACGTGCTTGCCGTCGATGCATGGGCACGCAAGGCCGTACAA
GAGCAGGTGAAACGGGGCACCCGTCGCCTGCCACTGCCAGCCTTGACAGCATGA

Upstream 100 bases:

>100_bases
GCCAATGTTCCCGAACTGCCATGACTGGAGCTCCTTGTTAAGACAAGCTTGCCAGTGTCTGGCCATCTAGTGGGAGACTG
GCTTCAACTGCCGGAACAGT

Downstream 100 bases:

>100_bases
ATTTCAAGGTGAGTCATCACCTACTTCTTTGCGCCACAGCCAACAAGGCGGCCTGTTGCAGTGCAGATGTCGGCAACGCC
AGCTGGGCCAATCTCAAAAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKAISVLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIQRHHPEVVALADASLLPELKQQLNALPSEQQPPH
LPQLLAGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAIKAGKDLALANKETLIAAAPVVLPELKRSGSRLLPADSEHS
AIFQCLQGTPWAENARLSTGVPTPGLRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEV
IEAHYLFGIDYNQIEIVIHPQSIIHSMIELADSSVLGQLGWPDMKLPILYCLSWPERLETPWRRLNLAEVGELTFRAPDT
KKYPCMKLAYAAGRAGGTMPAVLNAANEEAVAQFLEERIHFLDIPEVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQ
EQVKRGTRRLPLPALTA

Sequences:

>Translated_417_residues
MKAISVLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIQRHHPEVVALADASLLPELKQQLNALPSEQQPPH
LPQLLAGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAIKAGKDLALANKETLIAAAPVVLPELKRSGSRLLPADSEHS
AIFQCLQGTPWAENARLSTGVPTPGLRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEV
IEAHYLFGIDYNQIEIVIHPQSIIHSMIELADSSVLGQLGWPDMKLPILYCLSWPERLETPWRRLNLAEVGELTFRAPDT
KKYPCMKLAYAAGRAGGTMPAVLNAANEEAVAQFLEERIHFLDIPEVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQ
EQVKRGTRRLPLPALTA
>Mature_417_residues
MKAISVLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIQRHHPEVVALADASLLPELKQQLNALPSEQQPPH
LPQLLAGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAIKAGKDLALANKETLIAAAPVVLPELKRSGSRLLPADSEHS
AIFQCLQGTPWAENARLSTGVPTPGLRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEV
IEAHYLFGIDYNQIEIVIHPQSIIHSMIELADSSVLGQLGWPDMKLPILYCLSWPERLETPWRRLNLAEVGELTFRAPDT
KKYPCMKLAYAAGRAGGTMPAVLNAANEEAVAQFLEERIHFLDIPEVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQ
EQVKRGTRRLPLPALTA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=405, Percent_Identity=45.679012345679, Blast_Score=323, Evalue=1e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 45167; Mature: 45167

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAISVLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIQRHHPEVVALADAS
CCCEEEECCCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCEEEECCHH
LLPELKQQLNALPSEQQPPHLPQLLAGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAI
HHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
KAGKDLALANKETLIAAAPVVLPELKRSGSRLLPADSEHSAIFQCLQGTPWAENARLSTG
HCCCCEEECCCCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECCC
VPTPGLRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEV
CCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHCHHH
IEAHYLFGIDYNQIEIVIHPQSIIHSMIELADSSVLGQLGWPDMKLPILYCLSWPERLET
HHHHEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCC
PWRRLNLAEVGELTFRAPDTKKYPCMKLAYAAGRAGGTMPAVLNAANEEAVAQFLEERIH
HHHHCCHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHH
FLDIPEVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQEQVKRGTRRLPLPALTA
HCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKAISVLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIQRHHPEVVALADAS
CCCEEEECCCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCEEEECCHH
LLPELKQQLNALPSEQQPPHLPQLLAGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAI
HHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
KAGKDLALANKETLIAAAPVVLPELKRSGSRLLPADSEHSAIFQCLQGTPWAENARLSTG
HCCCCEEECCCCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECCC
VPTPGLRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEV
CCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHCHHH
IEAHYLFGIDYNQIEIVIHPQSIIHSMIELADSSVLGQLGWPDMKLPILYCLSWPERLET
HHHHEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCC
PWRRLNLAEVGELTFRAPDTKKYPCMKLAYAAGRAGGTMPAVLNAANEEAVAQFLEERIH
HHHHCCHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHH
FLDIPEVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQEQVKRGTRRLPLPALTA
HCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]