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The map label for this gene is ribA/ribB [H]

Identifier: 33862980

GI number: 33862980

Start: 763582

End: 765486

Strand: Reverse

Name: ribA/ribB [H]

Synonym: PMT0708

Alternate gene names: 33862980

Gene position: 765486-763582 (Counterclockwise)

Preceding gene: 33862982

Following gene: 33862974

Centisome position: 31.75

GC content: 50.81

Gene sequence:

>1905_bases
ATGGAGGTGGGGATGGTCCTCAAGCAATCTGATGGTTTGAAGACCGCCGTAGCCCGTAGCGCCGATAACCGCTACTCGGC
TGCCTCGAACCTGAGAAATGTCAGAGGCTGGAGAGCGAGGGGGACTTTCCATTGCCTTCATCGGACGCCGGCTGATCGTA
CTGGTGTCGATAATGAACCCAGTACGTTCATCCCTAAGGCCCTGAGGACATCTCCTATACCCGCTGAATCGGTCGAGATC
CGCTTCGACGAAATTTCTGATGCACTTGCCGCGATCCGAAACGGTGAATGCGTTGTGGTTGTTGATGATGAGCGCAGAGA
AAACGAGGGCGACCTAATTTGTGCTGCTCAGTTCGCTACGCCTGAGCAAATCAATTTCATGGCCACAGAGGCTCGTGGTC
TGATCTGCCTTGCGATGCAAGGCAGTCGCCTAGATCAACTTGACCTGCCGCTGATGGTTGATCGCAACACAGATGCCAAC
CAAACGGCTTTTACCGTAAGCATCGATGCAGGGCCTGAAAAAGGGGTTTCTACCGGTATTTCAGCGGAGGATCGAGCGCG
CACGATTCAAGTGGCCCTACATCCGGAGACTCGTCCAAGAGACCTACGCCGCCCAGGACATATTTTCCCCCTTAGAGCGA
GTCAAGGAGGTGTTCTCAAAAGGGCTGGACATACAGAATCCGCCGTGGATTTGTCACAGCTGGCAGGGCTTGCTCCAGCT
GGCGTGATCTGCGAGATCCAAAACTCAGACGGATCAATGGCAAGACTGCCGCAATTGCAAAACTATGCGCGGCGTTGGGG
ACTCAAGCTCATCAACATCGCCGATCTGATTCGTTACCGTCTTGAGAACGAACGCTTTGTATACCGTCAAGCCACTGCCG
ATTTACCAAGTCTCTTTGGCAGTTTTCAGGCAATCGGCTATTTAAATGGTTTGGATGGATCGGAACACATTGCTCTTGTC
AAGGGCGATCCACGAAAACTGAAAGAACCAGTTTTAGTGCGCATGCACTCCGAATGTCTTACGGGAGATGCTTTTGGATC
ACTGCGCTGCGATTGTCGCCCCCAACTTGAGGCAGCGTTAGCTCGCATCGAACAAGAAGGTGAAGGCGTGGTTGTTTATC
TCCGCCAGGAAGGTCGCGGCATTGGACTAATTAACAAATTAAAGGCCTATAGCCTTCAAGATGGCGGTCTAGACACTGTG
GAAGCCAATGAAAGTTTGGGTTTCCCTGCAGATCTGCGCAACTATGGGGTTGGTGCTCAAATTCTCACTGACCTTGGCAT
CCACCGTTTACGTCTACTTACAAACAACCCACGCAAAATTGCTGGACTGGGTGGATATGGCTTACAAGTCGAAAGTCGTG
TCCCCCTAGTGATCTGTCCTGGAGATCACAACGCCGCTTATTTAGCTGTTAAGCGGGAAAAACTTGGACACTTGATTGAT
GCTGGCAAATCAGAGAATAAAGCTCCAGAAGTTGGACCTTTTGTTGTGGTTGCCTGGGACGGTGAGGTGAACGGAGAGAC
GTTGGCTAAGCTGAGGACCCGTGCACATGATTGGGCCAAAAGCAATGAACTTGAGCTCATAGCAGAAAGCTCACCCCGTC
TACTTGCTCTATGGGATCGCCCCCTTTTTGTATGGCGTGTATGTCCACGAGTCAAAACCTCTTCTGAGGTTTCATCAGAT
CCACTTAAAAAAGCATCGCTGGAGTTACTGCTTCAAGAGTTGATTCAATGGTCAGGGAGCCGTCGAATTGGTCTTCTGCG
TACTGACCGTGCTGAGCAAGCAATGCATCCTCCTCAGGATCTAAAGAGAGAAGAGCGTTCGTTGGCAACACTATTTAAAG
ATGATTTTTCACCACTAAAAGATTGGGATGCCACGAGCTTTCCCAATCTGATCCTTTGGTCGTGA

