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The map label for this gene is xseA

Identifier: 32267231

GI number: 32267231

Start: 1656817

End: 1658070

Strand: Direct

Name: xseA

Synonym: HH1732

Alternate gene names: 32267231

Gene position: 1656817-1658070 (Clockwise)

Preceding gene: 32267228

Following gene: 32267234

Centisome position: 92.09

GC content: 37.32

Gene sequence:

>1254_bases
GTGAGAGCTTTAGAAGTAAGTGAGATTAACGCACAAATTAAAAGTATTTTAGAATCTACTTTTATGGATATTTGTGTGCG
TGGCGAAATAAGTAATGTAACAATTCATACAAGTGGACATATTTATCTCACTCTTAAAGATGAAAGCTCAAGCGTGCGTT
GTGTGATGTTTAAAGGCAATGCGCGTAACTTGAAAATAAAGCTTGAAGTAGGACAAAGTGTGCTTATAATGGGCTCACTT
AGTGTCTATGTGCCCAAAGGAGAATATCAGATTCTTTGTAAAAGTATCACACTTGCAGGTTTAGGCGAACTCTCTCAAGC
GTATGAAGCCCTTAAGACAAAGCTTGGCGCAAAGGGTTATTTTGAATCTGCTCATAAAAAGCCTTTACCACGCTTCCCCA
AACGTATTGCTTTGCTCACTTCTGCCACAGGTGCGGCAAAAGAGGATATGCTCAAAGTAGCTCATAAGCGTTGGAATCTT
GTGCATATTACGCTTTTTAATACACTTGTGCAAGGTGAAGGAGCAAAAGATTCTATAGTAGAGAATCTAAAACGAGCTGA
TAGTTTTTTTGGCACATCTGAAAGCTTTGATGTTATTGTCTTAGGGAGAGGTGGAGGAAGTATGGAGGATATGTGGGCAT
TTAATGAAGAATGCGTAGCAGATGCCATTTATTCTGCACGCACACCTATTATTTCTGCTGTAGGACACGAGGTTGATGTA
TTTATAAGTGATTTTGTCGCTGATGTGCGAGCTCCTACGCCTTCAGCGGCTATGGAAATACTTTTGCCTGACAAAAACGA
ATATTTGCGTGTGCTTGATGAAATAATGAATAGTTATTTTTATGCCCTTAAGCAGCAATTTGTGCTTAAAAGTCAAGCAT
TAGAGCGAATGCGAGAATATTTTAAGCTTTATAATTTTGAGCAGCGCTATTGCGCTAAGGTTGAGCAAATCAATATTTTT
CAACAAATGATGCGAGATTCTATGAATGCAGTACTTGAGGATAAAATGCTAAAATATGAACATATATTTTTATCTCTTAA
TGCTCGGTGTGAGGAGAAACTGCAGCAATGTCAATATGAATATGAGCGTATGTTGGAGGTGTTTAATGCTTTGAATCCAC
ACTCACTTTCCACTCGTGGGTATGCACAAATAAGTAAAGAAGGGAAACCTTGTAGATTAAGTGATATTGATATAAATGAA
GAATTTTATTTAAGTGATATGACACATTCTATTTTAGCAAAGCGTTTGCAATGA

Upstream 100 bases:

>100_bases
TGCATAACTTACCTTATTGTGTTGGGATAATGCTATTGTAGCAAAAAGTCTTTAAAAGTTCTAATGTGATAGAATGATTT
AATTGTTTTGAGGAGATGGA

Downstream 100 bases:

>100_bases
ATTAAAACTTTTATTAATGCACACTTCCTACTGAAGTAAAACGCGTTTTGCTTAAAAAGGCTGGAATTGAGTTCCAAATA
AAAACAAGCAAAAGACGTTG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MRALEVSEINAQIKSILESTFMDICVRGEISNVTIHTSGHIYLTLKDESSSVRCVMFKGNARNLKIKLEVGQSVLIMGSL
SVYVPKGEYQILCKSITLAGLGELSQAYEALKTKLGAKGYFESAHKKPLPRFPKRIALLTSATGAAKEDMLKVAHKRWNL
VHITLFNTLVQGEGAKDSIVENLKRADSFFGTSESFDVIVLGRGGGSMEDMWAFNEECVADAIYSARTPIISAVGHEVDV
FISDFVADVRAPTPSAAMEILLPDKNEYLRVLDEIMNSYFYALKQQFVLKSQALERMREYFKLYNFEQRYCAKVEQINIF
QQMMRDSMNAVLEDKMLKYEHIFLSLNARCEEKLQQCQYEYERMLEVFNALNPHSLSTRGYAQISKEGKPCRLSDIDINE
EFYLSDMTHSILAKRLQ

Sequences:

