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The map label for this gene is copA [H]

Identifier: 32266181

GI number: 32266181

Start: 660935

End: 663178

Strand: Direct

Name: copA [H]

Synonym: HH0682

Alternate gene names: 32266181

Gene position: 660935-663178 (Clockwise)

Preceding gene: 32266180

Following gene: 32266182

Centisome position: 36.74

GC content: 37.08

Gene sequence:

>2244_bases
ATGAAAGAGGCTTCTTTTTATATTGAACAAATGACTTGTCAAGCTTGTTCTAGTGGGATTGAGCGTAGTCTAAAGCGTAA
AAGTTTTTGCCAAGACATACAAGTGCATCTTTTAAGTAAAAAAGCCCATATTGTATATGATGAAACGCAAGCAAACCTTG
AAGATATTTTTAAACTCATAGCCAAAATGGGTTATGAGCCTCATTTAAATGATTCTACGCTTGATAAACGCTCTACCTCA
AAACACACTTCATTTTCACTCAATGCTCTTATAGAATCTTTTGATAATCGTTTCTTATCTACTCAAACCAAACTCATTGT
AAGCATAATCGCCACAATTATAGTTGTAGTGCTCTCTTGGAGTGAAATGTTTATAGGCATAAGTCTGCCATATACACTTC
ATTACACGCTTTTACTTGTTTTAAGCTTGGCAGTTATGCATATGGGAAGAATGTTTTATTTGCGTGGATTTAAAGCACTT
TTTGCGCGAAATCCCAATATGGATTCTCTGATTGCCATAAGCACTTCTAGTGCATTTTTATACAGCTTACAAGGCACATT
TAATGCACACTTTCATACATACTTTGATAGCGTATGCGTAATTATCACCCTTGTGCTTGTTGGAAAATCTATTGAAGAAC
GCTCCAAAAAAAATGCATTAGATAGTGCCTCGCTACTTTTGCAGCTTAACCAAAAAACGCTCCAAAAAATTCAACTCCCA
AATAATGCCACACTTGATATTCAAACCCTATCAAATGCACCTTGCAGGACAGTTACTGCACAAGATATTCAACAAGGAGA
TATACTTAAAGTCTTACCTGGTGAAATGATTATGGTAGATTCTATAATGATAGAGGGACATTCAAGCATAGATACATCTG
CTATTAATGGTGAATCACTCCCTCTTTTAGCTCATAAAGATGATAGACTTTTTTCAGGGAGCATAAACCTTGATGGCGTG
CTGTATGTGCGTGCAGAAAAAAATGCACAGCAATCTACTCTTGCACAGATTCTACAACTTGTGCAAAAAGCTCAAGAAAG
TAAAGCACCTATCGCCTCACTTGCGGATAAGGTGGCAGCATTTTTTGTGCCGCTTGTAATATGTTTGGCAGCAGGTGCTG
GTGTATTTTGGTGGGGTATGAGAGATTTTGAATTTGGGCTTAGTATTTTTATCGCTACTCTTGTTATTTCTTGCCCGTGC
GCACTTGGGCTTGCTACACCAATGGCGATTCTCCACGCACAAGCTATTTCAAATAAAATGGGCGTTTTTTTTAAAGATGC
TAAAAGCTTTCAAACACTCAGTCAAATCACACATATTGCATTTGATAAAACAGGCACACTCACTCAAGGACTGGAAATAG
CACAGATTCTCTCTTTTGATAAGCACTTGAGCCAACAAGAAATTTTTAATCTCGCCTACACTTTAGAATCCACAAGCACA
CATATTATTGCCCAAGCTTTTCACACTCACCCTATGAGTGCAAATGTTACGCTTTACCCCATTATAAATGCACAAAATAT
CATAGGCAGCGGTATTAAAGGCACTATTAATGATTGTGAATATTGGCTTGGTAATGCCCATTTGCTTCCACCACATCTTA
GAGGTGAGCTTGAAAATCTCCCGCAAGATGATAAAATCATACTTTATCTTGCTACAAATGAGCGCATTTTGGCACAATTT
GCATTACAAGACCATATCAAATCCGATGCACTTTCCACCCTTGCACATTTTAGAGAAAAAAATATAAGCTTTAGTCTTAT
AAGTGGGGATAATCTCCTCAATACACAAAAAATTGCCTTTGCTCTAGGTATTACAGATTTTACCGCCTTAGCAAAACCTC
AAGATAAAATGCGCCTCCTTGAACAGCTTAATGCAAACAATCACAAAGTTCTTATGGTTGGCGATGGGATTAATGATGTG
CCTGCTCTTGCTTATGCACATACTTCCATTGCTTTTGCCTCGCCTCAAGATATTGCTACACAAAGTGCCGATATTACTAT
TTACAATCAACATTTAATGAGTATTTATAACGCATACTCTCTTGCAAAAGCCAGTATTTTAAATATAAAACAGAATCTTG
TTTTCGCTTTTTGCTATAATATTGCTTTTATTCCTCTAGCAATGGGTGTATTAGGGGGATTTGGCATATTCTTACACCCG
ATGTTTTGCGCATTTGCAATGACCTGCTCAAGCCTAAGTGTCGTTGCCAATGCTGCAAGATTAAAAGCATTTAAAATTTT
ATAA

Upstream 100 bases:

>100_bases
ACTTTGGTGGCACAAACTAGGCTTTTTAAATATTCTTTTGCCTTTCATTTTTTTTTTTTTTGTTAGAATGTCGCCAAAAT
ATTTCAAAGGATATAACGCA

Downstream 100 bases:

>100_bases
AATCTCAAAAGGAGATGAAATGACAACGACTCTATCAGTAAGTGGTATGCGCTGTGGGAAATGTGTAGATAAAATTGAAA
AATTTATCGGAGAAATAGAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MKEASFYIEQMTCQACSSGIERSLKRKSFCQDIQVHLLSKKAHIVYDETQANLEDIFKLIAKMGYEPHLNDSTLDKRSTS
KHTSFSLNALIESFDNRFLSTQTKLIVSIIATIIVVVLSWSEMFIGISLPYTLHYTLLLVLSLAVMHMGRMFYLRGFKAL
FARNPNMDSLIAISTSSAFLYSLQGTFNAHFHTYFDSVCVIITLVLVGKSIEERSKKNALDSASLLLQLNQKTLQKIQLP
NNATLDIQTLSNAPCRTVTAQDIQQGDILKVLPGEMIMVDSIMIEGHSSIDTSAINGESLPLLAHKDDRLFSGSINLDGV
LYVRAEKNAQQSTLAQILQLVQKAQESKAPIASLADKVAAFFVPLVICLAAGAGVFWWGMRDFEFGLSIFIATLVISCPC
ALGLATPMAILHAQAISNKMGVFFKDAKSFQTLSQITHIAFDKTGTLTQGLEIAQILSFDKHLSQQEIFNLAYTLESTST
HIIAQAFHTHPMSANVTLYPIINAQNIIGSGIKGTINDCEYWLGNAHLLPPHLRGELENLPQDDKIILYLATNERILAQF
ALQDHIKSDALSTLAHFREKNISFSLISGDNLLNTQKIAFALGITDFTALAKPQDKMRLLEQLNANNHKVLMVGDGINDV
PALAYAHTSIAFASPQDIATQSADITIYNQHLMSIYNAYSLAKASILNIKQNLVFAFCYNIAFIPLAMGVLGGFGIFLHP
MFCAFAMTCSSLSVVANAARLKAFKIL

Sequences:

>Translated_747_residues
MKEASFYIEQMTCQACSSGIERSLKRKSFCQDIQVHLLSKKAHIVYDETQANLEDIFKLIAKMGYEPHLNDSTLDKRSTS
KHTSFSLNALIESFDNRFLSTQTKLIVSIIATIIVVVLSWSEMFIGISLPYTLHYTLLLVLSLAVMHMGRMFYLRGFKAL
FARNPNMDSLIAISTSSAFLYSLQGTFNAHFHTYFDSVCVIITLVLVGKSIEERSKKNALDSASLLLQLNQKTLQKIQLP
NNATLDIQTLSNAPCRTVTAQDIQQGDILKVLPGEMIMVDSIMIEGHSSIDTSAINGESLPLLAHKDDRLFSGSINLDGV
LYVRAEKNAQQSTLAQILQLVQKAQESKAPIASLADKVAAFFVPLVICLAAGAGVFWWGMRDFEFGLSIFIATLVISCPC
ALGLATPMAILHAQAISNKMGVFFKDAKSFQTLSQITHIAFDKTGTLTQGLEIAQILSFDKHLSQQEIFNLAYTLESTST
HIIAQAFHTHPMSANVTLYPIINAQNIIGSGIKGTINDCEYWLGNAHLLPPHLRGELENLPQDDKIILYLATNERILAQF
ALQDHIKSDALSTLAHFREKNISFSLISGDNLLNTQKIAFALGITDFTALAKPQDKMRLLEQLNANNHKVLMVGDGINDV
PALAYAHTSIAFASPQDIATQSADITIYNQHLMSIYNAYSLAKASILNIKQNLVFAFCYNIAFIPLAMGVLGGFGIFLHP
MFCAFAMTCSSLSVVANAARLKAFKIL
>Mature_747_residues
MKEASFYIEQMTCQACSSGIERSLKRKSFCQDIQVHLLSKKAHIVYDETQANLEDIFKLIAKMGYEPHLNDSTLDKRSTS
KHTSFSLNALIESFDNRFLSTQTKLIVSIIATIIVVVLSWSEMFIGISLPYTLHYTLLLVLSLAVMHMGRMFYLRGFKAL
FARNPNMDSLIAISTSSAFLYSLQGTFNAHFHTYFDSVCVIITLVLVGKSIEERSKKNALDSASLLLQLNQKTLQKIQLP
NNATLDIQTLSNAPCRTVTAQDIQQGDILKVLPGEMIMVDSIMIEGHSSIDTSAINGESLPLLAHKDDRLFSGSINLDGV
LYVRAEKNAQQSTLAQILQLVQKAQESKAPIASLADKVAAFFVPLVICLAAGAGVFWWGMRDFEFGLSIFIATLVISCPC
ALGLATPMAILHAQAISNKMGVFFKDAKSFQTLSQITHIAFDKTGTLTQGLEIAQILSFDKHLSQQEIFNLAYTLESTST
HIIAQAFHTHPMSANVTLYPIINAQNIIGSGIKGTINDCEYWLGNAHLLPPHLRGELENLPQDDKIILYLATNERILAQF
ALQDHIKSDALSTLAHFREKNISFSLISGDNLLNTQKIAFALGITDFTALAKPQDKMRLLEQLNANNHKVLMVGDGINDV
PALAYAHTSIAFASPQDIATQSADITIYNQHLMSIYNAYSLAKASILNIKQNLVFAFCYNIAFIPLAMGVLGGFGIFLHP
MFCAFAMTCSSLSVVANAARLKAFKIL

Specific function: Probably involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=797, Percent_Identity=26.8506900878294, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI115529486, Length=579, Percent_Identity=27.979274611399, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI55743073, Length=507, Percent_Identity=27.810650887574, Blast_Score=202, Evalue=1e-51,
Organism=Escherichia coli, GI1786691, Length=758, Percent_Identity=29.6833773087071, Blast_Score=302, Evalue=5e-83,
Organism=Escherichia coli, GI1789879, Length=746, Percent_Identity=25.4691689008043, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786914, Length=480, Percent_Identity=24.375, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17556548, Length=518, Percent_Identity=29.1505791505791, Blast_Score=189, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6320475, Length=630, Percent_Identity=28.8888888888889, Blast_Score=250, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6319772, Length=698, Percent_Identity=28.7965616045845, Blast_Score=248, Evalue=3e-66,
Organism=Drosophila melanogaster, GI221329854, Length=581, Percent_Identity=27.3666092943201, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.4 [H]

