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The map label for this gene is lpxK

Identifier: 32266508

GI number: 32266508

Start: 985198

End: 986100

Strand: Direct

Name: lpxK

Synonym: HH1009

Alternate gene names: 32266508

Gene position: 985198-986100 (Clockwise)

Preceding gene: 32266507

Following gene: 32266509

Centisome position: 54.76

GC content: 38.54

Gene sequence:

>903_bases
ATGCGATGGATTGATGCATATTTTTATCAGCCAAATTTTACCCAAAAGCTTGTGAGTTTTGCGCTTTTGCCTTTATCATT
GCTTTATGGAATCGGTTCTACTATGAGACGAAAATTAGCAAGATTCTATGATTTTGGCATACCTATTGTGAGTGTAGGGA
ATCTCATTGCTGGTGGCAGTGGCAAAACTCCTTTTATTATTGAAGTGGCAAAAACGTATGAACGTGCGGTAGTAATATCT
AGGGGTTATAAACGCACATCAAAAGGTCTTGTTCTCGTTAGTGAATGGGGCAATATCCAAGTCTCACAAGAAGAGGCTGG
AGATGAGCCTTACCTCATCGCGAGAGAACTCAAAAATGCAAGTGTAATTGTGTGCAAAAATAGAATCCAAGCCATAGAAA
AAGCAAAACAAATAGGCGCAAAAGTCATATTTTTAGACGATGGTTTCCGCTTCAAATTTGCCAAGCTCAATATCGTGCTT
GAACCATTGCTTAAACCCTATTTTACTTTTTGCTTGCCAAGTGGGATTTATCGCGAGCTACCAAATGCCCTTAAAGAAGC
GGATTTAATTGTGCGTGAAGGAATAGACTATACACGAGAGGTGCAAATAGAATCTCCAAGTGAGCGTATGCTGCTGCTCA
CGGCTATTGCTAATCCTTCAAGGCTTGATGCGTTTTTGCCCTCTGTGGTAGGGAAAATCACACTTGCTGACCACGCACAA
TTTGATAAAGATGCTTTACAAAAGGCAATGCAAGAATATAATGCTTCATCTTTGCTTGTAACAAGCAAAGATGAAGTCAA
GCTACTCCACAGCAACTTAAAATTAAGCGTGATGAGATTAGAACTTAAAATAAATCCTCAAGTGTTAGAACATATTAAAG
CATATGTAGAAAAATTTAAGTAA

Upstream 100 bases:

>100_bases
TGAATGCAATATGATAGAATCTCTAAGCACTCGTGTATGGAATAACACCTTTAAGCGCACTAAGCCAACCATATTAGAAT
ATAAAGTTTAAGGAGAATGT

Downstream 100 bases:

>100_bases
TATTTTGTTTAAAATATTAAGGAGAAAAAATGAAACTACAAAAAGGGGATAAAGCACCACAATTTAGGCTTAAAAATGCT
GATGAGATAGAAATCTCTTT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MRWIDAYFYQPNFTQKLVSFALLPLSLLYGIGSTMRRKLARFYDFGIPIVSVGNLIAGGSGKTPFIIEVAKTYERAVVIS
RGYKRTSKGLVLVSEWGNIQVSQEEAGDEPYLIARELKNASVIVCKNRIQAIEKAKQIGAKVIFLDDGFRFKFAKLNIVL
EPLLKPYFTFCLPSGIYRELPNALKEADLIVREGIDYTREVQIESPSERMLLLTAIANPSRLDAFLPSVVGKITLADHAQ
FDKDALQKAMQEYNASSLLVTSKDEVKLLHSNLKLSVMRLELKINPQVLEHIKAYVEKFK

Sequences:

>Translated_300_residues
MRWIDAYFYQPNFTQKLVSFALLPLSLLYGIGSTMRRKLARFYDFGIPIVSVGNLIAGGSGKTPFIIEVAKTYERAVVIS
RGYKRTSKGLVLVSEWGNIQVSQEEAGDEPYLIARELKNASVIVCKNRIQAIEKAKQIGAKVIFLDDGFRFKFAKLNIVL
EPLLKPYFTFCLPSGIYRELPNALKEADLIVREGIDYTREVQIESPSERMLLLTAIANPSRLDAFLPSVVGKITLADHAQ
FDKDALQKAMQEYNASSLLVTSKDEVKLLHSNLKLSVMRLELKINPQVLEHIKAYVEKFK
>Mature_300_residues
MRWIDAYFYQPNFTQKLVSFALLPLSLLYGIGSTMRRKLARFYDFGIPIVSVGNLIAGGSGKTPFIIEVAKTYERAVVIS
RGYKRTSKGLVLVSEWGNIQVSQEEAGDEPYLIARELKNASVIVCKNRIQAIEKAKQIGAKVIFLDDGFRFKFAKLNIVL
EPLLKPYFTFCLPSGIYRELPNALKEADLIVREGIDYTREVQIESPSERMLLLTAIANPSRLDAFLPSVVGKITLADHAQ
FDKDALQKAMQEYNASSLLVTSKDEVKLLHSNLKLSVMRLELKINPQVLEHIKAYVEKFK

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=288, Percent_Identity=30.9027777777778, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 33879; Mature: 33879

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWIDAYFYQPNFTQKLVSFALLPLSLLYGIGSTMRRKLARFYDFGIPIVSVGNLIAGGS
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHCCEEECCC
GKTPFIIEVAKTYERAVVISRGYKRTSKGLVLVSEWGNIQVSQEEAGDEPYLIARELKNA
CCCCEEEEEHHHHHHEEEEECCCCCCCCCEEEEECCCCEEEEHHHCCCCCEEEHHHCCCC
SVIVCKNRIQAIEKAKQIGAKVIFLDDGFRFKFAKLNIVLEPLLKPYFTFCLPSGIYREL
EEEEEHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHH
PNALKEADLIVREGIDYTREVQIESPSERMLLLTAIANPSRLDAFLPSVVGKITLADHAQ
HHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEHHCCC
FDKDALQKAMQEYNASSLLVTSKDEVKLLHSNLKLSVMRLELKINPQVLEHIKAYVEKFK
CCHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEEEEEEEECHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRWIDAYFYQPNFTQKLVSFALLPLSLLYGIGSTMRRKLARFYDFGIPIVSVGNLIAGGS
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHCCEEECCC
GKTPFIIEVAKTYERAVVISRGYKRTSKGLVLVSEWGNIQVSQEEAGDEPYLIARELKNA
CCCCEEEEEHHHHHHEEEEECCCCCCCCCEEEEECCCCEEEEHHHCCCCCEEEHHHCCCC
SVIVCKNRIQAIEKAKQIGAKVIFLDDGFRFKFAKLNIVLEPLLKPYFTFCLPSGIYREL
EEEEEHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHH
PNALKEADLIVREGIDYTREVQIESPSERMLLLTAIANPSRLDAFLPSVVGKITLADHAQ
HHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEHHCCC
FDKDALQKAMQEYNASSLLVTSKDEVKLLHSNLKLSVMRLELKINPQVLEHIKAYVEKFK
CCHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEEEEEEEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA