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The map label for this gene is argD

Identifier: 33862604

GI number: 33862604

Start: 378170

End: 379426

Strand: Reverse

Name: argD

Synonym: PMT0331

Alternate gene names: 33862604

Gene position: 379426-378170 (Counterclockwise)

Preceding gene: 33862605

Following gene: 33862603

Centisome position: 15.74

GC content: 55.77

Gene sequence:

>1257_bases
TTGGTAGACGCACTGGATTCAAAATCCAGCGCCTTCGGGCATGTGGGTTCAAGTCCCACCGCTCCCACTGCTGTGATGGG
CACCTACAAACGTTTTCCCGTCACTCTGTTACGCGGGAAAGGATGCTGGGTATGGGATGACCATGGTCATCAATACCTTG
ACGCGGTTGCCGGTATCGCGACCTGCGCCCTCGGTCACAGTGACCGGGCCCTGCGTCGCTCTCTTGGCCAGCAGCTGAAA
CAACTTCAGCATGTTTCTAATCTGTATCGGATTCCTGAACAAGAGGCTCTTGCCCATTGGTTAGTAGAAAACAGCTGTGC
AGACAGCGTGTTCTTCTGCAATTCCGGTGCAGAAGCCAACGAAGCCGCCATCAAGCTGGCTCGCAAACACGGTCATCGCC
GTCGCGGCATTGATCGGCCAATCATTCTCACCGCTAATTCCAGTTTCCACGGCCGCACACTTGCTGCGATAAGTGCCACA
GGTCAGCCCAACTTCCACAAAGGTTTCGAACCCATGGTTGAGGGATTTGAATTTTTCCCGTTCAATAACCTCCAAGCCTT
CGAGCAGCAGCTAAATCGCCTCGAAGCTCAGGGGCCCTCTGTTGCCGCCGTGCTAATCGAACCACTACAAGGTGAGGGTG
GCGTCAATCCAGGCGAAGCAGGCTTCTTCAGGCGCCTTAGAGAACTCTGTAGCCAGCATCAGATCCTGCTGATCTTTGAT
GAAGTTCAGGTCGGGATGGGCCGTTGTGGCAACTGGTGGGGGTATCAGCAGCTTGGGATCGAACCAGATGCCTTCACCTT
GGCCAAAGGACTCGGGGGAGGCCATGCCATCGGAGCGTTACTTGTTAAACAGCACGCTGATCTTTTCGAACCAGGTGACC
ACGCCAGTACTTTTGGCGGCAATCCCTTTGCTTGCAAGGCAGCTCTCACAGTTGCCAAGGAGATCGAACGACGGGGTTTG
ATCGCAAAGGTCCAGCAACGAGGCGCACAGCTGCGCGAAGGCCTCACTGACCTGGTGCAACGTTTCCCGAGGCAACTCAA
AGGGGTACGAGGCTGGGGGCTACTGCAAGGATTGGTGCTCCAAGACGAGAGCACATTCACAGCACCAAATGTCGCCCAGG
CCGCCCTTGAAGAAAAGCTACTGGTGATAGCAGCAGGTCCAAAGGTTGTGCGCATGGTGCCGCCGCTGATCATCAAACCA
AGCGAAATCCGCCAACTGCTCCAACGTCTGGAGGCCACCCTGGCGCACTTCCGCTAA

Upstream 100 bases:

>100_bases
AGATTGAAACCAAATTGAATGCATCTGGAGCCCATATCCTTCGGCATCAGCCCTCAGGATGACCCTGGCATAACATCACC
TCCAAGGGAGCGTGGCGGAA

Downstream 100 bases:

>100_bases
GTGTCCAAACCCACAAGTCCAAGCAAGGAAGATTTAAGCGATCTGATTCCTCGTTTTGATCAGCGGGGGATGGATCTTGA
TCTTGAGCGCATGCAACAAG

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWVWDDHGHQYLDAVAGIATCALGHSDRALRRSLGQQLK
QLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEANEAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISAT
GQPNFHKGFEPMVEGFEFFPFNNLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEAGFFRRLRELCSQHQILLIFD
EVQVGMGRCGNWWGYQQLGIEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGGNPFACKAALTVAKEIERRGL
IAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVLQDESTFTAPNVAQAALEEKLLVIAAGPKVVRMVPPLIIKP
SEIRQLLQRLEATLAHFR

Sequences:

>Translated_418_residues
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWVWDDHGHQYLDAVAGIATCALGHSDRALRRSLGQQLK
QLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEANEAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISAT
GQPNFHKGFEPMVEGFEFFPFNNLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEAGFFRRLRELCSQHQILLIFD
EVQVGMGRCGNWWGYQQLGIEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGGNPFACKAALTVAKEIERRGL
IAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVLQDESTFTAPNVAQAALEEKLLVIAAGPKVVRMVPPLIIKP
SEIRQLLQRLEATLAHFR
>Mature_418_residues
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWVWDDHGHQYLDAVAGIATCALGHSDRALRRSLGQQLK
QLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEANEAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISAT
GQPNFHKGFEPMVEGFEFFPFNNLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEAGFFRRLRELCSQHQILLIFD
EVQVGMGRCGNWWGYQQLGIEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGGNPFACKAALTVAKEIERRGL
IAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVLQDESTFTAPNVAQAALEEKLLVIAAGPKVVRMVPPLIIKP
SEIRQLLQRLEATLAHFR

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=394, Percent_Identity=33.756345177665, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI284507298, Length=308, Percent_Identity=36.6883116883117, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI37574042, Length=419, Percent_Identity=26.491646778043, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442705, Length=426, Percent_Identity=25.8215962441315, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI13994255, Length=381, Percent_Identity=28.8713910761155, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI24119277, Length=420, Percent_Identity=26.6666666666667, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI226442709, Length=338, Percent_Identity=27.810650887574, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI188536080, Length=446, Percent_Identity=24.2152466367713, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI38679950, Length=446, Percent_Identity=24.2152466367713, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI38679946, Length=446, Percent_Identity=24.2152466367713, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788044, Length=391, Percent_Identity=39.8976982097187, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1789759, Length=383, Percent_Identity=38.1201044386423, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI145693181, Length=382, Percent_Identity=34.0314136125654, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1789016, Length=399, Percent_Identity=31.077694235589, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787560, Length=401, Percent_Identity=30.1745635910224, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=28.5377358490566, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786349, Length=368, Percent_Identity=25.8152173913043, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=395, Percent_Identity=31.1392405063291, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI25144274, Length=280, Percent_Identity=31.7857142857143, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI32564660, Length=441, Percent_Identity=27.437641723356, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=423, Percent_Identity=26.7139479905437, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=447, Percent_Identity=25.2796420581655, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=32.9192546583851, Blast_Score=98, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=35.5555555555556, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6323470, Length=392, Percent_Identity=31.6326530612245, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6321456, Length=378, Percent_Identity=24.8677248677249, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=431, Percent_Identity=21.3457076566125, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357415, Length=392, Percent_Identity=31.8877551020408, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=27.803738317757, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28574759, Length=421, Percent_Identity=27.5534441805226, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21356575, Length=414, Percent_Identity=28.0193236714976, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI281366494, Length=433, Percent_Identity=27.0207852193995, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667139, Length=433, Percent_Identity=27.0207852193995, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667143, Length=433, Percent_Identity=27.0207852193995, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_PROMM (Q7V8L1)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894164.1
- ProteinModelPortal:   Q7V8L1
- SMR:   Q7V8L1
- STRING:   Q7V8L1
- GeneID:   1729610
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0331
- NMPDR:   fig|74547.1.peg.331
- eggNOG:   COG4992
- HOGENOM:   HBG725944
- OMA:   SKSSAFG
- ProtClustDB:   PRK02627
- BioCyc:   PMAR74547:PMT0331-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 45678; Mature: 45678

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 149-149 BINDING 152-152 BINDING 296-296 BINDING 297-297

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWVWDDHGHQYLDAVAGIA
CCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHCCEEEEECCCCEEECCCCHHHHHHHHHHH
TCALGHSDRALRRSLGQQLKQLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEAN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCHH
EAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISATGQPNFHKGFEPMVEGFEFFP
HHHHHHHHHHCHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCCC
FNNLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEAGFFRRLRELCSQHQILLIFD
CCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
EVQVGMGRCGNWWGYQQLGIEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGG
CHHHHHCCCCCCCCCHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
NPFACKAALTVAKEIERRGLIAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVL
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEE
QDESTFTAPNVAQAALEEKLLVIAAGPKVVRMVPPLIIKPSEIRQLLQRLEATLAHFR
ECCCCCCCCHHHHHHHHCCEEEEECCCHHHHHCCCCEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWVWDDHGHQYLDAVAGIA
CCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHCCEEEEECCCCEEECCCCHHHHHHHHHHH
TCALGHSDRALRRSLGQQLKQLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEAN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCHH
EAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISATGQPNFHKGFEPMVEGFEFFP
HHHHHHHHHHCHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCCC
FNNLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEAGFFRRLRELCSQHQILLIFD
CCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
EVQVGMGRCGNWWGYQQLGIEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGG
CHHHHHCCCCCCCCCHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
NPFACKAALTVAKEIERRGLIAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVL
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEE
QDESTFTAPNVAQAALEEKLLVIAAGPKVVRMVPPLIIKPSEIRQLLQRLEATLAHFR
ECCCCCCCCHHHHHHHHCCEEEEECCCHHHHHCCCCEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642