>Translated_417_residues
MRALEVSEINAQIKSILESTFMDICVRGEISNVTIHTSGHIYLTLKDESSSVRCVMFKGNARNLKIKLEVGQSVLIMGSL
SVYVPKGEYQILCKSITLAGLGELSQAYEALKTKLGAKGYFESAHKKPLPRFPKRIALLTSATGAAKEDMLKVAHKRWNL
VHITLFNTLVQGEGAKDSIVENLKRADSFFGTSESFDVIVLGRGGGSMEDMWAFNEECVADAIYSARTPIISAVGHEVDV
FISDFVADVRAPTPSAAMEILLPDKNEYLRVLDEIMNSYFYALKQQFVLKSQALERMREYFKLYNFEQRYCAKVEQINIF
QQMMRDSMNAVLEDKMLKYEHIFLSLNARCEEKLQQCQYEYERMLEVFNALNPHSLSTRGYAQISKEGKPCRLSDIDINE
EFYLSDMTHSILAKRLQ
>Mature_417_residues
MRALEVSEINAQIKSILESTFMDICVRGEISNVTIHTSGHIYLTLKDESSSVRCVMFKGNARNLKIKLEVGQSVLIMGSL
SVYVPKGEYQILCKSITLAGLGELSQAYEALKTKLGAKGYFESAHKKPLPRFPKRIALLTSATGAAKEDMLKVAHKRWNL
VHITLFNTLVQGEGAKDSIVENLKRADSFFGTSESFDVIVLGRGGGSMEDMWAFNEECVADAIYSARTPIISAVGHEVDV
FISDFVADVRAPTPSAAMEILLPDKNEYLRVLDEIMNSYFYALKQQFVLKSQALERMREYFKLYNFEQRYCAKVEQINIF
QQMMRDSMNAVLEDKMLKYEHIFLSLNARCEEKLQQCQYEYERMLEVFNALNPHSLSTRGYAQISKEGKPCRLSDIDINE
EFYLSDMTHSILAKRLQ

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=265, Percent_Identity=44.9056603773585, Blast_Score=248, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_HELHP (Q7VFE5)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861263.1
- GeneID:   1492279
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1732
- NMPDR:   fig|235279.1.peg.1732
- HOGENOM:   HBG634411
- OMA:   GHEIDFL
- ProtClustDB:   PRK00286
- BioCyc:   HHEP235279:HH_1732-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 47358; Mature: 47358

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALEVSEINAQIKSILESTFMDICVRGEISNVTIHTSGHIYLTLKDESSSVRCVMFKGN
CCCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCEEEEEEECCCCCEEEEEEECC
ARNLKIKLEVGQSVLIMGSLSVYVPKGEYQILCKSITLAGLGELSQAYEALKTKLGAKGY
CCEEEEEEEECCEEEEEEEEEEEEECCCCEEHEEHHHHHHHHHHHHHHHHHHHHCCCCCH
FESAHKKPLPRFPKRIALLTSATGAAKEDMLKVAHKRWNLVHITLFNTLVQGEGAKDSIV
HHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHH
ENLKRADSFFGTSESFDVIVLGRGGGSMEDMWAFNEECVADAIYSARTPIISAVGHEVDV
HHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHCCCHHHH
FISDFVADVRAPTPSAAMEILLPDKNEYLRVLDEIMNSYFYALKQQFVLKSQALERMREY
HHHHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKLYNFEQRYCAKVEQINIFQQMMRDSMNAVLEDKMLKYEHIFLSLNARCEEKLQQCQYE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHHHHHHHHH
YERMLEVFNALNPHSLSTRGYAQISKEGKPCRLSDIDINEEFYLSDMTHSILAKRLQ
HHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRALEVSEINAQIKSILESTFMDICVRGEISNVTIHTSGHIYLTLKDESSSVRCVMFKGN
CCCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCEEEEEEECCCCCEEEEEEECC
ARNLKIKLEVGQSVLIMGSLSVYVPKGEYQILCKSITLAGLGELSQAYEALKTKLGAKGY
CCEEEEEEEECCEEEEEEEEEEEEECCCCEEHEEHHHHHHHHHHHHHHHHHHHHCCCCCH
FESAHKKPLPRFPKRIALLTSATGAAKEDMLKVAHKRWNLVHITLFNTLVQGEGAKDSIV
HHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHH
ENLKRADSFFGTSESFDVIVLGRGGGSMEDMWAFNEECVADAIYSARTPIISAVGHEVDV
HHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHCCCHHHH
FISDFVADVRAPTPSAAMEILLPDKNEYLRVLDEIMNSYFYALKQQFVLKSQALERMREY
HHHHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKLYNFEQRYCAKVEQINIFQQMMRDSMNAVLEDKMLKYEHIFLSLNARCEEKLQQCQYE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHHHHHHHHH
YERMLEVFNALNPHSLSTRGYAQISKEGKPCRLSDIDINEEFYLSDMTHSILAKRLQ
HHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954