Molecular weight: Translated: 82341; Mature: 82341

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEASFYIEQMTCQACSSGIERSLKRKSFCQDIQVHLLSKKAHIVYDETQANLEDIFKLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
AKMGYEPHLNDSTLDKRSTSKHTSFSLNALIESFDNRFLSTQTKLIVSIIATIIVVVLSW
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEMFIGISLPYTLHYTLLLVLSLAVMHMGRMFYLRGFKALFARNPNMDSLIAISTSSAFL
HHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEE
YSLQGTFNAHFHTYFDSVCVIITLVLVGKSIEERSKKNALDSASLLLQLNQKTLQKIQLP
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
NNATLDIQTLSNAPCRTVTAQDIQQGDILKVLPGEMIMVDSIMIEGHSSIDTSAINGESL
CCCEEEEEECCCCCCCCCCHHHCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCC
PLLAHKDDRLFSGSINLDGVLYVRAEKNAQQSTLAQILQLVQKAQESKAPIASLADKVAA
EEEEECCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FFVPLVICLAAGAGVFWWGMRDFEFGLSIFIATLVISCPCALGLATPMAILHAQAISNKM
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVFFKDAKSFQTLSQITHIAFDKTGTLTQGLEIAQILSFDKHLSQQEIFNLAYTLESTST
CEEEHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHCCHHHHHHHHEEECCCCH
HIIAQAFHTHPMSANVTLYPIINAQNIIGSGIKGTINDCEYWLGNAHLLPPHLRGELENL
HHHHHHHHCCCCCCCEEEEEEECCHHHHCCCCCCCCCHHHHHCCCCEECCHHHHHHHHCC
PQDDKIILYLATNERILAQFALQDHIKSDALSTLAHFREKNISFSLISGDNLLNTQKIAF
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHEE
ALGITDFTALAKPQDKMRLLEQLNANNHKVLMVGDGINDVPALAYAHTSIAFASPQDIAT
EECCHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHEEECCCHHHCC
QSADITIYNQHLMSIYNAYSLAKASILNIKQNLVFAFCYNIAFIPLAMGVLGGFGIFLHP
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFCAFAMTCSSLSVVANAARLKAFKIL
HHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MKEASFYIEQMTCQACSSGIERSLKRKSFCQDIQVHLLSKKAHIVYDETQANLEDIFKLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
AKMGYEPHLNDSTLDKRSTSKHTSFSLNALIESFDNRFLSTQTKLIVSIIATIIVVVLSW
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEMFIGISLPYTLHYTLLLVLSLAVMHMGRMFYLRGFKALFARNPNMDSLIAISTSSAFL
HHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEE
YSLQGTFNAHFHTYFDSVCVIITLVLVGKSIEERSKKNALDSASLLLQLNQKTLQKIQLP
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
NNATLDIQTLSNAPCRTVTAQDIQQGDILKVLPGEMIMVDSIMIEGHSSIDTSAINGESL
CCCEEEEEECCCCCCCCCCHHHCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCC
PLLAHKDDRLFSGSINLDGVLYVRAEKNAQQSTLAQILQLVQKAQESKAPIASLADKVAA
EEEEECCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FFVPLVICLAAGAGVFWWGMRDFEFGLSIFIATLVISCPCALGLATPMAILHAQAISNKM
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVFFKDAKSFQTLSQITHIAFDKTGTLTQGLEIAQILSFDKHLSQQEIFNLAYTLESTST
CEEEHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHCCHHHHHHHHEEECCCCH
HIIAQAFHTHPMSANVTLYPIINAQNIIGSGIKGTINDCEYWLGNAHLLPPHLRGELENL
HHHHHHHHCCCCCCCEEEEEEECCHHHHCCCCCCCCCHHHHHCCCCEECCHHHHHHHHCC
PQDDKIILYLATNERILAQFALQDHIKSDALSTLAHFREKNISFSLISGDNLLNTQKIAF
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHEE
ALGITDFTALAKPQDKMRLLEQLNANNHKVLMVGDGINDVPALAYAHTSIAFASPQDIAT
EECCHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHEEECCCHHHCC
QSADITIYNQHLMSIYNAYSLAKASILNIKQNLVFAFCYNIAFIPLAMGVLGGFGIFLHP
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFCAFAMTCSSLSVVANAARLKAFKIL
HHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9440521 [H]