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The map label for this gene is purQ

Identifier: 32267120

GI number: 32267120

Start: 1543739

End: 1544407

Strand: Direct

Name: purQ

Synonym: HH1621

Alternate gene names: 32267120

Gene position: 1543739-1544407 (Clockwise)

Preceding gene: 32267119

Following gene: 32267121

Centisome position: 85.8

GC content: 37.52

Gene sequence:

>669_bases
ATGAGTGTAGCTATTGTTAGATTTCCGGGCACAAATTGTGAGTTTGACACGCAATATGCCTTTTCTTTATTCGGGGGAGT
TACTTATATTGTGTGGCATCAAGATAAGAGTTTGCCAACAGATTGCCATCTTGTTGTGATTCCAGGAGGCTTTAGCTATG
GGGATTATTTACGTTGTGGAGCTATTGCGCAGTTTTCACCTATTATGAGAGTGATTAAGGATTTTGCTTTACAAGGTGGC
TATGTGCTTGGTATTTGTAATGGTTTTCAGATTCTATGCGAGGCAGGATTATTGCCCGGTGCTTTAAAGCGCAATATTAA
TTTACATTTTATTTCACAGATGCAATCACTTAGAATCGTAAGCAAAAATAATGCTTTTTTACGCTCCTACGCTCCAAATC
AAGAAATAAGATTGCCTATTGCCCACGCTGATGGAAATTATTTTATTGATGAGAGAGAGTTATTAGAGCTTAGGGCAAAT
GAGCAAATTTTACTTGAATATACGGACAATCCTAATGGTTCGGTAGATTCTATTGCTGGAATATGTAATGAGAAAAAAAA
TGTTTTTGGCTTAATGCCCCACCCCGAAAGAGCTATTGAAGATATGCTTGGCAGCTGTGATGGCAAAGCAATGCTTGATA
ATCTTTTGCATATTGCAGAGATGAAATAA

Upstream 100 bases:

>100_bases
AAGAGAATAATGCAGATAAAGCATATAATTTAGCACAAAGTATGTGTGAGAATTTGCTTGCCAATGTAGTAATTGAAGAT
TATTCTATTGAGATTCTTAA

Downstream 100 bases:

>100_bases
GAGGTGAGAATAATGAAAATGTGGAAAATTATTTGTTATATTTTATTGATGGGTTTATGTTTGAATGCGCTAGCAGATAC
GACTAAACCCAAGATTGCTT

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSVAIVRFPGTNCEFDTQYAFSLFGGVTYIVWHQDKSLPTDCHLVVIPGGFSYGDYLRCGAIAQFSPIMRVIKDFALQGG
YVLGICNGFQILCEAGLLPGALKRNINLHFISQMQSLRIVSKNNAFLRSYAPNQEIRLPIAHADGNYFIDERELLELRAN
EQILLEYTDNPNGSVDSIAGICNEKKNVFGLMPHPERAIEDMLGSCDGKAMLDNLLHIAEMK

Sequences:

>Translated_222_residues
MSVAIVRFPGTNCEFDTQYAFSLFGGVTYIVWHQDKSLPTDCHLVVIPGGFSYGDYLRCGAIAQFSPIMRVIKDFALQGG
YVLGICNGFQILCEAGLLPGALKRNINLHFISQMQSLRIVSKNNAFLRSYAPNQEIRLPIAHADGNYFIDERELLELRAN
EQILLEYTDNPNGSVDSIAGICNEKKNVFGLMPHPERAIEDMLGSCDGKAMLDNLLHIAEMK
>Mature_221_residues
SVAIVRFPGTNCEFDTQYAFSLFGGVTYIVWHQDKSLPTDCHLVVIPGGFSYGDYLRCGAIAQFSPIMRVIKDFALQGGY
VLGICNGFQILCEAGLLPGALKRNINLHFISQMQSLRIVSKNNAFLRSYAPNQEIRLPIAHADGNYFIDERELLELRANE
QILLEYTDNPNGSVDSIAGICNEKKNVFGLMPHPERAIEDMLGSCDGKAMLDNLLHIAEMK

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=225, Percent_Identity=29.3333333333333, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582111, Length=182, Percent_Identity=31.3186813186813, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24582109, Length=182, Percent_Identity=31.3186813186813, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137292, Length=182, Percent_Identity=31.3186813186813, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_HELHP (Q7VFQ4)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861152.1
- ProteinModelPortal:   Q7VFQ4
- SMR:   Q7VFQ4
- GeneID:   1492168
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1621
- NMPDR:   fig|235279.1.peg.1621
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   HHEP235279:HH_1621-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 24707; Mature: 24576

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 194-194 ACT_SITE 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAIVRFPGTNCEFDTQYAFSLFGGVTYIVWHQDKSLPTDCHLVVIPGGFSYGDYLRCG
CCEEEEEECCCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHC
AIAQFSPIMRVIKDFALQGGYVLGICNGFQILCEAGLLPGALKRNINLHFISQMQSLRIV
CHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCHHHHCCCCEEEEHHHHHEEEE
SKNNAFLRSYAPNQEIRLPIAHADGNYFIDERELLELRANEQILLEYTDNPNGSVDSIAG
ECCCCEEEECCCCCCEEEEEEECCCCEEECHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
ICNEKKNVFGLMPHPERAIEDMLGSCDGKAMLDNLLHIAEMK
HHCCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVAIVRFPGTNCEFDTQYAFSLFGGVTYIVWHQDKSLPTDCHLVVIPGGFSYGDYLRCG
CEEEEEECCCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHC
AIAQFSPIMRVIKDFALQGGYVLGICNGFQILCEAGLLPGALKRNINLHFISQMQSLRIV
CHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCHHHHCCCCEEEEHHHHHEEEE
SKNNAFLRSYAPNQEIRLPIAHADGNYFIDERELLELRANEQILLEYTDNPNGSVDSIAG
ECCCCEEEECCCCCCEEEEEEECCCCEEECHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
ICNEKKNVFGLMPHPERAIEDMLGSCDGKAMLDNLLHIAEMK
HHCCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954