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The map label for this gene is lpxD

Identifier: 32266598

GI number: 32266598

Start: 1069035

End: 1070015

Strand: Direct

Name: lpxD

Synonym: HH1099

Alternate gene names: 32266598

Gene position: 1069035-1070015 (Clockwise)

Preceding gene: 32266593

Following gene: 32266599

Centisome position: 59.42

GC content: 40.67

Gene sequence:

>981_bases
ATGCTTCTCTCACTTGCCATAGATACCGCATTTAAAGGCTATCTTAGCCTACAAAATACCATAGAAAACGATTTTGAATT
AAATGGCATTGCCCCTTTAGAATCTGCCACACCCACACAAATAAGCTATATAGACCAAGATAAATACTTGAGTAATCTTA
CAGATTCTCAAGCGGGTGCTGTTTTTATCCGCCCTCACTTGCTTGATAAAGTTCCTTCACATATTCAGCCTCTTGTAGTA
GAGAATCCCCATCTTGCTTTTGCCTTGCTTTCACAGCTTTTTGCTGCGCCTTGTTTCACGCTCACCACTCAAAATCCCCG
TACAAATAATATTCAAATAGGTGCAAATGTCGTTATTGGCGATAATGTCAGCATTGGGGAGCATAGCATAATTATGCCAA
ATGTCGTTATTGGCGATAATGTCAGCATTGGGGAGCATTGTAAAATTTATCCTAATGTCGTCATTTATCGCGATAGTATT
ATTGGTAATCGTGTAAATATCCACGCAGGAAGCATAATAGGCTGTGATGGCTTTGGCTATGCGCATACAGCAGAAGGAAA
ACATATTAAAATTGAACATAATGGGCGCGTTGTTATAGAAGATGATGTGGAAATTGGTGCAAATAATACTATTGATAGGG
CTGTATTTGGGCAAACGCTTATAAAGCAAGGGGCAAAAATTGACAATCTTGTGCAAATAGGGCATAACTGCGTGGTTGGA
GAGCATACTCTCCTTGTCTCACAAGTAGGGCTTGCTGGCTCAACTACTACCGGGCGTAATGTCATAATGGGTGGACAAGC
TGGCACAGGAGGACATATTCATATTGGTGATTTTGTGCAAGTCGCTGGACGCGGAGCAGTAGGTAAAAATCTCCCTCCAC
ATACCAAATGGGGCGGACACCCGCTTATGGAACTCAATGAATGGATGAAATTCTATGTTTCATTGCGTAGATTGATAAAA
AAAGATTCTAAAAAGCTATAA

Upstream 100 bases:

>100_bases
TACACCAAATCCTTGAATCTAGCTAAATTTCACCGCTACAGCCCTAGATTCTGTAATGTTTATGTTATGATTACATTTTA
TCTTTAGCCAAAGGATATGT

Downstream 100 bases:

>100_bases
TGAAACTAAAAATATCATTGTCTTAAAAGGATACCGAATGAACAAATGGAATAACTTTGATACAAGCTGGATAATTTCTC
TTTTTGGAACAGCTGTGGGT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MLLSLAIDTAFKGYLSLQNTIENDFELNGIAPLESATPTQISYIDQDKYLSNLTDSQAGAVFIRPHLLDKVPSHIQPLVV
ENPHLAFALLSQLFAAPCFTLTTQNPRTNNIQIGANVVIGDNVSIGEHSIIMPNVVIGDNVSIGEHCKIYPNVVIYRDSI
IGNRVNIHAGSIIGCDGFGYAHTAEGKHIKIEHNGRVVIEDDVEIGANNTIDRAVFGQTLIKQGAKIDNLVQIGHNCVVG
EHTLLVSQVGLAGSTTTGRNVIMGGQAGTGGHIHIGDFVQVAGRGAVGKNLPPHTKWGGHPLMELNEWMKFYVSLRRLIK
KDSKKL

Sequences:

>Translated_326_residues
MLLSLAIDTAFKGYLSLQNTIENDFELNGIAPLESATPTQISYIDQDKYLSNLTDSQAGAVFIRPHLLDKVPSHIQPLVV
ENPHLAFALLSQLFAAPCFTLTTQNPRTNNIQIGANVVIGDNVSIGEHSIIMPNVVIGDNVSIGEHCKIYPNVVIYRDSI
IGNRVNIHAGSIIGCDGFGYAHTAEGKHIKIEHNGRVVIEDDVEIGANNTIDRAVFGQTLIKQGAKIDNLVQIGHNCVVG
EHTLLVSQVGLAGSTTTGRNVIMGGQAGTGGHIHIGDFVQVAGRGAVGKNLPPHTKWGGHPLMELNEWMKFYVSLRRLIK
KDSKKL
>Mature_326_residues
MLLSLAIDTAFKGYLSLQNTIENDFELNGIAPLESATPTQISYIDQDKYLSNLTDSQAGAVFIRPHLLDKVPSHIQPLVV
ENPHLAFALLSQLFAAPCFTLTTQNPRTNNIQIGANVVIGDNVSIGEHSIIMPNVVIGDNVSIGEHCKIYPNVVIYRDSI
IGNRVNIHAGSIIGCDGFGYAHTAEGKHIKIEHNGRVVIEDDVEIGANNTIDRAVFGQTLIKQGAKIDNLVQIGHNCVVG
EHTLLVSQVGLAGSTTTGRNVIMGGQAGTGGHIHIGDFVQVAGRGAVGKNLPPHTKWGGHPLMELNEWMKFYVSLRRLIK
KDSKKL

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=316, Percent_Identity=36.0759493670886, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_HELHP (Q7VH68)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860630.1
- ProteinModelPortal:   Q7VH68
- SMR:   Q7VH68
- GeneID:   1492788
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1099
- NMPDR:   fig|235279.1.peg.1099
- HOGENOM:   HBG469615
- OMA:   VQIGRVI
- ProtClustDB:   PRK00892
- BioCyc:   HHEP235279:HH_1099-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 35241; Mature: 35241

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSLAIDTAFKGYLSLQNTIENDFELNGIAPLESATPTQISYIDQDKYLSNLTDSQAGA
CEEEEEEHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCE
VFIRPHLLDKVPSHIQPLVVENPHLAFALLSQLFAAPCFTLTTQNPRTNNIQIGANVVIG
EEECHHHHHHCHHHCCCEEEECCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEEEC
DNVSIGEHSIIMPNVVIGDNVSIGEHCKIYPNVVIYRDSIIGNRVNIHAGSIIGCDGFGY
CCCCCCCCEEEECEEEECCCCCCCCCEEECCCEEEEECCCCCCEEEEECCCEEECCCCCC
AHTAEGKHIKIEHNGRVVIEDDVEIGANNTIDRAVFGQTLIKQGAKIDNLVQIGHNCVVG
EECCCCCEEEEECCCEEEEECCCEECCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCEEEC
EHTLLVSQVGLAGSTTTGRNVIMGGQAGTGGHIHIGDFVQVAGRGAVGKNLPPHTKWGGH
CCEEEEEECCCCCCCCCCCEEEECCCCCCCCEEEECHHHHHHCCCCCCCCCCCCCCCCCC
PLMELNEWMKFYVSLRRLIKKDSKKL
CHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLSLAIDTAFKGYLSLQNTIENDFELNGIAPLESATPTQISYIDQDKYLSNLTDSQAGA
CEEEEEEHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCE
VFIRPHLLDKVPSHIQPLVVENPHLAFALLSQLFAAPCFTLTTQNPRTNNIQIGANVVIG
EEECHHHHHHCHHHCCCEEEECCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEEEC
DNVSIGEHSIIMPNVVIGDNVSIGEHCKIYPNVVIYRDSIIGNRVNIHAGSIIGCDGFGY
CCCCCCCCEEEECEEEECCCCCCCCCEEECCCEEEEECCCCCCEEEEECCCEEECCCCCC
AHTAEGKHIKIEHNGRVVIEDDVEIGANNTIDRAVFGQTLIKQGAKIDNLVQIGHNCVVG
EECCCCCEEEEECCCEEEEECCCEECCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCEEEC
EHTLLVSQVGLAGSTTTGRNVIMGGQAGTGGHIHIGDFVQVAGRGAVGKNLPPHTKWGGH
CCEEEEEECCCCCCCCCCCEEEECCCCCCCCEEEECHHHHHHCCCCCCCCCCCCCCCCCC
PLMELNEWMKFYVSLRRLIKKDSKKL
CHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954