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The map label for this gene is thrA [H]

Identifier: 33863414

GI number: 33863414

Start: 1231938

End: 1233254

Strand: Direct

Name: thrA [H]

Synonym: PMT1143

Alternate gene names: 33863414

Gene position: 1231938-1233254 (Clockwise)

Preceding gene: 33863413

Following gene: 33863415

Centisome position: 51.1

GC content: 57.25

Gene sequence:

>1317_bases
ATGGGCACGAAATTAGGAATAGGTCTCCTGGGGCTTGGAACAGTAGGCGCCGGTGTAGCAGGCATCCTCCAAGCCCCTGA
AGGGCGGCATCCACTGGTGGCTGAGCTTGAACTGGTCCGTGTAGCGGTTCGAGATCTACAACGACCTCGCCCAATTGAGC
TCCGCCCATCCTTAGTGACCAACAACCCACAGGCCGTTGTTGATGATCCCTCTGTTCAAGTGGTTGTTGAAGTCATGGGA
GGGATCGAACCAGCCCGAACCCTGATCATGCGAGCCATTGCCGCCGGCAAAGCGGTCGTTACAGCTAACAAAGCGGTGAT
TGCAAGACATGGCGAAGAGATTGCCTCTGCTGCTGCAGCTGCTGGGGTCTACGTCCTGATCGAAGCTGCCGTCGGCGGTG
GCATCCCGATCATCGAGCCACTTAAGCAATCACTAGGTGGCAACCGGATCGAACGCGTGAGCGGCATCATCAACGGCACC
ACCAACTACATCCTCAGCCGCATGGCACAGGAAGGGGTGGCCTATGACGACGTGCTCAAGACCGCCCAAGATCTTGGCTA
CGCAGAGGCAGATCCAGCTGCCGACGTTGAGGGGTTCGATGCGGCCGACAAGATTGCCATCCTCACTGGGCTCGCCTTCG
GTGGACCTGTCGACCGTGACTCAATTCCCACCCAAGGCATCAACAACCTTCAAAGCCGCGATGTGGACTACGCCACACAG
CTTGGCTACAGGGTGAAACTATTGGCTATCGCCGAACGTCTCAACTCAGACGCTCAGACCAGTCAGTCCTTGCCCTTAGC
GGTAAGGGTGCAGCCAACCATGATTCCTCTCGACCACCCGCTTGCTGGCGTGAATGGCGTGAACAACGCCATCCTGGTTG
AGGGCGATCCGATCGGCCGCGTGATGTTTTATGGCCCAGGAGCAGGCTCTGGACCCACCGCCTCAGCTGTGGTGGCGGAC
ATCCTCAACATCGCTGGCATACGCCAATTAGGTGAAATCAACGGCAGCCTCGACCCCCTTCTTGCCGCAAGCAGTTGGCG
TTCCTGTCACCTCGTTGATCCAAGCGCCATCCTTCAGCGCAACTATGTGCGCTTCAACGCAGAAGACACCCCAGGAGTGA
TCGGTCGGATCGGTAGCTGCTTCGGCGATCGTGGCATCTCGATTCAATCAATCGTTCAATTCGATGCCTCCGATGCCGGC
GCCGAAATCGTTGTGATTACCCATGAAATAAGTCAAGGCCAGATGCAAGATGCCCTGACCGCAATCACCTCCATGGCTGA
GGTCAAAGGACTTGCCGCCCATCTGAGCTGTCTTTAA

Upstream 100 bases:

>100_bases
CTCCTCAATATGAAGGCCCAGGCCCAGCAACTTGCCAGGGTTTCGTCTTCAACAACTTCTTAGAGTCCGGCCAGCAATTA
AACGACTGGACGCAGTTGCC

Downstream 100 bases:

>100_bases
CTTCCAGCCTCCCCCTGACGAAGAGCCCCCTACTTACTTAAGAGTTATAAAACAAGTTGAGAGGCAAGTCTGCAGACGCT
GACCTGTGCCCCCAAAGGTT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MGTKLGIGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRDLQRPRPIELRPSLVTNNPQAVVDDPSVQVVVEVMG
GIEPARTLIMRAIAAGKAVVTANKAVIARHGEEIASAAAAAGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGT
TNYILSRMAQEGVAYDDVLKTAQDLGYAEADPAADVEGFDAADKIAILTGLAFGGPVDRDSIPTQGINNLQSRDVDYATQ
LGYRVKLLAIAERLNSDAQTSQSLPLAVRVQPTMIPLDHPLAGVNGVNNAILVEGDPIGRVMFYGPGAGSGPTASAVVAD
ILNIAGIRQLGEINGSLDPLLAASSWRSCHLVDPSAILQRNYVRFNAEDTPGVIGRIGSCFGDRGISIQSIVQFDASDAG
AEIVVITHEISQGQMQDALTAITSMAEVKGLAAHLSCL

