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The map label for this gene is yccK [H]

Identifier: 32266961

GI number: 32266961

Start: 1405284

End: 1406444

Strand: Direct

Name: yccK [H]

Synonym: HH1462

Alternate gene names: 32266961

Gene position: 1405284-1406444 (Clockwise)

Preceding gene: 32266960

Following gene: 32266963

Centisome position: 78.11

GC content: 41.69

Gene sequence:

>1161_bases
ATGAAAGAAAAATCAGCAAAAGCTTCAAGACGAGAGTTTTTAAAAACAAGTGCAGCACTTGCTACAATGGCATTTTTTAG
CTCTAGTGCGTTTGCAAAAGATTCTAAAGAATCTACTCAAGCACGCAAAGAGAGCACAAATACAAAGAATCGTGTAATTC
TACAAAGAAAAATTGGCGATTTCAAAGTCTCCGCGATTGGCTTAGGTTGTATGGGAATGAGTGCCAATCACGGACCTACA
AGGGATAAAAAAGAAATGATAAAGCTGCTGCATAAAGCGGTGGATTTGGGATATACATTCTTTGATACCGCTGAAGTGTA
TGGACCACATACCAATGAGGAGCTTTTGGGCGAGGCTTTGAAAGGTTATAAAGACAAAATCGTCATCAATACCAAATTTG
GCTTTTACTATCCCTTTGGCAAACAACAGCTAGATTCTAGTCGCAAGTCTATTATGCGCGCAGTTGATGGGAGCTTGAAA
CGTTTAAAAAGGGATTGTATTGACCTCTACACGCAGCATAGAGTGGATATTGACACGCCTATTGAGGAAGTGGCAGGGAC
GATGAAAGATTTAGTCAAAATGGGCAAAATCAAAGCGTGGGCGTTAGGCGAAGCAGGGATTAAGACAATAGAGAGGGCGC
ACAAAGTCTTTGCCCCTGTGGCAATGCAGAGTCAATACTCTATGGCATTCCGTGAATTAGAGCAAAATGGCATAATGGAT
ACTTGCCAAAAGCTAGGAATCACGATTGTCGCTTATTCTCCGCTTGATAGAGGATTTTTAGGTGGAAGCTTTAATAAAAA
CACGACTTTTCACAAAACGCTTGATTTCCGCGCGTCTATGCCACGTTACACCAAAGAAGCCCTAGAGGCAAATCAAAGTG
TGATTGAGTTTATCAAAAAGGTAGCGCAGAGTAAAAGCATTAATGGCAAACCAGCAAGTGTCGCACAAGTCGCCTTAGCG
TGGATTCTCTCTAACAAAAGCTTTGTCATTCCAATCCCTGAAACCACGAAAATCCACAGACTAGAGGAGAATCTTAACGC
AAGTTTATTGCACTTTAGCCTTAACGAGCTAAAAGAAATCAATAAGGAATTAAGCAAGATTGTCATCATAGGGGATAGAT
ACGCACCCAATAGCGATGCGGCAAAGAGCGTGGGGCTGTAG

Upstream 100 bases:

>100_bases
TCGGCTACCCTAGAAGCTTAAACGCCCTAAGTGCGCTTGATGAGATTGCGCCGTTGTAGTAATAGGGAAATAAATGATAG
CAAACATACAAGGAAATACA

Downstream 100 bases:

>100_bases
ATTTTAAATCTTATTTGCCCCTTGACAAATACTAAGTGTAAGGATTTATACTATTATTTTATCTTGAAAGGGGCAAATAT
ACAAAAATCACACGAAAAAT

Product: aldo-keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKEKSAKASRREFLKTSAALATMAFFSSSAFAKDSKESTQARKESTNTKNRVILQRKIGDFKVSAIGLGCMGMSANHGPT
RDKKEMIKLLHKAVDLGYTFFDTAEVYGPHTNEELLGEALKGYKDKIVINTKFGFYYPFGKQQLDSSRKSIMRAVDGSLK
RLKRDCIDLYTQHRVDIDTPIEEVAGTMKDLVKMGKIKAWALGEAGIKTIERAHKVFAPVAMQSQYSMAFRELEQNGIMD
TCQKLGITIVAYSPLDRGFLGGSFNKNTTFHKTLDFRASMPRYTKEALEANQSVIEFIKKVAQSKSINGKPASVAQVALA
WILSNKSFVIPIPETTKIHRLEENLNASLLHFSLNELKEINKELSKIVIIGDRYAPNSDAAKSVGL

Sequences:

>Translated_386_residues
MKEKSAKASRREFLKTSAALATMAFFSSSAFAKDSKESTQARKESTNTKNRVILQRKIGDFKVSAIGLGCMGMSANHGPT
RDKKEMIKLLHKAVDLGYTFFDTAEVYGPHTNEELLGEALKGYKDKIVINTKFGFYYPFGKQQLDSSRKSIMRAVDGSLK
RLKRDCIDLYTQHRVDIDTPIEEVAGTMKDLVKMGKIKAWALGEAGIKTIERAHKVFAPVAMQSQYSMAFRELEQNGIMD
TCQKLGITIVAYSPLDRGFLGGSFNKNTTFHKTLDFRASMPRYTKEALEANQSVIEFIKKVAQSKSINGKPASVAQVALA
WILSNKSFVIPIPETTKIHRLEENLNASLLHFSLNELKEINKELSKIVIIGDRYAPNSDAAKSVGL
>Mature_386_residues
MKEKSAKASRREFLKTSAALATMAFFSSSAFAKDSKESTQARKESTNTKNRVILQRKIGDFKVSAIGLGCMGMSANHGPT
RDKKEMIKLLHKAVDLGYTFFDTAEVYGPHTNEELLGEALKGYKDKIVINTKFGFYYPFGKQQLDSSRKSIMRAVDGSLK
RLKRDCIDLYTQHRVDIDTPIEEVAGTMKDLVKMGKIKAWALGEAGIKTIERAHKVFAPVAMQSQYSMAFRELEQNGIMD
TCQKLGITIVAYSPLDRGFLGGSFNKNTTFHKTLDFRASMPRYTKEALEANQSVIEFIKKVAQSKSINGKPASVAQVALA
WILSNKSFVIPIPETTKIHRLEENLNASLLHFSLNELKEINKELSKIVIIGDRYAPNSDAAKSVGL

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=354, Percent_Identity=27.1186440677966, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI27436966, Length=342, Percent_Identity=26.6081871345029, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI27436962, Length=334, Percent_Identity=26.6467065868263, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI27436969, Length=335, Percent_Identity=25.0746268656716, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4504825, Length=320, Percent_Identity=25.3125, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI27436971, Length=306, Percent_Identity=25.1633986928105, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87081735, Length=326, Percent_Identity=28.8343558282209, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1789375, Length=313, Percent_Identity=30.3514376996805, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788081, Length=309, Percent_Identity=25.5663430420712, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788070, Length=315, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787674, Length=319, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI48994888, Length=288, Percent_Identity=24.3055555555556, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325384, Length=338, Percent_Identity=26.3313609467456, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325169, Length=346, Percent_Identity=26.0115606936416, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323998, Length=285, Percent_Identity=24.5614035087719, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319958, Length=285, Percent_Identity=24.9122807017544, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319951, Length=337, Percent_Identity=22.5519287833828, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45549126, Length=358, Percent_Identity=25.9776536312849, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646155, Length=157, Percent_Identity=35.031847133758, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 43008; Mature: 43008

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKSAKASRREFLKTSAALATMAFFSSSAFAKDSKESTQARKESTNTKNRVILQRKIGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHEEEEEECCCC
FKVSAIGLGCMGMSANHGPTRDKKEMIKLLHKAVDLGYTFFDTAEVYGPHTNEELLGEAL
EEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCHHHCCCCCCHHHHHHHH
KGYKDKIVINTKFGFYYPFGKQQLDSSRKSIMRAVDGSLKRLKRDCIDLYTQHRVDIDTP
HCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IEEVAGTMKDLVKMGKIKAWALGEAGIKTIERAHKVFAPVAMQSQYSMAFRELEQNGIMD
HHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
TCQKLGITIVAYSPLDRGFLGGSFNKNTTFHKTLDFRASMPRYTKEALEANQSVIEFIKK
HHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECHHCCCCHHHHHHHHCCHHHHHHHHH
VAQSKSINGKPASVAQVALAWILSNKSFVIPIPETTKIHRLEENLNASLLHFSLNELKEI
HHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHH
NKELSKIVIIGDRYAPNSDAAKSVGL
HHHHHEEEEEECCCCCCCCCHHHCCC
>Mature Secondary Structure
MKEKSAKASRREFLKTSAALATMAFFSSSAFAKDSKESTQARKESTNTKNRVILQRKIGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHEEEEEECCCC
FKVSAIGLGCMGMSANHGPTRDKKEMIKLLHKAVDLGYTFFDTAEVYGPHTNEELLGEAL
EEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCHHHCCCCCCHHHHHHHH
KGYKDKIVINTKFGFYYPFGKQQLDSSRKSIMRAVDGSLKRLKRDCIDLYTQHRVDIDTP
HCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IEEVAGTMKDLVKMGKIKAWALGEAGIKTIERAHKVFAPVAMQSQYSMAFRELEQNGIMD
HHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
TCQKLGITIVAYSPLDRGFLGGSFNKNTTFHKTLDFRASMPRYTKEALEANQSVIEFIKK
HHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECHHCCCCHHHHHHHHCCHHHHHHHHH
VAQSKSINGKPASVAQVALAWILSNKSFVIPIPETTKIHRLEENLNASLLHFSLNELKEI
HHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHH
NKELSKIVIIGDRYAPNSDAAKSVGL
HHHHHEEEEEECCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]