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The map label for this gene is fabH

Identifier: 32266180

GI number: 32266180

Start: 659856

End: 660854

Strand: Direct

Name: fabH

Synonym: HH0681

Alternate gene names: 32266180

Gene position: 659856-660854 (Clockwise)

Preceding gene: 32266179

Following gene: 32266181

Centisome position: 36.68

GC content: 38.64

Gene sequence:

>999_bases
ATGGGCAAAATATATGCTTCACTTAAATCAATTGCTTCTTATATCCCTCCCACCTGCATAAGCAATGTTGATTTTGAAAA
AACACTTGATACAAATGATGAGTGGATTACCAAACGCACAGGTATTAAAACGCGTTATTTTGCCTTGCCTTCACAACAAA
CAAGTGACCTTGCTTATGAAGCAGGTAAAAAAGCAATAGAACGCGCAGGCATCGAACCAAAAGATATTGATGCAGTAATC
GTAGCAACTCTAAGCCCTGATTATCTCACAATGCCTAGCACTGCTTGTATTACTTCCTTTAAACTCGGTATTGAAAATAA
AGCCGCCTTTGATATTAGTGCGGCGTGTAGTGGATTTGTTTATCTTCTCTCTCTTGCTAAATCTTTTATAGAATCCGGCA
CTTATAAGCAAATCCTCATCATTGGTGCAGAAAAAACAAGTTCTGTTCTTGATTTTAGCGATAGAAGCACTTGTGTTCTT
TTTGGTGATGGGGCTGGAGCGTGTGTTATAGGTAGCACAAATGACGAGAAAGCAGCTATCTTGGGCGTGAATGTAAGTGC
AAATGGACGATATCAAGACTTTCTTTGCACTCCACGTGTTCATGCAACCTTTGGCGCTACTCAAGCACAAGAAAAGCAAT
CATTTATTCAAATGAAAGGCAATGAAACCTTTAAAGTTGCTGTGAAAACGCTTGTATCAGAAGTAAAAGAGATTCTAAAT
ACCCATCACATAAACCCTCAAGATGTATCATTTTTTATTCCTCATCAAGCAAATTTACGTATTATTAATGCAGTGGGAGA
GAATCTAAACTTCACTCCAGAACAAATCGTTGTAAGCATACAAAAATATGGTAATACTTCCGCAGCCTCTATTCCTATGG
CAATGAATGACCTTTACGAAGAAAAAAAGCTTAAATATGGGGATTTAATGCTACTAGATGCCCTTGGTGGTGGGCTTACT
TGGGGTTCAGCACTTGTGCACTTTGGTGGCACAAACTAG

Upstream 100 bases:

>100_bases
TATTTATCAAGCGCTTAATGCCATAGAATCTAATATATGTTCCAAGCTCTCTGATGCTTTTGCAAATAAACCTTCGAGCG
CTCAACAATAAGGATTCTCT

Downstream 100 bases:

>100_bases
GCTTTTTAAATATTCTTTTGCCTTTCATTTTTTTTTTTTTTGTTAGAATGTCGCCAAAATATTTCAAAGGATATAACGCA
ATGAAAGAGGCTTCTTTTTA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MGKIYASLKSIASYIPPTCISNVDFEKTLDTNDEWITKRTGIKTRYFALPSQQTSDLAYEAGKKAIERAGIEPKDIDAVI
VATLSPDYLTMPSTACITSFKLGIENKAAFDISAACSGFVYLLSLAKSFIESGTYKQILIIGAEKTSSVLDFSDRSTCVL
FGDGAGACVIGSTNDEKAAILGVNVSANGRYQDFLCTPRVHATFGATQAQEKQSFIQMKGNETFKVAVKTLVSEVKEILN
THHINPQDVSFFIPHQANLRIINAVGENLNFTPEQIVVSIQKYGNTSAASIPMAMNDLYEEKKLKYGDLMLLDALGGGLT
WGSALVHFGGTN

Sequences:

