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The map label for this gene is envZ [H]

Identifier: 33863076

GI number: 33863076

Start: 881121

End: 882443

Strand: Reverse

Name: envZ [H]

Synonym: PMT0804

Alternate gene names: 33863076

Gene position: 882443-881121 (Counterclockwise)

Preceding gene: 33863077

Following gene: 33863075

Centisome position: 36.6

GC content: 52.31

Gene sequence:

>1323_bases
ATGACGCGGACACAACGCAGGGCGGCGATCGTGTTCACTGCTTTGGGCTGGAGTGGCGTTGGTCTTGGCAGTTGGGCGCT
TTGTTTATTGGTTTTGCAGGTGCTCTTTGGCCGACAGTTAGAGATGCTTCAGACCGTTCAACTTGGTCGTGATCTATCAC
TCAACGTTCGTCTTACTGAGTTAGCTCTTGAGCGGTATCCCCCTGCTTTGGTTTCTGAGCTAACAGGGCTGGATCTAGCA
GTGATCGATCGACCACCAGATCCGCCCAGATTTGATCATTCTCTTCAGCGGCAAACAGATGCGCTTCAGAGGCAGCTATG
CCAACGACTCTCCCATTGTCCAATTTTGGTTCCTTTCTCGGCTGAAGCTGCGCAACGTGGAGCTTGGATTGAACTTATTT
CCCCTTTAGAGCCCGTTTGGCTCCGAGTTGGACTGCGTTCCGCGTTTGGTTGGCCACCGGAGCCAATCATGTTTGGGCTG
GCTTTGGTTGGTGCCGTGGTGATTTGTGGTGGTCTTTTTCTTCTCTTTCAGGTTGATCGACCGTTGAGGGGGCTGGAAAG
GGCTCTCGCTCGTGTTGGCGATGGTATTGATCCTGAGGCTGTAGCAGCAGTTGGCGCTCCTGAAGTTCAACGCCTCACAC
AACGTTTCAACGCCATGCTTTTACGCTTATCGGCCAACCGCCGTGAAAGGGCAACGATGCTTGCAGGCATCGCCCACGAT
CTGAGAGCCCCCATAACTCGACTCAGTTTTCGGCTGTCTTTGCCATCCCTCAGTGCTAAGGATCGTGAGCAATGTTCAAG
GGATTTAGAGTCTCTTGAGCGAATTACTGGCCAGTTTCTTCTTTTTGCCGGTGGTGGTGATAGCGAAGCCTTGGTGGAGT
TGCCTCTAGAGGCGTGGATGGCAGAAGTCTGCGCTGCTCATTCTGCCGACTTGCTGAGGCTTGATCTTCAACCTCTTATG
GCCAAGGTGAGGCCTGTTGCCTTGGGACGAGCAGTTGTCAATCTCATCGACAATGCATTTACCTACGGTTTAGCCCCCGT
GACTGTGTCACTGCGTGGTTTTGAAAACAGCTATCACATCGAAGTTTGGGACCAGGGGAAAGGCATGCCAATGGATCAGT
GGGAGCGAGCCTTACAACCTTTTCAACGCTTGGATGAATCACGCCGGGAACAGGGGCATAGCGGCCTCGGGTTGGCGATC
GTTGCTCATGTTGTTAGTCGACATGCAGGCCAACTTAGTTTTGTTGCTTCTGATGGAACCACTAAAGATCAACCTGGTCG
ATTTGCCGTAAGGCTTCAATTGCCTTTTAATCCTCCTGACTAG

Upstream 100 bases:

>100_bases
GAAGGTTGGTCGAACCCGATTCCAGTCGACCTCGCTATATCCAGACGGTATGGGGCTATGGATATGTTTTTGTCCCTGAT
GGTGAGCCCAGGTCTCGCTG

Downstream 100 bases:

