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The map label for this gene is lpxA

Identifier: 32266681

GI number: 32266681

Start: 1147001

End: 1147783

Strand: Direct

Name: lpxA

Synonym: HH1182

Alternate gene names: 32266681

Gene position: 1147001-1147783 (Clockwise)

Preceding gene: 32266680

Following gene: 32266682

Centisome position: 63.75

GC content: 37.93

Gene sequence:

>783_bases
ATGATAGGAAAAACAAGTATTGTTAAAGAAGGCGCAAAAATAGGAAAAAATGTCCAAATTGGCGAATTTTGCATTATTGA
TGAGAATACTATCATTGGTGATGAATGTATCATAGGCAATTATGTGCATATAAGTGGTTGCACAACTCTAGGTAAGCGCA
ACAAGGTTTTTAATAATGCTGCTGTTGGTGTGCCACCACAAGACTTAAAATATGCGGGAGAAAAGACAGAGCTTATCATC
GGAGATGATAATTTGATTCGTGAATTTACTACACTTAATCCCGGCACTGCAGGAGGAAGAGGAAAAACGATAATAGGCGA
TAGAAATTTATTTATGGCTTATGTCCATATAGCACACGATTGCATTGTAGGAAATGATTGTATTCTTGCAAATAATGCTA
CGCTTGGTGGGCACGTAGAGCTTGGTGATTATGTTAATATCGGGGGATTGACACCCGTGCATCAATTTGTCAAAGTCGGA
GATGGTTGTATGATAGCAGGAGGCTCTGTTTTAACACAGGATATGCCTCCATATTGCTTGGCAGAAGGCAATAGGGCTTA
TATTAGAGGATTAAATAAACATCGTATGCGAAAACTTTTTACACGTGAAGAAATTGACGAAATAAATCGTGTGTATAAGA
TTCTTTTTTCGCGCAGTGCACCCATTCGGGAACTTGCTCAATCTCAACTTGATAAGAATCCAAATAACACTATCCGCTAT
ATTTGTGAATTTATCCTTTCAACTACACGTGGTATCCCCTTTAAAGGAGTGCAAAGTGAATGA

Upstream 100 bases:

>100_bases
ATGGCAACTTGGAGCAAATGCTTTTGTTGAGGATAAACTTGTAAGTGAAGCTGAACTTAAAGCTATGATTACTGAAGCTA
AAGAATCTTAAGGAATATAT

Downstream 100 bases:

>100_bases
AATAAAAAAAAGATGTAGTTTTTGCAATAAAGAAGAAAGTTTAGATAATCCTATCATTAATTCAGGGATTACTCCAGATG
TATATATTTGTAATTATTGT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MIGKTSIVKEGAKIGKNVQIGEFCIIDENTIIGDECIIGNYVHISGCTTLGKRNKVFNNAAVGVPPQDLKYAGEKTELII
GDDNLIREFTTLNPGTAGGRGKTIIGDRNLFMAYVHIAHDCIVGNDCILANNATLGGHVELGDYVNIGGLTPVHQFVKVG
DGCMIAGGSVLTQDMPPYCLAEGNRAYIRGLNKHRMRKLFTREEIDEINRVYKILFSRSAPIRELAQSQLDKNPNNTIRY
ICEFILSTTRGIPFKGVQSE

Sequences:

>Translated_260_residues
MIGKTSIVKEGAKIGKNVQIGEFCIIDENTIIGDECIIGNYVHISGCTTLGKRNKVFNNAAVGVPPQDLKYAGEKTELII
GDDNLIREFTTLNPGTAGGRGKTIIGDRNLFMAYVHIAHDCIVGNDCILANNATLGGHVELGDYVNIGGLTPVHQFVKVG
DGCMIAGGSVLTQDMPPYCLAEGNRAYIRGLNKHRMRKLFTREEIDEINRVYKILFSRSAPIRELAQSQLDKNPNNTIRY
ICEFILSTTRGIPFKGVQSE
>Mature_260_residues
MIGKTSIVKEGAKIGKNVQIGEFCIIDENTIIGDECIIGNYVHISGCTTLGKRNKVFNNAAVGVPPQDLKYAGEKTELII
GDDNLIREFTTLNPGTAGGRGKTIIGDRNLFMAYVHIAHDCIVGNDCILANNATLGGHVELGDYVNIGGLTPVHQFVKVG
DGCMIAGGSVLTQDMPPYCLAEGNRAYIRGLNKHRMRKLFTREEIDEINRVYKILFSRSAPIRELAQSQLDKNPNNTIRY
ICEFILSTTRGIPFKGVQSE

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=260, Percent_Identity=42.3076923076923, Blast_Score=201, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28472; Mature: 28472

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGKTSIVKEGAKIGKNVQIGEFCIIDENTIIGDECIIGNYVHISGCTTLGKRNKVFNNA
CCCCHHHHHHHHHHCCCCEECCEEEEECCEEECCCEEECCEEEECCCCCCCCCCCCCCCC
AVGVPPQDLKYAGEKTELIIGDDNLIREFTTLNPGTAGGRGKTIIGDRNLFMAYVHIAHD
CCCCCCHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
CIVGNDCILANNATLGGHVELGDYVNIGGLTPVHQFVKVGDGCMIAGGSVLTQDMPPYCL
HEECCCEEEECCCCCCCEEEECCEEECCCCCHHHHHHHHCCCEEEECCCEECCCCCCCEE
AEGNRAYIRGLNKHRMRKLFTREEIDEINRVYKILFSRSAPIRELAQSQLDKNPNNTIRY
ECCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHH
ICEFILSTTRGIPFKGVQSE
HHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIGKTSIVKEGAKIGKNVQIGEFCIIDENTIIGDECIIGNYVHISGCTTLGKRNKVFNNA
CCCCHHHHHHHHHHCCCCEECCEEEEECCEEECCCEEECCEEEECCCCCCCCCCCCCCCC
AVGVPPQDLKYAGEKTELIIGDDNLIREFTTLNPGTAGGRGKTIIGDRNLFMAYVHIAHD
CCCCCCHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
CIVGNDCILANNATLGGHVELGDYVNIGGLTPVHQFVKVGDGCMIAGGSVLTQDMPPYCL
HEECCCEEEECCCCCCCEEEECCEEECCCCCHHHHHHHHCCCEEEECCCEECCCCCCCEE
AEGNRAYIRGLNKHRMRKLFTREEIDEINRVYKILFSRSAPIRELAQSQLDKNPNNTIRY
ECCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHH
ICEFILSTTRGIPFKGVQSE
HHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA