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The map label for this gene is frdA

Identifier: 32266185

GI number: 32266185

Start: 666043

End: 668019

Strand: Direct

Name: frdA

Synonym: HH0686

Alternate gene names: 32266185

Gene position: 666043-668019 (Clockwise)

Preceding gene: 32266184

Following gene: 32266186

Centisome position: 37.02

GC content: 41.88

Gene sequence:

>1977_bases
ATGAAAGTAGTATATTCAGATGCACTGATTATTGGCGGTGGTTTAGCAGGACTTCGTGCTTCTATTGCAGCAAAACAGGC
AGGGCTTAACACCATTGTGCTTTCTCTTGTGCCAGTCAAAAGAAGCCATTCAGCGGCTGCTCAAGGTGGTATGCAAGCAA
GTCTAGGTAATTCTGTAAAAAGTGATGGTGATAATGAAGATCTACACTTTGCAGACACGGTAAAAGGAAGTGATTGGGGT
TGTGATCAAAATGTAGCAAGAATGTTTGTTACTACCGCACCAAAAGCAATTCGCCAACTAGCAGGTTTTGGGGTGCCTTG
GACAAGAATCCAAAAAGGCGACCGCCCTGCAGTTATTAACGGCGAAAAAGTAACAATTACAGAAGATGATTTTAGACACG
GTTATATTCATTCACGCGATTTTGGTGGAACAAAAAAATGGCGAACTTGTTATACCGCCGATGCTACTGGACATACAATG
CTTTATGCAGTAGCAAACGAAGCTTACAAACTCGGTGTAGATATTCAAGATAGGAAAGAGGCTATCTCTCTTATCCATCA
AGATGGGAGATGTTATGGAGCCGTAGTGCGTGATTTGGTAACAGGAGAACTTATAGCTTATGTATCTAAAGGCACTTTAC
TCGCTACAGGAGGCTATGGTAGAGTATATCGCAACACTACAAATGCCGTTATCTGTGAAGGAACAGGTGCAGCTATTGCA
ATGGAAACAGGCGTAGCAAAACTTGGGAATATGGAAGCTGTGCAGTTTCACCCTACTCCGATTGTGCCAAGTGGAATCCT
CCTTACAGAAGGTTGTCGTGGCGATGGTGGTGTTCTACGTGATGTTGATGGCTACCGCTTTATGCCTGATTATGAGCCAG
AGAAAAAAGAACTTGCAAGTCGTGATGTTGTCTCAAGAAGAATGCTTGAACATATCCGCAATGGTAAAGGCGTAAAATCT
CCTTATGGCGACCACTTATGGCTTGATATCTCTATCTTAGGACGTGCTCACGTAGAGAGAAACTTGCGTGATGTGCAAGA
TATTTGTAAAACATTTGCAGGAATTGACCCTGCAACACCGGGTGTTTGGGCTCCCGTGCGACCAATGCAGCACTACTCTA
TGGGCGGTATCCGTACAGATTATAGAGGAGAAACTTACCTTAAAGGGCTATTTGCTGCTGGTGAAGTAGCTTGTTGGGAC
CTACACGGATTCAATCGTCTTGGCGGAAACTCTGTAAGCGAAGCTGTAGTAGCTGGTATGATTATTGGAGAATACTTTAC
AGAATACTGCCAAGGAGCAAACCTTGATGTCCAAACAACCTTGCTTGAAAAATTTGTCAAAAAAGAAGAAGAATATCTCG
CTTCATTGCTTAATAGCACAGGAAATGAAGATGTCTATGTGCTTAAAAATGCTATGAAAGACATTATGGATAATGATGTG
GGAATCTTCCGTGATGGCAAAAGTTTGCAAGAGGCTGTGAATAAACTTGAAGATCTCTATAAACGCAGTAAGAATGTTCG
TGTGCAAAACAAAAAACTTCATAACAATCCCGAGCTTGAAGATGCTTACCGCACACCAAAAATGCTTAAAATTGCATTAT
GTGTTGCAAAAGGTGCACTTGATAGAACAGAATCTCGTGGTGCACATACACGCGAAGATTATCCAAAACGTGATGATGCG
AATTGGTTAAAACGTACACTTACAAGCTGGGAAGACCCAAATCAAACATTACCAACGGTTACTTATGAAGATTTGGATAT
TATGAAAATGGAAATTGCACCCGGCTTCCGTGGCTATGGCGCAAAAGGTATGATTATTGAACATCCAAATAGTGCTATTC
GCCAAGCTGAGATTGAGAAAATTACACAAGAGATTCAAGCAAAGGGCGGTGATAGATATGCCTTGCAAGAAGCCTTGATG
CCTTTCAATCTCCAACCACAATTTAAAGCAAGAAACCAACGACTAGGAGATAAGTAA

Upstream 100 bases:

>100_bases
ATATGTGGCGTATATGCAAATTGGACACGGACTAGATAGTAGCTACAGTATTCAGGAATATAGAATAATCGATGAGCACA
CACAAGGGAAAGGAGAGTAA

Downstream 100 bases:

>100_bases
TGAGTGCAACACAACAAAAAGGAAGAACACTAACTATTCGAGCATTAAAGTTTGACCCACAAAGTGCAGTGTCGAAACCA
CATTTTCGTGAGTATCAGGT

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MKVVYSDALIIGGGLAGLRASIAAKQAGLNTIVLSLVPVKRSHSAAAQGGMQASLGNSVKSDGDNEDLHFADTVKGSDWG
CDQNVARMFVTTAPKAIRQLAGFGVPWTRIQKGDRPAVINGEKVTITEDDFRHGYIHSRDFGGTKKWRTCYTADATGHTM
LYAVANEAYKLGVDIQDRKEAISLIHQDGRCYGAVVRDLVTGELIAYVSKGTLLATGGYGRVYRNTTNAVICEGTGAAIA
METGVAKLGNMEAVQFHPTPIVPSGILLTEGCRGDGGVLRDVDGYRFMPDYEPEKKELASRDVVSRRMLEHIRNGKGVKS
PYGDHLWLDISILGRAHVERNLRDVQDICKTFAGIDPATPGVWAPVRPMQHYSMGGIRTDYRGETYLKGLFAAGEVACWD
LHGFNRLGGNSVSEAVVAGMIIGEYFTEYCQGANLDVQTTLLEKFVKKEEEYLASLLNSTGNEDVYVLKNAMKDIMDNDV
GIFRDGKSLQEAVNKLEDLYKRSKNVRVQNKKLHNNPELEDAYRTPKMLKIALCVAKGALDRTESRGAHTREDYPKRDDA
NWLKRTLTSWEDPNQTLPTVTYEDLDIMKMEIAPGFRGYGAKGMIIEHPNSAIRQAEIEKITQEIQAKGGDRYALQEALM
PFNLQPQFKARNQRLGDK

Sequences:

>Translated_658_residues
MKVVYSDALIIGGGLAGLRASIAAKQAGLNTIVLSLVPVKRSHSAAAQGGMQASLGNSVKSDGDNEDLHFADTVKGSDWG
CDQNVARMFVTTAPKAIRQLAGFGVPWTRIQKGDRPAVINGEKVTITEDDFRHGYIHSRDFGGTKKWRTCYTADATGHTM
LYAVANEAYKLGVDIQDRKEAISLIHQDGRCYGAVVRDLVTGELIAYVSKGTLLATGGYGRVYRNTTNAVICEGTGAAIA
METGVAKLGNMEAVQFHPTPIVPSGILLTEGCRGDGGVLRDVDGYRFMPDYEPEKKELASRDVVSRRMLEHIRNGKGVKS
PYGDHLWLDISILGRAHVERNLRDVQDICKTFAGIDPATPGVWAPVRPMQHYSMGGIRTDYRGETYLKGLFAAGEVACWD
LHGFNRLGGNSVSEAVVAGMIIGEYFTEYCQGANLDVQTTLLEKFVKKEEEYLASLLNSTGNEDVYVLKNAMKDIMDNDV
GIFRDGKSLQEAVNKLEDLYKRSKNVRVQNKKLHNNPELEDAYRTPKMLKIALCVAKGALDRTESRGAHTREDYPKRDDA
NWLKRTLTSWEDPNQTLPTVTYEDLDIMKMEIAPGFRGYGAKGMIIEHPNSAIRQAEIEKITQEIQAKGGDRYALQEALM
PFNLQPQFKARNQRLGDK
>Mature_658_residues
MKVVYSDALIIGGGLAGLRASIAAKQAGLNTIVLSLVPVKRSHSAAAQGGMQASLGNSVKSDGDNEDLHFADTVKGSDWG
CDQNVARMFVTTAPKAIRQLAGFGVPWTRIQKGDRPAVINGEKVTITEDDFRHGYIHSRDFGGTKKWRTCYTADATGHTM
LYAVANEAYKLGVDIQDRKEAISLIHQDGRCYGAVVRDLVTGELIAYVSKGTLLATGGYGRVYRNTTNAVICEGTGAAIA
METGVAKLGNMEAVQFHPTPIVPSGILLTEGCRGDGGVLRDVDGYRFMPDYEPEKKELASRDVVSRRMLEHIRNGKGVKS
PYGDHLWLDISILGRAHVERNLRDVQDICKTFAGIDPATPGVWAPVRPMQHYSMGGIRTDYRGETYLKGLFAAGEVACWD
LHGFNRLGGNSVSEAVVAGMIIGEYFTEYCQGANLDVQTTLLEKFVKKEEEYLASLLNSTGNEDVYVLKNAMKDIMDNDV
GIFRDGKSLQEAVNKLEDLYKRSKNVRVQNKKLHNNPELEDAYRTPKMLKIALCVAKGALDRTESRGAHTREDYPKRDDA
NWLKRTLTSWEDPNQTLPTVTYEDLDIMKMEIAPGFRGYGAKGMIIEHPNSAIRQAEIEKITQEIQAKGGDRYALQEALM
PFNLQPQFKARNQRLGDK

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=553, Percent_Identity=35.4430379746835, Blast_Score=301, Evalue=9e-82,
Organism=Escherichia coli, GI1790597, Length=583, Percent_Identity=37.0497427101201, Blast_Score=331, Evalue=1e-91,
Organism=Escherichia coli, GI1786942, Length=609, Percent_Identity=36.4532019704434, Blast_Score=330, Evalue=3e-91,
Organism=Escherichia coli, GI1788928, Length=565, Percent_Identity=31.3274336283186, Blast_Score=183, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17505833, Length=547, Percent_Identity=36.563071297989, Blast_Score=308, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI17550100, Length=546, Percent_Identity=35.8974358974359, Blast_Score=301, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI71986328, Length=462, Percent_Identity=25.1082251082251, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322701, Length=584, Percent_Identity=36.1301369863014, Blast_Score=319, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6322416, Length=599, Percent_Identity=35.0584307178631, Blast_Score=316, Evalue=9e-87,
Organism=Drosophila melanogaster, GI17137288, Length=613, Percent_Identity=34.42088091354, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24655642, Length=613, Percent_Identity=34.42088091354, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24655647, Length=613, Percent_Identity=34.42088091354, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24663005, Length=574, Percent_Identity=33.4494773519164, Blast_Score=275, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 72606; Mature: 72606

