Click here to switch to the map view.

The map label for this gene is clpX

Identifier: 32266682

GI number: 32266682

Start: 1147776

End: 1149056

Strand: Direct

Name: clpX

Synonym: HH1183

Alternate gene names: 32266682

Gene position: 1147776-1149056 (Clockwise)

Preceding gene: 32266681

Following gene: 32266683

Centisome position: 63.8

GC content: 34.5

Gene sequence:

>1281_bases
GTGAATGAAATAAAAAAAAGATGTAGTTTTTGCAATAAAGAAGAAAGTTTAGATAATCCTATCATTAATTCAGGGATTAC
TCCAGATGTATATATTTGTAATTATTGTTTGATTGTTGGAAGTGAAATTTTGACAGGTTATTTGAATAAAAATCCACAAC
AAGATCAAGAAGCAATAGACATTAAAACGCCATCACCAAAAGAACTTAAAGCCAAACTTGATGAATATGTGATAGGACAA
GATGAAGCAAAACGTGTATTCTCAGTCGCAGTATATAATCATTATAAACGTATCAAAGCAAATAGTCTTTCTGAAGAAGA
AATGCCAAATCCAATTTTACAAGATGATGTAGAGCTCTCTAAATCAAATATTTTACTCATTGGTCCAACAGGTAGCGGAA
AAACATTAATGGCACAGACTTTAGCACGTTTTTTAGACATTCCCATTGCTATTTCTGATGCGACAAGTCTTACAGAGGCA
GGGTATGTGGGTGAAGATGTAGAAAATATCCTTACTCGACTTCTTCAAGCTGCTGATGGTGATGTCAAAAAAGCAGAGAA
AGGTATTGTATTTATTGATGAGATTGACAAAATTTCGCGTCTTTCTGAAAATCGTTCTATTACACGTGATGTATCAGGAG
AAGGCGTGCAACAAGCATTACTTAAAATTATTGAGGGTAGTGTGGTAAATATTCCCCCAAAAGGTGGGAGAAAGCACCCT
AATCAAGAATTTGTGCAAATTAATACAAGCGATATTTTATTTGTATGCGGCGGTGCATTTGATGGGTTGGGCGATATTAT
TAAAAGACGTTTGGGTGGAAATGTGCTTGGATTTCACGGAGAGAAAAAAGGTAAAAGCGAAGAAGATGCTTTACTCAAAT
ATGTAGAACCTGATGATCTTATTAGCTATGGGTTGATTCCAGAGCTTATCGGCAGACTCCATATGATTACAACACTTTCT
CCAATTAGCAAAGAAGCAATGGTAGAGATTCTCACAAAACCTAAAAATGCACTTATAAAACAATACCAAAAAATTTTTGA
AATTGATGGTGCAACATTACATTTTGAAAAAGATGCCATTGAGTCGATTGCCGAACTTGCTATTGCAAGAAAAACAGGTG
CTAGAGGCTTAAGGTCTATTATGGAGGGAGCAATGATTGATTTAATGTATGATTTACCAGAGCTTGCAGGTTATGAAATT
ACCATTTCTAAAGAATGTATTATGGACAAGCAAAGTCCTCTTCGCGTTAAAAAAAAGAGAAATATACAAAAAAGAGCTTA
A

Upstream 100 bases:

>100_bases
GCTCAATCTCAACTTGATAAGAATCCAAATAACACTATCCGCTATATTTGTGAATTTATCCTTTCAACTACACGTGGTAT
CCCCTTTAAAGGAGTGCAAA

Downstream 100 bases:

>100_bases
TTTAACATAAAACAAAAGGTTTAGCAAAGGATTAGAATGTATAATGCACAAATTATTTTGTAATATTTTTTAAGGAGCTT
TTATGTTGGTGGATAGACTC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNEIKKRCSFCNKEESLDNPIINSGITPDVYICNYCLIVGSEILTGYLNKNPQQDQEAIDIKTPSPKELKAKLDEYVIGQ
DEAKRVFSVAVYNHYKRIKANSLSEEEMPNPILQDDVELSKSNILLIGPTGSGKTLMAQTLARFLDIPIAISDATSLTEA
GYVGEDVENILTRLLQAADGDVKKAEKGIVFIDEIDKISRLSENRSITRDVSGEGVQQALLKIIEGSVVNIPPKGGRKHP
NQEFVQINTSDILFVCGGAFDGLGDIIKRRLGGNVLGFHGEKKGKSEEDALLKYVEPDDLISYGLIPELIGRLHMITTLS
PISKEAMVEILTKPKNALIKQYQKIFEIDGATLHFEKDAIESIAELAIARKTGARGLRSIMEGAMIDLMYDLPELAGYEI
TISKECIMDKQSPLRVKKKRNIQKRA

Sequences:

>Translated_426_residues
MNEIKKRCSFCNKEESLDNPIINSGITPDVYICNYCLIVGSEILTGYLNKNPQQDQEAIDIKTPSPKELKAKLDEYVIGQ
DEAKRVFSVAVYNHYKRIKANSLSEEEMPNPILQDDVELSKSNILLIGPTGSGKTLMAQTLARFLDIPIAISDATSLTEA
GYVGEDVENILTRLLQAADGDVKKAEKGIVFIDEIDKISRLSENRSITRDVSGEGVQQALLKIIEGSVVNIPPKGGRKHP
NQEFVQINTSDILFVCGGAFDGLGDIIKRRLGGNVLGFHGEKKGKSEEDALLKYVEPDDLISYGLIPELIGRLHMITTLS
PISKEAMVEILTKPKNALIKQYQKIFEIDGATLHFEKDAIESIAELAIARKTGARGLRSIMEGAMIDLMYDLPELAGYEI
TISKECIMDKQSPLRVKKKRNIQKRA
>Mature_426_residues
MNEIKKRCSFCNKEESLDNPIINSGITPDVYICNYCLIVGSEILTGYLNKNPQQDQEAIDIKTPSPKELKAKLDEYVIGQ
DEAKRVFSVAVYNHYKRIKANSLSEEEMPNPILQDDVELSKSNILLIGPTGSGKTLMAQTLARFLDIPIAISDATSLTEA
GYVGEDVENILTRLLQAADGDVKKAEKGIVFIDEIDKISRLSENRSITRDVSGEGVQQALLKIIEGSVVNIPPKGGRKHP
NQEFVQINTSDILFVCGGAFDGLGDIIKRRLGGNVLGFHGEKKGKSEEDALLKYVEPDDLISYGLIPELIGRLHMITTLS
PISKEAMVEILTKPKNALIKQYQKIFEIDGATLHFEKDAIESIAELAIARKTGARGLRSIMEGAMIDLMYDLPELAGYEI
TISKECIMDKQSPLRVKKKRNIQKRA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=324, Percent_Identity=47.5308641975309, Blast_Score=295, Evalue=4e-80,
Organism=Escherichia coli, GI1786642, Length=423, Percent_Identity=53.9007092198582, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1790366, Length=114, Percent_Identity=40.3508771929825, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982908, Length=314, Percent_Identity=46.1783439490446, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71982905, Length=314, Percent_Identity=46.1783439490446, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71988663, Length=388, Percent_Identity=40.2061855670103, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71988660, Length=257, Percent_Identity=41.6342412451362, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319704, Length=408, Percent_Identity=41.6666666666667, Blast_Score=270, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24648291, Length=305, Percent_Identity=46.2295081967213, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24648289, Length=305, Percent_Identity=46.2295081967213, Blast_Score=275, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_HELHP (Q7VGY5)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860714.1
- ProteinModelPortal:   Q7VGY5
- GeneID:   1492871
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1183
- NMPDR:   fig|235279.1.peg.1183
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   HHEP235279:HH_1183-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR002078
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 47177; Mature: 47177

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00676 SIGMA54_INTERACT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIKKRCSFCNKEESLDNPIINSGITPDVYICNYCLIVGSEILTGYLNKNPQQDQEAID
CCHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEE
IKTPSPKELKAKLDEYVIGQDEAKRVFSVAVYNHYKRIKANSLSEEEMPNPILQDDVELS
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHC
KSNILLIGPTGSGKTLMAQTLARFLDIPIAISDATSLTEAGYVGEDVENILTRLLQAADG
CCCEEEEECCCCCCHHHHHHHHHHHCCCEEECCCHHHHHCCCCCHHHHHHHHHHHHHCCC
DVKKAEKGIVFIDEIDKISRLSENRSITRDVSGEGVQQALLKIIEGSVVNIPPKGGRKHP
CHHHHCCCEEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCC
NQEFVQINTSDILFVCGGAFDGLGDIIKRRLGGNVLGFHGEKKGKSEEDALLKYVEPDDL
CCCEEEECCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCHHH
ISYGLIPELIGRLHMITTLSPISKEAMVEILTKPKNALIKQYQKIFEIDGATLHFEKDAI
HHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECHHHH
ESIAELAIARKTGARGLRSIMEGAMIDLMYDLPELAGYEITISKECIMDKQSPLRVKKKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHCCCCCCCHHHHHC
NIQKRA
CCCCCC
>Mature Secondary Structure
MNEIKKRCSFCNKEESLDNPIINSGITPDVYICNYCLIVGSEILTGYLNKNPQQDQEAID
CCHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEE
IKTPSPKELKAKLDEYVIGQDEAKRVFSVAVYNHYKRIKANSLSEEEMPNPILQDDVELS
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHC
KSNILLIGPTGSGKTLMAQTLARFLDIPIAISDATSLTEAGYVGEDVENILTRLLQAADG
CCCEEEEECCCCCCHHHHHHHHHHHCCCEEECCCHHHHHCCCCCHHHHHHHHHHHHHCCC
DVKKAEKGIVFIDEIDKISRLSENRSITRDVSGEGVQQALLKIIEGSVVNIPPKGGRKHP
CHHHHCCCEEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCC
NQEFVQINTSDILFVCGGAFDGLGDIIKRRLGGNVLGFHGEKKGKSEEDALLKYVEPDDL
CCCEEEECCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCHHH
ISYGLIPELIGRLHMITTLSPISKEAMVEILTKPKNALIKQYQKIFEIDGATLHFEKDAI
HHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECHHHH
ESIAELAIARKTGARGLRSIMEGAMIDLMYDLPELAGYEITISKECIMDKQSPLRVKKKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHCCCCCCCHHHHHC
NIQKRA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954