Upstream 100 bases:

>100_bases
GATCGGGAGATTGAACTTCAGGATCATCAAGGATGGGTAAAAAAGGGCAAAGCTCACTCCATCGCCTGCCGGCACTTCGT
TCGCCGCCCAGGTAGGTCAC

Downstream 100 bases:

>100_bases
AAGAGACCAACTGTATATTTTCAATTCTCTTGAATGGTTACTTTATTGATCCTAGAGCCGTTCTTTAAGGCTAAGACCAC
ATCCATGTTGGCAGCCTGAC

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MEVGMVLKQSDGLKTAVARSADNRYSAASNLRNVRGWRARGTFHCLHRTPADRTGVDNEPSTFIPKALRTSPIPAESVEI
RFDEISDALAAIRNGECVVVVDDERRENEGDLICAAQFATPEQINFMATEARGLICLAMQGSRLDQLDLPLMVDRNTDAN
QTAFTVSIDAGPEKGVSTGISAEDRARTIQVALHPETRPRDLRRPGHIFPLRASQGGVLKRAGHTESAVDLSQLAGLAPA
GVICEIQNSDGSMARLPQLQNYARRWGLKLINIADLIRYRLENERFVYRQATADLPSLFGSFQAIGYLNGLDGSEHIALV
KGDPRKLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALARIEQEGEGVVVYLRQEGRGIGLINKLKAYSLQDGGLDTV
EANESLGFPADLRNYGVGAQILTDLGIHRLRLLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLAVKREKLGHLID
AGKSENKAPEVGPFVVVAWDGEVNGETLAKLRTRAHDWAKSNELELIAESSPRLLALWDRPLFVWRVCPRVKTSSEVSSD
PLKKASLELLLQELIQWSGSRRIGLLRTDRAEQAMHPPQDLKREERSLATLFKDDFSPLKDWDATSFPNLILWS

Sequences:

>Translated_634_residues
MEVGMVLKQSDGLKTAVARSADNRYSAASNLRNVRGWRARGTFHCLHRTPADRTGVDNEPSTFIPKALRTSPIPAESVEI
RFDEISDALAAIRNGECVVVVDDERRENEGDLICAAQFATPEQINFMATEARGLICLAMQGSRLDQLDLPLMVDRNTDAN
QTAFTVSIDAGPEKGVSTGISAEDRARTIQVALHPETRPRDLRRPGHIFPLRASQGGVLKRAGHTESAVDLSQLAGLAPA
GVICEIQNSDGSMARLPQLQNYARRWGLKLINIADLIRYRLENERFVYRQATADLPSLFGSFQAIGYLNGLDGSEHIALV
KGDPRKLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALARIEQEGEGVVVYLRQEGRGIGLINKLKAYSLQDGGLDTV
EANESLGFPADLRNYGVGAQILTDLGIHRLRLLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLAVKREKLGHLID
AGKSENKAPEVGPFVVVAWDGEVNGETLAKLRTRAHDWAKSNELELIAESSPRLLALWDRPLFVWRVCPRVKTSSEVSSD
PLKKASLELLLQELIQWSGSRRIGLLRTDRAEQAMHPPQDLKREERSLATLFKDDFSPLKDWDATSFPNLILWS
>Mature_634_residues
MEVGMVLKQSDGLKTAVARSADNRYSAASNLRNVRGWRARGTFHCLHRTPADRTGVDNEPSTFIPKALRTSPIPAESVEI
RFDEISDALAAIRNGECVVVVDDERRENEGDLICAAQFATPEQINFMATEARGLICLAMQGSRLDQLDLPLMVDRNTDAN
QTAFTVSIDAGPEKGVSTGISAEDRARTIQVALHPETRPRDLRRPGHIFPLRASQGGVLKRAGHTESAVDLSQLAGLAPA
GVICEIQNSDGSMARLPQLQNYARRWGLKLINIADLIRYRLENERFVYRQATADLPSLFGSFQAIGYLNGLDGSEHIALV
KGDPRKLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALARIEQEGEGVVVYLRQEGRGIGLINKLKAYSLQDGGLDTV
EANESLGFPADLRNYGVGAQILTDLGIHRLRLLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLAVKREKLGHLID
AGKSENKAPEVGPFVVVAWDGEVNGETLAKLRTRAHDWAKSNELELIAESSPRLLALWDRPLFVWRVCPRVKTSSEVSSD
PLKKASLELLLQELIQWSGSRRIGLLRTDRAEQAMHPPQDLKREERSLATLFKDDFSPLKDWDATSFPNLILWS

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=204, Percent_Identity=49.5098039215686, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=51.5625, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=41.2621359223301, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=46.4705882352941, Blast_Score=128, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 69913; Mature: 69913

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVGMVLKQSDGLKTAVARSADNRYSAASNLRNVRGWRARGTFHCLHRTPADRTGVDNEP
CCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCCCCC
STFIPKALRTSPIPAESVEIRFDEISDALAAIRNGECVVVVDDERRENEGDLICAAQFAT
CCCCCHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCC
PEQINFMATEARGLICLAMQGSRLDQLDLPLMVDRNTDANQTAFTVSIDAGPEKGVSTGI
CCCCEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCC
SAEDRARTIQVALHPETRPRDLRRPGHIFPLRASQGGVLKRAGHTESAVDLSQLAGLAPA
CCCCCCEEEEEEECCCCCCHHCCCCCCEEEEECCCCCCEEECCCCCHHHHHHHHCCCCCC
GVICEIQNSDGSMARLPQLQNYARRWGLKLINIADLIRYRLENERFVYRQATADLPSLFG
CEEEEEECCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCEEEEEEHHHHHHHHHH
SFQAIGYLNGLDGSEHIALVKGDPRKLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAAL
HHHHHEEEECCCCCCEEEEEECCHHHHCCCCEEEEHHHHHCCCCCCCEECCCCHHHHHHH
ARIEQEGEGVVVYLRQEGRGIGLINKLKAYSLQDGGLDTVEANESLGFPADLRNYGVGAQ
HHHHCCCCCEEEEEEECCCCCCHHHHHHHEEECCCCCCEEECCCCCCCCHHHHHCCCCHH
ILTDLGIHRLRLLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLAVKREKLGHLID
HHHHHCHHEEEEEECCCCEEEECCCCCEEECCCCCEEEECCCCCEEEEEEEHHHHHHHHC
AGKSENKAPEVGPFVVVAWDGEVNGETLAKLRTRAHDWAKSNELELIAESSPRLLALWDR
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECC
PLFVWRVCPRVKTSSEVSSDPLKKASLELLLQELIQWSGSRRIGLLRTDRAEQAMHPPQD
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCHHH
LKREERSLATLFKDDFSPLKDWDATSFPNLILWS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MEVGMVLKQSDGLKTAVARSADNRYSAASNLRNVRGWRARGTFHCLHRTPADRTGVDNEP
CCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCCCCC
STFIPKALRTSPIPAESVEIRFDEISDALAAIRNGECVVVVDDERRENEGDLICAAQFAT
CCCCCHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCC
PEQINFMATEARGLICLAMQGSRLDQLDLPLMVDRNTDANQTAFTVSIDAGPEKGVSTGI
CCCCEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCC
SAEDRARTIQVALHPETRPRDLRRPGHIFPLRASQGGVLKRAGHTESAVDLSQLAGLAPA
CCCCCCEEEEEEECCCCCCHHCCCCCCEEEEECCCCCCEEECCCCCHHHHHHHHCCCCCC
GVICEIQNSDGSMARLPQLQNYARRWGLKLINIADLIRYRLENERFVYRQATADLPSLFG
CEEEEEECCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCEEEEEEHHHHHHHHHH
SFQAIGYLNGLDGSEHIALVKGDPRKLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAAL
HHHHHEEEECCCCCCEEEEEECCHHHHCCCCEEEEHHHHHCCCCCCCEECCCCHHHHHHH
ARIEQEGEGVVVYLRQEGRGIGLINKLKAYSLQDGGLDTVEANESLGFPADLRNYGVGAQ
HHHHCCCCCEEEEEEECCCCCCHHHHHHHEEECCCCCCEEECCCCCCCCHHHHHCCCCHH
ILTDLGIHRLRLLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLAVKREKLGHLID
HHHHHCHHEEEEEECCCCEEEECCCCCEEECCCCCEEEECCCCCEEEEEEEHHHHHHHHC
AGKSENKAPEVGPFVVVAWDGEVNGETLAKLRTRAHDWAKSNELELIAESSPRLLALWDR
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECC
PLFVWRVCPRVKTSSEVSSDPLKKASLELLLQELIQWSGSRRIGLLRTDRAEQAMHPPQD
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCHHH
LKREERSLATLFKDDFSPLKDWDATSFPNLILWS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]