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The map label for this gene is ugd [H]

Identifier: 33864170

GI number: 33864170

Start: 2007329

End: 2008777

Strand: Reverse

Name: ugd [H]

Synonym: PMT1904

Alternate gene names: 33864170

Gene position: 2008777-2007329 (Counterclockwise)

Preceding gene: 161350040

Following gene: 33864169

Centisome position: 83.32

GC content: 54.38

Gene sequence:

>1449_bases
ATGGCTGCCTTTCCGATCCGCAACATCTGTTGCATTGGTGCGGGTTATGTAGGCGGTCCGACTATGGCGGTGATTGCCGA
TCGCTGTCCACAGATACAGGTGACCGTGGTGGACCTCAATGAGGCCCGCATTGAAGCTTGGAATGACCTTGATCTCAGCA
AACTGCCTGTGTATGAGCCTGGGTTGGATGCGGTGGTCGAGCGGGCTCGCGGGCGCAATCTCACTTTCTCTACGCATGTG
GACGCTGCGATTGCTGCTGCTGACATGGTGTTCATTTCGGTGAATACACCAACCAAAACAAAAGGGCTGGGGGCGGGTCA
GGCCAGTGATCTGCGTTGGGTGGAAGCTTGCGCTCGTCAGGTTGCTCAATCTGCGCAGGGTCACACGATTGTGGTTGAGA
AGAGCACGCTGCCAGTGCGAACCGCTGAAGTTGTGCGTTCGATTCTTGAGGCAGCTCAGCGGCAGGCGGTTGATGGAGAG
CTACCGATCAGTTTTTCTGTGTTGTCCAACCCGGAGTTCCTTGCCGAGGGCACGGCGATTCGTGATTTGGAGTCGCCGGA
CCGTGTGTTGATCGGTGGTGAAAACCCCGTTGCCATTCAGTCTTTGGCAGAGATTTATGGCCATTGGGTGCCAGTTGAGA
AAATTCTGCTTACAAATCTTTGGAGCAGTGAGCTCTCCAAGCTCACCGCCAATGCGTTTCTTGCTCAGCGCATCAGTTCC
ATTAACTCAGTGGCGGCTCTTTGCGAACGCACTGGTGCGGATGTGCGTGAGGTGGCGCGCGCTATTGGAAGCGATACTCG
CATTGGCTCCAAGTTCCTTCAAGCTGGGCCTGGGTTTGGTGGGAGTTGTTTTCAGAAAGACATCCTCAATCTGGTTTATC
TTTGTCGTCATTTTGGTTTGCCGGATGTGGCGGACTATTGGGAAAATGTGGTAGCTCTCAATACTTGGCAGCAGCACCGC
ATTTCTCGTTTGGTGGTTCAAAAGCTTTTTGGAACGGTTACAGGTAAGCGGCTGGCACTGCTCGGCTTTGCTTTTAAGGC
AGACACCAACGACACTCGAGAAGCGCCGGCGATTCGTATTGCACATGATCTGCTGGAGGAGGGTGCTCAGCTGGCTATTT
ATGATCCGAAGGTGGATCCGCAACAGATTGCGTTTGATTTGCAGCTGTCGGCTAGTTCCCCGCCAGATGTCCAGGCAGGC
CCTACCCGTGCCGCCCTTAGCGGTGAAGGAACCTGGTGGTCCGGCACTAGCGTTGCCGATACAGTCGCTGGTGCTGATGC
TGCGCTGATCCTGACTGAGTGGCATGAGTTTAGACAGCTTGATTGGGTCACCTTGGCCCCTTTGATGCGTCAACCTGCCT
GGGTGTTTGATGCTCGCGCTGTTGTCGATCCAGAAGTTGTGAAATCGTCAGGTTTGATGCTTTGGCGAGTTGGAGATGGT
GCTGTATGA

Upstream 100 bases:

>100_bases
CGTATAACTTTCTTCCCAGGCGGAGGTTCCACTTAATTTTTTGCCATGACTGAGCAGGTCTCTCCCCTCATCTTTTGTTG
AACTCGCTGTTTACAACGCT

Downstream 100 bases:

>100_bases
GTCGATGCGTTGTTGTTACCGGTGCTGCAGGATTCATTGGTGCTGCCCTCGTTCAGAGGCTGTTAGCCCAGGGTGACCGT
GTCATTGGCATTGACAACCT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MAAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVTVVDLNEARIEAWNDLDLSKLPVYEPGLDAVVERARGRNLTFSTHV
DAAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQVAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGE
LPISFSVLSNPEFLAEGTAIRDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISS
INSVAALCERTGADVREVARAIGSDTRIGSKFLQAGPGFGGSCFQKDILNLVYLCRHFGLPDVADYWENVVALNTWQQHR
ISRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRIAHDLLEEGAQLAIYDPKVDPQQIAFDLQLSASSPPDVQAG
PTRAALSGEGTWWSGTSVADTVAGADAALILTEWHEFRQLDWVTLAPLMRQPAWVFDARAVVDPEVVKSSGLMLWRVGDG
AV

