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The map label for this gene is ubiB [C]

Identifier: 33863338

GI number: 33863338

Start: 1151528

End: 1153174

Strand: Direct

Name: ubiB [C]

Synonym: PMT1067

Alternate gene names: 33863338

Gene position: 1151528-1153174 (Clockwise)

Preceding gene: 33863335

Following gene: 33863340

Centisome position: 47.76

GC content: 50.15

Gene sequence:

>1647_bases
ATGCGTTACGACGCCAATCAGGATCTGCTCTGGTTGCTAACCAGGCCCTGGGTGTGGATACCTCGATTGATTCATGTGCT
CACCTCACTGCTCACACTGGCGGTGGGAGTGCTGGCTCAGGGCTCTAACAACGACGAAGAGGCACAAAAAAGGCTCGCAA
AAAAACTGCTAATCACCCTCACCAACCTCGGGCCTTGCTTTATCAAGGTGGGCCAAGCCCTTTCCACCCGACCAGACCTA
ATCAAGCGTGAATGGCTCGAGGAACTCACCAGCCTCCAAGACAATTTGCCCGCCTTCAACCATGCCACGGCCCTCGCCAC
GTTGGCAGAAGATCTTGGGGCTCCAGCTAGTCAACTCTTTGAAGAGTTTCCTAGCCAACCAATTGCTGCAGCCAGCCTGG
GCCAGGTCTACAAAGCTCGCCTACACCGCAATCAATGGGTAGCCGTGAAAGTACAACGTCCTCAACTGGCGTTCATCTTG
CGCCGCGATCTCGTCATTATCCGCCTGCTCGGCGTGCTGTCAGCACCAGTGCTCCCGCTCAACCTGGGCTTTGGACTAGG
CAACATCATTGATGAATTCGGTCGCAGCCTATTTGAGGAGATTGATTACGAACAAGAAGCTAACAATGCTGAACGATTTG
CGGCTCTTTTCGCCAAAGACCCAACGGTGACGGTCCCAAGGGTGGAGCGATTGTTGTCATCCCGCCGTGTACTAACCACA
AGCTGGATCGAGGGCACGAAGCTCCGAGACCGCAAGGAGTTAAAAGCCCAACTTCTTAATCCAACAGCACTGATCAGGAC
CGCCGTCATCAGCGGTCTTCAACAACTTTTTGAGTTCGGCTATTTCCATGCTGATCCTCACCCAGGCAACATTTTTGCCC
TCAGTGGTCAAAGCAAAAAGATGGGTCATCTTGCCTACTGCGATTTCGGCATGATGGATTCAATTAGTGATGACGATCGT
CTCACTCTTACTGGAGCAGTAGTTCACCTAATCAACAACGATTTTAATGCGCTAGCTAAAGACTTTCAAAAACTGGGCTT
CCTTAGTCTAACAAGTGATCTAACAACAATCATACCGGCACTAGAAGAAGTACTTGGTGGCTCTCTTGGTGAATCAGTGG
AGTCCTTCAACTTCAAGGCAATCACCGATCGTTTCTCAGAACTGATGTTCGATTACCCCTTCAGAGTCCCGGCGAGATTT
GCCTTGATCATCCGAGCTGTTGTTAGTCAAGAAGGTCTTGCATTAAGGCTAGATCCAGACTTCAAGATCATCGCAATTGC
CTACCCATATGTGGCCAAACGTCTACTGGCAGGAGACTCAATGGAGATGCGAGAGAAACTGTTGGAGGTGATTTTTGATA
ATAATGGGCACCTGCGCCTGGAGCGAATTGAAAGTTTACTGAAAGTGATAAGCCAAGACGCTGTAGCACCAGATGCAGAA
CTAATCCCTGTAGCAGGAGCAGGCCTAAAACTGCTACTTGGCCCAGATGGATCCACTTTGCGTAGTCGTCTACTGATGAC
ATTGATCAAAGACGAGCGTTTATGCGCATCTGATATAAAGGCCTTAATGAGCCTGCTAAGGCGAACCTTCAGCCCTCGCA
AGATCGCAAATGGCATGCTGCAAACCCTTACTCCACGAACCACCTAA

Upstream 100 bases:

>100_bases
AAGGTGAATCGCCGTTTCTAAAGTCTGATGATCAACGTGCCCGGGCGGTCTGTTGAACAGCTCCAATCCATCGTCCGCTT
CAGCATCCCGCAAAGCACCG

Downstream 100 bases:

>100_bases
ATATGGGCATAAAGAATAACAATCGATAGGGGGAAAGAAACTACTCCACAATACAAGTCTCTGCTATTCATCAATGCTCT
GATTCCACAATAGCCATCTG

Product: kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MRYDANQDLLWLLTRPWVWIPRLIHVLTSLLTLAVGVLAQGSNNDEEAQKRLAKKLLITLTNLGPCFIKVGQALSTRPDL
IKREWLEELTSLQDNLPAFNHATALATLAEDLGAPASQLFEEFPSQPIAAASLGQVYKARLHRNQWVAVKVQRPQLAFIL
RRDLVIIRLLGVLSAPVLPLNLGFGLGNIIDEFGRSLFEEIDYEQEANNAERFAALFAKDPTVTVPRVERLLSSRRVLTT
SWIEGTKLRDRKELKAQLLNPTALIRTAVISGLQQLFEFGYFHADPHPGNIFALSGQSKKMGHLAYCDFGMMDSISDDDR
LTLTGAVVHLINNDFNALAKDFQKLGFLSLTSDLTTIIPALEEVLGGSLGESVESFNFKAITDRFSELMFDYPFRVPARF
ALIIRAVVSQEGLALRLDPDFKIIAIAYPYVAKRLLAGDSMEMREKLLEVIFDNNGHLRLERIESLLKVISQDAVAPDAE
LIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLCASDIKALMSLLRRTFSPRKIANGMLQTLTPRTT

Sequences:

>Translated_548_residues
MRYDANQDLLWLLTRPWVWIPRLIHVLTSLLTLAVGVLAQGSNNDEEAQKRLAKKLLITLTNLGPCFIKVGQALSTRPDL
IKREWLEELTSLQDNLPAFNHATALATLAEDLGAPASQLFEEFPSQPIAAASLGQVYKARLHRNQWVAVKVQRPQLAFIL
RRDLVIIRLLGVLSAPVLPLNLGFGLGNIIDEFGRSLFEEIDYEQEANNAERFAALFAKDPTVTVPRVERLLSSRRVLTT
SWIEGTKLRDRKELKAQLLNPTALIRTAVISGLQQLFEFGYFHADPHPGNIFALSGQSKKMGHLAYCDFGMMDSISDDDR
LTLTGAVVHLINNDFNALAKDFQKLGFLSLTSDLTTIIPALEEVLGGSLGESVESFNFKAITDRFSELMFDYPFRVPARF
ALIIRAVVSQEGLALRLDPDFKIIAIAYPYVAKRLLAGDSMEMREKLLEVIFDNNGHLRLERIESLLKVISQDAVAPDAE
LIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLCASDIKALMSLLRRTFSPRKIANGMLQTLTPRTT
>Mature_548_residues
MRYDANQDLLWLLTRPWVWIPRLIHVLTSLLTLAVGVLAQGSNNDEEAQKRLAKKLLITLTNLGPCFIKVGQALSTRPDL
IKREWLEELTSLQDNLPAFNHATALATLAEDLGAPASQLFEEFPSQPIAAASLGQVYKARLHRNQWVAVKVQRPQLAFIL
RRDLVIIRLLGVLSAPVLPLNLGFGLGNIIDEFGRSLFEEIDYEQEANNAERFAALFAKDPTVTVPRVERLLSSRRVLTT
SWIEGTKLRDRKELKAQLLNPTALIRTAVISGLQQLFEFGYFHADPHPGNIFALSGQSKKMGHLAYCDFGMMDSISDDDR
LTLTGAVVHLINNDFNALAKDFQKLGFLSLTSDLTTIIPALEEVLGGSLGESVESFNFKAITDRFSELMFDYPFRVPARF
ALIIRAVVSQEGLALRLDPDFKIIAIAYPYVAKRLLAGDSMEMREKLLEVIFDNNGHLRLERIESLLKVISQDAVAPDAE
LIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLCASDIKALMSLLRRTFSPRKIANGMLQTLTPRTT

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=277, Percent_Identity=33.5740072202166, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI40254938, Length=297, Percent_Identity=28.6195286195286, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI217035081, Length=279, Percent_Identity=26.1648745519713, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI34147522, Length=262, Percent_Identity=31.2977099236641, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI27363457, Length=245, Percent_Identity=30.2040816326531, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI217416386, Length=187, Percent_Identity=32.0855614973262, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI2367309, Length=389, Percent_Identity=25.1928020565553, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17559152, Length=330, Percent_Identity=29.3939393939394, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI32565180, Length=275, Percent_Identity=31.2727272727273, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323282, Length=251, Percent_Identity=30.2788844621514, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=399, Percent_Identity=26.5664160401003, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6325148, Length=430, Percent_Identity=22.7906976744186, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24662575, Length=273, Percent_Identity=32.967032967033, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI22024280, Length=299, Percent_Identity=27.0903010033445, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18859849, Length=317, Percent_Identity=29.0220820189274, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61062; Mature: 61062

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDANQDLLWLLTRPWVWIPRLIHVLTSLLTLAVGVLAQGSNNDEEAQKRLAKKLLITL
CCCCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TNLGPCFIKVGQALSTRPDLIKREWLEELTSLQDNLPAFNHATALATLAEDLGAPASQLF
HCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
EEFPSQPIAAASLGQVYKARLHRNQWVAVKVQRPQLAFILRRDLVIIRLLGVLSAPVLPL
HHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEE
NLGFGLGNIIDEFGRSLFEEIDYEQEANNAERFAALFAKDPTVTVPRVERLLSSRRVLTT
ECCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEE
SWIEGTKLRDRKELKAQLLNPTALIRTAVISGLQQLFEFGYFHADPHPGNIFALSGQSKK
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
MGHLAYCDFGMMDSISDDDRLTLTGAVVHLINNDFNALAKDFQKLGFLSLTSDLTTIIPA
CCCEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHH
LEEVLGGSLGESVESFNFKAITDRFSELMFDYPFRVPARFALIIRAVVSQEGLALRLDPD
HHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCC
FKIIAIAYPYVAKRLLAGDSMEMREKLLEVIFDNNGHLRLERIESLLKVISQDAVAPDAE
EEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCCC
LIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLCASDIKALMSLLRRTFSPRKIANGML
EEEECCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QTLTPRTT
HHCCCCCC
>Mature Secondary Structure
MRYDANQDLLWLLTRPWVWIPRLIHVLTSLLTLAVGVLAQGSNNDEEAQKRLAKKLLITL
CCCCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TNLGPCFIKVGQALSTRPDLIKREWLEELTSLQDNLPAFNHATALATLAEDLGAPASQLF
HCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
EEFPSQPIAAASLGQVYKARLHRNQWVAVKVQRPQLAFILRRDLVIIRLLGVLSAPVLPL
HHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEE
NLGFGLGNIIDEFGRSLFEEIDYEQEANNAERFAALFAKDPTVTVPRVERLLSSRRVLTT
ECCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEE
SWIEGTKLRDRKELKAQLLNPTALIRTAVISGLQQLFEFGYFHADPHPGNIFALSGQSKK
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
MGHLAYCDFGMMDSISDDDRLTLTGAVVHLINNDFNALAKDFQKLGFLSLTSDLTTIIPA
CCCEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHH
LEEVLGGSLGESVESFNFKAITDRFSELMFDYPFRVPARFALIIRAVVSQEGLALRLDPD
HHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCC
FKIIAIAYPYVAKRLLAGDSMEMREKLLEVIFDNNGHLRLERIESLLKVISQDAVAPDAE
EEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCCC
LIPVAGAGLKLLLGPDGSTLRSRLLMTLIKDERLCASDIKALMSLLRRTFSPRKIANGML
EEEECCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QTLTPRTT
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]