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The map label for this gene is thiE [H]

Identifier: 32266997

GI number: 32266997

Start: 1435161

End: 1435760

Strand: Direct

Name: thiE [H]

Synonym: HH1498

Alternate gene names: 32266997

Gene position: 1435161-1435760 (Clockwise)

Preceding gene: 32266996

Following gene: 32266999

Centisome position: 79.77

GC content: 34.83

Gene sequence:

>600_bases
ATGAAGAACACTGATTTTATTACACTTCTTATTACGCCTCATATTAATGGGGCATATCTTGAGAATCTTCAGCTTAAAAT
ACAATCTTTGTCTGTTGATTGGATTATGTATCGTCATCAAAATAGTGAATGGATAGAATCTTTTACACAATCTTTATCAT
TCTTGCATAAACCTCTTTTGCTCAATATTCCTTTTAAAAACACAGAAGAGATATTGCAATTATCAAAAGACTTTGCAGGT
GTGCATTTAAAGTCAATATATCTTTCTTGGATTACTCCCTTAAGAGAATCTTATCTTGCCTTAGGTGAAAAAAAAATCAT
TGGATATAGCGCGCATAGTATAGATGAGGTAACATATGCTTTGGCGTGTGGGGCAGATTATTGCACACTTAGTCCAATAT
TTTCTACGCCAAATAAAGGCACACCATTAGGTATGGAAGTCTTTTATCAGATTCCGAAATCTTTGCGTTCGCGCATTATC
GCACTTGGTGGTATTAATAATTATCATATCCCACTTCTTAAGGAGTTAGGATTACTTGGTTTTGCTGGAATCCGTTGTTT
TGAGGAAACTAACGAGAATCATCGTGGAGTTGCGGATTAA

Upstream 100 bases:

>100_bases
CCTGTTGCTCCTTTTGCAATTCTTACTTTTATGGCATTACTTCAGGCTTTTGTGTTTATGATACTTACTTATGTGTATAT
TCACGGCGCAGTGGTCGTGG

Downstream 100 bases:

>100_bases
AAATTCGCCAAGCTATTGAGTAATCAAAAAGTTCTTTATAAGTAGAGCTAAAAGCCTTTTTGTAAGGTGTAAGATGTATT
TGCGTATCAGTAGAGAGCAA

Product: hypothetical protein

Products: NA

Alternate protein names: TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MKNTDFITLLITPHINGAYLENLQLKIQSLSVDWIMYRHQNSEWIESFTQSLSFLHKPLLLNIPFKNTEEILQLSKDFAG
VHLKSIYLSWITPLRESYLALGEKKIIGYSAHSIDEVTYALACGADYCTLSPIFSTPNKGTPLGMEVFYQIPKSLRSRII
ALGGINNYHIPLLKELGLLGFAGIRCFEETNENHRGVAD

Sequences:

>Translated_199_residues
MKNTDFITLLITPHINGAYLENLQLKIQSLSVDWIMYRHQNSEWIESFTQSLSFLHKPLLLNIPFKNTEEILQLSKDFAG
VHLKSIYLSWITPLRESYLALGEKKIIGYSAHSIDEVTYALACGADYCTLSPIFSTPNKGTPLGMEVFYQIPKSLRSRII
ALGGINNYHIPLLKELGLLGFAGIRCFEETNENHRGVAD
>Mature_199_residues
MKNTDFITLLITPHINGAYLENLQLKIQSLSVDWIMYRHQNSEWIESFTQSLSFLHKPLLLNIPFKNTEEILQLSKDFAG
VHLKSIYLSWITPLRESYLALGEKKIIGYSAHSIDEVTYALACGADYCTLSPIFSTPNKGTPLGMEVFYQIPKSLRSRII
ALGGINNYHIPLLKELGLLGFAGIRCFEETNENHRGVAD

Specific function: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [H]

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TMP-PPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF02581 TMP-TENI [H]

EC number: =2.5.1.3 [H]

Molecular weight: Translated: 22532; Mature: 22532

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTDFITLLITPHINGAYLENLQLKIQSLSVDWIMYRHQNSEWIESFTQSLSFLHKPLL
CCCCCEEEEEEECCCCCHHHHHEEEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCEE
LNIPFKNTEEILQLSKDFAGVHLKSIYLSWITPLRESYLALGEKKIIGYSAHSIDEVTYA
EECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
LACGADYCTLSPIFSTPNKGTPLGMEVFYQIPKSLRSRIIALGGINNYHIPLLKELGLLG
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHCCHHH
FAGIRCFEETNENHRGVAD
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKNTDFITLLITPHINGAYLENLQLKIQSLSVDWIMYRHQNSEWIESFTQSLSFLHKPLL
CCCCCEEEEEEECCCCCHHHHHEEEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCEE
LNIPFKNTEEILQLSKDFAGVHLKSIYLSWITPLRESYLALGEKKIIGYSAHSIDEVTYA
EECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
LACGADYCTLSPIFSTPNKGTPLGMEVFYQIPKSLRSRIIALGGINNYHIPLLKELGLLG
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHCCHHH
FAGIRCFEETNENHRGVAD
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA