Click here to switch to the map view.

The map label for this gene is hisS [H]

Identifier: 161350040

GI number: 161350040

Start: 2008881

End: 2010191

Strand: Reverse

Name: hisS [H]

Synonym: PMT1905

Alternate gene names: 161350040

Gene position: 2010191-2008881 (Counterclockwise)

Preceding gene: 33864172

Following gene: 33864170

Centisome position: 83.38

GC content: 54.92

Gene sequence:

>1311_bases
GTGACTCAGCTGCAGAGCCTGCGAGGAATGGTGGATCTATTACCGGAACAGACGAGGTGCTGGCAGGCGGTAGAAAGCGT
TGCGCGAGATCACTTCCGCAGAGCAGGATTGCAGGAAATTCGTACGCCTCTTTTGGAAGTGACTGAACTCTTCGCACGTG
GCATTGGTGAAGCTACGGATGTTGTTGGAAAGGAGATGTATACCTTTGTTGATCGGGGTGATCGATCCTGCACCCTTCGG
CCGGAGGGAACCGCTTCTGTTGTGCGTGCTGCTCTACAGCACGGCTTGTTGAGTCAGGGGCCACAGCGTTTTTGGTATGG
CGGTCCAATGTTTCGCTATGAGCGACCTCAGGCTGGTCGGCAACGACAGTTTTACCAGATTGGTGTGGAGTATCTCGGGG
TTGGCAGTCCTCGTAGTGATGCTGAGGTCATTGCATTGGCCTGGGCACTTCTGGTCGACTTGGGCGTGCAAGGTCTTGTT
CTGGAGATCAATAGCCTCGGCACCCTTCAGGATCGACAGAAGTATCGAGAGGAGCTTGTGGCGTGGCTAGAAGCCCGCAG
TGAAGAGCTTGATGACGATTCACGCAAGCGTTTGTATACCAACCCACTGCGTATCCTTGATAGTAAACACCCTGCAATAA
AGGAATTGTTGCAGGATGCTCCCACGCTTTTTGAGGCGCTCAGCGTGGAGAGTAAGGCCCGCTTTGAGGAGGTTCAGGTC
GACTTGGAGGCTCTCCAGATCCCTTTCCAACTCAATCCTCGTCTTGTGCGCGGCCTTGACTACTACGGCCATACCGCTTT
TGAGATCACTAGCGATCAGCTTGGGGCCCAGGCCACAGTCTGTGGAGGAGGACGATATGACGGGTTGGTTGAGCAGTTAG
GGGGGGCGCCCACTCCCGCTTTTGGTTGGGCTTTTGGTATGGAGCGGTTGATGCTTTTGCTGGAGGCTGCGGCGAGTATT
AATCCAAGTGGATCAGCTGCTCGCTTAAGGGCTTCCACGAGGCCGGATCTTTATGTGGTGAATCGGGGAGAGCAGGCGGA
ACGAGTCGCCCTGGTCATTGCCCATCAGCTACGGGCTGCGGGGCTCGTGGTGGAGCTGGATAGTTCTGGAGCTGCCTTTA
ATAAGCAGTTCAAGCGTGCCGGTCGCAGTAGGGCTACCTGGGCCTTGGTGATTGGTGATGATGAGGCCGAGCGGGGCGAG
GGACGCCTTAAGTATTTGCAGGAGGCAAAAACTCAAGCCAATCCGACTCCTATCGATAAACTCCATCGACTCGACGATGT
CACTGGTCTTGTTTGTTTGGTTCGAGAATGA

Upstream 100 bases:

>100_bases
GCCAATAGGTCAGGGGCATTGCGCAACTTGTTTGGTTGCCTCGTTTATTGAGCTTGGTGATCACTGGCCCGGCAGACTGC
CTACTGGTTGTTGGTGAAGA

Downstream 100 bases:

