Click here to switch to the map view.

The map label for this gene is maeB [H]

Identifier: 32266593

GI number: 32266593

Start: 1064330

End: 1065544

Strand: Direct

Name: maeB [H]

Synonym: HH1094

Alternate gene names: 32266593

Gene position: 1064330-1065544 (Clockwise)

Preceding gene: 32266592

Following gene: 32266598

Centisome position: 59.16

GC content: 40.82

Gene sequence:

>1215_bases
ATGGATTTACAAACTCTTAAAAAAGCCTATCCCAAAGCTCTACCTTACCACATTGGCGGCAAAGTTGGTATTCAGCCTCG
CAAAAGATTACGCTCTATTGATGAACTAGGATTAGCCTATACACCCGGCGTCGCTGTGCCTTGTAAGCAGATTGAGGCTA
ATCCTTTAAGCGCATATGATTACACTTCAAAAAGCAATCTTGTTGCAGTTATTAGCAACGGCACAGCAGTGCTTGGACTC
GGCGATATTGGAGCTATGGCAAGTAAGCCCGTTATGGAGGGAAAAGCCATTTTGTTTAAAACTTTCGCAGGAGTTGATGC
CTTTGATATTGAGATTAACGAAAAAGATGTGGATAAATTTGTCGCTGTAGTTAAGGCGATTTCGCCCACATTTGGTGGCA
TTAACCTAGAAGATATTAAAGCTCCGGAATGCTTTGAGATTGAGCGAAGACTCATTGAAGAGCTTGATATTCCTGTAATG
CACGATGACCAACACGGCACAGCAATTATCTCTACTGCAGGAATTATCAACGCCTTGCACCTTGTAAATAAAAAAGCAAA
GGATATTAAGGTTGTCGTATTTGGTGCGGGAGCTGCAGCTGTGGCGTGTGCAAAAATGTATAAAGCATTTGGCGTGAAAA
ATCTTGTAATGTTTGATTCTAAAGGTGCAATTAGTGCAAATAGAACCGATTTAAATGATTTGAAAAAAGAGTTTATCTGC
CAAGAGAACTATGCCTCATATAAAGACGCGCTTAATGGCGCAGATGTAATGCTTGGGCTATCAAAGGGCAATTTATTAAG
CGGAGATGATATTAAGGGAATGAATGAATCTCCCCTCATTTTCGCACTAAGTAATCCTACGCCAGAAATTATGCCCGATG
AGGTGAAAAAAGCACGTCCTGATGCAATAGTTGCCACAGGACGCAGTGATTTCCCCAATCAAATTAATAATGTGCTTGGA
TTTCCCTACATCTTTAAAGGTGCGCTTAAAGTGCGTGCGAGCAAAATTAACGAAGAAATGAAATTTGCCGCAGCTTATGC
AATCGCTAATCTTGCACGTGAACCAATCACCGAAAAACTTGAAAAACTTTTAAAGAAAAAAATGAGTTTTGGCAAAGAAT
ATATTATCCCCTCTGCCTTTGATGAAAGACTTGATGATGTCGTCTCAAATGCCGTAGCAGATGCAGCGATAAAAAGCGGC
GTGGCAAGGGTGTAA

Upstream 100 bases:

>100_bases
ATTTGGGGGCGTAGAATAATATCTTTATGTTTTATTTGCAAAAAAGTGCTAAAACTTCGCTGTATATAACCATATCTTCT
ATAAAAATTAAGGATATATA

Downstream 100 bases:

>100_bases
AGCAAAAAACGAACTATTTTATATCGGGTTTTTGTGGAGCTTCCCATTTTCACAGGCTCAAATTGTTTGATACGCTCCAC
AGGATAATTATAGTGAAGTA

Product: malate oxidoreductase

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDLQTLKKAYPKALPYHIGGKVGIQPRKRLRSIDELGLAYTPGVAVPCKQIEANPLSAYDYTSKSNLVAVISNGTAVLGL
GDIGAMASKPVMEGKAILFKTFAGVDAFDIEINEKDVDKFVAVVKAISPTFGGINLEDIKAPECFEIERRLIEELDIPVM
HDDQHGTAIISTAGIINALHLVNKKAKDIKVVVFGAGAAAVACAKMYKAFGVKNLVMFDSKGAISANRTDLNDLKKEFIC
QENYASYKDALNGADVMLGLSKGNLLSGDDIKGMNESPLIFALSNPTPEIMPDEVKKARPDAIVATGRSDFPNQINNVLG
FPYIFKGALKVRASKINEEMKFAAAYAIANLAREPITEKLEKLLKKKMSFGKEYIIPSAFDERLDDVVSNAVADAAIKSG
VARV

Sequences:

>Translated_404_residues
MDLQTLKKAYPKALPYHIGGKVGIQPRKRLRSIDELGLAYTPGVAVPCKQIEANPLSAYDYTSKSNLVAVISNGTAVLGL
GDIGAMASKPVMEGKAILFKTFAGVDAFDIEINEKDVDKFVAVVKAISPTFGGINLEDIKAPECFEIERRLIEELDIPVM
HDDQHGTAIISTAGIINALHLVNKKAKDIKVVVFGAGAAAVACAKMYKAFGVKNLVMFDSKGAISANRTDLNDLKKEFIC
QENYASYKDALNGADVMLGLSKGNLLSGDDIKGMNESPLIFALSNPTPEIMPDEVKKARPDAIVATGRSDFPNQINNVLG
FPYIFKGALKVRASKINEEMKFAAAYAIANLAREPITEKLEKLLKKKMSFGKEYIIPSAFDERLDDVVSNAVADAAIKSG
VARV
>Mature_404_residues
MDLQTLKKAYPKALPYHIGGKVGIQPRKRLRSIDELGLAYTPGVAVPCKQIEANPLSAYDYTSKSNLVAVISNGTAVLGL
GDIGAMASKPVMEGKAILFKTFAGVDAFDIEINEKDVDKFVAVVKAISPTFGGINLEDIKAPECFEIERRLIEELDIPVM
HDDQHGTAIISTAGIINALHLVNKKAKDIKVVVFGAGAAAVACAKMYKAFGVKNLVMFDSKGAISANRTDLNDLKKEFIC
QENYASYKDALNGADVMLGLSKGNLLSGDDIKGMNESPLIFALSNPTPEIMPDEVKKARPDAIVATGRSDFPNQINNVLG
FPYIFKGALKVRASKINEEMKFAAAYAIANLAREPITEKLEKLLKKKMSFGKEYIIPSAFDERLDDVVSNAVADAAIKSG
VARV

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=397, Percent_Identity=24.9370277078086, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788806, Length=398, Percent_Identity=54.7738693467337, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322823, Length=277, Percent_Identity=29.6028880866426, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI78707242, Length=353, Percent_Identity=24.6458923512748, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI78707238, Length=353, Percent_Identity=24.6458923512748, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI78707240, Length=353, Percent_Identity=24.6458923512748, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 43614; Mature: 43614

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQTLKKAYPKALPYHIGGKVGIQPRKRLRSIDELGLAYTPGVAVPCKQIEANPLSAYD
CCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCCHHHCCCCCCCCCC
YTSKSNLVAVISNGTAVLGLGDIGAMASKPVMEGKAILFKTFAGVDAFDIEINEKDVDKF
CCCCCCEEEEEECCEEEEEECCHHHHHCCCCCCCCEEEEEHHCCCEEEEEEECHHHHHHH
VAVVKAISPTFGGINLEDIKAPECFEIERRLIEELDIPVMHDDQHGTAIISTAGIINALH
HHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
LVNKKAKDIKVVVFGAGAAAVACAKMYKAFGVKNLVMFDSKGAISANRTDLNDLKKEFIC
HHCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
QENYASYKDALNGADVMLGLSKGNLLSGDDIKGMNESPLIFALSNPTPEIMPDEVKKARP
HCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHCCC
DAIVATGRSDFPNQINNVLGFPYIFKGALKVRASKINEEMKFAAAYAIANLAREPITEKL
CEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLLKKKMSFGKEYIIPSAFDERLDDVVSNAVADAAIKSGVARV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDLQTLKKAYPKALPYHIGGKVGIQPRKRLRSIDELGLAYTPGVAVPCKQIEANPLSAYD
CCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCCHHHCCCCCCCCCC
YTSKSNLVAVISNGTAVLGLGDIGAMASKPVMEGKAILFKTFAGVDAFDIEINEKDVDKF
CCCCCCEEEEEECCEEEEEECCHHHHHCCCCCCCCEEEEEHHCCCEEEEEEECHHHHHHH
VAVVKAISPTFGGINLEDIKAPECFEIERRLIEELDIPVMHDDQHGTAIISTAGIINALH
HHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
LVNKKAKDIKVVVFGAGAAAVACAKMYKAFGVKNLVMFDSKGAISANRTDLNDLKKEFIC
HHCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
QENYASYKDALNGADVMLGLSKGNLLSGDDIKGMNESPLIFALSNPTPEIMPDEVKKARP
HCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHCCC
DAIVATGRSDFPNQINNVLGFPYIFKGALKVRASKINEEMKFAAAYAIANLAREPITEKL
CEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLLKKKMSFGKEYIIPSAFDERLDDVVSNAVADAAIKSGVARV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]