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The map label for this gene is uppS

Identifier: 32266592

GI number: 32266592

Start: 1063535

End: 1064248

Strand: Direct

Name: uppS

Synonym: HH1093

Alternate gene names: 32266592

Gene position: 1063535-1064248 (Clockwise)

Preceding gene: 32266591

Following gene: 32266593

Centisome position: 59.11

GC content: 40.2

Gene sequence:

>714_bases
ATGAAGCCCTCTTATCCACAGCATATTGCAGTGATTATGGACGGCAATGGACGTTGGGCAAAAAAACAGGGTAAAAAACG
CACACAAGGGCACAAAGAAGGTGCAAAAATTGTCCGAGATATAACGCAATGGTGTGCAGAAAAAGGGATTCCATATCTCA
CGCTCTATGCGTTTTCTACCGAAAATTGGAAACGCCCCAAAATTGAGGTGGATTTTTTAATGAAACTTTTAGAAAAATAT
TTGCACGATGAAAAACCAGTGTATATGAAAAATCATATCCGATTCCGGGTCATTGGAGATATTAGCGTTTTTAACACACG
CCTTAAAAATGCTATTTTAGAGCTTGAACACGCCACGCAAAACCACACAAAACTCACGCAAATTCTCGCTCTTAATTATG
GCTCTCGCGATGAAATTGCGCGCACTTTTATTAAACTTGCTCATACGCTCACCCCGCACACTCTTGCATCGCTTAGTAGT
CAAGATATAATTTCTATGATTAATGCCAACCTTGATACAGCCACGCTGCCCGATGTAGATATGCTAATACGAACAGGTGG
CGAAAAACGTATCTCAAATTTTATGCTTTGGCAGGCAAGCTATGCCGAACTTTTTTTCACACCTACTTTATTTCCTAGCT
TTGGTAAAAATGAACTTAATGCTATGCTTGAAGAATTCTTGCAACGACAGAGACGATTTGGGGGCGTAGAATAA

Upstream 100 bases:

>100_bases
AAAGTGGATATTATGCAGGAAATCCTGCACGTTGTATTCGCCCACTTAATCCTACTTTTACGCCAACACAATCGCCCAAT
CCAAACACAAAAGATAATCA

Downstream 100 bases:

>100_bases
TATCTTTATGTTTTATTTGCAAAAAAGTGCTAAAACTTCGCTGTATATAACCATATCTTCTATAAAAATTAAGGATATAT
AATGGATTTACAAACTCTTA

Product: hypothetical protein

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKPSYPQHIAVIMDGNGRWAKKQGKKRTQGHKEGAKIVRDITQWCAEKGIPYLTLYAFSTENWKRPKIEVDFLMKLLEKY
LHDEKPVYMKNHIRFRVIGDISVFNTRLKNAILELEHATQNHTKLTQILALNYGSRDEIARTFIKLAHTLTPHTLASLSS
QDIISMINANLDTATLPDVDMLIRTGGEKRISNFMLWQASYAELFFTPTLFPSFGKNELNAMLEEFLQRQRRFGGVE

Sequences:

>Translated_237_residues
MKPSYPQHIAVIMDGNGRWAKKQGKKRTQGHKEGAKIVRDITQWCAEKGIPYLTLYAFSTENWKRPKIEVDFLMKLLEKY
LHDEKPVYMKNHIRFRVIGDISVFNTRLKNAILELEHATQNHTKLTQILALNYGSRDEIARTFIKLAHTLTPHTLASLSS
QDIISMINANLDTATLPDVDMLIRTGGEKRISNFMLWQASYAELFFTPTLFPSFGKNELNAMLEEFLQRQRRFGGVE
>Mature_237_residues
MKPSYPQHIAVIMDGNGRWAKKQGKKRTQGHKEGAKIVRDITQWCAEKGIPYLTLYAFSTENWKRPKIEVDFLMKLLEKY
LHDEKPVYMKNHIRFRVIGDISVFNTRLKNAILELEHATQNHTKLTQILALNYGSRDEIARTFIKLAHTLTPHTLASLSS
QDIISMINANLDTATLPDVDMLIRTGGEKRISNFMLWQASYAELFFTPTLFPSFGKNELNAMLEEFLQRQRRFGGVE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=213, Percent_Identity=38.9671361502347, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI45580742, Length=213, Percent_Identity=38.9671361502347, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=47.6190476190476, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71993029, Length=220, Percent_Identity=40, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=226, Percent_Identity=30.9734513274336, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=30.1369863013699, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI18857969, Length=211, Percent_Identity=35.5450236966825, Blast_Score=126, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_HELHP (Q7VH74)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860624.1
- ProteinModelPortal:   Q7VH74
- SMR:   Q7VH74
- GeneID:   1492782
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1093
- NMPDR:   fig|235279.1.peg.1093
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- BioCyc:   HHEP235279:HH_1093-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27370; Mature: 27370

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSYPQHIAVIMDGNGRWAKKQGKKRTQGHKEGAKIVRDITQWCAEKGIPYLTLYAFST
CCCCCCCEEEEEECCCCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
ENWKRPKIEVDFLMKLLEKYLHDEKPVYMKNHIRFRVIGDISVFNTRLKNAILELEHATQ
CCCCCCCEEHHHHHHHHHHHHCCCCCEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCC
NHTKLTQILALNYGSRDEIARTFIKLAHTLTPHTLASLSSQDIISMINANLDTATLPDVD
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCCCCCCHH
MLIRTGGEKRISNFMLWQASYAELFFTPTLFPSFGKNELNAMLEEFLQRQRRFGGVE
HHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKPSYPQHIAVIMDGNGRWAKKQGKKRTQGHKEGAKIVRDITQWCAEKGIPYLTLYAFST
CCCCCCCEEEEEECCCCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
ENWKRPKIEVDFLMKLLEKYLHDEKPVYMKNHIRFRVIGDISVFNTRLKNAILELEHATQ
CCCCCCCEEHHHHHHHHHHHHCCCCCEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCC
NHTKLTQILALNYGSRDEIARTFIKLAHTLTPHTLASLSSQDIISMINANLDTATLPDVD
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCCCCCCHH
MLIRTGGEKRISNFMLWQASYAELFFTPTLFPSFGKNELNAMLEEFLQRQRRFGGVE
HHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954