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The map label for this gene is murA

Identifier: 33862605

GI number: 33862605

Start: 379465

End: 380769

Strand: Reverse

Name: murA

Synonym: PMT0332

Alternate gene names: 33862605

Gene position: 380769-379465 (Counterclockwise)

Preceding gene: 33862612

Following gene: 33862604

Centisome position: 15.79

GC content: 54.71

Gene sequence:

>1305_bases
ATGCCCGCAGCGGTATCCATATCTCAAGAGATTCTCAAGCCGCATCTGGAGATTCAAGGCGGACATACTCTTTCCAGAGA
GCTGAAAGTCAGCGGAGCTAAGAATTCTGCCCTCGTGCTCATGACCTCAGCCCTTCTCAGCGAAGGCCCCCTTGAGCTGC
ACAATGTCCCCCAGCTCACAGATATCCAGGGAATGGCAGACATCCTCGCCTCCTTGGGGGTACGAGTAAAACGGAGTCAG
GAGACCGTTTGGCTGCAGGCTGATGGCCTTCATCACGCCGAACCTCCCTACGATCTAGTCAATGGCCTTAGAGCTAGCTT
TTTCTGCATTGGCCCACTGCTAGGACGACTCGGTCACGCCAAAGTCCCCCTGCCGGGTGGTTGCCGCATCGGAGCCCGGC
CTGTTGTTGAGCACATCAGAGGGCTTAAAGCTCTTGGTGCCATGGTGAAAGTTGAGCATGGCGTTGTCACAGCTTCAGTG
CCAGGAACGTCACGGCGACTTAAAGGTGCTGCAATCGTGCTCGACTGCCCAAGTGTCGGTGCAACCGAGACCATTCTCAT
GGCAGCTGTGTTGGCGGAAGGCACTAGCACCATCGAAAACGCTGCCCAGGAGCCTGAGGTTCAAGACCTGGCCAAAATGC
TCAATGCCATGGGTGCTCGTGTAAGCGGTGCTGGTGGTCCAATCATCACCATCGAAGGCGTTGAACGTTTACACGGCTGC
AACTATTCGGTAATCCCTGATCGCATTGAAGCAGGGACCTTCCTGATAGCAGCGGCAATCACCCGCTCGATTGTTCGAGT
GTCTCCAGTCATCCCTGAGCATCTCAATGCCGTGCTCCAGAAACTGAGAGATTGCGGCTGCACCCTTGAGATTGACAAGC
AAGGAATCACTCTTATCCCGGGGGATCTTCATGGTGTTGACATCATCACCCAACCTTTCCCAGGCTTCCCAACGGACTTG
CAGGCCCCCTTTATGGCCCTATTAACCACAGCCAAAGGCACAAGCGTGGTGACAGAAAAGATCTACGAAAACCGCATGCA
ACATGTCGCTGAGCTGCAAAGAATGGGCGCTTCGATTCGTCTTCAAGGAAACACGGCTGTGGTCGAAGGCATCCCCCAGC
TAAGTGCTGCACCAGTTAGTGGTAACGACTTAAGAGCCGCAGCGGCGCTCGTGTTAGCAGGCCTTGCCGCACACGGCATC
AGTCAAGTTGATGGCCTCAACCACCTCGATCGCGGTTATGACGAGATTGAAACCAAATTGAATGCATCTGGAGCCCATAT
CCTTCGGCATCAGCCCTCAGGATGA

Upstream 100 bases:

>100_bases
ATCTCAACCTGACAGTTTTGAACCAGTTTGAGGTCTGGACGTCTAGACTGTCTCACCTGTAATTGTCAATATGTCTTCGT
TCAAGAATAATTAACGGGAC

Downstream 100 bases:

>100_bases
CCCTGGCATAACATCACCTCCAAGGGAGCGTGGCGGAATTGGTAGACGCACTGGATTCAAAATCCAGCGCCTTCGGGCAT
GTGGGTTCAAGTCCCACCGC

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MPAAVSISQEILKPHLEIQGGHTLSRELKVSGAKNSALVLMTSALLSEGPLELHNVPQLTDIQGMADILASLGVRVKRSQ
ETVWLQADGLHHAEPPYDLVNGLRASFFCIGPLLGRLGHAKVPLPGGCRIGARPVVEHIRGLKALGAMVKVEHGVVTASV
PGTSRRLKGAAIVLDCPSVGATETILMAAVLAEGTSTIENAAQEPEVQDLAKMLNAMGARVSGAGGPIITIEGVERLHGC
NYSVIPDRIEAGTFLIAAAITRSIVRVSPVIPEHLNAVLQKLRDCGCTLEIDKQGITLIPGDLHGVDIITQPFPGFPTDL
QAPFMALLTTAKGTSVVTEKIYENRMQHVAELQRMGASIRLQGNTAVVEGIPQLSAAPVSGNDLRAAAALVLAGLAAHGI
SQVDGLNHLDRGYDEIETKLNASGAHILRHQPSG

Sequences:

>Translated_434_residues
MPAAVSISQEILKPHLEIQGGHTLSRELKVSGAKNSALVLMTSALLSEGPLELHNVPQLTDIQGMADILASLGVRVKRSQ
ETVWLQADGLHHAEPPYDLVNGLRASFFCIGPLLGRLGHAKVPLPGGCRIGARPVVEHIRGLKALGAMVKVEHGVVTASV
PGTSRRLKGAAIVLDCPSVGATETILMAAVLAEGTSTIENAAQEPEVQDLAKMLNAMGARVSGAGGPIITIEGVERLHGC
NYSVIPDRIEAGTFLIAAAITRSIVRVSPVIPEHLNAVLQKLRDCGCTLEIDKQGITLIPGDLHGVDIITQPFPGFPTDL
QAPFMALLTTAKGTSVVTEKIYENRMQHVAELQRMGASIRLQGNTAVVEGIPQLSAAPVSGNDLRAAAALVLAGLAAHGI
SQVDGLNHLDRGYDEIETKLNASGAHILRHQPSG
>Mature_433_residues
PAAVSISQEILKPHLEIQGGHTLSRELKVSGAKNSALVLMTSALLSEGPLELHNVPQLTDIQGMADILASLGVRVKRSQE
TVWLQADGLHHAEPPYDLVNGLRASFFCIGPLLGRLGHAKVPLPGGCRIGARPVVEHIRGLKALGAMVKVEHGVVTASVP
GTSRRLKGAAIVLDCPSVGATETILMAAVLAEGTSTIENAAQEPEVQDLAKMLNAMGARVSGAGGPIITIEGVERLHGCN
YSVIPDRIEAGTFLIAAAITRSIVRVSPVIPEHLNAVLQKLRDCGCTLEIDKQGITLIPGDLHGVDIITQPFPGFPTDLQ
APFMALLTTAKGTSVVTEKIYENRMQHVAELQRMGASIRLQGNTAVVEGIPQLSAAPVSGNDLRAAAALVLAGLAAHGIS
QVDGLNHLDRGYDEIETKLNASGAHILRHQPSG

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=419, Percent_Identity=50.3579952267303, Blast_Score=387, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_PROMM (Q7V8L0)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894165.1
- ProteinModelPortal:   Q7V8L0
- SMR:   Q7V8L0
- STRING:   Q7V8L0
- GeneID:   1727532
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0332
- NMPDR:   fig|74547.1.peg.332
- eggNOG:   COG0766
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   PMAR74547:PMT0332-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45612; Mature: 45481

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00449 ATPASE_A

Important sites: ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAVSISQEILKPHLEIQGGHTLSRELKVSGAKNSALVLMTSALLSEGPLELHNVPQLT
CCCCCHHHHHHHCCCEEECCCCEECCEEEECCCCCCEEEEEEHHHHCCCCCCCCCCCCCH
DIQGMADILASLGVRVKRSQETVWLQADGLHHAEPPYDLVNGLRASFFCIGPLLGRLGHA
HHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
KVPLPGGCRIGARPVVEHIRGLKALGAMVKVEHGVVTASVPGTSRRLKGAAIVLDCPSVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCHHCCCCEEEEECCCCC
ATETILMAAVLAEGTSTIENAAQEPEVQDLAKMLNAMGARVSGAGGPIITIEGVERLHGC
CHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCEECCCCCCEEEECCHHHHCCC
NYSVIPDRIEAGTFLIAAAITRSIVRVSPVIPEHLNAVLQKLRDCGCTLEIDKQGITLIP
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEC
GDLHGVDIITQPFPGFPTDLQAPFMALLTTAKGTSVVTEKIYENRMQHVAELQRMGASIR
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
LQGNTAVVEGIPQLSAAPVSGNDLRAAAALVLAGLAAHGISQVDGLNHLDRGYDEIETKL
ECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCCHHHHCCHHHHHHHC
NASGAHILRHQPSG
CCCCCEEEECCCCC
>Mature Secondary Structure 
PAAVSISQEILKPHLEIQGGHTLSRELKVSGAKNSALVLMTSALLSEGPLELHNVPQLT
CCCCHHHHHHHCCCEEECCCCEECCEEEECCCCCCEEEEEEHHHHCCCCCCCCCCCCCH
DIQGMADILASLGVRVKRSQETVWLQADGLHHAEPPYDLVNGLRASFFCIGPLLGRLGHA
HHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
KVPLPGGCRIGARPVVEHIRGLKALGAMVKVEHGVVTASVPGTSRRLKGAAIVLDCPSVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCHHCCCCEEEEECCCCC
ATETILMAAVLAEGTSTIENAAQEPEVQDLAKMLNAMGARVSGAGGPIITIEGVERLHGC
CHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCEECCCCCCEEEECCHHHHCCC
NYSVIPDRIEAGTFLIAAAITRSIVRVSPVIPEHLNAVLQKLRDCGCTLEIDKQGITLIP
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEC
GDLHGVDIITQPFPGFPTDLQAPFMALLTTAKGTSVVTEKIYENRMQHVAELQRMGASIR
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
LQGNTAVVEGIPQLSAAPVSGNDLRAAAALVLAGLAAHGISQVDGLNHLDRGYDEIETKL
ECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCCHHHHCCHHHHHHHC
NASGAHILRHQPSG
CCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642