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The map label for this gene is pepA

Identifier: 32266871

GI number: 32266871

Start: 1325120

End: 1326544

Strand: Direct

Name: pepA

Synonym: HH1372

Alternate gene names: 32266871

Gene position: 1325120-1326544 (Clockwise)

Preceding gene: 32266870

Following gene: 32266872

Centisome position: 73.65

GC content: 38.95

Gene sequence:

>1425_bases
ATGAAAGTAAGTATTTCTCACAAAAATAATTTTAAGGGTGTGTCATATCAAGCACAGGCTTTATTGATGAGTAAAAGTGT
CTTTGCAAAATCCCCTTATGCAAAGTTATGTAAGAGTTTTGGTTTTGAGGGAGAGGGCAAATTTTTTCTTCAAGAGCAAG
CTTTGCTTTTGGTGTGCGTAGAAGAATTAGGACTTGATTCTATCCGAGAGGCTGGAGCAAGTATCGCGCGGCATTTTAGG
ACATTGCCTTATAAGAATGTGAATGTTGCATTAAATGGCAAACTTGATGATTCTAAAGCTTATGCCTTGCTTTTAGGGGC
ATTACTTGGAGTATATGAATGTGTAAGTTATAAAACGAAAACCCCTCCTTTACACCTTAAAGAGATAATATTGCTTGATG
AAAAGAATGAGGTTGCAAGTGAGAGTGTGCTTAAAAAGGTGCATATAGTCGCCCAAAGTGTCAATGAAGTGCGTGAGATT
ATCAATACAATCCCACAAGTAGCAACACCTAAATACCTTGCTAAATATGCTAAAGAATTGAGCAAAGAAGTAGGGAATCT
TGAATGTAAAATATTAGATGAGGAAGCATTGCAAAAGGAAAAAATGGGTGCATTTTTAGCAGTTAATCGTGCTTCGTGCA
ATCCACCGCGTTTGATACATTTAAGTTATAAACCCAAAGGTGCTAAAAAGCGTATTGTGCTTGTAGGTAAGGGACTTACT
TATGATTGTGGTGGGCTTTCACTCAAGCCTGCAGATTTTATGGTAACTATGAAAGCTGATAAGAGCGGAGGTTGTGCTGT
TATGGGCATAATTAAAGCCATAGCACAGCTAGGTGCGAATATTGAAGTGCATTCAATTATAGGTGCAGCAGAAAATATGA
TAGGTGGCAATGCGTATAAGCCTGATGATGTGCTGTATTCTCGTGAGGGCAAGAGCATTGAGGTAAGAAATACTGATGCG
GAAGGACGTTTGGTGCTTGTTGATTGTCTAAGTTATGCTCAAGATTTAAAACCTGATATTCTCATTGATTTTGCGACACT
CACAGGAGCGTGTGTAGTAGCTTTGGGTGAATTTACAAGTGGCATTATGGGACATAATGACAGACTTAAAGCCCAATTTG
AAAAATGTGCCCTTGAGAGTGGCGAACTTATGGCAACTTTGCCTTTTAATCGTCATCTTAAAAAACTTATAGAATCTAAA
ATTGCAGATGTATGTAATGTCGGCTCTTCGCGTTATGGTGGTGCGATAAGTGCGGGATTGTTTTTGAGTGAATTTATCCG
AGAAGAGTTTAAGCAAAAGTGGCTTCATATTGATATTGCAGGACCCGCGTATGTGGAAAAAGAGTGGGATATTAACCCAA
GTGGAGCGAGTGGTGCAGGCGTGAGGGCAGGAATAGAATTTATTTTAGCACAAGGAAAAGCATAA

Upstream 100 bases:

>100_bases
AAAGATTGCTAAGATTCAAAGAGAGCTTGAAAACAAAGAAAAAATAAGCAATACACAATAGTATAAGAGTTGCTTAAAAA
CTAAAACTAAGGAGCAGTTT

Downstream 100 bases:

>100_bases
ATGGGATTATCAATCGGTATTGTAGGGTTGCCAAATGTTGGTAAATCTACGACTTTTAATGCTCTCACAAAAGCACAAAA
TGCGGAGGCAGCAAATTATC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKVSISHKNNFKGVSYQAQALLMSKSVFAKSPYAKLCKSFGFEGEGKFFLQEQALLLVCVEELGLDSIREAGASIARHFR
TLPYKNVNVALNGKLDDSKAYALLLGALLGVYECVSYKTKTPPLHLKEIILLDEKNEVASESVLKKVHIVAQSVNEVREI
INTIPQVATPKYLAKYAKELSKEVGNLECKILDEEALQKEKMGAFLAVNRASCNPPRLIHLSYKPKGAKKRIVLVGKGLT
YDCGGLSLKPADFMVTMKADKSGGCAVMGIIKAIAQLGANIEVHSIIGAAENMIGGNAYKPDDVLYSREGKSIEVRNTDA
EGRLVLVDCLSYAQDLKPDILIDFATLTGACVVALGEFTSGIMGHNDRLKAQFEKCALESGELMATLPFNRHLKKLIESK
IADVCNVGSSRYGGAISAGLFLSEFIREEFKQKWLHIDIAGPAYVEKEWDINPSGASGAGVRAGIEFILAQGKA

Sequences:

>Translated_474_residues
MKVSISHKNNFKGVSYQAQALLMSKSVFAKSPYAKLCKSFGFEGEGKFFLQEQALLLVCVEELGLDSIREAGASIARHFR
TLPYKNVNVALNGKLDDSKAYALLLGALLGVYECVSYKTKTPPLHLKEIILLDEKNEVASESVLKKVHIVAQSVNEVREI
INTIPQVATPKYLAKYAKELSKEVGNLECKILDEEALQKEKMGAFLAVNRASCNPPRLIHLSYKPKGAKKRIVLVGKGLT
YDCGGLSLKPADFMVTMKADKSGGCAVMGIIKAIAQLGANIEVHSIIGAAENMIGGNAYKPDDVLYSREGKSIEVRNTDA
EGRLVLVDCLSYAQDLKPDILIDFATLTGACVVALGEFTSGIMGHNDRLKAQFEKCALESGELMATLPFNRHLKKLIESK
IADVCNVGSSRYGGAISAGLFLSEFIREEFKQKWLHIDIAGPAYVEKEWDINPSGASGAGVRAGIEFILAQGKA
>Mature_474_residues
MKVSISHKNNFKGVSYQAQALLMSKSVFAKSPYAKLCKSFGFEGEGKFFLQEQALLLVCVEELGLDSIREAGASIARHFR
TLPYKNVNVALNGKLDDSKAYALLLGALLGVYECVSYKTKTPPLHLKEIILLDEKNEVASESVLKKVHIVAQSVNEVREI
INTIPQVATPKYLAKYAKELSKEVGNLECKILDEEALQKEKMGAFLAVNRASCNPPRLIHLSYKPKGAKKRIVLVGKGLT
YDCGGLSLKPADFMVTMKADKSGGCAVMGIIKAIAQLGANIEVHSIIGAAENMIGGNAYKPDDVLYSREGKSIEVRNTDA
EGRLVLVDCLSYAQDLKPDILIDFATLTGACVVALGEFTSGIMGHNDRLKAQFEKCALESGELMATLPFNRHLKKLIESK
IADVCNVGSSRYGGAISAGLFLSEFIREEFKQKWLHIDIAGPAYVEKEWDINPSGASGAGVRAGIEFILAQGKA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=410, Percent_Identity=33.1707317073171, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI47155554, Length=321, Percent_Identity=35.8255451713396, Blast_Score=178, Evalue=8e-45,
Organism=Escherichia coli, GI1790710, Length=311, Percent_Identity=39.871382636656, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=38.0503144654088, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=300, Percent_Identity=34, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=266, Percent_Identity=33.4586466165414, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21357381, Length=324, Percent_Identity=33.641975308642, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI221379063, Length=324, Percent_Identity=33.641975308642, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI221379062, Length=324, Percent_Identity=33.641975308642, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24661038, Length=407, Percent_Identity=31.2039312039312, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21355725, Length=407, Percent_Identity=30.958230958231, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24662227, Length=390, Percent_Identity=27.1794871794872, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI20129969, Length=301, Percent_Identity=29.2358803986711, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI20129963, Length=338, Percent_Identity=28.698224852071, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19922386, Length=347, Percent_Identity=26.8011527377522, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161077148, Length=452, Percent_Identity=26.3274336283186, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI20130057, Length=452, Percent_Identity=26.3274336283186, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24646701, Length=369, Percent_Identity=29.810298102981, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646703, Length=369, Percent_Identity=29.810298102981, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21358201, Length=369, Percent_Identity=29.810298102981, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21355645, Length=388, Percent_Identity=24.7422680412371, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24662223, Length=388, Percent_Identity=24.7422680412371, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_HELHP (Q7VGF0)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860903.1
- ProteinModelPortal:   Q7VGF0
- SMR:   Q7VGF0
- GeneID:   1493060
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1372
- NMPDR:   fig|235279.1.peg.1372
- HOGENOM:   HBG742580
- OMA:   CTEEAQL
- ProtClustDB:   PRK00913
- BioCyc:   HHEP235279:HH_1372-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51523; Mature: 51523

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00631 CYTOSOL_AP; PS00659 GLYCOSYL_HYDROL_F5

Important sites: ACT_SITE 249-249 ACT_SITE 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSISHKNNFKGVSYQAQALLMSKSVFAKSPYAKLCKSFGFEGEGKFFLQEQALLLVCV
CEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEHHHHHHHHHH
EELGLDSIREAGASIARHFRTLPYKNVNVALNGKLDDSKAYALLLGALLGVYECVSYKTK
HHHCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TPPLHLKEIILLDEKNEVASESVLKKVHIVAQSVNEVREIINTIPQVATPKYLAKYAKEL
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SKEVGNLECKILDEEALQKEKMGAFLAVNRASCNPPRLIHLSYKPKGAKKRIVLVGKGLT
HHHHCCCEEEEECHHHHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCE
YDCGGLSLKPADFMVTMKADKSGGCAVMGIIKAIAQLGANIEVHSIIGAAENMIGGNAYK
ECCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCC
PDDVLYSREGKSIEVRNTDAEGRLVLVDCLSYAQDLKPDILIDFATLTGACVVALGEFTS
CCCCEEECCCCEEEEECCCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
GIMGHNDRLKAQFEKCALESGELMATLPFNRHLKKLIESKIADVCNVGSSRYGGAISAGL
HHCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
FLSEFIREEFKQKWLHIDIAGPAYVEKEWDINPSGASGAGVRAGIEFILAQGKA
HHHHHHHHHHHHCEEEEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHEECCCC
>Mature Secondary Structure
MKVSISHKNNFKGVSYQAQALLMSKSVFAKSPYAKLCKSFGFEGEGKFFLQEQALLLVCV
CEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEHHHHHHHHHH
EELGLDSIREAGASIARHFRTLPYKNVNVALNGKLDDSKAYALLLGALLGVYECVSYKTK
HHHCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TPPLHLKEIILLDEKNEVASESVLKKVHIVAQSVNEVREIINTIPQVATPKYLAKYAKEL
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SKEVGNLECKILDEEALQKEKMGAFLAVNRASCNPPRLIHLSYKPKGAKKRIVLVGKGLT
HHHHCCCEEEEECHHHHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCE
YDCGGLSLKPADFMVTMKADKSGGCAVMGIIKAIAQLGANIEVHSIIGAAENMIGGNAYK
ECCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCC
PDDVLYSREGKSIEVRNTDAEGRLVLVDCLSYAQDLKPDILIDFATLTGACVVALGEFTS
CCCCEEECCCCEEEEECCCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
GIMGHNDRLKAQFEKCALESGELMATLPFNRHLKKLIESKIADVCNVGSSRYGGAISAGL
HHCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
FLSEFIREEFKQKWLHIDIAGPAYVEKEWDINPSGASGAGVRAGIEFILAQGKA
HHHHHHHHHHHHCEEEEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954