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The map label for this gene is coaE

Identifier: 32267199

GI number: 32267199

Start: 1626959

End: 1627582

Strand: Direct

Name: coaE

Synonym: HH1700

Alternate gene names: 32267199

Gene position: 1626959-1627582 (Clockwise)

Preceding gene: 161546621

Following gene: 32267200

Centisome position: 90.43

GC content: 36.38

Gene sequence:

>624_bases
ATGGATAAGCAACTAAGATATGCAATTGCCCTCACTGGTTCAATAGGGAGCGGCAAAAGCACATTTGTAAGTTTACTCTC
GCTTTATGGATACCAAAGTATTTGTGCAGATTCCATAGCACATAAAGTGCTTGAAGAACATAGTGCGGAGGTAATTGCAT
ATTTTGGTAATGAGATTTTGCAAAGTGATAATACAATTAATCGCAAAGTGCTTGGCAATATTATTTTTGCTTCATCATCT
AAACGTGAGGAGTTACAAGCTATACTTCATCCACATATCCAAAAGGCAATTCTTACTCAAGCACAGCAGCTTGAAGAAAA
GAAAGTATGGTATTTTATAGATATTCCTTTATTTTTTGAAGTTGGGGGTAAGGAAGCCTATCCTGTGGCTCGCTCACTTG
TCATCTATACGCCTAAAGCAAAAGCGATTGAGCGCATTATGAAACGAAATAATTTTACTTTTGAAGAAGCCAAAGCGCGT
ATAGATGCACAGATGCCCATTGAGAATAAATGTCGTTTAGCTGATGATATAATTAATAATGAGGGTGATTTGCGCACTTT
GCAACATAATGCAGAAACTTATATACAATCTTTACCTTGTGTAGATTGTGTGCAAAGTTCTTAA

Upstream 100 bases:

>100_bases
TACCTCATTTGCACTATTACAATGCTAAGATTCACGAAAATGCTTTTACCTTGCCAAATTTTATATTTGAGAAAATACAG
GATATTGCAAAGTTCTAATT

Downstream 100 bases:

>100_bases
AATGGAGGATTGTATGCGTTTTGTAAAATATAGTAGCAATGGCAATGATTTTCTTATTTTCACTACTCATACCTATGATG
ATGGCTCTCGCACTGCTTTA

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MDKQLRYAIALTGSIGSGKSTFVSLLSLYGYQSICADSIAHKVLEEHSAEVIAYFGNEILQSDNTINRKVLGNIIFASSS
KREELQAILHPHIQKAILTQAQQLEEKKVWYFIDIPLFFEVGGKEAYPVARSLVIYTPKAKAIERIMKRNNFTFEEAKAR
IDAQMPIENKCRLADDIINNEGDLRTLQHNAETYIQSLPCVDCVQSS

Sequences:

>Translated_207_residues
MDKQLRYAIALTGSIGSGKSTFVSLLSLYGYQSICADSIAHKVLEEHSAEVIAYFGNEILQSDNTINRKVLGNIIFASSS
KREELQAILHPHIQKAILTQAQQLEEKKVWYFIDIPLFFEVGGKEAYPVARSLVIYTPKAKAIERIMKRNNFTFEEAKAR
IDAQMPIENKCRLADDIINNEGDLRTLQHNAETYIQSLPCVDCVQSS
>Mature_207_residues
MDKQLRYAIALTGSIGSGKSTFVSLLSLYGYQSICADSIAHKVLEEHSAEVIAYFGNEILQSDNTINRKVLGNIIFASSS
KREELQAILHPHIQKAILTQAQQLEEKKVWYFIDIPLFFEVGGKEAYPVARSLVIYTPKAKAIERIMKRNNFTFEEAKAR
IDAQMPIENKCRLADDIINNEGDLRTLQHNAETYIQSLPCVDCVQSS

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=181, Percent_Identity=33.7016574585635, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI191252795, Length=181, Percent_Identity=33.7016574585635, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI110227607, Length=163, Percent_Identity=31.2883435582822, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI110227605, Length=163, Percent_Identity=31.2883435582822, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI110227603, Length=163, Percent_Identity=31.2883435582822, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI110227601, Length=163, Percent_Identity=31.2883435582822, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI205277394, Length=163, Percent_Identity=31.2883435582822, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1786292, Length=182, Percent_Identity=35.1648351648352, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17554944, Length=197, Percent_Identity=29.4416243654822, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320402, Length=208, Percent_Identity=29.3269230769231, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644728, Length=189, Percent_Identity=32.2751322751323, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24658602, Length=213, Percent_Identity=26.7605633802817, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_HELHP (Q7VFH6)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861231.1
- ProteinModelPortal:   Q7VFH6
- SMR:   Q7VFH6
- GeneID:   1492247
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1700
- NMPDR:   fig|235279.1.peg.1700
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK00081
- BioCyc:   HHEP235279:HH_1700-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 23326; Mature: 23326

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKQLRYAIALTGSIGSGKSTFVSLLSLYGYQSICADSIAHKVLEEHSAEVIAYFGNEIL
CCCCEEEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
QSDNTINRKVLGNIIFASSSKREELQAILHPHIQKAILTQAQQLEEKKVWYFIDIPLFFE
HCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECEEEEE
VGGKEAYPVARSLVIYTPKAKAIERIMKRNNFTFEEAKARIDAQMPIENKCRLADDIINN
ECCCCCCHHHCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCC
EGDLRTLQHNAETYIQSLPCVDCVQSS
CCCHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MDKQLRYAIALTGSIGSGKSTFVSLLSLYGYQSICADSIAHKVLEEHSAEVIAYFGNEIL
CCCCEEEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
QSDNTINRKVLGNIIFASSSKREELQAILHPHIQKAILTQAQQLEEKKVWYFIDIPLFFE
HCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECEEEEE
VGGKEAYPVARSLVIYTPKAKAIERIMKRNNFTFEEAKARIDAQMPIENKCRLADDIINN
ECCCCCCHHHCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCC
EGDLRTLQHNAETYIQSLPCVDCVQSS
CCCHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954