Sequences:

>Translated_482_residues
MAAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVTVVDLNEARIEAWNDLDLSKLPVYEPGLDAVVERARGRNLTFSTHV
DAAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQVAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGE
LPISFSVLSNPEFLAEGTAIRDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISS
INSVAALCERTGADVREVARAIGSDTRIGSKFLQAGPGFGGSCFQKDILNLVYLCRHFGLPDVADYWENVVALNTWQQHR
ISRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRIAHDLLEEGAQLAIYDPKVDPQQIAFDLQLSASSPPDVQAG
PTRAALSGEGTWWSGTSVADTVAGADAALILTEWHEFRQLDWVTLAPLMRQPAWVFDARAVVDPEVVKSSGLMLWRVGDG
AV
>Mature_481_residues
AAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVTVVDLNEARIEAWNDLDLSKLPVYEPGLDAVVERARGRNLTFSTHVD
AAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQVAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGEL
PISFSVLSNPEFLAEGTAIRDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISSI
NSVAALCERTGADVREVARAIGSDTRIGSKFLQAGPGFGGSCFQKDILNLVYLCRHFGLPDVADYWENVVALNTWQQHRI
SRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRIAHDLLEEGAQLAIYDPKVDPQQIAFDLQLSASSPPDVQAGP
TRAALSGEGTWWSGTSVADTVAGADAALILTEWHEFRQLDWVTLAPLMRQPAWVFDARAVVDPEVVKSSGLMLWRVGDGA
V

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=464, Percent_Identity=56.25, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI296040438, Length=365, Percent_Identity=53.1506849315069, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI296040443, Length=305, Percent_Identity=55.4098360655738, Blast_Score=333, Evalue=2e-91,
Organism=Escherichia coli, GI48994968, Length=368, Percent_Identity=30.1630434782609, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788340, Length=375, Percent_Identity=24.2666666666667, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560350, Length=477, Percent_Identity=52.6205450733753, Blast_Score=500, Evalue=1e-142,
Organism=Drosophila melanogaster, GI17136908, Length=477, Percent_Identity=53.6687631027254, Blast_Score=504, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 52044; Mature: 51913

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVTVVDLNEARIEAWNDLDLSKLPVYEP
CCCCCCCCEEEECCCCCCCCHHHHHHCCCCEEEEEEEECCCHHHHCCCCCCCCCCCCCCC
GLDAVVERARGRNLTFSTHVDAAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQ
CHHHHHHHHCCCCCEEECCCCHHHHEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
VAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGELPISFSVLSNPEFLAEGTAI
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCEE
RDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISS
CCCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INSVAALCERTGADVREVARAIGSDTRIGSKFLQAGPGFGGSCFQKDILNLVYLCRHFGL
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
PDVADYWENVVALNTWQQHRISRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRI
CCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHH
AHDLLEEGAQLAIYDPKVDPQQIAFDLQLSASSPPDVQAGPTRAALSGEGTWWSGTSVAD
HHHHHHCCCEEEEECCCCCHHHEEEEEEECCCCCCCCCCCCCCEEECCCCCEECCCCHHH
TVAGADAALILTEWHEFRQLDWVTLAPLMRQPAWVFDARAVVDPEVVKSSGLMLWRVGDG
HHCCCCCEEEEHHHHHHHHCCHHHHHHHHCCCCCEECCHHHCCHHHHHCCCEEEEECCCC
AV
CC
>Mature Secondary Structure 
AAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVTVVDLNEARIEAWNDLDLSKLPVYEP
CCCCCCCEEEECCCCCCCCHHHHHHCCCCEEEEEEEECCCHHHHCCCCCCCCCCCCCCC
GLDAVVERARGRNLTFSTHVDAAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQ
CHHHHHHHHCCCCCEEECCCCHHHHEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
VAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGELPISFSVLSNPEFLAEGTAI
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCEE
RDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISS
CCCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INSVAALCERTGADVREVARAIGSDTRIGSKFLQAGPGFGGSCFQKDILNLVYLCRHFGL
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
PDVADYWENVVALNTWQQHRISRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRI
CCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHH
AHDLLEEGAQLAIYDPKVDPQQIAFDLQLSASSPPDVQAGPTRAALSGEGTWWSGTSVAD
HHHHHHCCCEEEEECCCCCHHHEEEEEEECCCCCCCCCCCCCCEEECCCCCEECCCCHHH
TVAGADAALILTEWHEFRQLDWVTLAPLMRQPAWVFDARAVVDPEVVKSSGLMLWRVGDG
HHCCCCCEEEEHHHHHHHHCCHHHHHHHHCCCCCEECCHHHCCHHHHHCCCEEEEECCCC
AV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]