>Translated_332_residues
MGKIYASLKSIASYIPPTCISNVDFEKTLDTNDEWITKRTGIKTRYFALPSQQTSDLAYEAGKKAIERAGIEPKDIDAVI
VATLSPDYLTMPSTACITSFKLGIENKAAFDISAACSGFVYLLSLAKSFIESGTYKQILIIGAEKTSSVLDFSDRSTCVL
FGDGAGACVIGSTNDEKAAILGVNVSANGRYQDFLCTPRVHATFGATQAQEKQSFIQMKGNETFKVAVKTLVSEVKEILN
THHINPQDVSFFIPHQANLRIINAVGENLNFTPEQIVVSIQKYGNTSAASIPMAMNDLYEEKKLKYGDLMLLDALGGGLT
WGSALVHFGGTN
>Mature_331_residues
GKIYASLKSIASYIPPTCISNVDFEKTLDTNDEWITKRTGIKTRYFALPSQQTSDLAYEAGKKAIERAGIEPKDIDAVIV
ATLSPDYLTMPSTACITSFKLGIENKAAFDISAACSGFVYLLSLAKSFIESGTYKQILIIGAEKTSSVLDFSDRSTCVLF
GDGAGACVIGSTNDEKAAILGVNVSANGRYQDFLCTPRVHATFGATQAQEKQSFIQMKGNETFKVAVKTLVSEVKEILNT
HHINPQDVSFFIPHQANLRIINAVGENLNFTPEQIVVSIQKYGNTSAASIPMAMNDLYEEKKLKYGDLMLLDALGGGLTW
GSALVHFGGTN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=328, Percent_Identity=40.8536585365854, Blast_Score=267, Evalue=8e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_HELHP (P59813)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860212.1
- ProteinModelPortal:   P59813
- SMR:   P59813
- GeneID:   1493735
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0681
- NMPDR:   fig|235279.1.peg.681
- HOGENOM:   HBG649927
- OMA:   DAGISAN
- ProtClustDB:   PRK09352
- BioCyc:   HHEP235279:HH_0681-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 35943; Mature: 35812

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: ACT_SITE 116-116 ACT_SITE 255-255 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIYASLKSIASYIPPTCISNVDFEKTLDTNDEWITKRTGIKTRYFALPSQQTSDLAYE
CCHHHHHHHHHHHHCCCHHHCCCCCHHCCCCCCHHEEHHCCCCEEEEECCCCCCHHHHHH
AGKKAIERAGIEPKDIDAVIVATLSPDYLTMPSTACITSFKLGIENKAAFDISAACSGFV
HHHHHHHHCCCCCCCCCEEEEEEECCCEEECCCHHHHHHEEECCCCCCCEEHHHHHHHHH
YLLSLAKSFIESGTYKQILIIGAEKTSSVLDFSDRSTCVLFGDGAGACVIGSTNDEKAAI
HHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCEEEEEECCCCEEEEECCCCCCEEE
LGVNVSANGRYQDFLCTPRVHATFGATQAQEKQSFIQMKGNETFKVAVKTLVSEVKEILN
EEEEECCCCCEEEEEECCCEEEECCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
THHINPQDVSFFIPHQANLRIINAVGENLNFTPEQIVVSIQKYGNTSAASIPMAMNDLYE
HCCCCCCCEEEECCCCCCEEEEEECCCCCCCCHHHHEEEHHHCCCCCCCCCCHHHHHHHH
EKKLKYGDLMLLDALGGGLTWGSALVHFGGTN
HHCCCCCCEEEEECCCCCCCCCHHEEECCCCC
>Mature Secondary Structure 
GKIYASLKSIASYIPPTCISNVDFEKTLDTNDEWITKRTGIKTRYFALPSQQTSDLAYE
CHHHHHHHHHHHHCCCHHHCCCCCHHCCCCCCHHEEHHCCCCEEEEECCCCCCHHHHHH
AGKKAIERAGIEPKDIDAVIVATLSPDYLTMPSTACITSFKLGIENKAAFDISAACSGFV
HHHHHHHHCCCCCCCCCEEEEEEECCCEEECCCHHHHHHEEECCCCCCCEEHHHHHHHHH
YLLSLAKSFIESGTYKQILIIGAEKTSSVLDFSDRSTCVLFGDGAGACVIGSTNDEKAAI
HHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCEEEEEECCCCEEEEECCCCCCEEE
LGVNVSANGRYQDFLCTPRVHATFGATQAQEKQSFIQMKGNETFKVAVKTLVSEVKEILN
EEEEECCCCCEEEEEECCCEEEECCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
THHINPQDVSFFIPHQANLRIINAVGENLNFTPEQIVVSIQKYGNTSAASIPMAMNDLYE
HCCCCCCCEEEECCCCCCEEEEEECCCCCCCCHHHHEEEHHHCCCCCCCCCCHHHHHHHH
EKKLKYGDLMLLDALGGGLTWGSALVHFGGTN
HHCCCCCCEEEEECCCCCCCCCHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954