>100_bases
TCATTGGCGGAAAACGCCGTTGATATTCTCAATTGTTTTTGTCAGATTGCTCAAGGATTGAGAAAACTTGATTGATGTTG
TCTTTTTGTCACTTTAGCAG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MTRTQRRAAIVFTALGWSGVGLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTELALERYPPALVSELTGLDLA
VIDRPPDPPRFDHSLQRQTDALQRQLCQRLSHCPILVPFSAEAAQRGAWIELISPLEPVWLRVGLRSAFGWPPEPIMFGL
ALVGAVVICGGLFLLFQVDRPLRGLERALARVGDGIDPEAVAAVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHD
LRAPITRLSFRLSLPSLSAKDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLEAWMAEVCAAHSADLLRLDLQPLM
AKVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFENSYHIEVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAI
VAHVVSRHAGQLSFVASDGTTKDQPGRFAVRLQLPFNPPD

Sequences:

>Translated_440_residues
MTRTQRRAAIVFTALGWSGVGLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTELALERYPPALVSELTGLDLA
VIDRPPDPPRFDHSLQRQTDALQRQLCQRLSHCPILVPFSAEAAQRGAWIELISPLEPVWLRVGLRSAFGWPPEPIMFGL
ALVGAVVICGGLFLLFQVDRPLRGLERALARVGDGIDPEAVAAVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHD
LRAPITRLSFRLSLPSLSAKDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLEAWMAEVCAAHSADLLRLDLQPLM
AKVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFENSYHIEVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAI
VAHVVSRHAGQLSFVASDGTTKDQPGRFAVRLQLPFNPPD
>Mature_439_residues
TRTQRRAAIVFTALGWSGVGLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTELALERYPPALVSELTGLDLAV
IDRPPDPPRFDHSLQRQTDALQRQLCQRLSHCPILVPFSAEAAQRGAWIELISPLEPVWLRVGLRSAFGWPPEPIMFGLA
LVGAVVICGGLFLLFQVDRPLRGLERALARVGDGIDPEAVAAVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHDL
RAPITRLSFRLSLPSLSAKDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLEAWMAEVCAAHSADLLRLDLQPLMA
KVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFENSYHIEVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAIV
AHVVSRHAGQLSFVASDGTTKDQPGRFAVRLQLPFNPPD

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=348, Percent_Identity=31.6091954022989, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787894, Length=277, Percent_Identity=29.9638989169675, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790346, Length=251, Percent_Identity=30.2788844621514, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48535; Mature: 48404

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTQRRAAIVFTALGWSGVGLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTE
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEHHH
LALERYPPALVSELTGLDLAVIDRPPDPPRFDHSLQRQTDALQRQLCQRLSHCPILVPFS
HHHHHCCHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECC
AEAAQRGAWIELISPLEPVWLRVGLRSAFGWPPEPIMFGLALVGAVVICGGLFLLFQVDR
HHHHHCCCHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLRGLERALARVGDGIDPEAVAAVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHD
HHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LRAPITRLSFRLSLPSLSAKDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLEAWM
HHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
AEVCAAHSADLLRLDLQPLMAKVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFENSYHI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEE
EVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAIVAHVVSRHAGQLSFVASDGT
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
TKDQPGRFAVRLQLPFNPPD
CCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
TRTQRRAAIVFTALGWSGVGLGSWALCLLVLQVLFGRQLEMLQTVQLGRDLSLNVRLTE
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEHHH
LALERYPPALVSELTGLDLAVIDRPPDPPRFDHSLQRQTDALQRQLCQRLSHCPILVPFS
HHHHHCCHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECC
AEAAQRGAWIELISPLEPVWLRVGLRSAFGWPPEPIMFGLALVGAVVICGGLFLLFQVDR
HHHHHCCCHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLRGLERALARVGDGIDPEAVAAVGAPEVQRLTQRFNAMLLRLSANRRERATMLAGIAHD
HHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LRAPITRLSFRLSLPSLSAKDREQCSRDLESLERITGQFLLFAGGGDSEALVELPLEAWM
HHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
AEVCAAHSADLLRLDLQPLMAKVRPVALGRAVVNLIDNAFTYGLAPVTVSLRGFENSYHI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEE
EVWDQGKGMPMDQWERALQPFQRLDESRREQGHSGLGLAIVAHVVSRHAGQLSFVASDGT
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
TKDQPGRFAVRLQLPFNPPD
CCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]