>100_bases
CTTCGTATAACTTTCTTCCCAGGCGGAGGTTCCACTTAATTTTTTGCCATGACTGAGCAGGTCTCTCCCCTCATCTTTTG
TTGAACTCGCTGTTTACAAC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATDVVGKEMYTFVDRGDRSCTLR
PEGTASVVRAALQHGLLSQGPQRFWYGGPMFRYERPQAGRQRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLV
LEINSLGTLQDRQKYREELVAWLEARSEELDDDSRKRLYTNPLRILDSKHPAIKELLQDAPTLFEALSVESKARFEEVQV
DLEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPAFGWAFGMERLMLLLEAAASI
NPSGSAARLRASTRPDLYVVNRGEQAERVALVIAHQLRAAGLVVELDSSGAAFNKQFKRAGRSRATWALVIGDDEAERGE
GRLKYLQEAKTQANPTPIDKLHRLDDVTGLVCLVRE

Sequences:

>Translated_436_residues
MTQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATDVVGKEMYTFVDRGDRSCTLR
PEGTASVVRAALQHGLLSQGPQRFWYGGPMFRYERPQAGRQRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLV
LEINSLGTLQDRQKYREELVAWLEARSEELDDDSRKRLYTNPLRILDSKHPAIKELLQDAPTLFEALSVESKARFEEVQV
DLEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPAFGWAFGMERLMLLLEAAASI
NPSGSAARLRASTRPDLYVVNRGEQAERVALVIAHQLRAAGLVVELDSSGAAFNKQFKRAGRSRATWALVIGDDEAERGE
GRLKYLQEAKTQANPTPIDKLHRLDDVTGLVCLVRE
>Mature_435_residues
TQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATDVVGKEMYTFVDRGDRSCTLRP
EGTASVVRAALQHGLLSQGPQRFWYGGPMFRYERPQAGRQRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLVL
EINSLGTLQDRQKYREELVAWLEARSEELDDDSRKRLYTNPLRILDSKHPAIKELLQDAPTLFEALSVESKARFEEVQVD
LEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPAFGWAFGMERLMLLLEAAASIN
PSGSAARLRASTRPDLYVVNRGEQAERVALVIAHQLRAAGLVVELDSSGAAFNKQFKRAGRSRATWALVIGDDEAERGEG
RLKYLQEAKTQANPTPIDKLHRLDDVTGLVCLVRE

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=348, Percent_Identity=25.2873563218391, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788861, Length=414, Percent_Identity=47.5845410628019, Blast_Score=370, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71993686, Length=450, Percent_Identity=24.4444444444444, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71993693, Length=450, Percent_Identity=24.4444444444444, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 48476; Mature: 48345

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATD
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHH
VVGKEMYTFVDRGDRSCTLRPEGTASVVRAALQHGLLSQGPQRFWYGGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCCCCCH
QRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLVLEINSLGTLQDRQKYREELV
HHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHH
AWLEARSEELDDDSRKRLYTNPLRILDSKHPAIKELLQDAPTLFEALSVESKARFEEVQV
HHHHHHHHHCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPA
HHHHHCCCCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHHHHCCCCCCH
FGWAFGMERLMLLLEAAASINPSGSAARLRASTRPDLYVVNRGEQAERVALVIAHQLRAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHC
GLVVELDSSGAAFNKQFKRAGRSRATWALVIGDDEAERGEGRLKYLQEAKTQANPTPIDK
CEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHH
LHRLDDVTGLVCLVRE
HHHHHHHCCCEEEECC
>Mature Secondary Structure 
TQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATD
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHH
VVGKEMYTFVDRGDRSCTLRPEGTASVVRAALQHGLLSQGPQRFWYGGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCCCCCH
QRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLVLEINSLGTLQDRQKYREELV
HHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHH
AWLEARSEELDDDSRKRLYTNPLRILDSKHPAIKELLQDAPTLFEALSVESKARFEEVQV
HHHHHHHHHCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPA
HHHHHCCCCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHHHHCCCCCCH
FGWAFGMERLMLLLEAAASINPSGSAARLRASTRPDLYVVNRGEQAERVALVIAHQLRAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHC
GLVVELDSSGAAFNKQFKRAGRSRATWALVIGDDEAERGEGRLKYLQEAKTQANPTPIDK
CEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHH
LHRLDDVTGLVCLVRE
HHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA