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The map label for this gene is trpS

Identifier: 32266057

GI number: 32266057

Start: 535467

End: 536465

Strand: Direct

Name: trpS

Synonym: HH0558

Alternate gene names: 32266057

Gene position: 535467-536465 (Clockwise)

Preceding gene: 32266056

Following gene: 32266058

Centisome position: 29.76

GC content: 38.94

Gene sequence:

>999_bases
ATGTCTCACACTTCAAGCAAAAAGCGCATTTTTTCAGGCATTCAACCCACAGGCAATATTCATTTAGGCAATTATTTAGG
TGCGGTGCGGCATTGGGTAGATTCACAAGAGCAATATGAAAATATCTTTTGTGTAGTCAATTCTCACGCTATTACGATAC
GACAAGACCCACAAGAATTACAAAACAAAACCTATGAACTTGCAGGCATTCTCCTTGCTTGTGGGATTGATACGAAAAAA
TCACATCTTTTTATTCAAAGTCAAATTGACGAGCACGCTGCATTAGCGTGGATTTTGGATTGCAATATTCCTATGGGTGA
TATGAGTCGTATGACGCAGTTTAAAGACAAATCAAATAAGAATCCAAAAAATATTAATGTCGGCTTATTTAATTATCCTG
CACTTATGGCGGCAGATATTTTGCTCTATCAAGCCGATTTTGTGCCTGTGGGTGAAGACCAAAAGCAGCATTTAGAGCTT
ACACGCGATGTTGCAATGCGATTTAATCGCGATTATGGAGAGTGCTTCAATATCCCAGAACCGATGATACCTCAAGTTGG
TGCGCGTGTAATGGGACTAGATAATCCACAAAGCAAAATGAGTAAATCTGCTCAAGGTGAAAATCACGCAATATTTTTAC
TTGATAGCCCCGATGTCATCACGCGCAAATGCAAGAAGGCAGTTACAGATTCTCAAAGCAATATCGTCTTTGATGAATCT
CGCGCAGGGCTGTATAATTTGCTTTGCATTTATGAGATTTTCACACAAAAAAGCCGCAAAAGCATTGAGGCAGAATTTGA
AGGCAAAGGCTATGGGCATTTAAAAATGGCTCTTGCAGAAGTCATTATAGAATCTTTGCGTCCTATTCAGCAATCCTATG
CCAAAATCAGCCAAGACAAAACCTATATCCAATCTGTGCTTACAAAAAGTGCAGATTCTATCCGCCCTATTGCAAAAAAT
ACTTATGAAAATGCTAAAAGATTAGTAGGGCTTGTATGA

Upstream 100 bases:

>100_bases
AACTTAATATCGAAGTAAAATATATAAGTGATATAAGCTAAAATTGATACAATACTGCTTTTGGAACTTAATTTCTATAA
ACTTTATTTTAAGGAATAGT

Downstream 100 bases:

>100_bases
GGATTTTTATATGTTTGCTGTGTGGCTTATGCTTTTTAAGCTGCCAATCACAAAACAAAGAGAGCAAACAGAATAGCATT
CATAATAATGCCACCTTAGA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSHTSSKKRIFSGIQPTGNIHLGNYLGAVRHWVDSQEQYENIFCVVNSHAITIRQDPQELQNKTYELAGILLACGIDTKK
SHLFIQSQIDEHAALAWILDCNIPMGDMSRMTQFKDKSNKNPKNINVGLFNYPALMAADILLYQADFVPVGEDQKQHLEL
TRDVAMRFNRDYGECFNIPEPMIPQVGARVMGLDNPQSKMSKSAQGENHAIFLLDSPDVITRKCKKAVTDSQSNIVFDES
RAGLYNLLCIYEIFTQKSRKSIEAEFEGKGYGHLKMALAEVIIESLRPIQQSYAKISQDKTYIQSVLTKSADSIRPIAKN
TYENAKRLVGLV

Sequences:

>Translated_332_residues
MSHTSSKKRIFSGIQPTGNIHLGNYLGAVRHWVDSQEQYENIFCVVNSHAITIRQDPQELQNKTYELAGILLACGIDTKK
SHLFIQSQIDEHAALAWILDCNIPMGDMSRMTQFKDKSNKNPKNINVGLFNYPALMAADILLYQADFVPVGEDQKQHLEL
TRDVAMRFNRDYGECFNIPEPMIPQVGARVMGLDNPQSKMSKSAQGENHAIFLLDSPDVITRKCKKAVTDSQSNIVFDES
RAGLYNLLCIYEIFTQKSRKSIEAEFEGKGYGHLKMALAEVIIESLRPIQQSYAKISQDKTYIQSVLTKSADSIRPIAKN
TYENAKRLVGLV
>Mature_331_residues
SHTSSKKRIFSGIQPTGNIHLGNYLGAVRHWVDSQEQYENIFCVVNSHAITIRQDPQELQNKTYELAGILLACGIDTKKS
HLFIQSQIDEHAALAWILDCNIPMGDMSRMTQFKDKSNKNPKNINVGLFNYPALMAADILLYQADFVPVGEDQKQHLELT
RDVAMRFNRDYGECFNIPEPMIPQVGARVMGLDNPQSKMSKSAQGENHAIFLLDSPDVITRKCKKAVTDSQSNIVFDESR
AGLYNLLCIYEIFTQKSRKSIEAEFEGKGYGHLKMALAEVIIESLRPIQQSYAKISQDKTYIQSVLTKSADSIRPIAKNT
YENAKRLVGLV

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=329, Percent_Identity=40.7294832826748, Blast_Score=271, Evalue=4e-73,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=50.2793296089386, Blast_Score=201, Evalue=9e-52,
Organism=Escherichia coli, GI1789786, Length=330, Percent_Identity=48.7878787878788, Blast_Score=333, Evalue=9e-93,
Organism=Caenorhabditis elegans, GI71982800, Length=330, Percent_Identity=36.6666666666667, Blast_Score=213, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI71982793, Length=330, Percent_Identity=36.6666666666667, Blast_Score=212, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6320474, Length=352, Percent_Identity=38.9204545454545, Blast_Score=212, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24666151, Length=327, Percent_Identity=40.9785932721713, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_HELHP (Q7VIP6)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860089.1
- ProteinModelPortal:   Q7VIP6
- SMR:   Q7VIP6
- GeneID:   1493612
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0558
- NMPDR:   fig|235279.1.peg.558
- HOGENOM:   HBG293263
- OMA:   NKPGVSN
- ProtClustDB:   PRK00927
- BioCyc:   HHEP235279:HH_0558-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 37421; Mature: 37290

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 202-202

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTSSKKRIFSGIQPTGNIHLGNYLGAVRHWVDSQEQYENIFCVVNSHAITIRQDPQEL
CCCCCCHHHHHHCCCCCCCEEHHHHHHHHHHHHCCHHHHCCEEEEEECCEEEEECCHHHH
QNKTYELAGILLACGIDTKKSHLFIQSQIDEHAALAWILDCNIPMGDMSRMTQFKDKSNK
HHHHHHHHHHHHEECCCCCCCEEEEEHHCCCHHEEEEEEECCCCCCHHHHHHHHHHHCCC
NPKNINVGLFNYPALMAADILLYQADFVPVGEDQKQHLELTRDVAMRFNRDYGECFNIPE
CCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCC
PMIPQVGARVMGLDNPQSKMSKSAQGENHAIFLLDSPDVITRKCKKAVTDSQSNIVFDES
CCHHHHCCEEECCCCCHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEECC
RAGLYNLLCIYEIFTQKSRKSIEAEFEGKGYGHLKMALAEVIIESLRPIQQSYAKISQDK
CCCHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYIQSVLTKSADSIRPIAKNTYENAKRLVGLV
HHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHTSSKKRIFSGIQPTGNIHLGNYLGAVRHWVDSQEQYENIFCVVNSHAITIRQDPQEL
CCCCCHHHHHHCCCCCCCEEHHHHHHHHHHHHCCHHHHCCEEEEEECCEEEEECCHHHH
QNKTYELAGILLACGIDTKKSHLFIQSQIDEHAALAWILDCNIPMGDMSRMTQFKDKSNK
HHHHHHHHHHHHEECCCCCCCEEEEEHHCCCHHEEEEEEECCCCCCHHHHHHHHHHHCCC
NPKNINVGLFNYPALMAADILLYQADFVPVGEDQKQHLELTRDVAMRFNRDYGECFNIPE
CCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCC
PMIPQVGARVMGLDNPQSKMSKSAQGENHAIFLLDSPDVITRKCKKAVTDSQSNIVFDES
CCHHHHCCEEECCCCCHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEECC
RAGLYNLLCIYEIFTQKSRKSIEAEFEGKGYGHLKMALAEVIIESLRPIQQSYAKISQDK
CCCHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYIQSVLTKSADSIRPIAKNTYENAKRLVGLV
HHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954