Sequences:

>Translated_438_residues
MGTKLGIGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRDLQRPRPIELRPSLVTNNPQAVVDDPSVQVVVEVMG
GIEPARTLIMRAIAAGKAVVTANKAVIARHGEEIASAAAAAGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGT
TNYILSRMAQEGVAYDDVLKTAQDLGYAEADPAADVEGFDAADKIAILTGLAFGGPVDRDSIPTQGINNLQSRDVDYATQ
LGYRVKLLAIAERLNSDAQTSQSLPLAVRVQPTMIPLDHPLAGVNGVNNAILVEGDPIGRVMFYGPGAGSGPTASAVVAD
ILNIAGIRQLGEINGSLDPLLAASSWRSCHLVDPSAILQRNYVRFNAEDTPGVIGRIGSCFGDRGISIQSIVQFDASDAG
AEIVVITHEISQGQMQDALTAITSMAEVKGLAAHLSCL
>Mature_437_residues
GTKLGIGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRDLQRPRPIELRPSLVTNNPQAVVDDPSVQVVVEVMGG
IEPARTLIMRAIAAGKAVVTANKAVIARHGEEIASAAAAAGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGTT
NYILSRMAQEGVAYDDVLKTAQDLGYAEADPAADVEGFDAADKIAILTGLAFGGPVDRDSIPTQGINNLQSRDVDYATQL
GYRVKLLAIAERLNSDAQTSQSLPLAVRVQPTMIPLDHPLAGVNGVNNAILVEGDPIGRVMFYGPGAGSGPTASAVVADI
LNIAGIRQLGEINGSLDPLLAASSWRSCHLVDPSAILQRNYVRFNAEDTPGVIGRIGSCFGDRGISIQSIVQFDASDAGA
EIVVITHEISQGQMQDALTAITSMAEVKGLAAHLSCL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=117, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790376, Length=260, Percent_Identity=25, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=193, Percent_Identity=29.0155440414508, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45450; Mature: 45318

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTKLGIGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRDLQRPRPIELRPSLVT
CCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEC
NNPQAVVDDPSVQVVVEVMGGIEPARTLIMRAIAAGKAVVTANKAVIARHGEEIASAAAA
CCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHH
AGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGTTNYILSRMAQEGVAYDDVLK
CCEEEEEEEHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
TAQDLGYAEADPAADVEGFDAADKIAILTGLAFGGPVDRDSIPTQGINNLQSRDVDYATQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCHHHH
LGYRVKLLAIAERLNSDAQTSQSLPLAVRVQPTMIPLDHPLAGVNGVNNAILVEGDPIGR
CCCHHHHHHHHHHHCCCHHHCCCCCEEEEECCEEECCCCCCCCCCCCCCEEEEECCCCCE
VMFYGPGAGSGPTASAVVADILNIAGIRQLGEINGSLDPLLAASSWRSCHLVDPSAILQR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECHHHHHHC
NYVRFNAEDTPGVIGRIGSCFGDRGISIQSIVQFDASDAGAEIVVITHEISQGQMQDALT
CCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHEECCCCCCCEEEEEEECCCCHHHHHHHH
AITSMAEVKGLAAHLSCL
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GTKLGIGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRDLQRPRPIELRPSLVT
CCCCCCCEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEC
NNPQAVVDDPSVQVVVEVMGGIEPARTLIMRAIAAGKAVVTANKAVIARHGEEIASAAAA
CCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHH
AGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGTTNYILSRMAQEGVAYDDVLK
CCEEEEEEEHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
TAQDLGYAEADPAADVEGFDAADKIAILTGLAFGGPVDRDSIPTQGINNLQSRDVDYATQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCHHHH
LGYRVKLLAIAERLNSDAQTSQSLPLAVRVQPTMIPLDHPLAGVNGVNNAILVEGDPIGR
CCCHHHHHHHHHHHCCCHHHCCCCCEEEEECCEEECCCCCCCCCCCCCCEEEEECCCCCE
VMFYGPGAGSGPTASAVVADILNIAGIRQLGEINGSLDPLLAASSWRSCHLVDPSAILQR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECHHHHHHC
NYVRFNAEDTPGVIGRIGSCFGDRGISIQSIVQFDASDAGAEIVVITHEISQGQMQDALT
CCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHEECCCCCCCEEEEEEECCCCHHHHHHHH
AITSMAEVKGLAAHLSCL
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]