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVYSDALIIGGGLAGLRASIAAKQAGLNTIVLSLVPVKRSHSAAAQGGMQASLGNSVK
CEEEEECCEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCHHHCCCCCC
SDGDNEDLHFADTVKGSDWGCDQNVARMFVTTAPKAIRQLAGFGVPWTRIQKGDRPAVIN
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCHHHHCCCCCCEEEC
GEKVTITEDDFRHGYIHSRDFGGTKKWRTCYTADATGHTMLYAVANEAYKLGVDIQDRKE
CCEEEEECCCCCCCCEECCCCCCCCCCCEEEEECCCCCEEEEEEECCCEEECCCHHHHHH
AISLIHQDGRCYGAVVRDLVTGELIAYVSKGTLLATGGYGRVYRNTTNAVICEGTGAAIA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCEEEECCCCCEEE
METGVAKLGNMEAVQFHPTPIVPSGILLTEGCRGDGGVLRDVDGYRFMPDYEPEKKELAS
EECCHHHHCCCCEEEECCCCCCCCCEEEECCCCCCCCCEECCCCCCCCCCCCCHHHHHHH
RDVVSRRMLEHIRNGKGVKSPYGDHLWLDISILGRAHVERNLRDVQDICKTFAGIDPATP
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GVWAPVRPMQHYSMGGIRTDYRGETYLKGLFAAGEVACWDLHGFNRLGGNSVSEAVVAGM
CCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCHHCCCCHHHHHHHHHH
IIGEYFTEYCQGANLDVQTTLLEKFVKKEEEYLASLLNSTGNEDVYVLKNAMKDIMDNDV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCC
GIFRDGKSLQEAVNKLEDLYKRSKNVRVQNKKLHNNPELEDAYRTPKMLKIALCVAKGAL
CEEECCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHCCH
DRTESRGAHTREDYPKRDDANWLKRTLTSWEDPNQTLPTVTYEDLDIMKMEIAPGFRGYG
HHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEECCCCCCCC
AKGMIIEHPNSAIRQAEIEKITQEIQAKGGDRYALQEALMPFNLQPQFKARNQRLGDK
CCCEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MKVVYSDALIIGGGLAGLRASIAAKQAGLNTIVLSLVPVKRSHSAAAQGGMQASLGNSVK
CEEEEECCEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCHHHCCCCCC
SDGDNEDLHFADTVKGSDWGCDQNVARMFVTTAPKAIRQLAGFGVPWTRIQKGDRPAVIN
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCHHHHCCCCCCEEEC
GEKVTITEDDFRHGYIHSRDFGGTKKWRTCYTADATGHTMLYAVANEAYKLGVDIQDRKE
CCEEEEECCCCCCCCEECCCCCCCCCCCEEEEECCCCCEEEEEEECCCEEECCCHHHHHH
AISLIHQDGRCYGAVVRDLVTGELIAYVSKGTLLATGGYGRVYRNTTNAVICEGTGAAIA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCEEEECCCCCEEE
METGVAKLGNMEAVQFHPTPIVPSGILLTEGCRGDGGVLRDVDGYRFMPDYEPEKKELAS
EECCHHHHCCCCEEEECCCCCCCCCEEEECCCCCCCCCEECCCCCCCCCCCCCHHHHHHH
RDVVSRRMLEHIRNGKGVKSPYGDHLWLDISILGRAHVERNLRDVQDICKTFAGIDPATP
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GVWAPVRPMQHYSMGGIRTDYRGETYLKGLFAAGEVACWDLHGFNRLGGNSVSEAVVAGM
CCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCHHCCCCHHHHHHHHHH
IIGEYFTEYCQGANLDVQTTLLEKFVKKEEEYLASLLNSTGNEDVYVLKNAMKDIMDNDV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCC
GIFRDGKSLQEAVNKLEDLYKRSKNVRVQNKKLHNNPELEDAYRTPKMLKIALCVAKGAL
CEEECCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHCCH
DRTESRGAHTREDYPKRDDANWLKRTLTSWEDPNQTLPTVTYEDLDIMKMEIAPGFRGYG
HHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEECCCCCCCC
AKGMIIEHPNSAIRQAEIEKITQEIQAKGGDRYALQEALMPFNLQPQFKARNQRLGDK
CCCEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]